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The map label for this gene is deoA [H]

Identifier: 59711112

GI number: 59711112

Start: 542171

End: 543502

Strand: Direct

Name: deoA [H]

Synonym: VF_0505

Alternate gene names: 59711112

Gene position: 542171-543502 (Clockwise)

Preceding gene: 59711111

Following gene: 59711113

Centisome position: 18.71

GC content: 41.29

Gene sequence:

>1332_bases
ATGTATCTACCACAAGAGATTATTCGCAAAAAACGTGACAATAAAGAGCTAACAGCAGAAGAAATTAACTTCTTTATTCA
AGGCGTAGCAAAAGAAACCGTTTCAGAAGGCCAAATTGCAGCGTTTGCAATGGCGGTATATTTTAATGAAATGACGATGC
CTGAACGTATCGCATTGACTTGTGCTATGCGTGATTCTGGTATGGTTATCGATTGGAGCCACATGAACTTTGATGGCCCA
ATTGTTGATAAACACTCAACAGGTGGTGTTGGTGATGTAACTTCATTAATGCTTGGCCCTATGGTTGCAGCATGTGGCGG
TTATGTACCAATGATCTCTGGTCGTGGTTTAGGTCACACTGGTGGTACGCTTGATAAATTAGAATCGATTGCGGGTTATA
ACATTACTCCGAGTAACGATGTATTTGGAAAAGTAACTAAGGAAGCGGGTGTTGCTATTATTGGTCAGACTGGAGACCTA
GCACCTGCGGATAAGCGTGTTTATGCGACTCGTGATGTAACGGCTACAGTGGATAATATTTCATTAATCACTGCGTCTAT
TTTATCTAAGAAATTAGCGGCTGGTTTAGATTCTCTTGTTATGGACGTAAAAGTAGGTTCTGGCGCATTTATGCCAACTT
ACGAAGCATCAGAAGAGTTAGCTAAATCAATCGTAGCGGTAGCAAATGGTGCTGGTACTAAAACGACAGCATTGCTTACT
GATATGAACCAAGTACTAGCTTCAACAGCAGGTAACGCATTAGAAGTTCGTGAAGCGATTCGTTTCTTAACTGGTGAGTA
CCGCAATCCTCGTTTATATGAAGTAACAATGGCACTTTGTGCTGAAATGCTAGTGATTGCTAACTTAGCAAAAGATGAGC
AAGACGCTCGTGCTAAATTACAAACAGTATTAGATAACGGTAAAGCAGCAGAGTGTTTTGGTAAAATGGTCTTTGGTCTT
GGTGGACCAAGCGATATTATCGAAAATTACGATAATCATTTAGAAAGCGCACAAATCATTAAACCTGTTTTTGCTGATAC
AACGGGTTTTGTTCAGGCAATGGATACACGTGATTTAGGCATGGCTGTTGTAGGAATGGGTGGTGGTCGCCGTGTTGCTA
GCGATACGATCGATTATGCTGTAGGGTTAAGCGATATGATTCGTTTAGGTCAAACTGCGGATAATCAACAACCACTTGCA
ATGATTCATGCTCGTAATGAAGAGCAATGGCAACAAGCTGCCAATGCAGTAAAAGCAGCGATTGTGATTAGTGAGAAACA
ACCAGAAGCGACTCCTGAAGTTTACCGTAAAATTCGCCCTGAAGATGTGTAA

Upstream 100 bases:

>100_bases
TTTATAGCTAAGAAATAAATCGACTTAGGTGAGACATACTCGTCTCACCTACCTCAACCCTACCTATTTTAATTACCCAA
CCAAGATTGGGGAGGCACTA

Downstream 100 bases:

>100_bases
GGAATAAAACATGAAACGTGCAATAATTTTAGTTCTCGATTCATTTGGAATTGGTGCAGCAGGCGATGCTGATAAATTTG
GTGATGTAGGTTCAGATACG

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MYLPQEIIRKKRDNKELTAEEINFFIQGVAKETVSEGQIAAFAMAVYFNEMTMPERIALTCAMRDSGMVIDWSHMNFDGP
IVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLESIAGYNITPSNDVFGKVTKEAGVAIIGQTGDL
APADKRVYATRDVTATVDNISLITASILSKKLAAGLDSLVMDVKVGSGAFMPTYEASEELAKSIVAVANGAGTKTTALLT
DMNQVLASTAGNALEVREAIRFLTGEYRNPRLYEVTMALCAEMLVIANLAKDEQDARAKLQTVLDNGKAAECFGKMVFGL
GGPSDIIENYDNHLESAQIIKPVFADTTGFVQAMDTRDLGMAVVGMGGGRRVASDTIDYAVGLSDMIRLGQTADNQQPLA
MIHARNEEQWQQAANAVKAAIVISEKQPEATPEVYRKIRPEDV

Sequences:

>Translated_443_residues
MYLPQEIIRKKRDNKELTAEEINFFIQGVAKETVSEGQIAAFAMAVYFNEMTMPERIALTCAMRDSGMVIDWSHMNFDGP
IVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLESIAGYNITPSNDVFGKVTKEAGVAIIGQTGDL
APADKRVYATRDVTATVDNISLITASILSKKLAAGLDSLVMDVKVGSGAFMPTYEASEELAKSIVAVANGAGTKTTALLT
DMNQVLASTAGNALEVREAIRFLTGEYRNPRLYEVTMALCAEMLVIANLAKDEQDARAKLQTVLDNGKAAECFGKMVFGL
GGPSDIIENYDNHLESAQIIKPVFADTTGFVQAMDTRDLGMAVVGMGGGRRVASDTIDYAVGLSDMIRLGQTADNQQPLA
MIHARNEEQWQQAANAVKAAIVISEKQPEATPEVYRKIRPEDV
>Mature_443_residues
MYLPQEIIRKKRDNKELTAEEINFFIQGVAKETVSEGQIAAFAMAVYFNEMTMPERIALTCAMRDSGMVIDWSHMNFDGP
IVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLESIAGYNITPSNDVFGKVTKEAGVAIIGQTGDL
APADKRVYATRDVTATVDNISLITASILSKKLAAGLDSLVMDVKVGSGAFMPTYEASEELAKSIVAVANGAGTKTTALLT
DMNQVLASTAGNALEVREAIRFLTGEYRNPRLYEVTMALCAEMLVIANLAKDEQDARAKLQTVLDNGKAAECFGKMVFGL
GGPSDIIENYDNHLESAQIIKPVFADTTGFVQAMDTRDLGMAVVGMGGGRRVASDTIDYAVGLSDMIRLGQTADNQQPLA
MIHARNEEQWQQAANAVKAAIVISEKQPEATPEVYRKIRPEDV

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis [H]

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=445, Percent_Identity=37.752808988764, Blast_Score=266, Evalue=4e-71,
Organism=Homo sapiens, GI4503445, Length=445, Percent_Identity=37.752808988764, Blast_Score=266, Evalue=4e-71,
Organism=Homo sapiens, GI166158922, Length=445, Percent_Identity=37.752808988764, Blast_Score=266, Evalue=4e-71,
Organism=Escherichia coli, GI1790842, Length=438, Percent_Identity=71.2328767123288, Blast_Score=642, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013465 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 47445; Mature: 47445

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLPQEIIRKKRDNKELTAEEINFFIQGVAKETVSEGQIAAFAMAVYFNEMTMPERIALT
CCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEE
CAMRDSGMVIDWSHMNFDGPIVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHT
EEECCCCCEEEECCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCC
GGTLDKLESIAGYNITPSNDVFGKVTKEAGVAIIGQTGDLAPADKRVYATRDVTATVDNI
CCCHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCEEEECCCEEEHHHH
SLITASILSKKLAAGLDSLVMDVKVGSGAFMPTYEASEELAKSIVAVANGAGTKTTALLT
HHHHHHHHHHHHHHCHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
DMNQVLASTAGNALEVREAIRFLTGEYRNPRLYEVTMALCAEMLVIANLAKDEQDARAKL
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QTVLDNGKAAECFGKMVFGLGGPSDIIENYDNHLESAQIIKPVFADTTGFVQAMDTRDLG
HHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCCCC
MAVVGMGGGRRVASDTIDYAVGLSDMIRLGQTADNQQPLAMIHARNEEQWQQAANAVKAA
EEEEECCCCCCHHHHHHHHHHCHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHEEE
IVISEKQPEATPEVYRKIRPEDV
EEEECCCCCCCHHHHHHCCCCCC
>Mature Secondary Structure
MYLPQEIIRKKRDNKELTAEEINFFIQGVAKETVSEGQIAAFAMAVYFNEMTMPERIALT
CCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEE
CAMRDSGMVIDWSHMNFDGPIVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHT
EEECCCCCEEEECCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCC
GGTLDKLESIAGYNITPSNDVFGKVTKEAGVAIIGQTGDLAPADKRVYATRDVTATVDNI
CCCHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCEEEECCCEEEHHHH
SLITASILSKKLAAGLDSLVMDVKVGSGAFMPTYEASEELAKSIVAVANGAGTKTTALLT
HHHHHHHHHHHHHHCHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
DMNQVLASTAGNALEVREAIRFLTGEYRNPRLYEVTMALCAEMLVIANLAKDEQDARAKL
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QTVLDNGKAAECFGKMVFGLGGPSDIIENYDNHLESAQIIKPVFADTTGFVQAMDTRDLG
HHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCCCC
MAVVGMGGGRRVASDTIDYAVGLSDMIRLGQTADNQQPLAMIHARNEEQWQQAANAVKAA
EEEEECCCCCCHHHHHHHHHHCHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHEEE
IVISEKQPEATPEVYRKIRPEDV
EEEECCCCCCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA