| Definition | Ehrlichia ruminantium str. Gardel, complete genome. |
|---|---|
| Accession | NC_006831 |
| Length | 1,499,920 |
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The map label for this gene is clpB [H]
Identifier: 58617389
GI number: 58617389
Start: 1045645
End: 1048236
Strand: Reverse
Name: clpB [H]
Synonym: ERGA_CDS_06620
Alternate gene names: 58617389
Gene position: 1048236-1045645 (Counterclockwise)
Preceding gene: 58617391
Following gene: 58617387
Centisome position: 69.89
GC content: 33.76
Gene sequence:
>2592_bases ATGAAGTTAGTTATGGATTTAAATAAATTTACTGATATATCAAAGAATTTCATAGTGCAAGCGCAAACTTCAGCTGTTGC ATTAGGGCATCAGTCTTTAGTACCTGAGCATTTGCTTAAGGTAATGTTGGATGATAAAGATGAGATAGTTGAAGTTTTGC TTACTTCTTGTGGGTGTGATGTAGAGACGTTACGTAATGATGTGGTATCGGCTTTAAATAAATTACCAGTTGTAAGTGGT CCAGGTAGTGGTCATATACATTTATCAAAGGAAATGGCGCAAGTTTTACAAGAGGCTGTTAATCTTGCAAAAAGACATCA GGACTCTTATGTTACTGTCGAAAGATTACTGCAAGCTCTGACAATAATAAAGGACAGTAATGTTTCTAGGATATTAATTG CACATGGTGTGACTCCTCAGAAGTTGGAATCATTAATAGTAAACATGCGTAATGGTGCTAAAGCTGATAGTGTAAATTCT GAGCAAAGGTTTAATGCACTAAAAAAATATGCTAAAGATGTGACTGAAGTTGCTAGAGCAGGAAAATTAGATCCAGTAAT TGGAAGAGATGAGGAAATTAGACGTACAATACAGGTATTATTGAGAAGAACAAAAAATAATCCTGTATTAATTGGAGAGC CTGGTGTTGGTAAAACAGCAATTATTGAAGGGTTAGCACATAAGATAGTGAAGGGAGATGTTCCAATTGGATTGCGAGAT ATGAGAATAATGTCATTAGATCTTGGTATGCTTGTTGCTGGGACTAAATATAGAGGTGAATTTGAAGAAAGGTTGAAAGC TGTAGTTAATGAAATTGTTTCTTCAAATGGTAGTATTATATTATTCATTGATGAGTTGCATACATTAGTTGGTGCTGGTG CAACAGATGGAGCAATGGATGCATCAAATTTGTTGAAGCCAGCATTAGCTAGAGGTGAAATACATTGTATAGGTGCAACA ACATTGGATGAATATAGAAAGCATATAGAAAAAGATGTAGCACTTGCTAGAAGATTTCAAACTATATTTATTTCTGAGCC AACTTGTGATGATACAATTTCTATGTTACGTGGGTTAAAAGAGAGATATGAAGGACATCATGGTATAGATATTCCTGACA GATCAATAATTGCTGCTGTAGCTTTATCGCAGCGTTATATTACGGATAGGTATTTACCAGATAAAGCTATAGATCTTATT GATGAAGCAGCAAGTCGTGCGAGAATGGAGATTGATAGTAAACCTGAGGTTATTGATAAGTTAGATAGAAAGATAATGCA GCTAAAAATCGAGATAGGAGTATTAGAAAAAGAAAGTGATGAATCCTCAAAACAGAGGTTAATGAAGTTAAAAGATGAAC TAGAAAAACTAAATGTTCAGTCTGCTGAGCTAAGTAGTAAATGGCAAGCGGAAAAAATGAAAATGTCAAAGATGAAAGCA TGTAAGGAAAAGCTTGATATTGCTAGAAGTGATTTAGAAAGAGCACAAAGATCTGGTGATTTGGCAAAAGCTGGTGAGTT AATGTATGGTGTAATACCAGAAATTGAAAAAGAGTTAAAAGAACATGAAAAATTTACAAGTAGCCTTTTTAAGAAGGAAA TTACAGAACATGACATAGCAAGTATTGTATCAAAATGGACTGGTATTCCTATTGAGAACATAATGAGTAGTGAAAGAGAA AAATTACTGCGTATGGAGGAGGAGATAGGCAAAACAGTTATTGGTCAGGATAGTGCTGTAAAAGCAGTAAGTGATGCTGT CCGGAGATCACGTGCAGGGGTACAAGATGCACAGAAACCATTGGGGTCTTTTTTATTTCTTGGGCCAACTGGAGTAGGTA AAACTGAGTTGGTTAAAACATTAGCTGAGTTTTTATTTTGTGATAAGTCTGCACTTTTAAGATTTGACATGTCAGAATTC ATGGAAAAGCATGCTGTTTCACGATTAATAGGAGCTCCTCCAGGATATGTTGGATATGACCAAGGTGGTGCATTAACTGA AGCTGTGAGAAGAAGGCCTTATCAAGTAATATTATTTGATGAAATTGAAAAAGCACATGGAGATATTTTCAATATTTTAT TGCAAGTATTAGATGAAGGAAGATTGACTGATAATCATGGGAAGTTAGTGGATTTCCGTAATACAATACTGGTATTAACT TCAAATTTAGGACAAGAAATATTAATGAACAATGAATCTGGAAATATCAATGAAGAGTCAGTTAAAGAGTCTATTACTAA TGTGTTGCGTAGTCATTTTCGGCCAGAATTTTTAAATAGATTGGATGAAATTATTATATTCCATAGGTTAACTAAAGAAC ATATTGAAAGAATTATTGATGTGCAATTTTCTATATTACAAAAAATTGTTGCTCAAAGAAAATTAGAGATTACTTTATCT TCAGATGCAAAAACATGGTTGATAAATAATGGTTATGATTCCTTATATGGAGCAAGACCTTTAAAGAGGTTAATACAACA GCAAATACAGAATAACTTGGCAAAGTTAATACTTGCTAATCAGGTAGCTGAGGGTAATAAATTAAGGGTAGATTTATTGG ATGATAATCTTGTTATTCATAAGATTAGTTAA
Upstream 100 bases:
>100_bases CTAATAATGTTATTAATGGAATATTTTTGCTTGTATAAAATTGTCAACATATCTTTAATTCCTTTGAATAATGCTTATAT AGTTTATTATAAATTGTTCA
Downstream 100 bases:
>100_bases TTCTATAAATAAGGTAGATTTTGGAGGTTTATAGTTGGAAAGTTTTCGGGGTGAATTTTTTTACTTCTATGGTGGCAAGT ATAGATTTTGTGATATTTGT
Product: ClpB protein
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 863; Mature: 863
Protein sequence:
>863_residues MKLVMDLNKFTDISKNFIVQAQTSAVALGHQSLVPEHLLKVMLDDKDEIVEVLLTSCGCDVETLRNDVVSALNKLPVVSG PGSGHIHLSKEMAQVLQEAVNLAKRHQDSYVTVERLLQALTIIKDSNVSRILIAHGVTPQKLESLIVNMRNGAKADSVNS EQRFNALKKYAKDVTEVARAGKLDPVIGRDEEIRRTIQVLLRRTKNNPVLIGEPGVGKTAIIEGLAHKIVKGDVPIGLRD MRIMSLDLGMLVAGTKYRGEFEERLKAVVNEIVSSNGSIILFIDELHTLVGAGATDGAMDASNLLKPALARGEIHCIGAT TLDEYRKHIEKDVALARRFQTIFISEPTCDDTISMLRGLKERYEGHHGIDIPDRSIIAAVALSQRYITDRYLPDKAIDLI DEAASRARMEIDSKPEVIDKLDRKIMQLKIEIGVLEKESDESSKQRLMKLKDELEKLNVQSAELSSKWQAEKMKMSKMKA CKEKLDIARSDLERAQRSGDLAKAGELMYGVIPEIEKELKEHEKFTSSLFKKEITEHDIASIVSKWTGIPIENIMSSERE KLLRMEEEIGKTVIGQDSAVKAVSDAVRRSRAGVQDAQKPLGSFLFLGPTGVGKTELVKTLAEFLFCDKSALLRFDMSEF MEKHAVSRLIGAPPGYVGYDQGGALTEAVRRRPYQVILFDEIEKAHGDIFNILLQVLDEGRLTDNHGKLVDFRNTILVLT SNLGQEILMNNESGNINEESVKESITNVLRSHFRPEFLNRLDEIIIFHRLTKEHIERIIDVQFSILQKIVAQRKLEITLS SDAKTWLINNGYDSLYGARPLKRLIQQQIQNNLAKLILANQVAEGNKLRVDLLDDNLVIHKIS
Sequences:
>Translated_863_residues MKLVMDLNKFTDISKNFIVQAQTSAVALGHQSLVPEHLLKVMLDDKDEIVEVLLTSCGCDVETLRNDVVSALNKLPVVSG PGSGHIHLSKEMAQVLQEAVNLAKRHQDSYVTVERLLQALTIIKDSNVSRILIAHGVTPQKLESLIVNMRNGAKADSVNS EQRFNALKKYAKDVTEVARAGKLDPVIGRDEEIRRTIQVLLRRTKNNPVLIGEPGVGKTAIIEGLAHKIVKGDVPIGLRD MRIMSLDLGMLVAGTKYRGEFEERLKAVVNEIVSSNGSIILFIDELHTLVGAGATDGAMDASNLLKPALARGEIHCIGAT TLDEYRKHIEKDVALARRFQTIFISEPTCDDTISMLRGLKERYEGHHGIDIPDRSIIAAVALSQRYITDRYLPDKAIDLI DEAASRARMEIDSKPEVIDKLDRKIMQLKIEIGVLEKESDESSKQRLMKLKDELEKLNVQSAELSSKWQAEKMKMSKMKA CKEKLDIARSDLERAQRSGDLAKAGELMYGVIPEIEKELKEHEKFTSSLFKKEITEHDIASIVSKWTGIPIENIMSSERE KLLRMEEEIGKTVIGQDSAVKAVSDAVRRSRAGVQDAQKPLGSFLFLGPTGVGKTELVKTLAEFLFCDKSALLRFDMSEF MEKHAVSRLIGAPPGYVGYDQGGALTEAVRRRPYQVILFDEIEKAHGDIFNILLQVLDEGRLTDNHGKLVDFRNTILVLT SNLGQEILMNNESGNINEESVKESITNVLRSHFRPEFLNRLDEIIIFHRLTKEHIERIIDVQFSILQKIVAQRKLEITLS SDAKTWLINNGYDSLYGARPLKRLIQQQIQNNLAKLILANQVAEGNKLRVDLLDDNLVIHKIS >Mature_863_residues MKLVMDLNKFTDISKNFIVQAQTSAVALGHQSLVPEHLLKVMLDDKDEIVEVLLTSCGCDVETLRNDVVSALNKLPVVSG PGSGHIHLSKEMAQVLQEAVNLAKRHQDSYVTVERLLQALTIIKDSNVSRILIAHGVTPQKLESLIVNMRNGAKADSVNS EQRFNALKKYAKDVTEVARAGKLDPVIGRDEEIRRTIQVLLRRTKNNPVLIGEPGVGKTAIIEGLAHKIVKGDVPIGLRD MRIMSLDLGMLVAGTKYRGEFEERLKAVVNEIVSSNGSIILFIDELHTLVGAGATDGAMDASNLLKPALARGEIHCIGAT TLDEYRKHIEKDVALARRFQTIFISEPTCDDTISMLRGLKERYEGHHGIDIPDRSIIAAVALSQRYITDRYLPDKAIDLI DEAASRARMEIDSKPEVIDKLDRKIMQLKIEIGVLEKESDESSKQRLMKLKDELEKLNVQSAELSSKWQAEKMKMSKMKA CKEKLDIARSDLERAQRSGDLAKAGELMYGVIPEIEKELKEHEKFTSSLFKKEITEHDIASIVSKWTGIPIENIMSSERE KLLRMEEEIGKTVIGQDSAVKAVSDAVRRSRAGVQDAQKPLGSFLFLGPTGVGKTELVKTLAEFLFCDKSALLRFDMSEF MEKHAVSRLIGAPPGYVGYDQGGALTEAVRRRPYQVILFDEIEKAHGDIFNILLQVLDEGRLTDNHGKLVDFRNTILVLT SNLGQEILMNNESGNINEESVKESITNVLRSHFRPEFLNRLDEIIIFHRLTKEHIERIIDVQFSILQKIVAQRKLEITLS SDAKTWLINNGYDSLYGARPLKRLIQQQIQNNLAKLILANQVAEGNKLRVDLLDDNLVIHKIS
Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase
COG id: COG0542
COG function: function code O; ATPases with chaperone activity, ATP-binding subunit
Gene ontology:
Cell location: Cytoplasm (Probable) [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the clpA/clpB family [H]
Homologues:
Organism=Homo sapiens, GI13540606, Length=321, Percent_Identity=35.5140186915888, Blast_Score=205, Evalue=1e-52, Organism=Escherichia coli, GI1788943, Length=857, Percent_Identity=54.6091015169195, Blast_Score=944, Evalue=0.0, Organism=Escherichia coli, GI1787109, Length=444, Percent_Identity=39.1891891891892, Blast_Score=288, Evalue=9e-79, Organism=Saccharomyces cerevisiae, GI6320464, Length=709, Percent_Identity=53.4555712270804, Blast_Score=769, Evalue=0.0, Organism=Saccharomyces cerevisiae, GI6323002, Length=864, Percent_Identity=40.162037037037, Blast_Score=637, Evalue=0.0,
Paralogues:
None
Copy number: 560 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003593 - InterPro: IPR013093 - InterPro: IPR003959 - InterPro: IPR018368 - InterPro: IPR017730 - InterPro: IPR001270 - InterPro: IPR019489 - InterPro: IPR004176 - InterPro: IPR023150 [H]
Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]
EC number: NA
Molecular weight: Translated: 96586; Mature: 96586
Theoretical pI: Translated: 6.90; Mature: 6.90
Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 3.2 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 2.5 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKLVMDLNKFTDISKNFIVQAQTSAVALGHQSLVPEHLLKVMLDDKDEIVEVLLTSCGCD CCEEECCHHHHCCCHHHEEEECCHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC VETLRNDVVSALNKLPVVSGPGSGHIHLSKEMAQVLQEAVNLAKRHQDSYVTVERLLQAL HHHHHHHHHHHHHHCCCEECCCCCCEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH TIIKDSNVSRILIAHGVTPQKLESLIVNMRNGAKADSVNSEQRFNALKKYAKDVTEVARA HHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC GKLDPVIGRDEEIRRTIQVLLRRTKNNPVLIGEPGVGKTAIIEGLAHKIVKGDVPIGLRD CCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHH MRIMSLDLGMLVAGTKYRGEFEERLKAVVNEIVSSNGSIILFIDELHTLVGAGATDGAMD CEEEEECCHHHEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCC ASNLLKPALARGEIHCIGATTLDEYRKHIEKDVALARRFQTIFISEPTCDDTISMLRGLK HHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHH ERYEGHHGIDIPDRSIIAAVALSQRYITDRYLPDKAIDLIDEAASRARMEIDSKPEVIDK HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH LDRKIMQLKIEIGVLEKESDESSKQRLMKLKDELEKLNVQSAELSSKWQAEKMKMSKMKA HHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH CKEKLDIARSDLERAQRSGDLAKAGELMYGVIPEIEKELKEHEKFTSSLFKKEITEHDIA HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH SIVSKWTGIPIENIMSSEREKLLRMEEEIGKTVIGQDSAVKAVSDAVRRSRAGVQDAQKP HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHCCHHHHHHH LGSFLFLGPTGVGKTELVKTLAEFLFCDKSALLRFDMSEFMEKHAVSRLIGAPPGYVGYD HHCEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC QGGALTEAVRRRPYQVILFDEIEKAHGDIFNILLQVLDEGRLTDNHGKLVDFRNTILVLT CCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEE SNLGQEILMNNESGNINEESVKESITNVLRSHFRPEFLNRLDEIIIFHRLTKEHIERIID CCCCHHHEECCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH VQFSILQKIVAQRKLEITLSSDAKTWLINNGYDSLYGARPLKRLIQQQIQNNLAKLILAN HHHHHHHHHHHHHHEEEEECCCCCEEEEECCCHHHCCCHHHHHHHHHHHHHHHHHHHHHH QVAEGNKLRVDLLDDNLVIHKIS HCCCCCEEEEEEECCCEEEEECC >Mature Secondary Structure MKLVMDLNKFTDISKNFIVQAQTSAVALGHQSLVPEHLLKVMLDDKDEIVEVLLTSCGCD CCEEECCHHHHCCCHHHEEEECCHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC VETLRNDVVSALNKLPVVSGPGSGHIHLSKEMAQVLQEAVNLAKRHQDSYVTVERLLQAL HHHHHHHHHHHHHHCCCEECCCCCCEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH TIIKDSNVSRILIAHGVTPQKLESLIVNMRNGAKADSVNSEQRFNALKKYAKDVTEVARA HHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC GKLDPVIGRDEEIRRTIQVLLRRTKNNPVLIGEPGVGKTAIIEGLAHKIVKGDVPIGLRD CCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHH MRIMSLDLGMLVAGTKYRGEFEERLKAVVNEIVSSNGSIILFIDELHTLVGAGATDGAMD CEEEEECCHHHEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCC ASNLLKPALARGEIHCIGATTLDEYRKHIEKDVALARRFQTIFISEPTCDDTISMLRGLK HHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHH ERYEGHHGIDIPDRSIIAAVALSQRYITDRYLPDKAIDLIDEAASRARMEIDSKPEVIDK HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH LDRKIMQLKIEIGVLEKESDESSKQRLMKLKDELEKLNVQSAELSSKWQAEKMKMSKMKA HHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH CKEKLDIARSDLERAQRSGDLAKAGELMYGVIPEIEKELKEHEKFTSSLFKKEITEHDIA HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH SIVSKWTGIPIENIMSSEREKLLRMEEEIGKTVIGQDSAVKAVSDAVRRSRAGVQDAQKP HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHCCHHHHHHH LGSFLFLGPTGVGKTELVKTLAEFLFCDKSALLRFDMSEFMEKHAVSRLIGAPPGYVGYD HHCEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC QGGALTEAVRRRPYQVILFDEIEKAHGDIFNILLQVLDEGRLTDNHGKLVDFRNTILVLT CCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEE SNLGQEILMNNESGNINEESVKESITNVLRSHFRPEFLNRLDEIIIFHRLTKEHIERIID CCCCHHHEECCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH VQFSILQKIVAQRKLEITLSSDAKTWLINNGYDSLYGARPLKRLIQQQIQNNLAKLILAN HHHHHHHHHHHHHHEEEEECCCCCEEEEECCCHHHCCCHHHHHHHHHHHHHHHHHHHHHH QVAEGNKLRVDLLDDNLVIHKIS HCCCCCEEEEEEECCCEEEEECC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA