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The map label for this gene is mreB [H]

Identifier: 59710979

GI number: 59710979

Start: 404559

End: 405602

Strand: Direct

Name: mreB [H]

Synonym: VF_0372

Alternate gene names: 59710979

Gene position: 404559-405602 (Clockwise)

Preceding gene: 59710978

Following gene: 59710980

Centisome position: 13.96

GC content: 44.83

Gene sequence:

>1044_bases
ATGTTCAAGAAACTTCGTGGCATGTTTTCAAACGATCTATCGATTGATCTAGGTACTGCCAACACACTTATCTATGTAAA
AGGTCAAGGCATTGTTCTTGATGAGCCTTCAGTGGTTGCTATTCGTCAAGATCGTTCTGGTTCAGCTAAAAGTGTAGCTG
CCGTTGGTCATGATGCAAAACAGATGCTAGGCCGTACTCCTGGTAACATTTCTGCAATCCGCCCAATGAAAGATGGCGTT
ATTGCTGACTTTTACGTAACAGAAAAAATGCTTCAGCACTTCATTAAGCAAGTGCATGACAACAGCGTGTTACGTCCAAG
TCCTCGCGTATTAGTTTGTGTTCCTTGTGGTTCTACACAAGTTGAGCGTCGTGCTATCCGTGAATCTGCACAAGGTGCCG
GCGCGCGTGAAGTGTTCCTTATTGATGAGCCAATGGCTGCTGCTATCGGTGCTGGTCTTCCTGTATCTGAAGCAACAGGT
TCAATGGTGGTTGATATCGGTGGTGGTACAACAGAAGTTGCTGTTATCTCTCTAAACGGTGTGGTTTATTCATCGTCTGT
ACGTATCGGTGGTGACCGTTTTGATGAAGCAATCATTAACTACGTTCGTCGTAACTACGGCAGCTTAATTGGTGAAGCAA
CAGCTGAACGTATTAAGCATGAAATCGGTTCAGCTTACCCTGGTGATGACGTATGTGAAATTGAAGTGCGTGGCCGTAAC
CTTGCTGAAGGTGTGCCTCGTAGCTTTACACTAAACTCGAACGAAATTCTTGAAGCTCTTCAAGAGCCTTTATCTGGTAT
CGTATCTGCAGTAATGGTTGCACTAGAACAGTGTCCACCAGAATTAGCTTCTGATATTTCAGAGCATGGTATGGTATTAA
CGGGTGGTGGCGCACTACTTCGTGATTTAGACCGTCTTCTAACAGAAGAAACTGGTATTCCAGTAGTGGTTGCTGAAGAG
CCTCTAACATGTGTGGCTCGTGGCGGCGGTAAAGCATTAGAAATGATCGATATGCACGGTGGCGATCTATTTAGTGAAGA
GTAA

Upstream 100 bases:

>100_bases
TGCTTCAGGATTCTGTAGCAATACCTTGCTGATTCGGCTAGGCATTGGTACATTTAATAAAATTTATCTTATTCTCACGT
TTTCAGGAAATACGAAGATT

Downstream 100 bases:

>100_bases
TAACAGTTAACGGGTGAGTGGATATGACTCCAATCTTTGGTAGAGGTCCTTCTCTACAATTTCGCCTGTTTATTGCAGTA
ATGGTATCGGCTAGCCTAAT

Product: rod shape-determining protein MreB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MFKKLRGMFSNDLSIDLGTANTLIYVKGQGIVLDEPSVVAIRQDRSGSAKSVAAVGHDAKQMLGRTPGNISAIRPMKDGV
IADFYVTEKMLQHFIKQVHDNSVLRPSPRVLVCVPCGSTQVERRAIRESAQGAGAREVFLIDEPMAAAIGAGLPVSEATG
SMVVDIGGGTTEVAVISLNGVVYSSSVRIGGDRFDEAIINYVRRNYGSLIGEATAERIKHEIGSAYPGDDVCEIEVRGRN
LAEGVPRSFTLNSNEILEALQEPLSGIVSAVMVALEQCPPELASDISEHGMVLTGGGALLRDLDRLLTEETGIPVVVAEE
PLTCVARGGGKALEMIDMHGGDLFSEE

Sequences:

>Translated_347_residues
MFKKLRGMFSNDLSIDLGTANTLIYVKGQGIVLDEPSVVAIRQDRSGSAKSVAAVGHDAKQMLGRTPGNISAIRPMKDGV
IADFYVTEKMLQHFIKQVHDNSVLRPSPRVLVCVPCGSTQVERRAIRESAQGAGAREVFLIDEPMAAAIGAGLPVSEATG
SMVVDIGGGTTEVAVISLNGVVYSSSVRIGGDRFDEAIINYVRRNYGSLIGEATAERIKHEIGSAYPGDDVCEIEVRGRN
LAEGVPRSFTLNSNEILEALQEPLSGIVSAVMVALEQCPPELASDISEHGMVLTGGGALLRDLDRLLTEETGIPVVVAEE
PLTCVARGGGKALEMIDMHGGDLFSEE
>Mature_347_residues
MFKKLRGMFSNDLSIDLGTANTLIYVKGQGIVLDEPSVVAIRQDRSGSAKSVAAVGHDAKQMLGRTPGNISAIRPMKDGV
IADFYVTEKMLQHFIKQVHDNSVLRPSPRVLVCVPCGSTQVERRAIRESAQGAGAREVFLIDEPMAAAIGAGLPVSEATG
SMVVDIGGGTTEVAVISLNGVVYSSSVRIGGDRFDEAIINYVRRNYGSLIGEATAERIKHEIGSAYPGDDVCEIEVRGRN
LAEGVPRSFTLNSNEILEALQEPLSGIVSAVMVALEQCPPELASDISEHGMVLTGGGALLRDLDRLLTEETGIPVVVAEE
PLTCVARGGGKALEMIDMHGGDLFSEE

Specific function: Involved in formation of the rod shape of the cell. May act as a negative regulator of ftsI [H]

COG id: COG1077

COG function: function code D; Actin-like ATPase involved in cell morphogenesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsA/mreB family [H]

Homologues:

Organism=Homo sapiens, GI34419635, Length=353, Percent_Identity=25.4957507082153, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87082236, Length=347, Percent_Identity=93.9481268011527, Blast_Score=658, Evalue=0.0,
Organism=Escherichia coli, GI1788875, Length=247, Percent_Identity=24.6963562753036, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17568549, Length=279, Percent_Identity=24.3727598566308, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324120, Length=371, Percent_Identity=23.4501347708895, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319972, Length=371, Percent_Identity=22.911051212938, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001023
- InterPro:   IPR004753 [H]

Pfam domain/function: PF06723 MreB_Mbl [H]

EC number: NA

Molecular weight: Translated: 36859; Mature: 36859

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKLRGMFSNDLSIDLGTANTLIYVKGQGIVLDEPSVVAIRQDRSGSAKSVAAVGHDAK
CCHHHHHHHCCCCEEEECCCCEEEEEECCEEEECCCCEEEEECCCCCCCCHHHHHCCHHH
QMLGRTPGNISAIRPMKDGVIADFYVTEKMLQHFIKQVHDNSVLRPSPRVLVCVPCGSTQ
HHHCCCCCCCEEECCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHH
VERRAIRESAQGAGAREVFLIDEPMAAAIGAGLPVSEATGSMVVDIGGGTTEVAVISLNG
HHHHHHHHHHCCCCCEEEEEECCCHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEEEECC
VVYSSSVRIGGDRFDEAIINYVRRNYGSLIGEATAERIKHEIGSAYPGDDVCEIEVRGRN
EEEECEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCC
LAEGVPRSFTLNSNEILEALQEPLSGIVSAVMVALEQCPPELASDISEHGMVLTGGGALL
HHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEECCCHHH
RDLDRLLTEETGIPVVVAEEPLTCVARGGGKALEMIDMHGGDLFSEE
HHHHHHHHHCCCCCEEEECCCCEEEECCCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure
MFKKLRGMFSNDLSIDLGTANTLIYVKGQGIVLDEPSVVAIRQDRSGSAKSVAAVGHDAK
CCHHHHHHHCCCCEEEECCCCEEEEEECCEEEECCCCEEEEECCCCCCCCHHHHHCCHHH
QMLGRTPGNISAIRPMKDGVIADFYVTEKMLQHFIKQVHDNSVLRPSPRVLVCVPCGSTQ
HHHCCCCCCCEEECCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHH
VERRAIRESAQGAGAREVFLIDEPMAAAIGAGLPVSEATGSMVVDIGGGTTEVAVISLNG
HHHHHHHHHHCCCCCEEEEEECCCHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEEEECC
VVYSSSVRIGGDRFDEAIINYVRRNYGSLIGEATAERIKHEIGSAYPGDDVCEIEVRGRN
EEEECEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCC
LAEGVPRSFTLNSNEILEALQEPLSGIVSAVMVALEQCPPELASDISEHGMVLTGGGALL
HHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEECCCHHH
RDLDRLLTEETGIPVVVAEEPLTCVARGGGKALEMIDMHGGDLFSEE
HHHHHHHHHCCCCCEEEECCCCEEEECCCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]