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The map label for this gene is pdhR [H]

Identifier: 59712789

GI number: 59712789

Start: 2453565

End: 2454335

Strand: Reverse

Name: pdhR [H]

Synonym: VF_2182

Alternate gene names: 59712789

Gene position: 2454335-2453565 (Counterclockwise)

Preceding gene: 59712790

Following gene: 172087759

Centisome position: 84.7

GC content: 42.02

Gene sequence:

>771_bases
ATGACATATCAAAGGATACGCCAGCCAAAACTGTCCGATGTAATCGAACAAGAGTTAGAAAGGCTGATATTAGAAGGAAT
CCTTTCTCCTGGTCAGAAGTTACCGGCAGAAAGAGAGTTAGCAAAACAGTTTGATGTTTCTCGGCCGTCAGTTCGAGAGG
CGATACAACGTTTAGAAGCGAAGCATTTATTGACTCGGCGTCAAGGGGGCGGAACCTTTGTAAATAAAGGGTTATGGCAA
AGTTTTTCTGAGCCTTTGTTGGATTTATTAGCCACTCACCCTGAAACGCAATTTGATTTACTTGAGTCACGCCACGCATT
AGAAGGTATTTCAGCCTACTATGCCGCTTTACGTGGTAACGAAGAAGATTTTAAACGGATCAAAGAGTCACATCGTTTGA
TCCAACAAGCACAAAAAAATGGTGATCTTGAAGCGGAAGCTTCTGCGGTTATGCACTATCTTATAACAGTAACCGAATCA
GCACATAATGTGGTGCTGCTCCATATGGTTCGTAGTCTGGAACCTTTGCTTGAACAAAACGTATTACAAAATTTTACCTT
ATTAAATCGTCGAGAATCGGTGGTGGAGAAGGTAAGAGAGCACAGAGCTGAAATTGTAGAAGCCATCGTGTCAGGTAAGC
CTGAAGAAGCACGTTTAGCCTCACACTCTCATCTCGCTTATATTGAAGAAACGTTGCTGGAATTGACCAAAGAGGAATCA
CGACGTGAGTGTTCACTTCGTCGAATTCAGCAAAATAACGATATGAATTAA

Upstream 100 bases:

>100_bases
TAACTTTTGCATCAAATAAAATTGGTAATACCAATTATTAAAGTGACGAATGACTCACGGAAATGTGGGAAGTAATCAAC
TTAAATTAGGTTGAGCTACG

Downstream 100 bases:

>100_bases
GCAAGAGAATATCGTTGATACCCTATTTGAACCAACAAATAAAAGGATAGCTCGCATGTCTGACATGAAGCATGACGTTG
ATGCACTAGAAACTCAGGAT

Product: transcriptional regulator PdhR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MTYQRIRQPKLSDVIEQELERLILEGILSPGQKLPAERELAKQFDVSRPSVREAIQRLEAKHLLTRRQGGGTFVNKGLWQ
SFSEPLLDLLATHPETQFDLLESRHALEGISAYYAALRGNEEDFKRIKESHRLIQQAQKNGDLEAEASAVMHYLITVTES
AHNVVLLHMVRSLEPLLEQNVLQNFTLLNRRESVVEKVREHRAEIVEAIVSGKPEEARLASHSHLAYIEETLLELTKEES
RRECSLRRIQQNNDMN

Sequences:

>Translated_256_residues
MTYQRIRQPKLSDVIEQELERLILEGILSPGQKLPAERELAKQFDVSRPSVREAIQRLEAKHLLTRRQGGGTFVNKGLWQ
SFSEPLLDLLATHPETQFDLLESRHALEGISAYYAALRGNEEDFKRIKESHRLIQQAQKNGDLEAEASAVMHYLITVTES
AHNVVLLHMVRSLEPLLEQNVLQNFTLLNRRESVVEKVREHRAEIVEAIVSGKPEEARLASHSHLAYIEETLLELTKEES
RRECSLRRIQQNNDMN
>Mature_255_residues
TYQRIRQPKLSDVIEQELERLILEGILSPGQKLPAERELAKQFDVSRPSVREAIQRLEAKHLLTRRQGGGTFVNKGLWQS
FSEPLLDLLATHPETQFDLLESRHALEGISAYYAALRGNEEDFKRIKESHRLIQQAQKNGDLEAEASAVMHYLITVTESA
HNVVLLHMVRSLEPLLEQNVLQNFTLLNRRESVVEKVREHRAEIVEAIVSGKPEEARLASHSHLAYIEETLLELTKEESR
RECSLRRIQQNNDMN

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=234, Percent_Identity=68.8034188034188, Blast_Score=330, Evalue=8e-92,
Organism=Escherichia coli, GI1790032, Length=236, Percent_Identity=33.0508474576271, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1789353, Length=232, Percent_Identity=29.3103448275862, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1790780, Length=219, Percent_Identity=30.1369863013699, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI48994955, Length=232, Percent_Identity=28.448275862069, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 29471; Mature: 29340

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYQRIRQPKLSDVIEQELERLILEGILSPGQKLPAERELAKQFDVSRPSVREAIQRLEA
CCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
KHLLTRRQGGGTFVNKGLWQSFSEPLLDLLATHPETQFDLLESRHALEGISAYYAALRGN
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
EEDFKRIKESHRLIQQAQKNGDLEAEASAVMHYLITVTESAHNVVLLHMVRSLEPLLEQN
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
VLQNFTLLNRRESVVEKVREHRAEIVEAIVSGKPEEARLASHSHLAYIEETLLELTKEES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RRECSLRRIQQNNDMN
HHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TYQRIRQPKLSDVIEQELERLILEGILSPGQKLPAERELAKQFDVSRPSVREAIQRLEA
CHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
KHLLTRRQGGGTFVNKGLWQSFSEPLLDLLATHPETQFDLLESRHALEGISAYYAALRGN
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
EEDFKRIKESHRLIQQAQKNGDLEAEASAVMHYLITVTESAHNVVLLHMVRSLEPLLEQN
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
VLQNFTLLNRRESVVEKVREHRAEIVEAIVSGKPEEARLASHSHLAYIEETLLELTKEES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RRECSLRRIQQNNDMN
HHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]