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The map label for this gene is tktA

Identifier: 59711047

GI number: 59711047

Start: 467063

End: 469057

Strand: Direct

Name: tktA

Synonym: VF_0440

Alternate gene names: 59711047

Gene position: 467063-469057 (Clockwise)

Preceding gene: 59711039

Following gene: 59711048

Centisome position: 16.12

GC content: 44.81

Gene sequence:

>1995_bases
ATGTCTTCACGTAAACATCTAGCAAATGCAATCCGCGCTTTAAGCATGGATGGTGTTCAACAAGCAAATTCTGGTCACCC
AGGCGCACCTATGGGTATGGCAGATATCGCTGAAGTATTATGGCGTAGCCACCTAAATCACAACCCACAAAATCCAGAGT
GGGCTGACCGCGACCGTTTCATTCTTTCAAACGGCCATGGCTCTATGCTGATTTATTCTCTGCTTCATCTTTCAGGTTAT
GACCTGTCTATCGAAGACTTAAAGAATTTCCGTCAACTGCATTCTAAAACTCCAGGTCACCCTGAGTACGGTTATGCACC
AGGCGTAGAAACAACTACGGGTCCATTAGGTCAAGGCATCACTAACGGTGTTGGTATGGCGATGGCTGAAAAAGCATTAG
CGGCACAATTTAACCGTGAAGGCCACGATATCGTTGATCACAACACATACGTGTTCATGGGTGACGGTTGTCTAATGGAA
GGTATCTCTCACGAAGCGTGTTCACTTGCTGGTACATTAGGTCTAGGCAAATTAATCGCATTTTGGGATGACAACGGTAT
CTCTATCGATGGTGAAGTTGAAGGTTGGTTCTCTGATGACACGCCTAAACGCTTTGAAGCTTACGGCTGGCACGTAATTC
CTGCTGTTGATGGTCACGATTCAGACGCTATCAATGCAGCAATTGAAGCGGCTAAAGCTGACCCTCGTCCTTCTTTAATT
TGTACTAAAACAGTAATTGGTTTTGGCTCTCCAAATAAACAAGGTACACACGACTGTCACGGCGCTCCATTAGGTGCTGA
AGAAATTGCAGCAACTAAAGCTCAATTAGGTTGGGAATACGGTGCATTTGATATCCCTGCTGACGTATATGCAGGCTGGG
ATGCAAAAGAAGTTGGTGCTGAAAAAGAAGCAGCTTGGAATGCGAAATTTGACGCATACGCAGCAGCACACCCTGAATTA
GCAGCTGAATATAAACGCCGCGTAAATGGTGATTTACCTGCGGAGTGGGAAGAAAAAGCAAATACAATCATTGCTGATCT
TCAAGCAAATCCTGCAAATATCGCTTCTCGTAAAGCATCTCAAAACGCATTAGAAGCGTTTGGTGCTATGCTACCTGAAT
TCATGGGCGGCTCTGCTGACCTTGCACCATCTAACTTAACGATGTGGTCGGGTTCTAAATCTTTAGAAGCAAATGACTTC
TCTGGTAACTACATTCACTACGGTGTGCGTGAATTTGGTATGACAGCAATCATGAATGGTATTGCTTTGCACGGTGGTTT
CGTACCATACGGCGCAACGTTCCTAATGTTCATGGAATACGCTCGTAACGCAATGCGTATGGCTGCACTAATGAAAGTGC
AAAACATTCAAGTTTACACGCATGACTCTATCGGTCTTGGCGAAGATGGTCCAACTCACCAACCAGTTGAGCAAATCGCT
TCTCTACGTCTAACTCCTAACATGAGCACATGGCGTCCATGTGATCAAGTTGAGTCTGCTGTAGCATGGAAATTGGCTAT
CGAGCGTAAAGATGGTCCTTCTTCTTTAATCTTCTCTCGTCAAAACCTTGCACAGCAAGAGCGTACACAAGAGCAAGTTG
CAGATATCGCTAAAGGTGCATACATCCTTAAGGATTGTGAGGGCCAACCTGAGTTGATCCTTATTGCAACGGGTTCAGAA
GTTGAGCTAGCAGTTGAAGCTGCAGCGCAATTGACAGCAGAAGGTAAAGCGGTACGTGTTGTTTCAATGCCATCAACCGA
TGCATTTGATAAGCAAGACGAAGGATACCGTGAAGCAGTATTTCCATCAGCGGTAACTAAACGTATCGCAATTGAAGCGG
GTATTGCTGATTTCTGGTACAAGTATGTTGGTTTTGGTGGCAAGATCATCGGCATGACAACATTTGGTGAGTCAGCGCCT
GCTGATGAGCTATTCAAAATGTTTGGTTTCACTACTGAAAATGTAGTAAACACGGCGAAAGAACTTTTAGCTTAA

Upstream 100 bases:

>100_bases
GCCGATGAGGCTTTGCGACAATACGCACCTGCAAATTTAGGTTAATCAATAGTGGTTAACTTGCTCAACAATATAGTCCT
TCGAATTTTCAGGAGCAGGC

Downstream 100 bases:

>100_bases
TTAAAAAACATTAGCTTAATTTAGCGATAAGTAAAAATAAGATGAAGAGCGAAGTTATTGAAAGGTAACTTCGCTTTTTT
GATCCTTTAAGAAAAAAGCG

Product: transketolase

Products: NA

Alternate protein names: TK 1

Number of amino acids: Translated: 664; Mature: 663

Protein sequence:

>664_residues
MSSRKHLANAIRALSMDGVQQANSGHPGAPMGMADIAEVLWRSHLNHNPQNPEWADRDRFILSNGHGSMLIYSLLHLSGY
DLSIEDLKNFRQLHSKTPGHPEYGYAPGVETTTGPLGQGITNGVGMAMAEKALAAQFNREGHDIVDHNTYVFMGDGCLME
GISHEACSLAGTLGLGKLIAFWDDNGISIDGEVEGWFSDDTPKRFEAYGWHVIPAVDGHDSDAINAAIEAAKADPRPSLI
CTKTVIGFGSPNKQGTHDCHGAPLGAEEIAATKAQLGWEYGAFDIPADVYAGWDAKEVGAEKEAAWNAKFDAYAAAHPEL
AAEYKRRVNGDLPAEWEEKANTIIADLQANPANIASRKASQNALEAFGAMLPEFMGGSADLAPSNLTMWSGSKSLEANDF
SGNYIHYGVREFGMTAIMNGIALHGGFVPYGATFLMFMEYARNAMRMAALMKVQNIQVYTHDSIGLGEDGPTHQPVEQIA
SLRLTPNMSTWRPCDQVESAVAWKLAIERKDGPSSLIFSRQNLAQQERTQEQVADIAKGAYILKDCEGQPELILIATGSE
VELAVEAAAQLTAEGKAVRVVSMPSTDAFDKQDEGYREAVFPSAVTKRIAIEAGIADFWYKYVGFGGKIIGMTTFGESAP
ADELFKMFGFTTENVVNTAKELLA

Sequences:

>Translated_664_residues
MSSRKHLANAIRALSMDGVQQANSGHPGAPMGMADIAEVLWRSHLNHNPQNPEWADRDRFILSNGHGSMLIYSLLHLSGY
DLSIEDLKNFRQLHSKTPGHPEYGYAPGVETTTGPLGQGITNGVGMAMAEKALAAQFNREGHDIVDHNTYVFMGDGCLME
GISHEACSLAGTLGLGKLIAFWDDNGISIDGEVEGWFSDDTPKRFEAYGWHVIPAVDGHDSDAINAAIEAAKADPRPSLI
CTKTVIGFGSPNKQGTHDCHGAPLGAEEIAATKAQLGWEYGAFDIPADVYAGWDAKEVGAEKEAAWNAKFDAYAAAHPEL
AAEYKRRVNGDLPAEWEEKANTIIADLQANPANIASRKASQNALEAFGAMLPEFMGGSADLAPSNLTMWSGSKSLEANDF
SGNYIHYGVREFGMTAIMNGIALHGGFVPYGATFLMFMEYARNAMRMAALMKVQNIQVYTHDSIGLGEDGPTHQPVEQIA
SLRLTPNMSTWRPCDQVESAVAWKLAIERKDGPSSLIFSRQNLAQQERTQEQVADIAKGAYILKDCEGQPELILIATGSE
VELAVEAAAQLTAEGKAVRVVSMPSTDAFDKQDEGYREAVFPSAVTKRIAIEAGIADFWYKYVGFGGKIIGMTTFGESAP
ADELFKMFGFTTENVVNTAKELLA
>Mature_663_residues
SSRKHLANAIRALSMDGVQQANSGHPGAPMGMADIAEVLWRSHLNHNPQNPEWADRDRFILSNGHGSMLIYSLLHLSGYD
LSIEDLKNFRQLHSKTPGHPEYGYAPGVETTTGPLGQGITNGVGMAMAEKALAAQFNREGHDIVDHNTYVFMGDGCLMEG
ISHEACSLAGTLGLGKLIAFWDDNGISIDGEVEGWFSDDTPKRFEAYGWHVIPAVDGHDSDAINAAIEAAKADPRPSLIC
TKTVIGFGSPNKQGTHDCHGAPLGAEEIAATKAQLGWEYGAFDIPADVYAGWDAKEVGAEKEAAWNAKFDAYAAAHPELA
AEYKRRVNGDLPAEWEEKANTIIADLQANPANIASRKASQNALEAFGAMLPEFMGGSADLAPSNLTMWSGSKSLEANDFS
GNYIHYGVREFGMTAIMNGIALHGGFVPYGATFLMFMEYARNAMRMAALMKVQNIQVYTHDSIGLGEDGPTHQPVEQIAS
LRLTPNMSTWRPCDQVESAVAWKLAIERKDGPSSLIFSRQNLAQQERTQEQVADIAKGAYILKDCEGQPELILIATGSEV
ELAVEAAAQLTAEGKAVRVVSMPSTDAFDKQDEGYREAVFPSAVTKRIAIEAGIADFWYKYVGFGGKIIGMTTFGESAPA
DELFKMFGFTTENVVNTAKELLA

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family

Homologues:

Organism=Homo sapiens, GI205277463, Length=681, Percent_Identity=26.2848751835536, Blast_Score=160, Evalue=4e-39,
Organism=Homo sapiens, GI4507521, Length=681, Percent_Identity=26.2848751835536, Blast_Score=160, Evalue=4e-39,
Organism=Homo sapiens, GI133778974, Length=670, Percent_Identity=24.4776119402985, Blast_Score=141, Evalue=2e-33,
Organism=Escherichia coli, GI48994911, Length=664, Percent_Identity=75.9036144578313, Blast_Score=1074, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=662, Percent_Identity=70.392749244713, Blast_Score=992, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=680, Percent_Identity=24.7058823529412, Blast_Score=157, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6325331, Length=671, Percent_Identity=49.1803278688525, Blast_Score=599, Evalue=1e-172,
Organism=Saccharomyces cerevisiae, GI6319593, Length=671, Percent_Identity=45.3055141579732, Blast_Score=556, Evalue=1e-159,
Organism=Drosophila melanogaster, GI45551847, Length=682, Percent_Identity=26.9794721407625, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI45550715, Length=682, Percent_Identity=26.9794721407625, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24645119, Length=648, Percent_Identity=26.2345679012346, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24666278, Length=663, Percent_Identity=24.73604826546, Blast_Score=144, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TKT1_VIBF1 (Q5E7R1)

Other databases:

- EMBL:   CP000020
- RefSeq:   YP_203823.1
- ProteinModelPortal:   Q5E7R1
- SMR:   Q5E7R1
- STRING:   Q5E7R1
- GeneID:   3278177
- GenomeReviews:   CP000020_GR
- KEGG:   vfi:VF_0440
- NMPDR:   fig|312309.3.peg.440
- eggNOG:   COG0021
- HOGENOM:   HBG565885
- OMA:   KEAAWNA
- PhylomeDB:   Q5E7R1
- ProtClustDB:   PRK05899
- BioCyc:   VFIS312309:VF0440-MONOMER
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- PANTHER:   PTHR11624:SF1
- SMART:   SM00861
- TIGRFAMs:   TIGR00232

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N; SSF52922 Transketo_C_like

EC number: =2.2.1.1

Molecular weight: Translated: 71806; Mature: 71675

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRKHLANAIRALSMDGVQQANSGHPGAPMGMADIAEVLWRSHLNHNPQNPEWADRDRF
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCE
ILSNGHGSMLIYSLLHLSGYDLSIEDLKNFRQLHSKTPGHPEYGYAPGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
TNGVGMAMAEKALAAQFNREGHDIVDHNTYVFMGDGCLMEGISHEACSLAGTLGLGKLIA
HCCHHHHHHHHHHHHHHCCCCCCEECCCEEEEECCCHHHHCCCHHHHHHHHHHCCCCEEE
FWDDNGISIDGEVEGWFSDDTPKRFEAYGWHVIPAVDGHDSDAINAAIEAAKADPRPSLI
EECCCCEEECCCCCCCCCCCCCCHHHHCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCEE
CTKTVIGFGSPNKQGTHDCHGAPLGAEEIAATKAQLGWEYGAFDIPADVYAGWDAKEVGA
EEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCCHHHHCC
EKEAAWNAKFDAYAAAHPELAAEYKRRVNGDLPAEWEEKANTIIADLQANPANIASRKAS
CHHHCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCHHHCCCEEEEECCCCCHHHHHHHHH
QNALEAFGAMLPEFMGGSADLAPSNLTMWSGSKSLEANDFSGNYIHYGVREFGMTAIMNG
HHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEECHHHHHHHHHHHH
IALHGGFVPYGATFLMFMEYARNAMRMAALMKVQNIQVYTHDSIGLGEDGPTHQPVEQIA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCHHHHHHH
SLRLTPNMSTWRPCDQVESAVAWKLAIERKDGPSSLIFSRQNLAQQERTQEQVADIAKGA
HEECCCCCCCCCCHHHHHHHHEEEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCC
YILKDCEGQPELILIATGSEVELAVEAAAQLTAEGKAVRVVSMPSTDAFDKQDEGYREAV
EEEECCCCCCCEEEEECCCCEEHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHH
FPSAVTKRIAIEAGIADFWYKYVGFGGKIIGMTTFGESAPADELFKMFGFTTENVVNTAK
CHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHH
ELLA
HHHC
>Mature Secondary Structure 
SSRKHLANAIRALSMDGVQQANSGHPGAPMGMADIAEVLWRSHLNHNPQNPEWADRDRF
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCE
ILSNGHGSMLIYSLLHLSGYDLSIEDLKNFRQLHSKTPGHPEYGYAPGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
TNGVGMAMAEKALAAQFNREGHDIVDHNTYVFMGDGCLMEGISHEACSLAGTLGLGKLIA
HCCHHHHHHHHHHHHHHCCCCCCEECCCEEEEECCCHHHHCCCHHHHHHHHHHCCCCEEE
FWDDNGISIDGEVEGWFSDDTPKRFEAYGWHVIPAVDGHDSDAINAAIEAAKADPRPSLI
EECCCCEEECCCCCCCCCCCCCCHHHHCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCEE
CTKTVIGFGSPNKQGTHDCHGAPLGAEEIAATKAQLGWEYGAFDIPADVYAGWDAKEVGA
EEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCCHHHHCC
EKEAAWNAKFDAYAAAHPELAAEYKRRVNGDLPAEWEEKANTIIADLQANPANIASRKAS
CHHHCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCHHHCCCEEEEECCCCCHHHHHHHHH
QNALEAFGAMLPEFMGGSADLAPSNLTMWSGSKSLEANDFSGNYIHYGVREFGMTAIMNG
HHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEECHHHHHHHHHHHH
IALHGGFVPYGATFLMFMEYARNAMRMAALMKVQNIQVYTHDSIGLGEDGPTHQPVEQIA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCHHHHHHH
SLRLTPNMSTWRPCDQVESAVAWKLAIERKDGPSSLIFSRQNLAQQERTQEQVADIAKGA
HEECCCCCCCCCCHHHHHHHHEEEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCC
YILKDCEGQPELILIATGSEVELAVEAAAQLTAEGKAVRVVSMPSTDAFDKQDEGYREAV
EEEECCCCCCCEEEEECCCCEEHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHH
FPSAVTKRIAIEAGIADFWYKYVGFGGKIIGMTTFGESAPADELFKMFGFTTENVVNTAK
CHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHH
ELLA
HHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA