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The map label for this gene is fabR [H]

Identifier: 172087777

GI number: 172087777

Start: 2738030

End: 2738707

Strand: Reverse

Name: fabR [H]

Synonym: VF_2438

Alternate gene names: 172087777

Gene position: 2738707-2738030 (Counterclockwise)

Preceding gene: 59713047

Following gene: 59713044

Centisome position: 94.52

GC content: 42.77

Gene sequence:

>678_bases
ATGTATCCTGAATTTGAAGTTGATGATCTCAATGCAGTCTCAGAAGTAAAGCGCCCAGTGAGTGCAAAAGGCGTTCGTGC
TCAACAAAAAGAAAGAACTCGAAGAACCATTATTGACGCTGCTTTTTGCCTATTATGTGCCGAGCGAGGTTTTACAAGCT
TAAGCTTACGAGAAGTTACTCGAGAAGCTGGAATTGCTCCAACGTCTTTTTATCGACACTTTAAAGATATGGATGAGTTA
GGCCTAACTCTAGTAGATGAAGGTGGTTTGATATTACGTCAATTAATGAGACAGGCTCGTCAACGTATCGTAGTTGAAGG
GAGTGTCATTAGAACTTCTGTTGAAACTTTCATGGAGTTTATTGAGGGAAGTCCTAACGTCTTTCGCTTATTACTACGTG
AACGCTCAGGAACATCACCCGCTTTTCGTGCCGCGGTAGCAAGAGAAATCCAACACTTTGTTGCGGAACTTACCGAATAT
TTAGTTGCCACAACAGGGGTAGCTCGTGAAGAAGCATTGGTTCAGGCTGAAGCATCGGTAACGCTTGTATTTAGCTCAGG
GGCAGAGGCATTAGATTTAGACTCGGCATCACGAACTGAATTATCTGAGCGACTGATTTTTCAATTACGAATGCTCTCTA
AAGGGGCCTACTGGTACCGTAAAGAGAATGAAAAATAG

Upstream 100 bases:

>100_bases
TGATTTCATTATTTACATAGGTAAGTAGAAATCGATAATGTGGGTTGGCGGAAGTTTGTGATACCCATTTAATTAAATCA
CACAACAAACGGTAAAGTAT

Downstream 100 bases:

>100_bases
AATTTAGGTACATTGTTCGCAGTGAATCAATGTCTGTATGAGGTAAAAACATGACACATGAAAATAGTAGAAATGAACGA
AAGACATTAGTGCTATCAGT

Product: DNA-binding transcriptional repressor FabR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MYPEFEVDDLNAVSEVKRPVSAKGVRAQQKERTRRTIIDAAFCLLCAERGFTSLSLREVTREAGIAPTSFYRHFKDMDEL
GLTLVDEGGLILRQLMRQARQRIVVEGSVIRTSVETFMEFIEGSPNVFRLLLRERSGTSPAFRAAVAREIQHFVAELTEY
LVATTGVAREEALVQAEASVTLVFSSGAEALDLDSASRTELSERLIFQLRMLSKGAYWYRKENEK

Sequences:

>Translated_225_residues
MYPEFEVDDLNAVSEVKRPVSAKGVRAQQKERTRRTIIDAAFCLLCAERGFTSLSLREVTREAGIAPTSFYRHFKDMDEL
GLTLVDEGGLILRQLMRQARQRIVVEGSVIRTSVETFMEFIEGSPNVFRLLLRERSGTSPAFRAAVAREIQHFVAELTEY
LVATTGVAREEALVQAEASVTLVFSSGAEALDLDSASRTELSERLIFQLRMLSKGAYWYRKENEK
>Mature_225_residues
MYPEFEVDDLNAVSEVKRPVSAKGVRAQQKERTRRTIIDAAFCLLCAERGFTSLSLREVTREAGIAPTSFYRHFKDMDEL
GLTLVDEGGLILRQLMRQARQRIVVEGSVIRTSVETFMEFIEGSPNVFRLLLRERSGTSPAFRAAVAREIQHFVAELTEY
LVATTGVAREEALVQAEASVTLVFSSGAEALDLDSASRTELSERLIFQLRMLSKGAYWYRKENEK

Specific function: Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, fabR directly influences the physical properties of the membrane bilayer [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI145693209, Length=203, Percent_Identity=71.9211822660099, Blast_Score=290, Evalue=5e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 25403; Mature: 25403

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYPEFEVDDLNAVSEVKRPVSAKGVRAQQKERTRRTIIDAAFCLLCAERGFTSLSLREVT
CCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
REAGIAPTSFYRHFKDMDELGLTLVDEGGLILRQLMRQARQRIVVEGSVIRTSVETFMEF
HHHCCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
IEGSPNVFRLLLRERSGTSPAFRAAVAREIQHFVAELTEYLVATTGVAREEALVQAEASV
HCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEE
TLVFSSGAEALDLDSASRTELSERLIFQLRMLSKGAYWYRKENEK
EEEECCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCC
>Mature Secondary Structure
MYPEFEVDDLNAVSEVKRPVSAKGVRAQQKERTRRTIIDAAFCLLCAERGFTSLSLREVT
CCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
REAGIAPTSFYRHFKDMDELGLTLVDEGGLILRQLMRQARQRIVVEGSVIRTSVETFMEF
HHHCCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
IEGSPNVFRLLLRERSGTSPAFRAAVAREIQHFVAELTEYLVATTGVAREEALVQAEASV
HCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEE
TLVFSSGAEALDLDSASRTELSERLIFQLRMLSKGAYWYRKENEK
EEEECCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA