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The map label for this gene is pdxA [H]

Identifier: 59710894

GI number: 59710894

Start: 291219

End: 292223

Strand: Reverse

Name: pdxA [H]

Synonym: VF_0287

Alternate gene names: 59710894

Gene position: 292223-291219 (Counterclockwise)

Preceding gene: 59710895

Following gene: 59710893

Centisome position: 10.09

GC content: 41.89

Gene sequence:

>1005_bases
ATGGTGAAGATGACAATGAATAATATTAAACGCATTGCGATCACTCCCGGCGAACCATCGGGTATTGGCCCAGATCTTGT
TATTGCTATTGCTCAACAAGACTGGCCTCATCAACTTGTCATTTGTGGTAGCAAACAAGTTTTAGCAGAAAGAGCTGCGC
AACTTGGTATTCAAATCCAAATTGAAGATTATAACGCTCAATTAGCAGCGACTAGTCATAAAGCGGGCACACTACTCGTA
GAAGATATCGAGTTAGGCTCTAGCGTTATTGCCGGTGAATTAAATGAAGCAAATGGGCACTATGTTCTTGAAACATTGCG
TCGTGCTGCACAAGGTAATATGGATGGTGAATTTGATGCCGTCGTCACAGGCCCTGTGCACAAAGGGGTAATCAACCGAG
CAGGTGTCGCTTTTAGTGGCCATACTGAATTTTTTGCTGAACAATCAAATACACAACAAGTTGTGATGATGCTTGCGACT
GAAGGGCTAAGAGTTGCATTAGTAACGACTCACATCCCACTCGCATATGTATCAAAAGCAATTACAGCGGATCGCTTAAA
GCAAGTTACCCGTATTTTGCACCAAGATTTAATAACCAAGTTTGGAATTGCTAACCCATCTATTTTTGTTTGCGGATTAA
ATCCTCACGCAGGCGAAGATGGCTGTCTTGGTCGCGAAGAAATTGATATCATAGCACCAGCATTAAATGAATTACGTGAG
CAAGAAGGAATGAACTTAATCGGTCCATTACCTGCTGATACGTTATTTCAAGATAAATACTTACAAGAAGCAGACGCGGT
ACTGGCTATGTATCACGATCAAGGTCTTCCTGTGCTAAAATTTAAAGGCTTCGGAAAATCCGTAAACATCACGTTAGGTT
TACCGTTTATCCGTACGTCCGTAGACCATGGTACTGCATTGGAATTAGCAGGTACTGGAAAAGCAGATGCAGGAAGCTTT
ATTACCGCACTTACCCATGCAATAGAACTGGTAGAAAATAAATGA

Upstream 100 bases:

>100_bases
GCATACCGAATTCTTCTTAACCGTAAATTTAATGAAGAAGCTGGTGCATGGCTACAAGAAATCCGTGCAAGTGCTTATGT
TGAAATCTTACAGGACGACG

Downstream 100 bases:

>100_bases
GTACAAGAAATGATGTCCATTTAGGCCATAAAGCAAGAAAACGCTTTGGTCAAAACTTCTTAAATGACCCTTATGTGATC
GATGGAATCGTATCTGCAAT

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MVKMTMNNIKRIAITPGEPSGIGPDLVIAIAQQDWPHQLVICGSKQVLAERAAQLGIQIQIEDYNAQLAATSHKAGTLLV
EDIELGSSVIAGELNEANGHYVLETLRRAAQGNMDGEFDAVVTGPVHKGVINRAGVAFSGHTEFFAEQSNTQQVVMMLAT
EGLRVALVTTHIPLAYVSKAITADRLKQVTRILHQDLITKFGIANPSIFVCGLNPHAGEDGCLGREEIDIIAPALNELRE
QEGMNLIGPLPADTLFQDKYLQEADAVLAMYHDQGLPVLKFKGFGKSVNITLGLPFIRTSVDHGTALELAGTGKADAGSF
ITALTHAIELVENK

Sequences:

>Translated_334_residues
MVKMTMNNIKRIAITPGEPSGIGPDLVIAIAQQDWPHQLVICGSKQVLAERAAQLGIQIQIEDYNAQLAATSHKAGTLLV
EDIELGSSVIAGELNEANGHYVLETLRRAAQGNMDGEFDAVVTGPVHKGVINRAGVAFSGHTEFFAEQSNTQQVVMMLAT
EGLRVALVTTHIPLAYVSKAITADRLKQVTRILHQDLITKFGIANPSIFVCGLNPHAGEDGCLGREEIDIIAPALNELRE
QEGMNLIGPLPADTLFQDKYLQEADAVLAMYHDQGLPVLKFKGFGKSVNITLGLPFIRTSVDHGTALELAGTGKADAGSF
ITALTHAIELVENK
>Mature_334_residues
MVKMTMNNIKRIAITPGEPSGIGPDLVIAIAQQDWPHQLVICGSKQVLAERAAQLGIQIQIEDYNAQLAATSHKAGTLLV
EDIELGSSVIAGELNEANGHYVLETLRRAAQGNMDGEFDAVVTGPVHKGVINRAGVAFSGHTEFFAEQSNTQQVVMMLAT
EGLRVALVTTHIPLAYVSKAITADRLKQVTRILHQDLITKFGIANPSIFVCGLNPHAGEDGCLGREEIDIIAPALNELRE
QEGMNLIGPLPADTLFQDKYLQEADAVLAMYHDQGLPVLKFKGFGKSVNITLGLPFIRTSVDHGTALELAGTGKADAGSF
ITALTHAIELVENK

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=328, Percent_Identity=63.719512195122, Blast_Score=423, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 35830; Mature: 35830

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKMTMNNIKRIAITPGEPSGIGPDLVIAIAQQDWPHQLVICGSKQVLAERAAQLGIQIQ
CEEEECCCCEEEEECCCCCCCCCCCEEEEEECCCCCCEEEEECCHHHHHHHHHHCCEEEE
IEDYNAQLAATSHKAGTLLVEDIELGSSVIAGELNEANGHYVLETLRRAAQGNMDGEFDA
EECCCCEEEEECCCCCEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEE
VVTGPVHKGVINRAGVAFSGHTEFFAEQSNTQQVVMMLATEGLRVALVTTHIPLAYVSKA
EEECCHHHHHHHHCCEEECCCHHHHHCCCCHHHEEEEEECCCCEEEEEEECCCHHHHHHH
ITADRLKQVTRILHQDLITKFGIANPSIFVCGLNPHAGEDGCLGREEIDIIAPALNELRE
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
QEGMNLIGPLPADTLFQDKYLQEADAVLAMYHDQGLPVLKFKGFGKSVNITLGLPFIRTS
HCCCCEECCCCCCHHHHHHHHHHHHHEEEEEECCCCCEEEEECCCCEEEEEEECHHHEEC
VDHGTALELAGTGKADAGSFITALTHAIELVENK
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVKMTMNNIKRIAITPGEPSGIGPDLVIAIAQQDWPHQLVICGSKQVLAERAAQLGIQIQ
CEEEECCCCEEEEECCCCCCCCCCCEEEEEECCCCCCEEEEECCHHHHHHHHHHCCEEEE
IEDYNAQLAATSHKAGTLLVEDIELGSSVIAGELNEANGHYVLETLRRAAQGNMDGEFDA
EECCCCEEEEECCCCCEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEE
VVTGPVHKGVINRAGVAFSGHTEFFAEQSNTQQVVMMLATEGLRVALVTTHIPLAYVSKA
EEECCHHHHHHHHCCEEECCCHHHHHCCCCHHHEEEEEECCCCEEEEEEECCCHHHHHHH
ITADRLKQVTRILHQDLITKFGIANPSIFVCGLNPHAGEDGCLGREEIDIIAPALNELRE
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
QEGMNLIGPLPADTLFQDKYLQEADAVLAMYHDQGLPVLKFKGFGKSVNITLGLPFIRTS
HCCCCEECCCCCCHHHHHHHHHHHHHEEEEEECCCCCEEEEECCCCEEEEEEECHHHEEC
VDHGTALELAGTGKADAGSFITALTHAIELVENK
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]