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The map label for this gene is pepA [H]

Identifier: 59711020

GI number: 59711020

Start: 442847

End: 444355

Strand: Reverse

Name: pepA [H]

Synonym: VF_0413

Alternate gene names: 59711020

Gene position: 444355-442847 (Counterclockwise)

Preceding gene: 59711023

Following gene: 59711019

Centisome position: 15.34

GC content: 44.27

Gene sequence:

>1509_bases
ATGGAGTTCAGTGTAAAAAGTGGTAGTCCAGAGAAACAACGCAGCGCTTGTATCGTTGTTGGTGTCTTTGAACCACGTCG
TTTATCTCCAATAGCTGAGCAGCTTGATAAAATCAGTGGCGGCTACATAAGTTCACTACTTCGTCGTGGTGATCTTGAAG
GAAAGCCAGGCCAAATGTTGCTATTGCACCAAGTGCCAAACATTCTTTCGGAGCGTGTTTTATTAGTTGGTTGTGGTAAA
GAGCGTGAACTTGGTGAGCGTCAATATAAAGATATCATCAAGAAAACTATCAGCACACTAAATGAAACAGGCTCTATGGA
AGCGGTATGTTTTCTTACAGAGCTTCACGTTAAAGGTCGCGATACGTATTGGAAAGTTCGCCAAGCCGTTGAGTCGACTA
AAGACAGCTTATACACCTTTAATCAATTTAAGAGCAATAAGCCTGAGACTCGTCGCCCATTACGTAAGTTAGTCTTCAAT
GTTCCGACTCGCCGTGAACTTAACTTAGGTGAAAAAGCGATTGCTCATGGTTTATCTATTGCTTCTGGTGTTAAAGCATC
GAAAGATTTAGGCAACATGCCACCAAACGTAGCAAACCCAGCTTATCTTGCTTCTCAAGCTCGTCGTCTTGCTGATGATT
ACGAAACCGTAACCACCAAGATCATTGGCGAAGAGGAAATGAAAAAGCTAGGCATGACCTCTTACTTAGCGGTTGGCCAG
GGCTCTCACAACGAATCTATGATGTCTATCATGGAATACAAAGGTCACCCTGACCCTGCTGCAAAACCAATCGTTCTAAT
TGGTAAAGGTTTAACGTTTGATTCAGGCGGTATTTCAATTAAGCCAAGCGAAGGCATGGATGAAATGAAATACGACATGT
GTGGCGCAGCTTCAGTATTTGGTGCAATGAAAGCACTAGCTAAACTGAACTTACCACTAAACGTTGTTGGTGTGCTTGCA
GGCTGTGAAAATATGCCAAGCAGCAACTCATACCGTCCAGGTGATATTCTAACTACGATGTCAGGCCAAACGGTTGAAGT
ATTAAATACCGATGCTGAAGGTCGACTAGTGCTTTGTGATGCGCTGACTTATGTTGAGCGTTATGAACCAGAATGTGTGG
TTGATGTCGCAACATTAACCGGTGCATGTGTTGTTGCACTTGGTCACCACATCAGCGGTTTGATTTCGAATCACAACCCA
CTTGCTCATGAGCTAATTAATGCGTCTGAACAATCGGGTGACCGTGCTTGGCGCTTACCAATGGCTGAAGAGTACAACGA
GCAACTAAGCAGCCCATTTGCAGATATGGGTAATATCGGCGGCAAAGCTGCTGGTACCATTACTGCAGGCTGTTTCCTTT
CTCGTTTTGCTAAGAAATACCACTGGGCTCATATTGACAGTGCAGGTACTGCTTGGGTCTCTGGTGCAAATAAAGGGTCA
ACAGGGCGACCAGTCTCATTGCTTGTCCAATTCCTACTGAATCGTTCAGGCCAAGAAAACGAAGAATAA

Upstream 100 bases:

>100_bases
TTAGCCTGTGAAATTAGTATACGAATATTACAGTATCTTGCTAGATTTTACTCATTATCTAACATTTAGTTCTATTTGTC
TTTAGGATGTAGGAGTACGC

Downstream 100 bases:

