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The map label for this gene is lon [H]

Identifier: 59711405

GI number: 59711405

Start: 873372

End: 875726

Strand: Direct

Name: lon [H]

Synonym: VF_0798

Alternate gene names: 59711405

Gene position: 873372-875726 (Clockwise)

Preceding gene: 59711404

Following gene: 59711406

Centisome position: 30.14

GC content: 39.66

Gene sequence:

>2355_bases
ATGAACCTGGAGCGTTCCGAGCGCATCGAGATACCAGTTCTACCATTACGCGATGTTGTGGTATATCCCCACATGGTTAT
TCCATTATTCGTAGGCCGTGAAAAATCCATCCGTTGCTTAGAAGCAGCAATGGAACAAAATAAGCAAGTTTTACTTGTGG
CACAAAAAGAAGCTGCAAAAGAAGAGCCACAGTTAGATGACTTGCACGGTGTTGGTACAATTGCGACGATTTTACAGTTA
TTAAAACTACCAGACGGCACAGTAAAAGTGTTAGTTGAAGGTCAGCAAAGAGCAAAAATTCACCAGTTTCTTGAGGCTGA
TTTCTTTACTGCCGATGCTGAATTCTTGCTGACACCTGTTATTGATGATTCAGAGCAAGAAGTGATCATGCGCTCTGCAA
TTAATCAATTTGAAGGCTTCATCAAATTAAATAAAAAGATTCCACCAGAAGTGTTAACTTCATTAAACGGAATTGAAGAT
GCTGCACGTCTTGCTGACACTATTGCTGCTCATATGCCATTAAAATTGGTTGATAAGCAAGAAGTATTAGAATTAACAGA
TGTGATTGCTCGTTTAGAATATTTAATGGGCATGATGGAATCGGAGATCGATTTACTTCAAATCGAAAAACGTATTCGTG
GCCGTGTTAAAAAACAAATGGAAAAAAGCCAACGTGAGTACTATTTGAATGAGCAAATGAAAGCCATTCAGAAAGAACTG
GGCGATTTGGATGATGCGCCTGATGAGTTTGAAGCACTACAAAAGAAAATTGTAGATGCAAAAATGCCAAAAGAAGCGCA
AGAAAAAGCAGAGCAAGAGCTTCAGAAATTAAAAATGATGTCTCCAATGTCAGCTGAAGCAACGGTAGTTCGTAGCTACA
TTGATTGCATGGTTGGTGTTCCATGGCATAAACGCTCTAAAGTTAAGAAAGACTTGGCAAAAGCAGAAGAGATCTTAAAT
TCAGATCACTACGGCTTAGAGCGAGTAAAAGAACGCATTTTAGAATATTTAGCGGTTCAAAGCCGAGTAAGTAAGCTAAA
AGGTCCTATCCTTTGTTTAGTTGGACCTCCTGGTGTAGGTAAAACCTCATTAGGCCAATCTATTGCGAAAGCAACGGGAC
GTAAATACACACGTATGGCTCTTGGTGGCGTACGTGATGAAGCTGAGATTCGAGGGCATCGTCGTACTTACATTGGTTCA
TTACCAGGTAAGTTAATCCAAAAACTGTCGAAAGTTGAAGTGAAAAACCCACTTTTCCTTTTGGATGAAATTGACAAAAT
GTCATCAGACATGCGTGGTGATCCGGCATCTGCTTTATTAGAAGTGCTTGACCCTGAACAAAACAGCGCATTCAGTGATC
ACTATTTAGAAGTTGATTACGATTTGTCAGATGTCATGTTTGTTGCAACATCTAACTCAATGAATATTCCGGGTCCATTA
TTGGACCGTATGGAAGTGATTCGTTTATCGGGTTATACAGAAGATGAAAAACTGAACATCGCTAAGAATCATTTACTGAC
AAAACAGATTAAGCGTAATGGCTTAAAAGAACATGAAATTGAGATTGATGATTCAGCAATCATTGGCATTATTCGTTATT
ACACGCGTGAAGCTGGTGTTCGTAGCTTAGAGCGAGAAATCTCTAAATTATGTCGTAAAGCGGTTAAGCAGATCTTACTT
GATAAATCGATTAAGAAAGTCACGATTAATCAAGATAACCTGAAAGATTTCTTAGGCGTTCAGCGTTGTGATTACGGTAA
AGCGGATGATGAGAATCGCATTGGTCAAGTTGTTGGTTTAGCTTGGACTGAAGTTGGTGGTGATTTACTTACTATTGAAG
CTGAGTCAATGATAGGTAAAGGTAAGCTTACTTATACAGGTTCGCTTGGTGACGTAATGAAAGAGTCAATCCAAGCTGCA
ATGACCGTGGTTCGTACTCGTGCTGAAAAATTAGGTATTAATCCTGATTTCTACGAAAAACGTGATATTCACGTACACGT
ACCAGAAGGTGCAACACCAAAAGATGGTCCAAGTGCAGGCATCGGTATGTGTACAGCACTTGTTTCAAGCCTAACTGGTA
ATCCGGTTCGTTCTGATGTTGCAATGACGGGTGAAATTACACTGCGTGGTGAAGTTCTGCCTATTGGCGGTTTAAAAGAA
AAACTGTTAGCTGCACACCGTGGTGGAATTAAAACCGTGATCATTCCAAAAGAGAATGAGCGTGATTTAGAAGACATTCC
AGCGAATGTAATTGCTGATTTATCTGTTCATCCAGTTAAGTGGATTGACGAAGTTTTGACATTGGCTTTACAAAGCGACC
CATCAGGTTTTAGTGTTGAACAATCTAAAAAGTGA

Upstream 100 bases:

>100_bases
CATTGGCCTCCTTTTTTATTTTTTAATGAAAATTATATTGAATCTTAGCGACTTGCCCCCATATTATTCCTAATAGATAC
TGACGGAAAGAGAGAAGAAT

Downstream 100 bases:

>100_bases
TGTGTAGCAAAAAACGTTGATATAACAGGGCTGACAAGTCGAAATGACTTGTCACTCTATATTGATATCGTTAAGTTAGA
CTCTATTGCTGTGAAGATCA

Product: DNA-binding ATP-dependent protease Lon (La)

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 784; Mature: 784

Protein sequence:

>784_residues
MNLERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMEQNKQVLLVAQKEAAKEEPQLDDLHGVGTIATILQL
LKLPDGTVKVLVEGQQRAKIHQFLEADFFTADAEFLLTPVIDDSEQEVIMRSAINQFEGFIKLNKKIPPEVLTSLNGIED
AARLADTIAAHMPLKLVDKQEVLELTDVIARLEYLMGMMESEIDLLQIEKRIRGRVKKQMEKSQREYYLNEQMKAIQKEL
GDLDDAPDEFEALQKKIVDAKMPKEAQEKAEQELQKLKMMSPMSAEATVVRSYIDCMVGVPWHKRSKVKKDLAKAEEILN
SDHYGLERVKERILEYLAVQSRVSKLKGPILCLVGPPGVGKTSLGQSIAKATGRKYTRMALGGVRDEAEIRGHRRTYIGS
LPGKLIQKLSKVEVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNSAFSDHYLEVDYDLSDVMFVATSNSMNIPGPL
LDRMEVIRLSGYTEDEKLNIAKNHLLTKQIKRNGLKEHEIEIDDSAIIGIIRYYTREAGVRSLEREISKLCRKAVKQILL
DKSIKKVTINQDNLKDFLGVQRCDYGKADDENRIGQVVGLAWTEVGGDLLTIEAESMIGKGKLTYTGSLGDVMKESIQAA
MTVVRTRAEKLGINPDFYEKRDIHVHVPEGATPKDGPSAGIGMCTALVSSLTGNPVRSDVAMTGEITLRGEVLPIGGLKE
KLLAAHRGGIKTVIIPKENERDLEDIPANVIADLSVHPVKWIDEVLTLALQSDPSGFSVEQSKK

Sequences:

>Translated_784_residues
MNLERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMEQNKQVLLVAQKEAAKEEPQLDDLHGVGTIATILQL
LKLPDGTVKVLVEGQQRAKIHQFLEADFFTADAEFLLTPVIDDSEQEVIMRSAINQFEGFIKLNKKIPPEVLTSLNGIED
AARLADTIAAHMPLKLVDKQEVLELTDVIARLEYLMGMMESEIDLLQIEKRIRGRVKKQMEKSQREYYLNEQMKAIQKEL
GDLDDAPDEFEALQKKIVDAKMPKEAQEKAEQELQKLKMMSPMSAEATVVRSYIDCMVGVPWHKRSKVKKDLAKAEEILN
SDHYGLERVKERILEYLAVQSRVSKLKGPILCLVGPPGVGKTSLGQSIAKATGRKYTRMALGGVRDEAEIRGHRRTYIGS
LPGKLIQKLSKVEVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNSAFSDHYLEVDYDLSDVMFVATSNSMNIPGPL
LDRMEVIRLSGYTEDEKLNIAKNHLLTKQIKRNGLKEHEIEIDDSAIIGIIRYYTREAGVRSLEREISKLCRKAVKQILL
DKSIKKVTINQDNLKDFLGVQRCDYGKADDENRIGQVVGLAWTEVGGDLLTIEAESMIGKGKLTYTGSLGDVMKESIQAA
MTVVRTRAEKLGINPDFYEKRDIHVHVPEGATPKDGPSAGIGMCTALVSSLTGNPVRSDVAMTGEITLRGEVLPIGGLKE
KLLAAHRGGIKTVIIPKENERDLEDIPANVIADLSVHPVKWIDEVLTLALQSDPSGFSVEQSKK
>Mature_784_residues
MNLERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMEQNKQVLLVAQKEAAKEEPQLDDLHGVGTIATILQL
LKLPDGTVKVLVEGQQRAKIHQFLEADFFTADAEFLLTPVIDDSEQEVIMRSAINQFEGFIKLNKKIPPEVLTSLNGIED
AARLADTIAAHMPLKLVDKQEVLELTDVIARLEYLMGMMESEIDLLQIEKRIRGRVKKQMEKSQREYYLNEQMKAIQKEL
GDLDDAPDEFEALQKKIVDAKMPKEAQEKAEQELQKLKMMSPMSAEATVVRSYIDCMVGVPWHKRSKVKKDLAKAEEILN
SDHYGLERVKERILEYLAVQSRVSKLKGPILCLVGPPGVGKTSLGQSIAKATGRKYTRMALGGVRDEAEIRGHRRTYIGS
LPGKLIQKLSKVEVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNSAFSDHYLEVDYDLSDVMFVATSNSMNIPGPL
LDRMEVIRLSGYTEDEKLNIAKNHLLTKQIKRNGLKEHEIEIDDSAIIGIIRYYTREAGVRSLEREISKLCRKAVKQILL
DKSIKKVTINQDNLKDFLGVQRCDYGKADDENRIGQVVGLAWTEVGGDLLTIEAESMIGKGKLTYTGSLGDVMKESIQAA
MTVVRTRAEKLGINPDFYEKRDIHVHVPEGATPKDGPSAGIGMCTALVSSLTGNPVRSDVAMTGEITLRGEVLPIGGLKE
KLLAAHRGGIKTVIIPKENERDLEDIPANVIADLSVHPVKWIDEVLTLALQSDPSGFSVEQSKK

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=787, Percent_Identity=40.1524777636595, Blast_Score=524, Evalue=1e-148,
Organism=Homo sapiens, GI21396489, Length=624, Percent_Identity=41.5064102564103, Blast_Score=497, Evalue=1e-140,
Organism=Escherichia coli, GI1786643, Length=784, Percent_Identity=82.780612244898, Blast_Score=1311, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=702, Percent_Identity=38.1766381766382, Blast_Score=479, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI17556486, Length=797, Percent_Identity=33.8770388958595, Blast_Score=431, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6319449, Length=675, Percent_Identity=40.5925925925926, Blast_Score=492, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24666867, Length=620, Percent_Identity=44.6774193548387, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI221513036, Length=620, Percent_Identity=44.6774193548387, Blast_Score=517, Evalue=1e-147,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87474; Mature: 87474

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMEQNKQVLLVAQKEAAK
CCCCCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEEHHHCC
EEPQLDDLHGVGTIATILQLLKLPDGTVKVLVEGQQRAKIHQFLEADFFTADAEFLLTPV
CCCCCHHHCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCEEEECC
IDDSEQEVIMRSAINQFEGFIKLNKKIPPEVLTSLNGIEDAARLADTIAAHMPLKLVDKQ
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCHHHCCHH
EVLELTDVIARLEYLMGMMESEIDLLQIEKRIRGRVKKQMEKSQREYYLNEQMKAIQKEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GDLDDAPDEFEALQKKIVDAKMPKEAQEKAEQELQKLKMMSPMSAEATVVRSYIDCMVGV
CCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
PWHKRSKVKKDLAKAEEILNSDHYGLERVKERILEYLAVQSRVSKLKGPILCLVGPPGVG
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
KTSLGQSIAKATGRKYTRMALGGVRDEAEIRGHRRTYIGSLPGKLIQKLSKVEVKNPLFL
HHHHHHHHHHHHCCHHHHHHHCCCCCHHHHCCCHHHHHHCCHHHHHHHHHHHHHCCCCHH
LDEIDKMSSDMRGDPASALLEVLDPEQNSAFSDHYLEVDYDLSDVMFVATSNSMNIPGPL
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCHHH
LDRMEVIRLSGYTEDEKLNIAKNHLLTKQIKRNGLKEHEIEIDDSAIIGIIRYYTREAGV
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHH
RSLEREISKLCRKAVKQILLDKSIKKVTINQDNLKDFLGVQRCDYGKADDENRIGQVVGL
HHHHHHHHHHHHHHHHHHHHHCCHHEEECCHHHHHHHHCCHHCCCCCCCCCHHHHHHHHH
AWTEVGGDLLTIEAESMIGKGKLTYTGSLGDVMKESIQAAMTVVRTRAEKLGINPDFYEK
HHHHCCCCEEEEEHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RDIHVHVPEGATPKDGPSAGIGMCTALVSSLTGNPVRSDVAMTGEITLRGEVLPIGGLKE
CCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECEEEECCCHHH
KLLAAHRGGIKTVIIPKENERDLEDIPANVIADLSVHPVKWIDEVLTLALQSDPSGFSVE
HHHHHHCCCCEEEEECCCCCCCHHHCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCC
QSKK
CCCC
>Mature Secondary Structure
MNLERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMEQNKQVLLVAQKEAAK
CCCCCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEEHHHCC
EEPQLDDLHGVGTIATILQLLKLPDGTVKVLVEGQQRAKIHQFLEADFFTADAEFLLTPV
CCCCCHHHCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCEEEECC
IDDSEQEVIMRSAINQFEGFIKLNKKIPPEVLTSLNGIEDAARLADTIAAHMPLKLVDKQ
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCHHHCCHH
EVLELTDVIARLEYLMGMMESEIDLLQIEKRIRGRVKKQMEKSQREYYLNEQMKAIQKEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GDLDDAPDEFEALQKKIVDAKMPKEAQEKAEQELQKLKMMSPMSAEATVVRSYIDCMVGV
CCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
PWHKRSKVKKDLAKAEEILNSDHYGLERVKERILEYLAVQSRVSKLKGPILCLVGPPGVG
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
KTSLGQSIAKATGRKYTRMALGGVRDEAEIRGHRRTYIGSLPGKLIQKLSKVEVKNPLFL
HHHHHHHHHHHHCCHHHHHHHCCCCCHHHHCCCHHHHHHCCHHHHHHHHHHHHHCCCCHH
LDEIDKMSSDMRGDPASALLEVLDPEQNSAFSDHYLEVDYDLSDVMFVATSNSMNIPGPL
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCHHH
LDRMEVIRLSGYTEDEKLNIAKNHLLTKQIKRNGLKEHEIEIDDSAIIGIIRYYTREAGV
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHH
RSLEREISKLCRKAVKQILLDKSIKKVTINQDNLKDFLGVQRCDYGKADDENRIGQVVGL
HHHHHHHHHHHHHHHHHHHHHCCHHEEECCHHHHHHHHCCHHCCCCCCCCCHHHHHHHHH
AWTEVGGDLLTIEAESMIGKGKLTYTGSLGDVMKESIQAAMTVVRTRAEKLGINPDFYEK
HHHHCCCCEEEEEHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RDIHVHVPEGATPKDGPSAGIGMCTALVSSLTGNPVRSDVAMTGEITLRGEVLPIGGLKE
CCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECEEEECCCHHH
KLLAAHRGGIKTVIIPKENERDLEDIPANVIADLSVHPVKWIDEVLTLALQSDPSGFSVE
HHHHHHCCCCEEEEECCCCCCCHHHCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCC
QSKK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]