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The map label for this gene is hemD [H]

Identifier: 59710672

GI number: 59710672

Start: 72977

End: 73738

Strand: Reverse

Name: hemD [H]

Synonym: VF_0065

Alternate gene names: 59710672

Gene position: 73738-72977 (Counterclockwise)

Preceding gene: 59710673

Following gene: 59710671

Centisome position: 2.54

GC content: 41.73

Gene sequence:

>762_bases
ATGACGATTTTGGTGACTCGCCCTGAGCAAGAGAGCCAAGCTTTATGTGATGCCTTGAATCAATCAGGGCATCCAGCTAT
TTCTCACCCTCTTATCACCATCCACCCCGGCAATGAACTGTCTCAACTCCCTAGGCTATTTTATTCACTTAATGATGGTG
ATTTTATTATCGCTGTTAGTCAGCACGCTGTTGAGCACACGCAAAATTATTTAAAACAGCTACAATTAGAGTGGAAACAG
GGGGTTAATTATATTGCGGTCGGTCAAAAGAGCGCTCAACACCTCAAAAAGTATATTTCAGATCCAGTACACTACCCAAC
CCATAGCGACAGTGAACATTTATTAGCCCTTCCTGTCTTACAAAACGCGACAGGGAAAAAAGCCATTATTCTTCGAGGAA
ATGGCGGACGGGATCTGATTTATCAAGTTCTGAACGATCTCAATGTGGACGTGACATATTGCGAGGCTTACCAACGTCAA
GCCATCGCATTTGATGCATCTATCAAAACTCGAGAGTGGCAAGAAAAGAACGTAAACACATTGATTGTGACCAGTGGTGA
ACAACTCTCTTTTTTCACCTCTCAATTTACAAGTACAGATTTAAATTGGGTACTGAAGCTTAGATTATTGGTACCAAGTG
AGCGCATTAACCAGTTTGCAAAAGAACTTGGTTATCAACATATTGAAACGGTTGGCGGAGCCTCTAATTCCGACTTGCTG
CACTATATCAGTGAGCATCATTATGATGGGATTTTCAAATGA

Upstream 100 bases:

>100_bases
CGGTTTCTGACGCGGAAGCTTTAGGTACTCAACTTGCAGATCAACTTTTAAACGATGGCGCGAAAGAAATTTTAGAACGC
CTATACGCAGAAGCGTAACT

Downstream 100 bases:

>100_bases
CAAAAAATAATAATACAACACAGCCAACCGAAGATAAGCCGGTTGTGACTACAGCCCCTGATATAAAAAAAGAGCCAGAG
AAAACCACCACACACTCTGC

Product: uroporphyrinogen III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MTILVTRPEQESQALCDALNQSGHPAISHPLITIHPGNELSQLPRLFYSLNDGDFIIAVSQHAVEHTQNYLKQLQLEWKQ
GVNYIAVGQKSAQHLKKYISDPVHYPTHSDSEHLLALPVLQNATGKKAIILRGNGGRDLIYQVLNDLNVDVTYCEAYQRQ
AIAFDASIKTREWQEKNVNTLIVTSGEQLSFFTSQFTSTDLNWVLKLRLLVPSERINQFAKELGYQHIETVGGASNSDLL
HYISEHHYDGIFK

Sequences:

>Translated_253_residues
MTILVTRPEQESQALCDALNQSGHPAISHPLITIHPGNELSQLPRLFYSLNDGDFIIAVSQHAVEHTQNYLKQLQLEWKQ
GVNYIAVGQKSAQHLKKYISDPVHYPTHSDSEHLLALPVLQNATGKKAIILRGNGGRDLIYQVLNDLNVDVTYCEAYQRQ
AIAFDASIKTREWQEKNVNTLIVTSGEQLSFFTSQFTSTDLNWVLKLRLLVPSERINQFAKELGYQHIETVGGASNSDLL
HYISEHHYDGIFK
>Mature_252_residues
TILVTRPEQESQALCDALNQSGHPAISHPLITIHPGNELSQLPRLFYSLNDGDFIIAVSQHAVEHTQNYLKQLQLEWKQG
VNYIAVGQKSAQHLKKYISDPVHYPTHSDSEHLLALPVLQNATGKKAIILRGNGGRDLIYQVLNDLNVDVTYCEAYQRQA
IAFDASIKTREWQEKNVNTLIVTSGEQLSFFTSQFTSTDLNWVLKLRLLVPSERINQFAKELGYQHIETVGGASNSDLLH
YISEHHYDGIFK

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790236, Length=247, Percent_Identity=40.8906882591093, Blast_Score=177, Evalue=7e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 28605; Mature: 28473

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILVTRPEQESQALCDALNQSGHPAISHPLITIHPGNELSQLPRLFYSLNDGDFIIAVS
CEEEEECCCHHHHHHHHHHCCCCCCCHHCCEEEEECCCHHHHHHHHHEECCCCCEEEEEC
QHAVEHTQNYLKQLQLEWKQGVNYIAVGQKSAQHLKKYISDPVHYPTHSDSEHLLALPVL
HHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEC
QNATGKKAIILRGNGGRDLIYQVLNDLNVDVTYCEAYQRQAIAFDASIKTREWQEKNVNT
CCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEHHHHHHHHEEECCCCCCCCHHHCCCCE
LIVTSGEQLSFFTSQFTSTDLNWVLKLRLLVPSERINQFAKELGYQHIETVGGASNSDLL
EEEECCCCHHHHHHHHCCCCHHEEEEEEEECCHHHHHHHHHHHCHHHHHHHCCCCCCHHH
HYISEHHYDGIFK
HHHHHHCCCCCCC
>Mature Secondary Structure 
TILVTRPEQESQALCDALNQSGHPAISHPLITIHPGNELSQLPRLFYSLNDGDFIIAVS
EEEEECCCHHHHHHHHHHCCCCCCCHHCCEEEEECCCHHHHHHHHHEECCCCCEEEEEC
QHAVEHTQNYLKQLQLEWKQGVNYIAVGQKSAQHLKKYISDPVHYPTHSDSEHLLALPVL
HHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEC
QNATGKKAIILRGNGGRDLIYQVLNDLNVDVTYCEAYQRQAIAFDASIKTREWQEKNVNT
CCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEHHHHHHHHEEECCCCCCCCHHHCCCCE
LIVTSGEQLSFFTSQFTSTDLNWVLKLRLLVPSERINQFAKELGYQHIETVGGASNSDLL
EEEECCCCHHHHHHHHCCCCHHEEEEEEEECCHHHHHHHHHHHCHHHHHHHCCCCCCHHH
HYISEHHYDGIFK
HHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3054815; 3320969; 3277628; 3040684; 1379743; 9278503 [H]