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The map label for this gene is tmk

Identifier: 58617504

GI number: 58617504

Start: 1241729

End: 1242337

Strand: Reverse

Name: tmk

Synonym: ERGA_CDS_07770

Alternate gene names: 58617504

Gene position: 1242337-1241729 (Counterclockwise)

Preceding gene: 58617505

Following gene: 58617503

Centisome position: 82.83

GC content: 29.23

Gene sequence:

>609_bases
ATGTTTATTACTTTTGAAGGGATAGATGGTTCAGGTAAAACCACTCAATCAAGATTACTAACAGAGTATTTATCAGGGGT
ATATGGTGTAGATAATGTTATATTGACTAGAGAACCTGGTGGTACTTTTTTTAATGAATCAGTACGTAATTTATTGTTTA
GTACTAAAAATCTAGATAAGTTATCTGAACTGCTTTTCTTTATTGCAATGCGTAGAGAACATTTTATGAAAGTAATTAAA
CCTGCATTAACTCAACAAAAAATAGTGATTTGTGATAGGTTTATTGATTCTACAATTGCATATCAAGGTTATGGTCACGG
TATTGATTGTAAGTTGATTGAAGAGTTGAATGATTTAGTAGTTGATATTTATCCGAATATTACATTTGTTCTTGATTCTG
ATATTAACCAGTCTGTTGCTAGATCTAATAAGAATGGATATGAATTTCTTGATTTGGAGTTTTATGCTAGGGTTAGAGAT
GGATTTCGTGATATTGTAAAAAGAAATCAATACCGTTGTTATCTAATTACCAATGTAGATGCAACGAAAAATATTAATGA
GATAAGTGCTATATATTTAAAAACGATAAAAATATTGCACGCATTGTGA

Upstream 100 bases:

>100_bases
AATGCTCAAGTTTTCTAAAGTGTATTTATTAAGTGATATGTACAAGCTTTGTTTTATCTTTATTGAATGTGTGTTTTGTA
TTAGGTTATAGGAATTTATT

Downstream 100 bases:

>100_bases
AATGAATATAGCATCTATGGTTTATTTTTTAGTAATTTATAAATGGAGGTTATTTTGAGTAGGAAATTTTTTATATGGTC
TTTAGTTTCACTGTTTTATG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MFITFEGIDGSGKTTQSRLLTEYLSGVYGVDNVILTREPGGTFFNESVRNLLFSTKNLDKLSELLFFIAMRREHFMKVIK
PALTQQKIVICDRFIDSTIAYQGYGHGIDCKLIEELNDLVVDIYPNITFVLDSDINQSVARSNKNGYEFLDLEFYARVRD
GFRDIVKRNQYRCYLITNVDATKNINEISAIYLKTIKILHAL

Sequences:

>Translated_202_residues
MFITFEGIDGSGKTTQSRLLTEYLSGVYGVDNVILTREPGGTFFNESVRNLLFSTKNLDKLSELLFFIAMRREHFMKVIK
PALTQQKIVICDRFIDSTIAYQGYGHGIDCKLIEELNDLVVDIYPNITFVLDSDINQSVARSNKNGYEFLDLEFYARVRD
GFRDIVKRNQYRCYLITNVDATKNINEISAIYLKTIKILHAL
>Mature_202_residues
MFITFEGIDGSGKTTQSRLLTEYLSGVYGVDNVILTREPGGTFFNESVRNLLFSTKNLDKLSELLFFIAMRREHFMKVIK
PALTQQKIVICDRFIDSTIAYQGYGHGIDCKLIEELNDLVVDIYPNITFVLDSDINQSVARSNKNGYEFLDLEFYARVRD
GFRDIVKRNQYRCYLITNVDATKNINEISAIYLKTIKILHAL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=198, Percent_Identity=33.8383838383838, Blast_Score=100, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_EHRRG (Q5FG91)

Other databases:

- EMBL:   CR925677
- RefSeq:   YP_196703.1
- ProteinModelPortal:   Q5FG91
- STRING:   Q5FG91
- GeneID:   3268770
- GenomeReviews:   CR925677_GR
- KEGG:   erg:ERGA_CDS_07770
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   KGHIVIS
- ProtClustDB:   PRK13976
- BioCyc:   ERUM302409:ERGA_CDS_07770-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23232; Mature: 23232

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFITFEGIDGSGKTTQSRLLTEYLSGVYGVDNVILTREPGGTFFNESVRNLLFSTKNLDK
CEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCHHH
LSELLFFIAMRREHFMKVIKPALTQQKIVICDRFIDSTIAYQGYGHGIDCKLIEELNDLV
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHE
VDIYPNITFVLDSDINQSVARSNKNGYEFLDLEFYARVRDGFRDIVKRNQYRCYLITNVD
EEECCCEEEEEECCCHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
ATKNINEISAIYLKTIKILHAL
CCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFITFEGIDGSGKTTQSRLLTEYLSGVYGVDNVILTREPGGTFFNESVRNLLFSTKNLDK
CEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCHHH
LSELLFFIAMRREHFMKVIKPALTQQKIVICDRFIDSTIAYQGYGHGIDCKLIEELNDLV
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHE
VDIYPNITFVLDSDINQSVARSNKNGYEFLDLEFYARVRDGFRDIVKRNQYRCYLITNVD
EEECCCEEEEEECCCHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
ATKNINEISAIYLKTIKILHAL
CCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA