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The map label for this gene is upp [H]

Identifier: 172087735

GI number: 172087735

Start: 2156288

End: 2156932

Strand: Reverse

Name: upp [H]

Synonym: VF_1927

Alternate gene names: 172087735

Gene position: 2156932-2156288 (Counterclockwise)

Preceding gene: 59712537

Following gene: 59712532

Centisome position: 74.44

GC content: 40.78

Gene sequence:

>645_bases
ATGTATCTGGAGTCAGAAATGAAAGTTGTTGAAGTAAAACACCCGCTAATAAAACATAAAATTGGTTTAATGCGCGAAGG
CGAGATCAGTACTAAACGTTTCCGTGAATTAGCAACGGAAGTAGGTAGCCTACTTACTTATGAAGCAACATCAGATTTTG
AAACAGAAAAAGTAACTATCAACGGCTGGAATGGCCCTGTTGAAGTTGACCAAATTAAAGGTAAAAAAGTAACTGTTGTT
CCAATTCTTCGTGCTGGTCTTGGTATGATGGATGGTGTTCTTGAGCATATCCCAAGCGCACGTATCAGTGTTGTTGGTAT
TTACCGTGACGAAGAAACACTAGAACCTGTACCATACTTCAACAAATTGGCTTCTAACATCGATGAGCGTATTGCTCTTG
TTGTTGACCCAATGTTAGCAACTGGCGGTTCTATGATTGCAACTCTGGATCTTCTTAAGGAGAAAGGTTGTAAGCACTTT
AAAGTTCTTGTGCTTGTTGCTGCTCCAGAAGGTATTGAAGCATTAGAAAAAGCGCACCCAGATGTAGAGCTTTACACCGC
CGCTATTGATGAGAAGCTAAATGACAAAGGTTACATCGTACCTGGTCTAGGCGATGCGGGTGATAAGATCTTCGGTACTA
AATAA

Upstream 100 bases:

>100_bases
AAAAATAATAAACTCGGTAAACGATTTCAATACTAGTGAATTATTTTCATATAACTTAATTTTTTAATGAAAAAGTATGT
ATAATTAGAAGGTTTGATTA

Downstream 100 bases:

>100_bases
TTTAGTTTAGAAACTAGAAATGAAGAATTAAAAAAAGGCTTGATGAATTAATCATCAAGCCTTTTTATTATCTAGACCCT
AACCCCTTAATCTATTTATC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MYLESEMKVVEVKHPLIKHKIGLMREGEISTKRFRELATEVGSLLTYEATSDFETEKVTINGWNGPVEVDQIKGKKVTVV
PILRAGLGMMDGVLEHIPSARISVVGIYRDEETLEPVPYFNKLASNIDERIALVVDPMLATGGSMIATLDLLKEKGCKHF
KVLVLVAAPEGIEALEKAHPDVELYTAAIDEKLNDKGYIVPGLGDAGDKIFGTK

Sequences:

>Translated_214_residues
MYLESEMKVVEVKHPLIKHKIGLMREGEISTKRFRELATEVGSLLTYEATSDFETEKVTINGWNGPVEVDQIKGKKVTVV
PILRAGLGMMDGVLEHIPSARISVVGIYRDEETLEPVPYFNKLASNIDERIALVVDPMLATGGSMIATLDLLKEKGCKHF
KVLVLVAAPEGIEALEKAHPDVELYTAAIDEKLNDKGYIVPGLGDAGDKIFGTK
>Mature_214_residues
MYLESEMKVVEVKHPLIKHKIGLMREGEISTKRFRELATEVGSLLTYEATSDFETEKVTINGWNGPVEVDQIKGKKVTVV
PILRAGLGMMDGVLEHIPSARISVVGIYRDEETLEPVPYFNKLASNIDERIALVVDPMLATGGSMIATLDLLKEKGCKHF
KVLVLVAAPEGIEALEKAHPDVELYTAAIDEKLNDKGYIVPGLGDAGDKIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=26.7326732673267, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=26.7326732673267, Blast_Score=75, Evalue=5e-14,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=84.1346153846154, Blast_Score=368, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=24.3781094527363, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=24.3781094527363, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6321920, Length=138, Percent_Identity=42.0289855072464, Blast_Score=107, Evalue=2e-24,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=28.0788177339901, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=28.0788177339901, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=28.0788177339901, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=28.0788177339901, Blast_Score=80, Evalue=7e-16,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23489; Mature: 23489

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLESEMKVVEVKHPLIKHKIGLMREGEISTKRFRELATEVGSLLTYEATSDFETEKVTI
CCCCCCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCEEEEE
NGWNGPVEVDQIKGKKVTVVPILRAGLGMMDGVLEHIPSARISVVGIYRDEETLEPVPYF
ECCCCCEEHEECCCCEEEEEHHHHHCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHH
NKLASNIDERIALVVDPMLATGGSMIATLDLLKEKGCKHFKVLVLVAAPEGIEALEKAHP
HHHHHCHHHHEEEEECHHHHCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHCCC
DVELYTAAIDEKLNDKGYIVPGLGDAGDKIFGTK
CCEEEHHHHHHCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MYLESEMKVVEVKHPLIKHKIGLMREGEISTKRFRELATEVGSLLTYEATSDFETEKVTI
CCCCCCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCEEEEE
NGWNGPVEVDQIKGKKVTVVPILRAGLGMMDGVLEHIPSARISVVGIYRDEETLEPVPYF
ECCCCCEEHEECCCCEEEEEHHHHHCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHH
NKLASNIDERIALVVDPMLATGGSMIATLDLLKEKGCKHFKVLVLVAAPEGIEALEKAHP
HHHHHCHHHHEEEEECHHHHCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHCCC
DVELYTAAIDEKLNDKGYIVPGLGDAGDKIFGTK
CCEEEHHHHHHCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA