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The map label for this gene is nanT [H]

Identifier: 59711275

GI number: 59711275

Start: 731756

End: 733273

Strand: Direct

Name: nanT [H]

Synonym: VF_0668

Alternate gene names: 59711275

Gene position: 731756-733273 (Clockwise)

Preceding gene: 59711274

Following gene: 59711276

Centisome position: 25.25

GC content: 38.93

Gene sequence:

>1518_bases
ATGGAAGCACAATCATTTGGTACATTAAATTACATTGCTCTCTTTGCCTATCTAGGGGCAATTATGGCAGTGGGTGTTTA
TTTTGCTCGTCGTCAAAAGTCAGCTGATGATTACTTTAAAGCTGGGGGAAGGATCCCCGGTTGGGCTGCTGGTTTCAGTG
TATTTGCAACAACTTTAAGCTCTATTACCTTTATGTCTATTCCGGCAAAAGCGTATACAAGTGACTGGACTTTCTTAATT
GGTCAGTATGTCGCTATTGCTATTCTTCCTATCGTTTTTTGGTTCTATATTCCCTTTTTTAGAAAGCTAAATCTGACTTC
TGTATATGAATACTTAGAAAGACGTTTTGATGTAAGAATGCGCTTATTCGGTAGTATTTCTTTCATGCTTTTCCATATTG
GTCGTATTGCTATTGTTACCTATTTAACGGCGTTGGCGTTAATGCCATTCATTGATATTAGCCCGTTAATGATTGTGTTC
TTAATTGGTGTTCTTTGTATTATTTATACCTTCCTTGGTGGTATCGAAGGGGTAATTTGGACCGATGTAATTCAAGGTGT
AATGCTTTCTGTTGCTGCCATTCTTATCTTTGTTGTTATTTGCTTTAATGTGGATGGCGGTATTGTTGAAGTGTTTAGCA
TGTCGAACCAAGCGGATAAATATTTCCCTGCAGAGCAATTTAGCTGGAGCTGGACGGACAGTACGATTCCAGTATTAATG
ATTGGTTTCTTCTTTGCTTCATTACAACAATTTACAGCGAGCCAAGATGTGGTTCAGCGCTACATTGTGACTGACAATAT
TGATGAGACTAAAAAAGCATTGATCACTAATGCGAAATTAGTGGCTTGTGTTCCTATTTTCTTCTTCGCTGTAGGTTCTG
CATTATTTGCTTACTACACTCAAAATCCAGAGCTGCTTCCTGAGAACTTTAACACGGGCGGTATTCTACCTTTCTACGTT
ATTTCTCAAATGCCTGTTGGGGTTGCTGGTCTAATTATCGCAGCGATATTTGCAGCGTCACAATCAAGTATTTCAAGTAG
TTTAAATAGTATTGCAGCGTGTTTTACTTCTGACATTTATGAAAAAGTGAGCAAGAACCCAACCTCAGAGCAGAAGCTAA
GAATTGGTCGAACACTAACTGTTGTTGCTGGTCTTTTAGGTGTCGTCGCTTCAACATACTTAATTATGTCTAACGAAAGT
GAAATTTGGGATGCGTTCAATAGCTTACTTGGCTTAATGGGTGGCCCAATGACAGGACTATTTATGCTTGGTATCTTTGT
TCGTCGTGCAAATGCAAACAGTGCGTTATTAGGTGTAGTTGCAAGTATCGCTACCGTACTGTGGGTTCGCTCTGCAACAG
ATTTAAACTTCTTCTTCTATGGTGTTATCGGTACTTTGATGGTGGTTATTGTGGGTTACCTAACCGCACCAATGTTTAAG
AATAATTTAAACAGTGATGAAATTGATGAGCTAAGTGCAACAAAAGAAAAGCGTTCAACCACTGCTGAAAAAGCGTAA

Upstream 100 bases:

>100_bases
GATTGATTGGTGTCGCTCATTGGGCTAGCAAAATACGTTAAAAAAGAACTTCTAAGAAATAGTAATTTAACCCTACAAAA
ATTATACAAGGTATATTCCG

Downstream 100 bases:

>100_bases
TTGATAATTGAGTTTGAGCCTTTGTTTTTATAAAGGCTCTTTTAAGGACAGTGTTATGATTTATGGTCATATTGAGCACC
AAAAAACAAATCAGTATTTA

Product: N-acetylneuraminate transporter, sodium-glucose/galactose cotransporter

Products: NA

Alternate protein names: Na(+)/glucose symporter [H]

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MEAQSFGTLNYIALFAYLGAIMAVGVYFARRQKSADDYFKAGGRIPGWAAGFSVFATTLSSITFMSIPAKAYTSDWTFLI
GQYVAIAILPIVFWFYIPFFRKLNLTSVYEYLERRFDVRMRLFGSISFMLFHIGRIAIVTYLTALALMPFIDISPLMIVF
LIGVLCIIYTFLGGIEGVIWTDVIQGVMLSVAAILIFVVICFNVDGGIVEVFSMSNQADKYFPAEQFSWSWTDSTIPVLM
IGFFFASLQQFTASQDVVQRYIVTDNIDETKKALITNAKLVACVPIFFFAVGSALFAYYTQNPELLPENFNTGGILPFYV
ISQMPVGVAGLIIAAIFAASQSSISSSLNSIAACFTSDIYEKVSKNPTSEQKLRIGRTLTVVAGLLGVVASTYLIMSNES
EIWDAFNSLLGLMGGPMTGLFMLGIFVRRANANSALLGVVASIATVLWVRSATDLNFFFYGVIGTLMVVIVGYLTAPMFK
NNLNSDEIDELSATKEKRSTTAEKA

Sequences:

>Translated_505_residues
MEAQSFGTLNYIALFAYLGAIMAVGVYFARRQKSADDYFKAGGRIPGWAAGFSVFATTLSSITFMSIPAKAYTSDWTFLI
GQYVAIAILPIVFWFYIPFFRKLNLTSVYEYLERRFDVRMRLFGSISFMLFHIGRIAIVTYLTALALMPFIDISPLMIVF
LIGVLCIIYTFLGGIEGVIWTDVIQGVMLSVAAILIFVVICFNVDGGIVEVFSMSNQADKYFPAEQFSWSWTDSTIPVLM
IGFFFASLQQFTASQDVVQRYIVTDNIDETKKALITNAKLVACVPIFFFAVGSALFAYYTQNPELLPENFNTGGILPFYV
ISQMPVGVAGLIIAAIFAASQSSISSSLNSIAACFTSDIYEKVSKNPTSEQKLRIGRTLTVVAGLLGVVASTYLIMSNES
EIWDAFNSLLGLMGGPMTGLFMLGIFVRRANANSALLGVVASIATVLWVRSATDLNFFFYGVIGTLMVVIVGYLTAPMFK
NNLNSDEIDELSATKEKRSTTAEKA
>Mature_505_residues
MEAQSFGTLNYIALFAYLGAIMAVGVYFARRQKSADDYFKAGGRIPGWAAGFSVFATTLSSITFMSIPAKAYTSDWTFLI
GQYVAIAILPIVFWFYIPFFRKLNLTSVYEYLERRFDVRMRLFGSISFMLFHIGRIAIVTYLTALALMPFIDISPLMIVF
LIGVLCIIYTFLGGIEGVIWTDVIQGVMLSVAAILIFVVICFNVDGGIVEVFSMSNQADKYFPAEQFSWSWTDSTIPVLM
IGFFFASLQQFTASQDVVQRYIVTDNIDETKKALITNAKLVACVPIFFFAVGSALFAYYTQNPELLPENFNTGGILPFYV
ISQMPVGVAGLIIAAIFAASQSSISSSLNSIAACFTSDIYEKVSKNPTSEQKLRIGRTLTVVAGLLGVVASTYLIMSNES
EIWDAFNSLLGLMGGPMTGLFMLGIFVRRANANSALLGVVASIATVLWVRSATDLNFFFYGVIGTLMVVIVGYLTAPMFK
NNLNSDEIDELSATKEKRSTTAEKA

Specific function: Actively transports glucose into cells by Na(+) cotransport [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI256985183, Length=467, Percent_Identity=28.051391862955, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI167466278, Length=460, Percent_Identity=29.7826086956522, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI4507035, Length=466, Percent_Identity=26.8240343347639, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI157671931, Length=470, Percent_Identity=26.3829787234043, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI14140236, Length=479, Percent_Identity=23.3820459290188, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI4507031, Length=455, Percent_Identity=25.2747252747253, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI109659836, Length=480, Percent_Identity=23.9583333333333, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI109659839, Length=490, Percent_Identity=23.0612244897959, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI17941285, Length=447, Percent_Identity=23.9373601789709, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI206597483, Length=447, Percent_Identity=23.0425055928412, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI110835708, Length=459, Percent_Identity=22.8758169934641, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI206597487, Length=374, Percent_Identity=23.5294117647059, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI4507033, Length=458, Percent_Identity=21.8340611353712, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1790113, Length=473, Percent_Identity=21.3530655391121, Blast_Score=82, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI115533094, Length=457, Percent_Identity=26.4770240700219, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI32566512, Length=363, Percent_Identity=26.4462809917355, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI115533096, Length=316, Percent_Identity=27.2151898734177, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24645928, Length=466, Percent_Identity=30.0429184549356, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24651739, Length=464, Percent_Identity=27.3706896551724, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI221459584, Length=469, Percent_Identity=28.7846481876333, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI221459588, Length=586, Percent_Identity=26.2798634812287, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI28573698, Length=444, Percent_Identity=26.5765765765766, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI221459586, Length=478, Percent_Identity=26.9874476987448, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI281362918, Length=467, Percent_Identity=26.9807280513919, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24640370, Length=484, Percent_Identity=26.4462809917355, Blast_Score=145, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24651741, Length=452, Percent_Identity=26.5486725663717, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI281362054, Length=458, Percent_Identity=27.292576419214, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI281362052, Length=458, Percent_Identity=27.292576419214, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI281362050, Length=458, Percent_Identity=27.292576419214, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24648056, Length=458, Percent_Identity=27.292576419214, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI21356827, Length=458, Percent_Identity=27.292576419214, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24641117, Length=457, Percent_Identity=27.7899343544858, Blast_Score=138, Evalue=7e-33,
Organism=Drosophila melanogaster, GI28574994, Length=454, Percent_Identity=26.8722466960352, Blast_Score=135, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24650192, Length=499, Percent_Identity=24.6492985971944, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI221459582, Length=483, Percent_Identity=27.3291925465839, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI161076631, Length=506, Percent_Identity=26.4822134387352, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI221379702, Length=478, Percent_Identity=24.8953974895398, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI281364280, Length=494, Percent_Identity=24.0890688259109, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI19920916, Length=494, Percent_Identity=26.5182186234818, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 55565; Mature: 55565

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure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CCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8652595; 10835424; 10757971 [H]