>100_bases
ACCAATTCGTTTTATGATATAAAGGGCCTATATTGAGGCCCTTTTTTAATACGTACTATTTATCCACTTAAGAGAGTTTA
TGAGCCAAGCCCTGTTTTAT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISGGYISSLLRRGDLEGKPGQMLLLHQVPNILSERVLLVGCGK
ERELGERQYKDIIKKTISTLNETGSMEAVCFLTELHVKGRDTYWKVRQAVESTKDSLYTFNQFKSNKPETRRPLRKLVFN
VPTRRELNLGEKAIAHGLSIASGVKASKDLGNMPPNVANPAYLASQARRLADDYETVTTKIIGEEEMKKLGMTSYLAVGQ
GSHNESMMSIMEYKGHPDPAAKPIVLIGKGLTFDSGGISIKPSEGMDEMKYDMCGAASVFGAMKALAKLNLPLNVVGVLA
GCENMPSSNSYRPGDILTTMSGQTVEVLNTDAEGRLVLCDALTYVERYEPECVVDVATLTGACVVALGHHISGLISNHNP
LAHELINASEQSGDRAWRLPMAEEYNEQLSSPFADMGNIGGKAAGTITAGCFLSRFAKKYHWAHIDSAGTAWVSGANKGS
TGRPVSLLVQFLLNRSGQENEE

Sequences:

>Translated_502_residues
MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISGGYISSLLRRGDLEGKPGQMLLLHQVPNILSERVLLVGCGK
ERELGERQYKDIIKKTISTLNETGSMEAVCFLTELHVKGRDTYWKVRQAVESTKDSLYTFNQFKSNKPETRRPLRKLVFN
VPTRRELNLGEKAIAHGLSIASGVKASKDLGNMPPNVANPAYLASQARRLADDYETVTTKIIGEEEMKKLGMTSYLAVGQ
GSHNESMMSIMEYKGHPDPAAKPIVLIGKGLTFDSGGISIKPSEGMDEMKYDMCGAASVFGAMKALAKLNLPLNVVGVLA
GCENMPSSNSYRPGDILTTMSGQTVEVLNTDAEGRLVLCDALTYVERYEPECVVDVATLTGACVVALGHHISGLISNHNP
LAHELINASEQSGDRAWRLPMAEEYNEQLSSPFADMGNIGGKAAGTITAGCFLSRFAKKYHWAHIDSAGTAWVSGANKGS
TGRPVSLLVQFLLNRSGQENEE
>Mature_502_residues
MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISGGYISSLLRRGDLEGKPGQMLLLHQVPNILSERVLLVGCGK
ERELGERQYKDIIKKTISTLNETGSMEAVCFLTELHVKGRDTYWKVRQAVESTKDSLYTFNQFKSNKPETRRPLRKLVFN
VPTRRELNLGEKAIAHGLSIASGVKASKDLGNMPPNVANPAYLASQARRLADDYETVTTKIIGEEEMKKLGMTSYLAVGQ
GSHNESMMSIMEYKGHPDPAAKPIVLIGKGLTFDSGGISIKPSEGMDEMKYDMCGAASVFGAMKALAKLNLPLNVVGVLA
GCENMPSSNSYRPGDILTTMSGQTVEVLNTDAEGRLVLCDALTYVERYEPECVVDVATLTGACVVALGHHISGLISNHNP
LAHELINASEQSGDRAWRLPMAEEYNEQLSSPFADMGNIGGKAAGTITAGCFLSRFAKKYHWAHIDSAGTAWVSGANKGS
TGRPVSLLVQFLLNRSGQENEE

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=337, Percent_Identity=40.9495548961424, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI47155554, Length=324, Percent_Identity=31.1728395061728, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1790710, Length=503, Percent_Identity=77.9324055666004, Blast_Score=831, Evalue=0.0,
Organism=Escherichia coli, GI87082123, Length=316, Percent_Identity=39.5569620253165, Blast_Score=193, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17556903, Length=346, Percent_Identity=31.2138728323699, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17565172, Length=146, Percent_Identity=34.2465753424658, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI20129969, Length=518, Percent_Identity=28.3783783783784, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI21355725, Length=324, Percent_Identity=33.3333333333333, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24661038, Length=324, Percent_Identity=33.641975308642, Blast_Score=188, Evalue=1e-47,
Organism=Drosophila melanogaster, GI161077148, Length=491, Percent_Identity=28.5132382892057, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI20130057, Length=491, Percent_Identity=28.5132382892057, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24662227, Length=514, Percent_Identity=27.6264591439689, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI21355645, Length=494, Percent_Identity=28.7449392712551, Blast_Score=178, Evalue=7e-45,
Organism=Drosophila melanogaster, GI24662223, Length=494, Percent_Identity=28.7449392712551, Blast_Score=178, Evalue=7e-45,
Organism=Drosophila melanogaster, GI19922386, Length=496, Percent_Identity=29.4354838709677, Blast_Score=169, Evalue=6e-42,
Organism=Drosophila melanogaster, GI20129963, Length=506, Percent_Identity=28.8537549407115, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI21357381, Length=317, Percent_Identity=31.2302839116719, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI221379063, Length=317, Percent_Identity=31.2302839116719, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI221379062, Length=317, Percent_Identity=31.2302839116719, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646701, Length=264, Percent_Identity=28.4090909090909, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24646703, Length=264, Percent_Identity=28.4090909090909, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21358201, Length=264, Percent_Identity=28.4090909090909, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 54558; Mature: 54558

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISGGYISSLLRRGDLEGKPGQML
CCCCCCCCCCHHHCCCEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEE
LLHQVPNILSERVLLVGCGKERELGERQYKDIIKKTISTLNETGSMEAVCFLTELHVKGR
EHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHCCC
DTYWKVRQAVESTKDSLYTFNQFKSNKPETRRPLRKLVFNVPTRRELNLGEKAIAHGLSI
CHHHHHHHHHHHHHHHHEEHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
ASGVKASKDLGNMPPNVANPAYLASQARRLADDYETVTTKIIGEEEMKKLGMTSYLAVGQ
HHCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHEEEECC
GSHNESMMSIMEYKGHPDPAAKPIVLIGKGLTFDSGGISIKPSEGMDEMKYDMCGAASVF
CCCHHHHHHHHHHCCCCCCCCCCEEEEECCCEECCCCEEECCCCCHHHHHHHHHHHHHHH
GAMKALAKLNLPLNVVGVLAGCENMPSSNSYRPGDILTTMSGQTVEVLNTDAEGRLVLCD
HHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEEH
ALTYVERYEPECVVDVATLTGACVVALGHHISGLISNHNPLAHELINASEQSGDRAWRLP
HHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEECC
MAEEYNEQLSSPFADMGNIGGKAAGTITAGCFLSRFAKKYHWAHIDSAGTAWVSGANKGS
CHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCEEECCCCCCEECCCCCCC
TGRPVSLLVQFLLNRSGQENEE
CCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISGGYISSLLRRGDLEGKPGQML
CCCCCCCCCCHHHCCCEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEE
LLHQVPNILSERVLLVGCGKERELGERQYKDIIKKTISTLNETGSMEAVCFLTELHVKGR
EHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHCCC
DTYWKVRQAVESTKDSLYTFNQFKSNKPETRRPLRKLVFNVPTRRELNLGEKAIAHGLSI
CHHHHHHHHHHHHHHHHEEHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
ASGVKASKDLGNMPPNVANPAYLASQARRLADDYETVTTKIIGEEEMKKLGMTSYLAVGQ
HHCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHEEEECC
GSHNESMMSIMEYKGHPDPAAKPIVLIGKGLTFDSGGISIKPSEGMDEMKYDMCGAASVF
CCCHHHHHHHHHHCCCCCCCCCCEEEEECCCEECCCCEEECCCCCHHHHHHHHHHHHHHH
GAMKALAKLNLPLNVVGVLAGCENMPSSNSYRPGDILTTMSGQTVEVLNTDAEGRLVLCD
HHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEEH
ALTYVERYEPECVVDVATLTGACVVALGHHISGLISNHNPLAHELINASEQSGDRAWRLP
HHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEECC
MAEEYNEQLSSPFADMGNIGGKAAGTITAGCFLSRFAKKYHWAHIDSAGTAWVSGANKGS
CHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCEEECCCCCCEECCCCCCC
TGRPVSLLVQFLLNRSGQENEE
CCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA