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The map label for this gene is aceE [H]

Identifier: 172087759

GI number: 172087759

Start: 2450846

End: 2453509

Strand: Reverse

Name: aceE [H]

Synonym: VF_2181

Alternate gene names: 172087759

Gene position: 2453509-2450846 (Counterclockwise)

Preceding gene: 59712789

Following gene: 59712786

Centisome position: 84.68

GC content: 43.06

Gene sequence:

>2664_bases
ATGTCTGACATGAAGCATGACGTTGATGCACTAGAAACTCAGGATTGGTTAGAAGCTCTTGAGTCTGTTGTACGTGAAGA
AGGTGTTGAACGCGCCCAGTATCTATTAGAGCAAGTTCTTGATAAAGCTCGCTTAGATGGCGTTGATATGCCAACAGGTA
TTAATACCAACTACATCAATACCATCCCTGCGGCACAAGAGCCTGCTTACCCAGGTGATGTTACTCTTGAACGTCGTATC
CGTTCAATTATTCGTTGGAACGCAATCATGATCGTTCTACGTGCTTCGAAGAAAGATTTGGATCTAGGTGGCCACATGGC
TTCTTACCAATCTGCAGCTGCATTCTACGAAGTATGTTTCAACCATTTCTTCCGTGCTCCTAATGAGACTGACGGTGGTG
ATTTAGTTTACTACCAAGGCCATATCTCTCCAGGCATCTACTCTCGTGCATTCGTTGAAGGCCGTCTAACTGAAGAGCAG
TTAGATAACTTCCGTCAAGAAGTTGATGGCAAAGGTATTCCTTCATACCCGCACCCTAAACTAATGCCTGAATTCTGGCA
GTTCCCTACAGTATCTATGGGTCTTGGTCCAATTTCTGCTATCTACCAAGCACGTTTCCTTAAGTACCTTGAAGGTCGTG
GTCTTAAAGATACTTCAGCTCAACGTGTATACGCTTTCCTAGGCGACGGTGAGATGGATGAGCCAGAATCACGCGGTGCG
ATTTCTTTCGCTGCACGTGAAAAACTAGATAACCTATGTTTCCTAATCAACTGTAACCTACAGCGTCTAGATGGCCCTGT
TATGGGTAACGGTAAGATCATTCAAGAACTTGAAGGTCTATTTAAAGGTGCTGGTTGGAACGTTGTTAAGGTTATCTGGG
GCAACAACTGGGATGCTCTATTAGCTAAAGATACAACAGGTAAGCTTCTTCAGCTTATGAATGAAACTATCGATGGCGAT
TACCAAACATTTAAATCTAAAGATGGCGCATACGTACGTGAGCACTTCTTTGGTAAGTACCCTGAAACAGCTGCACTAGT
TGCAGATATGACTGATGACCAAATCTTCGAATTGAAGCGTGGTGGTCACGACTCTTCTAAACTGTTTGCTGCATTTAACA
ATGCAAAAGAAACAGGTGGTAAACCAACAGTAATCCTAGCTAAAACAGTTAAAGGTTACGGCATGGGTGATGCTGCAGAA
GGTAAAAACATCGCACACGGTGTTAAGAAAATGGACATGACTCACGTACAATACTTACGTGATCGTCTAGGTCTACAAGA
CATTCTTTCTGATGAGAAAGTAGCTGAACTACCTTACTTGAAACTGGAAGAAGGTTCTGCTGAATACGAATACCTACACG
CTCGTCGTAAAGCGCTACAAGGTTACACGCCTCAGCGTCTACCTAAATTCACTCAAGAATTCAAAGTTCCTGAGCTTGAA
GAATTTGCTCCTCTACTAGGTGAGCAAAAGCGTGACATCTCTACAACGATGGCTTACGTTCGTACGTTAAACATCCTACT
TAAAAATAAGAACATCGGTAAAAACATTGTTCCTATTATCTGTGATGAAGCTCGTACATTCGGTATGGAAGGTCTGTTCC
GTCAGATTGGTATCTACAACCCACACGGTCAAGAATATACTCCTGAAGATAAAGGTATTGTTTCTTACTACAAAGAAGCA
ACGTCAGGTCAAGTTCTTCAAGAAGGTATCAACGAATTAGGTTCAATGGCATCTTGGGTTGCTGCTGCGACTTCTTACAG
CACAAACGATCTACCAATGATCCCATTCTACATCTACTACTCAATGTTCGGTTTCCAACGTATTGGTGACATGGCATGGT
TAGCAGGTGACCAACAAGCTCGTGGTTTCCTATTAGGTGCAACGGCTGGTCGTACAACGCTAAATGGTGAAGGTCTACAA
CACGAAGATGGTCATTCACACATCATGGCAAACACAGTTCCTAACTGTATCTCTTACGACCCAACGTTTGCTTACGAGCT
AGCGGTAATCATGCAAGACGGTATCCGTCGTATGTATGGTGAGAACCAAGAGAACATTTACTACTACCTAACAGTAATGA
ATGAAAACTACGCAATGCCAGCAATGCCTGAAGGCGCTGAAGAAGGCATCCGTAAAGGTATCTACAAGCTTGAATCTCAC
GCTGGTGCTAAAGGTAAAGTTCAATTAATGAGCTCTGGTACTATCATGAATGAAGTGCGTAAAGCAGCACAAATTCTAAG
TGAAGAGTACGGCGTAGCATCTGATATCTTCTCTGTAACGTCTTTTAACGAGCTAACTCGTGATGGTCAAGATGCAGAGC
GTTACAACATGCTACACCCAGAAGCAGAAGCGAAAGTACCGTACATCACAACCGTTCTTGGTAACGAACCAGCAATCGCT
GCGACTGATTACATGAAGAACTACGCTGAACAAGTACGTGCGTACATGCCAACTGAATCTTACAAAGTACTTGGTACTGA
TGGTTTTGGTCGTTCAGACAGCCGTGAGAACCTACGTCGTCACTTCGAAGTTAACGCAGGCTACGTAGTTGTTGCTGCTC
TAACTGAATTAGTGAAACGTGGTGATATTGAGAAATCTGTTGTTACAGAAGCAATTGCTAAATTCAATATCGATACAGAA
AAAACTAACCCGCAATACGCATAA

Upstream 100 bases:

>100_bases
GAGTGTTCACTTCGTCGAATTCAGCAAAATAACGATATGAATTAAGCAAGAGAATATCGTTGATACCCTATTTGAACCAA
CAAATAAAAGGATAGCTCGC

Downstream 100 bases:

>100_bases
GACTTCCATTAATTAAGGAAACAAACAATGACAATCGAAATTAATGTACCTGACATCGGTGCAGATGAGGTTGAAGTAAC
TGAGATTCTAGTTAAGGTCG

Product: pyruvate dehydrogenase, decarboxylase component E1, thiamin-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 887; Mature: 886

Protein sequence:

>887_residues
MSDMKHDVDALETQDWLEALESVVREEGVERAQYLLEQVLDKARLDGVDMPTGINTNYINTIPAAQEPAYPGDVTLERRI
RSIIRWNAIMIVLRASKKDLDLGGHMASYQSAAAFYEVCFNHFFRAPNETDGGDLVYYQGHISPGIYSRAFVEGRLTEEQ
LDNFRQEVDGKGIPSYPHPKLMPEFWQFPTVSMGLGPISAIYQARFLKYLEGRGLKDTSAQRVYAFLGDGEMDEPESRGA
ISFAAREKLDNLCFLINCNLQRLDGPVMGNGKIIQELEGLFKGAGWNVVKVIWGNNWDALLAKDTTGKLLQLMNETIDGD
YQTFKSKDGAYVREHFFGKYPETAALVADMTDDQIFELKRGGHDSSKLFAAFNNAKETGGKPTVILAKTVKGYGMGDAAE
GKNIAHGVKKMDMTHVQYLRDRLGLQDILSDEKVAELPYLKLEEGSAEYEYLHARRKALQGYTPQRLPKFTQEFKVPELE
EFAPLLGEQKRDISTTMAYVRTLNILLKNKNIGKNIVPIICDEARTFGMEGLFRQIGIYNPHGQEYTPEDKGIVSYYKEA
TSGQVLQEGINELGSMASWVAAATSYSTNDLPMIPFYIYYSMFGFQRIGDMAWLAGDQQARGFLLGATAGRTTLNGEGLQ
HEDGHSHIMANTVPNCISYDPTFAYELAVIMQDGIRRMYGENQENIYYYLTVMNENYAMPAMPEGAEEGIRKGIYKLESH
AGAKGKVQLMSSGTIMNEVRKAAQILSEEYGVASDIFSVTSFNELTRDGQDAERYNMLHPEAEAKVPYITTVLGNEPAIA
ATDYMKNYAEQVRAYMPTESYKVLGTDGFGRSDSRENLRRHFEVNAGYVVVAALTELVKRGDIEKSVVTEAIAKFNIDTE
KTNPQYA

Sequences:

>Translated_887_residues
MSDMKHDVDALETQDWLEALESVVREEGVERAQYLLEQVLDKARLDGVDMPTGINTNYINTIPAAQEPAYPGDVTLERRI
RSIIRWNAIMIVLRASKKDLDLGGHMASYQSAAAFYEVCFNHFFRAPNETDGGDLVYYQGHISPGIYSRAFVEGRLTEEQ
LDNFRQEVDGKGIPSYPHPKLMPEFWQFPTVSMGLGPISAIYQARFLKYLEGRGLKDTSAQRVYAFLGDGEMDEPESRGA
ISFAAREKLDNLCFLINCNLQRLDGPVMGNGKIIQELEGLFKGAGWNVVKVIWGNNWDALLAKDTTGKLLQLMNETIDGD
YQTFKSKDGAYVREHFFGKYPETAALVADMTDDQIFELKRGGHDSSKLFAAFNNAKETGGKPTVILAKTVKGYGMGDAAE
GKNIAHGVKKMDMTHVQYLRDRLGLQDILSDEKVAELPYLKLEEGSAEYEYLHARRKALQGYTPQRLPKFTQEFKVPELE
EFAPLLGEQKRDISTTMAYVRTLNILLKNKNIGKNIVPIICDEARTFGMEGLFRQIGIYNPHGQEYTPEDKGIVSYYKEA
TSGQVLQEGINELGSMASWVAAATSYSTNDLPMIPFYIYYSMFGFQRIGDMAWLAGDQQARGFLLGATAGRTTLNGEGLQ
HEDGHSHIMANTVPNCISYDPTFAYELAVIMQDGIRRMYGENQENIYYYLTVMNENYAMPAMPEGAEEGIRKGIYKLESH
AGAKGKVQLMSSGTIMNEVRKAAQILSEEYGVASDIFSVTSFNELTRDGQDAERYNMLHPEAEAKVPYITTVLGNEPAIA
ATDYMKNYAEQVRAYMPTESYKVLGTDGFGRSDSRENLRRHFEVNAGYVVVAALTELVKRGDIEKSVVTEAIAKFNIDTE
KTNPQYA
>Mature_886_residues
SDMKHDVDALETQDWLEALESVVREEGVERAQYLLEQVLDKARLDGVDMPTGINTNYINTIPAAQEPAYPGDVTLERRIR
SIIRWNAIMIVLRASKKDLDLGGHMASYQSAAAFYEVCFNHFFRAPNETDGGDLVYYQGHISPGIYSRAFVEGRLTEEQL
DNFRQEVDGKGIPSYPHPKLMPEFWQFPTVSMGLGPISAIYQARFLKYLEGRGLKDTSAQRVYAFLGDGEMDEPESRGAI
SFAAREKLDNLCFLINCNLQRLDGPVMGNGKIIQELEGLFKGAGWNVVKVIWGNNWDALLAKDTTGKLLQLMNETIDGDY
QTFKSKDGAYVREHFFGKYPETAALVADMTDDQIFELKRGGHDSSKLFAAFNNAKETGGKPTVILAKTVKGYGMGDAAEG
KNIAHGVKKMDMTHVQYLRDRLGLQDILSDEKVAELPYLKLEEGSAEYEYLHARRKALQGYTPQRLPKFTQEFKVPELEE
FAPLLGEQKRDISTTMAYVRTLNILLKNKNIGKNIVPIICDEARTFGMEGLFRQIGIYNPHGQEYTPEDKGIVSYYKEAT
SGQVLQEGINELGSMASWVAAATSYSTNDLPMIPFYIYYSMFGFQRIGDMAWLAGDQQARGFLLGATAGRTTLNGEGLQH
EDGHSHIMANTVPNCISYDPTFAYELAVIMQDGIRRMYGENQENIYYYLTVMNENYAMPAMPEGAEEGIRKGIYKLESHA
GAKGKVQLMSSGTIMNEVRKAAQILSEEYGVASDIFSVTSFNELTRDGQDAERYNMLHPEAEAKVPYITTVLGNEPAIAA
TDYMKNYAEQVRAYMPTESYKVLGTDGFGRSDSRENLRRHFEVNAGYVVVAALTELVKRGDIEKSVVTEAIAKFNIDTEK
TNPQYA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=883, Percent_Identity=72.2536806342016, Blast_Score=1377, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=226, Percent_Identity=29.2035398230088, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 99366; Mature: 99234

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDMKHDVDALETQDWLEALESVVREEGVERAQYLLEQVLDKARLDGVDMPTGINTNYIN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
TIPAAQEPAYPGDVTLERRIRSIIRWNAIMIVLRASKKDLDLGGHMASYQSAAAFYEVCF
CCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
NHFFRAPNETDGGDLVYYQGHISPGIYSRAFVEGRLTEEQLDNFRQEVDGKGIPSYPHPK
HHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCC
LMPEFWQFPTVSMGLGPISAIYQARFLKYLEGRGLKDTSAQRVYAFLGDGEMDEPESRGA
CCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHEEEEEECCCCCCCCCCCCC
ISFAAREKLDNLCFLINCNLQRLDGPVMGNGKIIQELEGLFKGAGWNVVKVIWGNNWDAL
CHHHHHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEE
LAKDTTGKLLQLMNETIDGDYQTFKSKDGAYVREHFFGKYPETAALVADMTDDQIFELKR
EECCCHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHCCCCCCHHHHEECCCCHHHHHHHC
GGHDSSKLFAAFNNAKETGGKPTVILAKTVKGYGMGDAAEGKNIAHGVKKMDMTHVQYLR
CCCCCHHHHHHHHCHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DRLGLQDILSDEKVAELPYLKLEEGSAEYEYLHARRKALQGYTPQRLPKFTQEFKVPELE
HHCCHHHHHCCCHHHHCCCEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHH
EFAPLLGEQKRDISTTMAYVRTLNILLKNKNIGKNIVPIICDEARTFGMEGLFRQIGIYN
HHHHHHCCCHHHHHHHHHHHHHHHHHEECCCCCCCCCEEEECCHHHHCHHHHHHHHCCCC
PHGQEYTPEDKGIVSYYKEATSGQVLQEGINELGSMASWVAAATSYSTNDLPMIPFYIYY
CCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
SMFGFQRIGDMAWLAGDQQARGFLLGATAGRTTLNGEGLQHEDGHSHIMANTVPNCISYD
HHHHHHHHCCHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCHHCCC
PTFAYELAVIMQDGIRRMYGENQENIYYYLTVMNENYAMPAMPEGAEEGIRKGIYKLESH
CCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHC
AGAKGKVQLMSSGTIMNEVRKAAQILSEEYGVASDIFSVTSFNELTRDGQDAERYNMLHP
CCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCC
EAEAKVPYITTVLGNEPAIAATDYMKNYAEQVRAYMPTESYKVLGTDGFGRSDSRENLRR
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHH
HFEVNAGYVVVAALTELVKRGDIEKSVVTEAIAKFNIDTEKTNPQYA
HEECCCCEEHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SDMKHDVDALETQDWLEALESVVREEGVERAQYLLEQVLDKARLDGVDMPTGINTNYIN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
TIPAAQEPAYPGDVTLERRIRSIIRWNAIMIVLRASKKDLDLGGHMASYQSAAAFYEVCF
CCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
NHFFRAPNETDGGDLVYYQGHISPGIYSRAFVEGRLTEEQLDNFRQEVDGKGIPSYPHPK
HHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCC
LMPEFWQFPTVSMGLGPISAIYQARFLKYLEGRGLKDTSAQRVYAFLGDGEMDEPESRGA
CCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHEEEEEECCCCCCCCCCCCC
ISFAAREKLDNLCFLINCNLQRLDGPVMGNGKIIQELEGLFKGAGWNVVKVIWGNNWDAL
CHHHHHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEE
LAKDTTGKLLQLMNETIDGDYQTFKSKDGAYVREHFFGKYPETAALVADMTDDQIFELKR
EECCCHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHCCCCCCHHHHEECCCCHHHHHHHC
GGHDSSKLFAAFNNAKETGGKPTVILAKTVKGYGMGDAAEGKNIAHGVKKMDMTHVQYLR
CCCCCHHHHHHHHCHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DRLGLQDILSDEKVAELPYLKLEEGSAEYEYLHARRKALQGYTPQRLPKFTQEFKVPELE
HHCCHHHHHCCCHHHHCCCEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHH
EFAPLLGEQKRDISTTMAYVRTLNILLKNKNIGKNIVPIICDEARTFGMEGLFRQIGIYN
HHHHHHCCCHHHHHHHHHHHHHHHHHEECCCCCCCCCEEEECCHHHHCHHHHHHHHCCCC
PHGQEYTPEDKGIVSYYKEATSGQVLQEGINELGSMASWVAAATSYSTNDLPMIPFYIYY
CCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
SMFGFQRIGDMAWLAGDQQARGFLLGATAGRTTLNGEGLQHEDGHSHIMANTVPNCISYD
HHHHHHHHCCHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCHHCCC
PTFAYELAVIMQDGIRRMYGENQENIYYYLTVMNENYAMPAMPEGAEEGIRKGIYKLESH
CCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHC
AGAKGKVQLMSSGTIMNEVRKAAQILSEEYGVASDIFSVTSFNELTRDGQDAERYNMLHP
CCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCC
EAEAKVPYITTVLGNEPAIAATDYMKNYAEQVRAYMPTESYKVLGTDGFGRSDSRENLRR
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHH
HFEVNAGYVVVAALTELVKRGDIEKSVVTEAIAKFNIDTEKTNPQYA
HEECCCCEEHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]