Click here to switch to the map view.

The map label for this gene is hscB

Identifier: 59711227

GI number: 59711227

Start: 676674

End: 677189

Strand: Direct

Name: hscB

Synonym: VF_0620

Alternate gene names: 59711227

Gene position: 676674-677189 (Clockwise)

Preceding gene: 59711226

Following gene: 59711228

Centisome position: 23.35

GC content: 37.21

Gene sequence:

>516_bases
ATGAATCATTTTGAATTATTTGGGCTACCGAACCAGTTTGAACTGGATGGTGGCCTTCTTTCTCTTCAATTTAGAGAGTT
GCAAAAACGCTTTCATCCAGATAATTTTGCAACATCTTCAGAGCGTGACCGTTTACTTTCCATTCAAAAAGCTGCGCAAA
TTAATGATGCGTATCAAACATTAAAAAATCCAGTATCACGAGCTGAATACATACTTTCAGAGCAAGGTCATGATATTCGT
GGTGAGCAAACCACAATGCAAGATCCTATGTTTTTAATGCAACAAATGGAACTGCGTGAAGAGTTAGAGTCATTACCATC
AAGCTCAGATCCTGAAAGTGCTTTGTTTGATTTTGCTGAGAATGTAACAGCAATGCGTAAATCACAGTTAGTTCAACTGC
AAGAACTATTGAAAAACGAAGCATGGATTGAAGCCGCTCAGAGCGTTCGAAAGCTCAAATTTATTGAAAAACTGAATCAA
GAAGTTGAGCAGTTAGAAGAGAAATTATTAGGTTAA

Upstream 100 bases:

>100_bases
AAAAGAAGGTCTAAATGAAGGCTTTAAATTCAACAACCCGAACGTAAAAAGTGAATGTGGGTGTGGTGAAAGCTTCAACG
TATAGAGCAAAACATTACTT

Downstream 100 bases:

>100_bases
CTCTTTTTGGGTTAATGAGATAAACGAAGGATACTTTCATGTTATTACAGATTGCTGAACCAGGACAAAGTGCTGTACCG
CACCAACATAAACTGGCGGT

Product: co-chaperone HscB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MNHFELFGLPNQFELDGGLLSLQFRELQKRFHPDNFATSSERDRLLSIQKAAQINDAYQTLKNPVSRAEYILSEQGHDIR
GEQTTMQDPMFLMQQMELREELESLPSSSDPESALFDFAENVTAMRKSQLVQLQELLKNEAWIEAAQSVRKLKFIEKLNQ
EVEQLEEKLLG

Sequences:

>Translated_171_residues
MNHFELFGLPNQFELDGGLLSLQFRELQKRFHPDNFATSSERDRLLSIQKAAQINDAYQTLKNPVSRAEYILSEQGHDIR
GEQTTMQDPMFLMQQMELREELESLPSSSDPESALFDFAENVTAMRKSQLVQLQELLKNEAWIEAAQSVRKLKFIEKLNQ
EVEQLEEKLLG
>Mature_171_residues
MNHFELFGLPNQFELDGGLLSLQFRELQKRFHPDNFATSSERDRLLSIQKAAQINDAYQTLKNPVSRAEYILSEQGHDIR
GEQTTMQDPMFLMQQMELREELESLPSSSDPESALFDFAENVTAMRKSQLVQLQELLKNEAWIEAAQSVRKLKFIEKLNQ
EVEQLEEKLLG

Specific function: Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward hscA

COG id: COG1076

COG function: function code O; DnaJ-domain-containing proteins 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 J domain

Homologues:

Organism=Homo sapiens, GI50301234, Length=162, Percent_Identity=25.3086419753086, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1788876, Length=170, Percent_Identity=47.6470588235294, Blast_Score=159, Evalue=8e-41,
Organism=Drosophila melanogaster, GI161084223, Length=171, Percent_Identity=26.3157894736842, Blast_Score=73, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HSCB_VIBF1 (Q5E781)

Other databases:

- EMBL:   CP000020
- RefSeq:   YP_204003.1
- ProteinModelPortal:   Q5E781
- SMR:   Q5E781
- STRING:   Q5E781
- GeneID:   3277802
- GenomeReviews:   CP000020_GR
- KEGG:   vfi:VF_0620
- NMPDR:   fig|312309.3.peg.1108
- eggNOG:   COG1076
- HOGENOM:   HBG751004
- OMA:   LNDAYQT
- PhylomeDB:   Q5E781
- ProtClustDB:   PRK05014
- BioCyc:   VFIS312309:VF0620-MONOMER
- HAMAP:   MF_00682
- InterPro:   IPR001623
- InterPro:   IPR009073
- InterPro:   IPR004640
- InterPro:   IPR015609
- Gene3D:   G3DSA:1.10.287.110
- Gene3D:   G3DSA:1.20.1280.20
- PANTHER:   PTHR11821
- SMART:   SM00271
- TIGRFAMs:   TIGR00714

Pfam domain/function: PF00226 DnaJ; PF07743 HSCB_C; SSF46565 DnaJ_N; SSF47144 HSC20_C

EC number: NA

Molecular weight: Translated: 19832; Mature: 19832

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00636 DNAJ_1; PS50076 DNAJ_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHFELFGLPNQFELDGGLLSLQFRELQKRFHPDNFATSSERDRLLSIQKAAQINDAYQT
CCCCCCCCCCCCEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LKNPVSRAEYILSEQGHDIRGEQTTMQDPMFLMQQMELREELESLPSSSDPESALFDFAE
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
NVTAMRKSQLVQLQELLKNEAWIEAAQSVRKLKFIEKLNQEVEQLEEKLLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNHFELFGLPNQFELDGGLLSLQFRELQKRFHPDNFATSSERDRLLSIQKAAQINDAYQT
CCCCCCCCCCCCEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LKNPVSRAEYILSEQGHDIRGEQTTMQDPMFLMQQMELREELESLPSSSDPESALFDFAE
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
NVTAMRKSQLVQLQELLKNEAWIEAAQSVRKLKFIEKLNQEVEQLEEKLLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA