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The map label for this gene is purC [H]

Identifier: 58617454

GI number: 58617454

Start: 1152183

End: 1152935

Strand: Reverse

Name: purC [H]

Synonym: ERGA_CDS_07270

Alternate gene names: 58617454

Gene position: 1152935-1152183 (Counterclockwise)

Preceding gene: 58617457

Following gene: 58617451

Centisome position: 76.87

GC content: 28.55

Gene sequence:

>753_bases
ATGAGCCCTTATATTTACCCGAAAATACATATGGTACAAAAAATTTACGAAGGAAAAGCAAAAGTTATATTTTCAACTTC
TAAGTCTACAGAGGTTATACAGCACTTTAAAGATAATATAACTGCATTTAACAATAAAAAAGCTGATATTATTCCAGAAA
AAGGAGTAGTGAATAACTATATAAGTGCATTTATAATGAAAAAGCTGACATCTACAGGTATAAAAACACATTTTATATCT
TTATTAAATGATAGAGAACAGTTAATAAAGCATGTTACAATCATACCAATTGAAGTTGTTGTAAGGAATGCATCAGCTGG
TAATTTTAGTAAAAGATTCAATATGAAAGATGGAATAACATTTAGATTACCTATTCTTGAATTTTATTATAAAGATGACG
AATTACATGATCCTATGATCAGTGAAAGCCATATTTTAAGTTTTCAATTACTAACATCATATGAGCTGGATATGATAAAA
AAGCTATCACTTCATATAAACGATGTTCTAAGCAAACTTTTTTTTGACGTGAATATTAAATTAGTAGATTTTAAACTAGA
ATTTGGTAGGTTATACAATAATCAAACTGAGCTACTTCTAGCTGATGAAATAAGTCCTGATACATGTAGGCTTTGGGATA
TATCAACTAATGAAAAGTTAGATAAGGATTGTTATCGACTTGATCTTGGAAATGTAATCGAGAGATATAAGGAAGTTGCA
CAAAGACTACATGCTATCCCAAGTTCTACTTGA

Upstream 100 bases:

>100_bases
TCAATCTACAAAAACACATATAATATAAAGAACTATTAAGTACACGATACATTGGTTAATATAAAAAAGGCGGTTGCTAA
AACGCTTATAGAAATATACA

Downstream 100 bases:

>100_bases
TAAGGTGTACACATTGTTAAAAAAAGCAATACACCAAAACTATATGTAAGTTTAATTGGTAAACTATAAATTTCATTTGA
TGCTTAATATTAAATTTATT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MSPYIYPKIHMVQKIYEGKAKVIFSTSKSTEVIQHFKDNITAFNNKKADIIPEKGVVNNYISAFIMKKLTSTGIKTHFIS
LLNDREQLIKHVTIIPIEVVVRNASAGNFSKRFNMKDGITFRLPILEFYYKDDELHDPMISESHILSFQLLTSYELDMIK
KLSLHINDVLSKLFFDVNIKLVDFKLEFGRLYNNQTELLLADEISPDTCRLWDISTNEKLDKDCYRLDLGNVIERYKEVA
QRLHAIPSST

Sequences:

>Translated_250_residues
MSPYIYPKIHMVQKIYEGKAKVIFSTSKSTEVIQHFKDNITAFNNKKADIIPEKGVVNNYISAFIMKKLTSTGIKTHFIS
LLNDREQLIKHVTIIPIEVVVRNASAGNFSKRFNMKDGITFRLPILEFYYKDDELHDPMISESHILSFQLLTSYELDMIK
KLSLHINDVLSKLFFDVNIKLVDFKLEFGRLYNNQTELLLADEISPDTCRLWDISTNEKLDKDCYRLDLGNVIERYKEVA
QRLHAIPSST
>Mature_249_residues
SPYIYPKIHMVQKIYEGKAKVIFSTSKSTEVIQHFKDNITAFNNKKADIIPEKGVVNNYISAFIMKKLTSTGIKTHFISL
LNDREQLIKHVTIIPIEVVVRNASAGNFSKRFNMKDGITFRLPILEFYYKDDELHDPMISESHILSFQLLTSYELDMIKK
LSLHINDVLSKLFFDVNIKLVDFKLEFGRLYNNQTELLLADEISPDTCRLWDISTNEKLDKDCYRLDLGNVIERYKEVAQ
RLHAIPSST

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=227, Percent_Identity=32.15859030837, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI5453539, Length=227, Percent_Identity=32.15859030837, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI119220559, Length=234, Percent_Identity=31.1965811965812, Blast_Score=104, Evalue=7e-23,
Organism=Escherichia coli, GI1788820, Length=230, Percent_Identity=43.0434782608696, Blast_Score=199, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17531275, Length=229, Percent_Identity=31.8777292576419, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI18860083, Length=248, Percent_Identity=29.8387096774194, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24583917, Length=248, Percent_Identity=28.2258064516129, Blast_Score=93, Evalue=1e-19,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 29013; Mature: 28882

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPYIYPKIHMVQKIYEGKAKVIFSTSKSTEVIQHFKDNITAFNNKKADIIPEKGVVNNY
CCCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHH
ISAFIMKKLTSTGIKTHFISLLNDREQLIKHVTIIPIEVVVRNASAGNFSKRFNMKDGIT
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCHHHCCCCCCCE
FRLPILEFYYKDDELHDPMISESHILSFQLLTSYELDMIKKLSLHINDVLSKLFFDVNIK
EEEEHHEEEECCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCEEE
LVDFKLEFGRLYNNQTELLLADEISPDTCRLWDISTNEKLDKDCYRLDLGNVIERYKEVA
EEEEEEEEHHHCCCCCEEEEEECCCCCCEEEEECCCCCCCCHHHHHCCHHHHHHHHHHHH
QRLHAIPSST
HHHHCCCCCC
>Mature Secondary Structure 
SPYIYPKIHMVQKIYEGKAKVIFSTSKSTEVIQHFKDNITAFNNKKADIIPEKGVVNNY
CCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHH
ISAFIMKKLTSTGIKTHFISLLNDREQLIKHVTIIPIEVVVRNASAGNFSKRFNMKDGIT
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCHHHCCCCCCCE
FRLPILEFYYKDDELHDPMISESHILSFQLLTSYELDMIKKLSLHINDVLSKLFFDVNIK
EEEEHHEEEECCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCEEE
LVDFKLEFGRLYNNQTELLLADEISPDTCRLWDISTNEKLDKDCYRLDLGNVIERYKEVA
EEEEEEEEHHHCCCCCEEEEEECCCCCCEEEEECCCCCCCCHHHHHCCHHHHHHHHHHHH
QRLHAIPSST
HHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA