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The map label for this gene is epd [H]

Identifier: 59711048

GI number: 59711048

Start: 469202

End: 470221

Strand: Direct

Name: epd [H]

Synonym: VF_0441

Alternate gene names: 59711048

Gene position: 469202-470221 (Clockwise)

Preceding gene: 59711047

Following gene: 59711049

Centisome position: 16.19

GC content: 39.02

Gene sequence:

>1020_bases
ATGTTGAGAGTGGCAATAAATGGATTTGGCCGAATTGGTCGTAGTGTACTTCGAGCGTTATACGAGAGTGATAAGCGCGA
TAAAATAGAAGTGGTGGCTGTTAATGAATTATCACAGCCTGAAGCGATGGCGCACTTATTTCAATATGATTCAACTCACG
GACGCTTTCAGCACAAAGTCACCCACGATCAAGAATACCCTTATAGTGATGTACCTGACAGCTCTCAAGATAAGGTTCGC
ATATTACATCAAGCGGATCTTTCCCTTTTACCATGGCAATCGTTAGAGGTTGATTTAGTTTTGGATTGCACGGGAGTGTA
CGGTTCTAAATCTGATGGTGAAAAACACATTACTGCTGGAGCTAAGAAGGTTCTATTTTCTCACCCTGGTGGCTCTGATT
TAGATAACACTATTATTTATGGTGTGAATCACGATACGTTATTACCAGAACATCGAATTGTTTCTAATGGGTCATGTACT
ACCAATTGCATTATTCCTGTTATTAAAGCGATTGATGATGCGTTTGGTATCGATTCTGGCACCATTACCACCATCCATTC
TTCAATGAATGATCAACAAGTTATTGATGCTTACCATTCTGATTTACGTCGTACTAGAGCTGCTAGTCAATCTATTATTC
CTGTTGATACTAAGTTGCATAAAGGTATTGAAAGAATATTTCCGAAATTTTCTAACAAGTTTGAAGCGATTTCTGTGCGA
GTACCAACGGTAAACGTAACTGCGATGGATTTAAGTGTAACAATTAATACAAATGTGAAAGTTAATGACATAAATCAAAC
CATTGTTAACGCATCTCGGTGTACATTACATAACATTGTTGACTATACTGAAGCGCCGCTTGTTTCTATCGACTTTAATC
ATGATCCCCACAGCGCCATTGTCGATGGATCACAAACAAGGGTGAGTAATGGGCATTTAGTTAAAATGCTAGTTTGGTGC
GATAACGAGTGGGGGTTTGCTAATCGGATGCTAGATACCGCATTAGCAATGAGTAAATAA

Upstream 100 bases:

>100_bases
AAGAGCGAAGTTATTGAAAGGTAACTTCGCTTTTTTGATCCTTTAAGAAAAAAGCGAAAAGAGTACAATAACCGCAAATG
GAAAAAGAGAGTTATGTATT

Downstream 100 bases:

>100_bases
ACTCAGTAATCAGTAAATTTGTGATGAAAAGATAAAAAAGATGAATTTTTATCTTGAAAAAAGTGAACTGCATCCCTATT
TACTGAATAATGCAGTAAGA

Product: erythrose 4-phosphate dehydrogenase

Products: NA

Alternate protein names: E4PDH [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MLRVAINGFGRIGRSVLRALYESDKRDKIEVVAVNELSQPEAMAHLFQYDSTHGRFQHKVTHDQEYPYSDVPDSSQDKVR
ILHQADLSLLPWQSLEVDLVLDCTGVYGSKSDGEKHITAGAKKVLFSHPGGSDLDNTIIYGVNHDTLLPEHRIVSNGSCT
TNCIIPVIKAIDDAFGIDSGTITTIHSSMNDQQVIDAYHSDLRRTRAASQSIIPVDTKLHKGIERIFPKFSNKFEAISVR
VPTVNVTAMDLSVTINTNVKVNDINQTIVNASRCTLHNIVDYTEAPLVSIDFNHDPHSAIVDGSQTRVSNGHLVKMLVWC
DNEWGFANRMLDTALAMSK

Sequences:

>Translated_339_residues
MLRVAINGFGRIGRSVLRALYESDKRDKIEVVAVNELSQPEAMAHLFQYDSTHGRFQHKVTHDQEYPYSDVPDSSQDKVR
ILHQADLSLLPWQSLEVDLVLDCTGVYGSKSDGEKHITAGAKKVLFSHPGGSDLDNTIIYGVNHDTLLPEHRIVSNGSCT
TNCIIPVIKAIDDAFGIDSGTITTIHSSMNDQQVIDAYHSDLRRTRAASQSIIPVDTKLHKGIERIFPKFSNKFEAISVR
VPTVNVTAMDLSVTINTNVKVNDINQTIVNASRCTLHNIVDYTEAPLVSIDFNHDPHSAIVDGSQTRVSNGHLVKMLVWC
DNEWGFANRMLDTALAMSK
>Mature_339_residues
MLRVAINGFGRIGRSVLRALYESDKRDKIEVVAVNELSQPEAMAHLFQYDSTHGRFQHKVTHDQEYPYSDVPDSSQDKVR
ILHQADLSLLPWQSLEVDLVLDCTGVYGSKSDGEKHITAGAKKVLFSHPGGSDLDNTIIYGVNHDTLLPEHRIVSNGSCT
TNCIIPVIKAIDDAFGIDSGTITTIHSSMNDQQVIDAYHSDLRRTRAASQSIIPVDTKLHKGIERIFPKFSNKFEAISVR
VPTVNVTAMDLSVTINTNVKVNDINQTIVNASRCTLHNIVDYTEAPLVSIDFNHDPHSAIVDGSQTRVSNGHLVKMLVWC
DNEWGFANRMLDTALAMSK

Specific function: Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate [H]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=339, Percent_Identity=35.9882005899705, Blast_Score=224, Evalue=8e-59,
Organism=Homo sapiens, GI7657116, Length=334, Percent_Identity=36.2275449101796, Blast_Score=210, Evalue=1e-54,
Organism=Escherichia coli, GI1789295, Length=337, Percent_Identity=67.3590504451039, Blast_Score=489, Evalue=1e-139,
Organism=Escherichia coli, GI1788079, Length=345, Percent_Identity=37.9710144927536, Blast_Score=236, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17534677, Length=332, Percent_Identity=38.5542168674699, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17534679, Length=332, Percent_Identity=38.2530120481928, Blast_Score=241, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI32566163, Length=334, Percent_Identity=38.622754491018, Blast_Score=234, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI17568413, Length=334, Percent_Identity=38.622754491018, Blast_Score=234, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6322409, Length=334, Percent_Identity=39.8203592814371, Blast_Score=252, Evalue=5e-68,
Organism=Saccharomyces cerevisiae, GI6322468, Length=334, Percent_Identity=39.2215568862275, Blast_Score=250, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6321631, Length=334, Percent_Identity=39.8203592814371, Blast_Score=250, Evalue=3e-67,
Organism=Drosophila melanogaster, GI85725000, Length=334, Percent_Identity=35.9281437125749, Blast_Score=221, Evalue=5e-58,
Organism=Drosophila melanogaster, GI22023983, Length=334, Percent_Identity=35.9281437125749, Blast_Score=221, Evalue=5e-58,
Organism=Drosophila melanogaster, GI17933600, Length=334, Percent_Identity=35.3293413173653, Blast_Score=218, Evalue=3e-57,
Organism=Drosophila melanogaster, GI18110149, Length=334, Percent_Identity=35.3293413173653, Blast_Score=218, Evalue=3e-57,
Organism=Drosophila melanogaster, GI19922412, Length=337, Percent_Identity=34.1246290801187, Blast_Score=217, Evalue=8e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006422
- InterPro:   IPR020831
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.72 [H]

Molecular weight: Translated: 37604; Mature: 37604

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRVAINGFGRIGRSVLRALYESDKRDKIEVVAVNELSQPEAMAHLFQYDSTHGRFQHKV
CEEEEECCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEC
THDQEYPYSDVPDSSQDKVRILHQADLSLLPWQSLEVDLVLDCTGVYGSKSDGEKHITAG
CCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHCC
AKKVLFSHPGGSDLDNTIIYGVNHDTLLPEHRIVSNGSCTTNCIIPVIKAIDDAFGIDSG
CCEEEEECCCCCCCCCCEEEECCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCC
TITTIHSSMNDQQVIDAYHSDLRRTRAASQSIIPVDTKLHKGIERIFPKFSNKFEAISVR
EEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEE
VPTVNVTAMDLSVTINTNVKVNDINQTIVNASRCTLHNIVDYTEAPLVSIDFNHDPHSAI
ECEEEEEEEEEEEEEECCEEEECCHHHHHCCHHHHHHHHHCCCCCCEEEEECCCCCCCEE
VDGSQTRVSNGHLVKMLVWCDNEWGFANRMLDTALAMSK
ECCCCEEECCCCEEEEEEEECCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MLRVAINGFGRIGRSVLRALYESDKRDKIEVVAVNELSQPEAMAHLFQYDSTHGRFQHKV
CEEEEECCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEC
THDQEYPYSDVPDSSQDKVRILHQADLSLLPWQSLEVDLVLDCTGVYGSKSDGEKHITAG
CCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHCC
AKKVLFSHPGGSDLDNTIIYGVNHDTLLPEHRIVSNGSCTTNCIIPVIKAIDDAFGIDSG
CCEEEEECCCCCCCCCCEEEECCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCC
TITTIHSSMNDQQVIDAYHSDLRRTRAASQSIIPVDTKLHKGIERIFPKFSNKFEAISVR
EEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEE
VPTVNVTAMDLSVTINTNVKVNDINQTIVNASRCTLHNIVDYTEAPLVSIDFNHDPHSAI
ECEEEEEEEEEEEEEECCEEEECCHHHHHCCHHHHHHHHHCCCCCCEEEEECCCCCCCEE
VDGSQTRVSNGHLVKMLVWCDNEWGFANRMLDTALAMSK
ECCCCEEECCCCEEEEEEEECCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA