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The map label for this gene is groEL [H]

Identifier: 58617391

GI number: 58617391

Start: 1051286

End: 1052941

Strand: Reverse

Name: groEL [H]

Synonym: ERGA_CDS_06640

Alternate gene names: 58617391

Gene position: 1052941-1051286 (Counterclockwise)

Preceding gene: 58617392

Following gene: 58617389

Centisome position: 70.2

GC content: 35.02

Gene sequence:

>1656_bases
ATGGCAAATATGGTTGTAACAGGGGAGCAACTAGACAAATCAATTAGGGAAGTTGTCCGTATTTTAGAAGACGCAGTAGG
ATGTACAGCTGGTCCAAAAGGATTGACTGTAGCTATTAGTAAACCTTATGGTGCACCAGAGGTGACAAAAGATGGATATA
AGGTTATGAAAAGTATAAAGCCAGAAGATCCATTGGCTCTTGCTATTGCTAATATAATTGCTCAAAGTGCTTCTCAATGT
AACGATAAAGTAGGTGATGGAACTACTACGTGTTCTATTTTAACTGCAAAGGTTATTGAGGAAGTATCTAAAGTTAAGGC
TGCTGGTGCAGATATTATTTGTGTTAGAGAAGGTGTACTTAAAGCTAAAGAGGCAGTATTAGAAGCTTTAAAATGCATGA
AGCGTGAAGTATTATCTGAAGAAGAAATTGCCCAAGTTGCAACTATCTCTGCAAATGGTGATAAAAATATAGGTACTAAA
ATTGCACAGTGTGTTAAAGAAGTTGGTAAAGATGGAGTTATTACAGTTGAAGAAAGCAAAGGATTTAAAGAGTTAGATGT
TGAAAAAACTGATGGTATGCAATTTGACAGAGGATATCTTTCTCCTTATTTTGTTACTAACTCAGAAAAGATGTTAGTTG
AGTTTGAAAATCCTTATATTTTATTAACAGAAAAGAAACTAAATATAATACAACCTCTATTGCCAATTTTAGAGAATATT
GCTAGATCAGGTAGACCACTTTTAATTATTGCAGAGGATGTAGAAGGTGAAGCACTGAGTACACTTGTATTGAATAAGTT
GCGTGGTGGTTTACATGTAGCTGCAGTTAAAGCTCCAGGGTTTGGAGATAGAAGAAAAGATATGTTAGGTGATATTGCAA
TTTTAACTGGAGCTAAACATGTAATAAATGATGAGCTTGCTATTAAAATGGAAGATTTGACTCTATGTGATTTAGGAACT
GCTAAGAATATACGTATTACAAAAGATACTACAACTATTATTGGTAGTGTAGATAATAGTTGTGCTCATGTTCAAAGTAG
AATTTGTCAAATTAGAATGCAAATTGATAATTCTACTTCAGATTATGATAAAGAAAAGCTACAAGAGCGTTTAGCAAAGC
TTTCTGGTGGTGTTGCTGTATTGAAAGTAGGTGGATCTAGTGAAGTTGAAGTTAAGGAACGTAAAGATCGTGTAGAAGAT
GCTCTTCATGCAACTAGAGCTGCTGTTGAAGAAGGTGTTGTGCCAGGTGGTGGTGCTGCATTATTGTATACATTATCAGC
GCTTGACAACTTAAAAAGTAAGAATGATGATGAACAGTTGGGTATTAATATTGTAAAGCGTGCTTTACAAGCTCCTATAA
AGCGTATTATTAAAAATGCTGGATCAGAAAATGCACCATGTGTTATTGCTCATTTATTGAAGCAAAATGATAAGGAACTT
ATCTTTAATGTGGACGTAATGAATTTTGCTAATGCATTTACTTCTGGAGTAATTGATCCACTTAAAGTAGTGCGTATAGC
ATTTGATTTTGCTGTATCTCTTGCTGCAGTATTTATGACACTTAATGCTATTGTTGTGGATATCCCATCTAAGGATGATA
ATAGTGCTGCAGGTGGTGCTGGTATGGGAGGCATGGGTGGTATGGGTGGTTTTTAA

Upstream 100 bases:

>100_bases
AATAGATTATATTTAGTATATTAAATAAAATATAGTTTTTTTGCAATTGCTGAAAGTATAGGTGTTTTAGTTAATTTTTC
ATTATAAATGGAGTAAAGAC

Downstream 100 bases:

>100_bases
GTAACCATATCTCCTTTAATATTATATGGAGGAAGTTTGTTTACTTCCTCCTGTACGTTTATGATGTAGTATTTTTTATA
AGTTAACTTATCTACTTTAT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 551; Mature: 550

Protein sequence:

>551_residues
MANMVVTGEQLDKSIREVVRILEDAVGCTAGPKGLTVAISKPYGAPEVTKDGYKVMKSIKPEDPLALAIANIIAQSASQC
NDKVGDGTTTCSILTAKVIEEVSKVKAAGADIICVREGVLKAKEAVLEALKCMKREVLSEEEIAQVATISANGDKNIGTK
IAQCVKEVGKDGVITVEESKGFKELDVEKTDGMQFDRGYLSPYFVTNSEKMLVEFENPYILLTEKKLNIIQPLLPILENI
ARSGRPLLIIAEDVEGEALSTLVLNKLRGGLHVAAVKAPGFGDRRKDMLGDIAILTGAKHVINDELAIKMEDLTLCDLGT
AKNIRITKDTTTIIGSVDNSCAHVQSRICQIRMQIDNSTSDYDKEKLQERLAKLSGGVAVLKVGGSSEVEVKERKDRVED
ALHATRAAVEEGVVPGGGAALLYTLSALDNLKSKNDDEQLGINIVKRALQAPIKRIIKNAGSENAPCVIAHLLKQNDKEL
IFNVDVMNFANAFTSGVIDPLKVVRIAFDFAVSLAAVFMTLNAIVVDIPSKDDNSAAGGAGMGGMGGMGGF

Sequences:

>Translated_551_residues
MANMVVTGEQLDKSIREVVRILEDAVGCTAGPKGLTVAISKPYGAPEVTKDGYKVMKSIKPEDPLALAIANIIAQSASQC
NDKVGDGTTTCSILTAKVIEEVSKVKAAGADIICVREGVLKAKEAVLEALKCMKREVLSEEEIAQVATISANGDKNIGTK
IAQCVKEVGKDGVITVEESKGFKELDVEKTDGMQFDRGYLSPYFVTNSEKMLVEFENPYILLTEKKLNIIQPLLPILENI
ARSGRPLLIIAEDVEGEALSTLVLNKLRGGLHVAAVKAPGFGDRRKDMLGDIAILTGAKHVINDELAIKMEDLTLCDLGT
AKNIRITKDTTTIIGSVDNSCAHVQSRICQIRMQIDNSTSDYDKEKLQERLAKLSGGVAVLKVGGSSEVEVKERKDRVED
ALHATRAAVEEGVVPGGGAALLYTLSALDNLKSKNDDEQLGINIVKRALQAPIKRIIKNAGSENAPCVIAHLLKQNDKEL
IFNVDVMNFANAFTSGVIDPLKVVRIAFDFAVSLAAVFMTLNAIVVDIPSKDDNSAAGGAGMGGMGGMGGF
>Mature_550_residues
ANMVVTGEQLDKSIREVVRILEDAVGCTAGPKGLTVAISKPYGAPEVTKDGYKVMKSIKPEDPLALAIANIIAQSASQCN
DKVGDGTTTCSILTAKVIEEVSKVKAAGADIICVREGVLKAKEAVLEALKCMKREVLSEEEIAQVATISANGDKNIGTKI
AQCVKEVGKDGVITVEESKGFKELDVEKTDGMQFDRGYLSPYFVTNSEKMLVEFENPYILLTEKKLNIIQPLLPILENIA
RSGRPLLIIAEDVEGEALSTLVLNKLRGGLHVAAVKAPGFGDRRKDMLGDIAILTGAKHVINDELAIKMEDLTLCDLGTA
KNIRITKDTTTIIGSVDNSCAHVQSRICQIRMQIDNSTSDYDKEKLQERLAKLSGGVAVLKVGGSSEVEVKERKDRVEDA
LHATRAAVEEGVVPGGGAALLYTLSALDNLKSKNDDEQLGINIVKRALQAPIKRIIKNAGSENAPCVIAHLLKQNDKELI
FNVDVMNFANAFTSGVIDPLKVVRIAFDFAVSLAAVFMTLNAIVVDIPSKDDNSAAGGAGMGGMGGMGGF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=517, Percent_Identity=47.5822050290135, Blast_Score=439, Evalue=1e-123,
Organism=Homo sapiens, GI31542947, Length=517, Percent_Identity=47.5822050290135, Blast_Score=439, Evalue=1e-123,
Organism=Escherichia coli, GI1790586, Length=515, Percent_Identity=51.0679611650485, Blast_Score=499, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17555558, Length=517, Percent_Identity=48.5493230174081, Blast_Score=451, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI193210679, Length=215, Percent_Identity=51.6279069767442, Blast_Score=197, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6323288, Length=512, Percent_Identity=47.0703125, Blast_Score=438, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24641193, Length=519, Percent_Identity=47.3988439306358, Blast_Score=445, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24641191, Length=519, Percent_Identity=47.3988439306358, Blast_Score=445, Evalue=1e-125,
Organism=Drosophila melanogaster, GI45550936, Length=513, Percent_Identity=44.8343079922027, Blast_Score=417, Evalue=1e-116,
Organism=Drosophila melanogaster, GI45550132, Length=513, Percent_Identity=44.8343079922027, Blast_Score=417, Evalue=1e-116,
Organism=Drosophila melanogaster, GI45550935, Length=513, Percent_Identity=44.8343079922027, Blast_Score=417, Evalue=1e-116,
Organism=Drosophila melanogaster, GI17864606, Length=531, Percent_Identity=41.2429378531073, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24584129, Length=534, Percent_Identity=34.0823970037453, Blast_Score=265, Evalue=4e-71,
Organism=Drosophila melanogaster, GI19921262, Length=534, Percent_Identity=34.0823970037453, Blast_Score=265, Evalue=4e-71,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58860; Mature: 58729

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANMVVTGEQLDKSIREVVRILEDAVGCTAGPKGLTVAISKPYGAPEVTKDGYKVMKSIK
CCCEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCC
PEDPLALAIANIIAQSASQCNDKVGDGTTTCSILTAKVIEEVSKVKAAGADIICVREGVL
CCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHH
KAKEAVLEALKCMKREVLSEEEIAQVATISANGDKNIGTKIAQCVKEVGKDGVITVEESK
HHHHHHHHHHHHHHHHHCCHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCC
GFKELDVEKTDGMQFDRGYLSPYFVTNSEKMLVEFENPYILLTEKKLNIIQPLLPILENI
CCCCCCCCCCCCCEECCCCCCCEEEECCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHH
ARSGRPLLIIAEDVEGEALSTLVLNKLRGGLHVAAVKAPGFGDRRKDMLGDIAILTGAKH
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCHH
VINDELAIKMEDLTLCDLGTAKNIRITKDTTTIIGSVDNSCAHVQSRICQIRMQIDNSTS
HHCCCCEEEEECEEEEECCCCCCEEEECCCEEEEECCCCHHHHHHHHHHHEEEEECCCCC
DYDKEKLQERLAKLSGGVAVLKVGGSSEVEVKERKDRVEDALHATRAAVEEGVVPGGGAA
CCCHHHHHHHHHHHCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
LLYTLSALDNLKSKNDDEQLGINIVKRALQAPIKRIIKNAGSENAPCVIAHLLKQNDKEL
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEE
IFNVDVMNFANAFTSGVIDPLKVVRIAFDFAVSLAAVFMTLNAIVVDIPSKDDNSAAGGA
EEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCC
GMGGMGGMGGF
CCCCCCCCCCC
>Mature Secondary Structure 
ANMVVTGEQLDKSIREVVRILEDAVGCTAGPKGLTVAISKPYGAPEVTKDGYKVMKSIK
CCEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCC
PEDPLALAIANIIAQSASQCNDKVGDGTTTCSILTAKVIEEVSKVKAAGADIICVREGVL
CCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHH
KAKEAVLEALKCMKREVLSEEEIAQVATISANGDKNIGTKIAQCVKEVGKDGVITVEESK
HHHHHHHHHHHHHHHHHCCHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCC
GFKELDVEKTDGMQFDRGYLSPYFVTNSEKMLVEFENPYILLTEKKLNIIQPLLPILENI
CCCCCCCCCCCCCEECCCCCCCEEEECCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHH
ARSGRPLLIIAEDVEGEALSTLVLNKLRGGLHVAAVKAPGFGDRRKDMLGDIAILTGAKH
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCHH
VINDELAIKMEDLTLCDLGTAKNIRITKDTTTIIGSVDNSCAHVQSRICQIRMQIDNSTS
HHCCCCEEEEECEEEEECCCCCCEEEECCCEEEEECCCCHHHHHHHHHHHEEEEECCCCC
DYDKEKLQERLAKLSGGVAVLKVGGSSEVEVKERKDRVEDALHATRAAVEEGVVPGGGAA
CCCHHHHHHHHHHHCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
LLYTLSALDNLKSKNDDEQLGINIVKRALQAPIKRIIKNAGSENAPCVIAHLLKQNDKEL
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEE
IFNVDVMNFANAFTSGVIDPLKVVRIAFDFAVSLAAVFMTLNAIVVDIPSKDDNSAAGGA
EEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCC
GMGGMGGMGGF
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA