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The map label for this gene is fkpB [H]

Identifier: 59711076

GI number: 59711076

Start: 501852

End: 502280

Strand: Direct

Name: fkpB [H]

Synonym: VF_0469

Alternate gene names: 59711076

Gene position: 501852-502280 (Clockwise)

Preceding gene: 59711075

Following gene: 59711077

Centisome position: 17.32

GC content: 38.69

Gene sequence:

>429_bases
ATGAAAATAGAAAATAACAGTGAAGTTACCCTACATTTCACCATAAAATTAAAAGATGGCTCTGTTGCGGATAGTACACA
TAGTTCAGGTAAACCAGCAAAATTTACTATGGGTGATGGTAGCCTAAGTGAAAATTTTGAGAAATGTTTACTTGGTTTAG
AAGCCGAGCAAGCTAAAAGTATTGAATTATGTGCTGAAGATGCATTTGGCCTTCCAAACCCTGATAATATCCATCATATG
GATAGAAATCGCTTTGTAGGTGATGCAGCGGCTGAAGTCGGAACTATTATGGCCTTTAGTGGCCCTGATGGAATGGATAT
TCCAGGCATCATAACAGAGATTGCTGGTGACTCAGTGACAGTTGATTTTAATCACCCATTAGCGGGTCAAGATGTTATCT
TTGATGTAGAGATTGTAGCGGTTGGTTAA

Upstream 100 bases:

>100_bases
GTCTCCGCTCTGGTAAAAAAGAGCAATAAAACTCATAGAGCATAATCAATGAACGCTACCCGAGCAGTCGAGTGGCGTTT
TTTTTCAAGGAAAGATTGAA

Downstream 100 bases:

>100_bases
TCCAACACAATAAAGAGAAAGAAAATGAAAATAGTATTAGCTAATCCTCGTGGTTTTTGTGCCGGTGTTGATCGTGCCAT
TAGCATTGTTGAGCGTGCTT

Product: FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase)

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 142; Mature: 142

Protein sequence:

>142_residues
MKIENNSEVTLHFTIKLKDGSVADSTHSSGKPAKFTMGDGSLSENFEKCLLGLEAEQAKSIELCAEDAFGLPNPDNIHHM
DRNRFVGDAAAEVGTIMAFSGPDGMDIPGIITEIAGDSVTVDFNHPLAGQDVIFDVEIVAVG

Sequences:

>Translated_142_residues
MKIENNSEVTLHFTIKLKDGSVADSTHSSGKPAKFTMGDGSLSENFEKCLLGLEAEQAKSIELCAEDAFGLPNPDNIHHM
DRNRFVGDAAAEVGTIMAFSGPDGMDIPGIITEIAGDSVTVDFNHPLAGQDVIFDVEIVAVG
>Mature_142_residues
MKIENNSEVTLHFTIKLKDGSVADSTHSSGKPAKFTMGDGSLSENFEKCLLGLEAEQAKSIELCAEDAFGLPNPDNIHHM
DRNRFVGDAAAEVGTIMAFSGPDGMDIPGIITEIAGDSVTVDFNHPLAGQDVIFDVEIVAVG

Specific function: PPIases accelerate the folding of proteins. Substrate specificity carried out with 'Suc-Ala-Xaa-Pro-Phe-4-nitroanilide', where Xaa is the amino acid tested, was found to be Phe > Leu >> Ile > Lys = Ala > Trp > His >> Gln [H]

COG id: COG1047

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI1786211, Length=139, Percent_Identity=49.6402877697842, Blast_Score=147, Evalue=2e-37,
Organism=Escherichia coli, GI1789748, Length=141, Percent_Identity=31.2056737588652, Blast_Score=67, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 15063; Mature: 15063

Theoretical pI: Translated: 4.15; Mature: 4.15

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIENNSEVTLHFTIKLKDGSVADSTHSSGKPAKFTMGDGSLSENFEKCLLGLEAEQAKS
CCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCC
IELCAEDAFGLPNPDNIHHMDRNRFVGDAAAEVGTIMAFSGPDGMDIPGIITEIAGDSVT
EEEEHHCCCCCCCCCCCEECCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHCCCEEE
VDFNHPLAGQDVIFDVEIVAVG
EEECCCCCCCCEEEEEEEEEEC
>Mature Secondary Structure
MKIENNSEVTLHFTIKLKDGSVADSTHSSGKPAKFTMGDGSLSENFEKCLLGLEAEQAKS
CCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCC
IELCAEDAFGLPNPDNIHHMDRNRFVGDAAAEVGTIMAFSGPDGMDIPGIITEIAGDSVT
EEEEHHCCCCCCCCCCCEECCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHCCCEEE
VDFNHPLAGQDVIFDVEIVAVG
EEECCCCCCCCEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]