Click here to switch to the map view.

The map label for this gene is menA [H]

Identifier: 59710819

GI number: 59710819

Start: 234737

End: 235645

Strand: Reverse

Name: menA [H]

Synonym: VF_0212

Alternate gene names: 59710819

Gene position: 235645-234737 (Counterclockwise)

Preceding gene: 172087645

Following gene: 59710818

Centisome position: 8.13

GC content: 40.81

Gene sequence:

>909_bases
ATGAAAACTTCTCCTTTTTCCATTTGGCTCAACGCCGCTCGTCCAAAAACACTCCCTCTTGCCCTAGCCTCAATCATGAC
AGGCTCTGTGTTGGCATATTGGAATAACCATGCCTCTTTTACTATCACGTTAATGGCATTTATCACCGCAACGTTATTGC
AAATATTGTCGAATCTAGCAAATGACTATGGCGATGCAGTAAAAGGCACAGATAACGAAGATCGCCTTGGTCCACAACGA
GCAATGCAAACCGGCCTTGTAACGCAAGAAACAATGAAAAAAGCCATTGGTATTAATATTGTTCTGACGATCATTAGTGG
CTTAATTTTGGTATTTAGTTCATTACACCAAACCATGGATATTATTGGATTCATCGCTCTTGGGTTATTAGCTATTGGCG
CTGCTATTGCTTATACCATGGGTGATAAGCCTTATGGTTACCGTGGCTTAAGAGATATCTCTGTTTTTATCTTTTTTGGT
TTATTAGGGGTTGCCGGTACGTATTACCTTCATACTGGTCACTTATCATCTGCTCTATTCTTACCAGCGACTGCCTGCGG
TTTATTAGCTGTCGCAGTATTAAATATTAATAACCTACGTGATATAGAGAATGACGAAGCGTGCGGAAAAATGACATTGG
TCGTTCGCATGGGCGCAAACTGGGGTCGTAAATATCATGCTGTATTAATGGCCGTGAGTTTTATCTGTCTTGCTGTTTTT
AGTGCGACTCAAATTCATTCACTAACTGGTTGGTTATTTTTAGCAATTGCACCTTTCGTCTTCAATCATGTTATGTCAGT
AATGCGAGCACCAAATGGTGAAGCAATCAGACCTATGATGGGCACCGTTGTGCAATGCGCACTATTTACCAATGTACTAT
TTGCTGTTGGCTTGTACTTATCCGTTTAA

Upstream 100 bases:

>100_bases
ACTGGGAAAATAAATTAATTTCGCTATCTTCTGCGCCAAATTTGGGGTTCTTCCAAAAATAGTGAATAATAGAGACTCTA
TTCACTATTTTTGCGATGCT

Downstream 100 bases:

>100_bases
AAACGAAAGCGGCTTATCTCACTGACCTAAGTAAATCAGGATAAATTTGCGGTTTGTCATAGTATTGCCTAAAAAAGCAC
GTATATTGAACAGTTACAAA

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MKTSPFSIWLNAARPKTLPLALASIMTGSVLAYWNNHASFTITLMAFITATLLQILSNLANDYGDAVKGTDNEDRLGPQR
AMQTGLVTQETMKKAIGINIVLTIISGLILVFSSLHQTMDIIGFIALGLLAIGAAIAYTMGDKPYGYRGLRDISVFIFFG
LLGVAGTYYLHTGHLSSALFLPATACGLLAVAVLNINNLRDIENDEACGKMTLVVRMGANWGRKYHAVLMAVSFICLAVF
SATQIHSLTGWLFLAIAPFVFNHVMSVMRAPNGEAIRPMMGTVVQCALFTNVLFAVGLYLSV

Sequences:

>Translated_302_residues
MKTSPFSIWLNAARPKTLPLALASIMTGSVLAYWNNHASFTITLMAFITATLLQILSNLANDYGDAVKGTDNEDRLGPQR
AMQTGLVTQETMKKAIGINIVLTIISGLILVFSSLHQTMDIIGFIALGLLAIGAAIAYTMGDKPYGYRGLRDISVFIFFG
LLGVAGTYYLHTGHLSSALFLPATACGLLAVAVLNINNLRDIENDEACGKMTLVVRMGANWGRKYHAVLMAVSFICLAVF
SATQIHSLTGWLFLAIAPFVFNHVMSVMRAPNGEAIRPMMGTVVQCALFTNVLFAVGLYLSV
>Mature_302_residues
MKTSPFSIWLNAARPKTLPLALASIMTGSVLAYWNNHASFTITLMAFITATLLQILSNLANDYGDAVKGTDNEDRLGPQR
AMQTGLVTQETMKKAIGINIVLTIISGLILVFSSLHQTMDIIGFIALGLLAIGAAIAYTMGDKPYGYRGLRDISVFIFFG
LLGVAGTYYLHTGHLSSALFLPATACGLLAVAVLNINNLRDIENDEACGKMTLVVRMGANWGRKYHAVLMAVSFICLAVF
SATQIHSLTGWLFLAIAPFVFNHVMSVMRAPNGEAIRPMMGTVVQCALFTNVLFAVGLYLSV

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Escherichia coli, GI1790365, Length=300, Percent_Identity=55, Blast_Score=325, Evalue=2e-90,
Organism=Drosophila melanogaster, GI17737429, Length=235, Percent_Identity=25.531914893617, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 32589; Mature: 32589

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTSPFSIWLNAARPKTLPLALASIMTGSVLAYWNNHASFTITLMAFITATLLQILSNLA
CCCCCEEEEEECCCCCHHHHHHHHHHHCCHHEEECCCCHHHHHHHHHHHHHHHHHHHHHH
NDYGDAVKGTDNEDRLGPQRAMQTGLVTQETMKKAIGINIVLTIISGLILVFSSLHQTMD
HHHCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIGFIALGLLAIGAAIAYTMGDKPYGYRGLRDISVFIFFGLLGVAGTYYLHTGHLSSALF
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCHHH
LPATACGLLAVAVLNINNLRDIENDEACGKMTLVVRMGANWGRKYHAVLMAVSFICLAVF
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
SATQIHSLTGWLFLAIAPFVFNHVMSVMRAPNGEAIRPMMGTVVQCALFTNVLFAVGLYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SV
CC
>Mature Secondary Structure
MKTSPFSIWLNAARPKTLPLALASIMTGSVLAYWNNHASFTITLMAFITATLLQILSNLA
CCCCCEEEEEECCCCCHHHHHHHHHHHCCHHEEECCCCHHHHHHHHHHHHHHHHHHHHHH
NDYGDAVKGTDNEDRLGPQRAMQTGLVTQETMKKAIGINIVLTIISGLILVFSSLHQTMD
HHHCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIGFIALGLLAIGAAIAYTMGDKPYGYRGLRDISVFIFFGLLGVAGTYYLHTGHLSSALF
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCHHH
LPATACGLLAVAVLNINNLRDIENDEACGKMTLVVRMGANWGRKYHAVLMAVSFICLAVF
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
SATQIHSLTGWLFLAIAPFVFNHVMSVMRAPNGEAIRPMMGTVVQCALFTNVLFAVGLYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SV
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9573170; 8346018; 9278503 [H]