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The map label for this gene is hemC [H]

Identifier: 59710673

GI number: 59710673

Start: 73741

End: 74676

Strand: Reverse

Name: hemC [H]

Synonym: VF_0066

Alternate gene names: 59710673

Gene position: 74676-73741 (Counterclockwise)

Preceding gene: 59710676

Following gene: 59710672

Centisome position: 2.58

GC content: 44.87

Gene sequence:

>936_bases
ATGTCACAGCAATTACCTGTTCGTATCGCCACTCGTAAAAGCCCTTTGGCTCTATGGCAAGCCCACTTTGTTAAAGATGC
ACTACAAGCCGCTCACCCAGGTTTGGAAGTTGAATTGGTTACTATGGTAACGAAAGGCGACATTATTCTTGATACGCCAT
TAGCAAAAGTTGGCGGAAAAGGCTTATTCGTTAAAGAACTTGAAGTTGCGATGCTAGAAGGCCGCGCAGACCTTGCTGTT
CACTCAATGAAAGACGTGCCAGTTGAATTTCCTGAAGGTCTAGGTCTTGTTACGATTTGTGAGCGTGAAGACCCACGTGA
CGCATTTGTATCGAACACTTACAACAATATTGATGAGTTACCTCAAGGCGCCGTTGTTGGTACTTGTAGCCTACGTCGTC
AATGCCAACTTAAAGAAGCTCGTCCTGATCTTATTATCAAAGAATTACGCGGTAATGTGGGAACTCGTCTACAAAAACTG
GATGATGGTAACTACGATGCGATCATTCTTGCTTGTGCTGGTTTAATTCGTTTAGGTCTAGAAGACCGAATCAAAAGTGC
AATCGAACCTGAGCAATCATTACCTGCTGTAGGTCAAGGTGCCGTTGGTATTGAAGCTCGCTTAGATGACGATCGCCTTC
GTGCTTTACTTGAACCTCTAAATCACCCAGAAACAGCAAACCGAGTTCTGTGTGAACGTGCGATGAATAATCGCCTAGAA
GGTGGTTGCCAAGTACCAATCGGTAGCTACTCACTAATTGATGGTGACCAAATTTGGTTACGTGCTCTTGTTGGCGAACC
TGATGGCTCAGTGATGATCCGTGGTGAAGTATCTGGACCGGTTTCTGACGCGGAAGCTTTAGGTACTCAACTTGCAGATC
AACTTTTAAACGATGGCGCGAAAGAAATTTTAGAACGCCTATACGCAGAAGCGTAA

Upstream 100 bases:

>100_bases
CTGATGTTTTTAACCCATAATCACACTGTTGTCATCCAGTATTTTCACCTCACCCTTAAGTAATGGTAGGATAAGGTAAT
TATTTTGATCGGATACTACT

Downstream 100 bases:

>100_bases
CTATGACGATTTTGGTGACTCGCCCTGAGCAAGAGAGCCAAGCTTTATGTGATGCCTTGAATCAATCAGGGCATCCAGCT
ATTTCTCACCCTCTTATCAC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MSQQLPVRIATRKSPLALWQAHFVKDALQAAHPGLEVELVTMVTKGDIILDTPLAKVGGKGLFVKELEVAMLEGRADLAV
HSMKDVPVEFPEGLGLVTICEREDPRDAFVSNTYNNIDELPQGAVVGTCSLRRQCQLKEARPDLIIKELRGNVGTRLQKL
DDGNYDAIILACAGLIRLGLEDRIKSAIEPEQSLPAVGQGAVGIEARLDDDRLRALLEPLNHPETANRVLCERAMNNRLE
GGCQVPIGSYSLIDGDQIWLRALVGEPDGSVMIRGEVSGPVSDAEALGTQLADQLLNDGAKEILERLYAEA

Sequences:

>Translated_311_residues
MSQQLPVRIATRKSPLALWQAHFVKDALQAAHPGLEVELVTMVTKGDIILDTPLAKVGGKGLFVKELEVAMLEGRADLAV
HSMKDVPVEFPEGLGLVTICEREDPRDAFVSNTYNNIDELPQGAVVGTCSLRRQCQLKEARPDLIIKELRGNVGTRLQKL
DDGNYDAIILACAGLIRLGLEDRIKSAIEPEQSLPAVGQGAVGIEARLDDDRLRALLEPLNHPETANRVLCERAMNNRLE
GGCQVPIGSYSLIDGDQIWLRALVGEPDGSVMIRGEVSGPVSDAEALGTQLADQLLNDGAKEILERLYAEA
>Mature_310_residues
SQQLPVRIATRKSPLALWQAHFVKDALQAAHPGLEVELVTMVTKGDIILDTPLAKVGGKGLFVKELEVAMLEGRADLAVH
SMKDVPVEFPEGLGLVTICEREDPRDAFVSNTYNNIDELPQGAVVGTCSLRRQCQLKEARPDLIIKELRGNVGTRLQKLD
DGNYDAIILACAGLIRLGLEDRIKSAIEPEQSLPAVGQGAVGIEARLDDDRLRALLEPLNHPETANRVLCERAMNNRLEG
GCQVPIGSYSLIDGDQIWLRALVGEPDGSVMIRGEVSGPVSDAEALGTQLADQLLNDGAKEILERLYAEA

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=332, Percent_Identity=40.6626506024096, Blast_Score=231, Evalue=5e-61,
Organism=Homo sapiens, GI66933009, Length=332, Percent_Identity=40.6626506024096, Blast_Score=231, Evalue=6e-61,
Organism=Escherichia coli, GI48994974, Length=303, Percent_Identity=76.2376237623762, Blast_Score=459, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6319996, Length=316, Percent_Identity=39.5569620253165, Blast_Score=206, Evalue=3e-54,
Organism=Drosophila melanogaster, GI20130425, Length=323, Percent_Identity=38.0804953560372, Blast_Score=205, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33737; Mature: 33606

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQQLPVRIATRKSPLALWQAHFVKDALQAAHPGLEVELVTMVTKGDIILDTPLAKVGGK
CCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCEEEECCHHHHCCC
GLFVKELEVAMLEGRADLAVHSMKDVPVEFPEGLGLVTICEREDPRDAFVSNTYNNIDEL
CEEHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHCCHHHHHHC
PQGAVVGTCSLRRQCQLKEARPDLIIKELRGNVGTRLQKLDDGNYDAIILACAGLIRLGL
CCCCEEEEHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCH
EDRIKSAIEPEQSLPAVGQGAVGIEARLDDDRLRALLEPLNHPETANRVLCERAMNNRLE
HHHHHHHCCCHHCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
GGCQVPIGSYSLIDGDQIWLRALVGEPDGSVMIRGEVSGPVSDAEALGTQLADQLLNDGA
CCEECCCCCEEEECCHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCHH
KEILERLYAEA
HHHHHHHHHCC
>Mature Secondary Structure 
SQQLPVRIATRKSPLALWQAHFVKDALQAAHPGLEVELVTMVTKGDIILDTPLAKVGGK
CCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCEEEECCHHHHCCC
GLFVKELEVAMLEGRADLAVHSMKDVPVEFPEGLGLVTICEREDPRDAFVSNTYNNIDEL
CEEHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHCCHHHHHHC
PQGAVVGTCSLRRQCQLKEARPDLIIKELRGNVGTRLQKLDDGNYDAIILACAGLIRLGL
CCCCEEEEHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCH
EDRIKSAIEPEQSLPAVGQGAVGIEARLDDDRLRALLEPLNHPETANRVLCERAMNNRLE
HHHHHHHCCCHHCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
GGCQVPIGSYSLIDGDQIWLRALVGEPDGSVMIRGEVSGPVSDAEALGTQLADQLLNDGA
CCEECCCCCEEEECCHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCHH
KEILERLYAEA
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA