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The map label for this gene is adk [H]

Identifier: 58617336

GI number: 58617336

Start: 983737

End: 984399

Strand: Reverse

Name: adk [H]

Synonym: ERGA_CDS_06090

Alternate gene names: 58617336

Gene position: 984399-983737 (Counterclockwise)

Preceding gene: 58617337

Following gene: 58617335

Centisome position: 65.63

GC content: 30.77

Gene sequence:

>663_bases
ATGGAAAATAAAATAAATATGTTGATATTTGGTCCACCTGGGTCTGGTAAGGGTACTCAGTGTCGTATTTTGTCAGAGAT
TTATCCTAGTATTTCTGTTATTTCAACTGGGGATTTGTTGAGGGATCAGGCAAAGCTTGATACTGATGATGGACGTAAGA
TTAGGCATATTATGGAATCTGGTGATTTAGTGGATGATGATTTAGTATGCAGGATGTTTTCAGTATCTATTAATAGTATC
AGTAATGGGTTTTTATTAGATGGTTTCCCAAGAAATTTAAGTCAAGCGAAGTTTCTAACTAAAATTTTGGAAGAGCGTAA
TAATAAGATTAATATAGTGATACAATTACAATTAGATTTAGACACTATAAAAAGTAGGCTTTGTGGACGTATTGTATGTA
AGGATTGTGGACAGGTTTCTAATTTACATTTTTTTGATAAAGCAATAGATGAAATCACTTGTAAGTTTTGTAAAGGTCGG
TTAGATTATAGATATGATGATAAGATTGAAGTGATAGTCAAAAGAGTTAATCAATACTATGAGGAGATGAAAGATTTAGA
ATTGTATTACCATGATAAGATCATACAAATTGATGCAGGTAAATCAATTGATAAGGTTACTCAGGATATAAAGGTACGCA
TAGAATATTTAATTATTGATTGA

Upstream 100 bases:

>100_bases
GTTTTCTAATAATAGTTAATGTTATTATTGATACATTTTCTCAAATTCAAACACATTTGTATTCAAGTCGTTATAGTACA
TTAATTAAAAAGTCTGAATT

Downstream 100 bases:

>100_bases
CGTTAATTGACAAATTTGCTATATTGCAAGACATTTATTATCTTGTGGAGGAAAGTTAGTGGCACGTATAGCTGGAGTTA
ATATTCCTACAAATAAGCGT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MENKINMLIFGPPGSGKGTQCRILSEIYPSISVISTGDLLRDQAKLDTDDGRKIRHIMESGDLVDDDLVCRMFSVSINSI
SNGFLLDGFPRNLSQAKFLTKILEERNNKINIVIQLQLDLDTIKSRLCGRIVCKDCGQVSNLHFFDKAIDEITCKFCKGR
LDYRYDDKIEVIVKRVNQYYEEMKDLELYYHDKIIQIDAGKSIDKVTQDIKVRIEYLIID

Sequences:

>Translated_220_residues
MENKINMLIFGPPGSGKGTQCRILSEIYPSISVISTGDLLRDQAKLDTDDGRKIRHIMESGDLVDDDLVCRMFSVSINSI
SNGFLLDGFPRNLSQAKFLTKILEERNNKINIVIQLQLDLDTIKSRLCGRIVCKDCGQVSNLHFFDKAIDEITCKFCKGR
LDYRYDDKIEVIVKRVNQYYEEMKDLELYYHDKIIQIDAGKSIDKVTQDIKVRIEYLIID
>Mature_220_residues
MENKINMLIFGPPGSGKGTQCRILSEIYPSISVISTGDLLRDQAKLDTDDGRKIRHIMESGDLVDDDLVCRMFSVSINSI
SNGFLLDGFPRNLSQAKFLTKILEERNNKINIVIQLQLDLDTIKSRLCGRIVCKDCGQVSNLHFFDKAIDEITCKFCKGR
LDYRYDDKIEVIVKRVNQYYEEMKDLELYYHDKIIQIDAGKSIDKVTQDIKVRIEYLIID

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=210, Percent_Identity=30.952380952381, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI4502013, Length=210, Percent_Identity=30.952380952381, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI310110345, Length=207, Percent_Identity=33.8164251207729, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI53832003, Length=207, Percent_Identity=33.8164251207729, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI8051579, Length=207, Percent_Identity=33.8164251207729, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI53832001, Length=207, Percent_Identity=33.8164251207729, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI19923437, Length=208, Percent_Identity=32.6923076923077, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI4502011, Length=216, Percent_Identity=30.5555555555556, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI28144899, Length=190, Percent_Identity=30, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI28144897, Length=190, Percent_Identity=30, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI7706497, Length=215, Percent_Identity=27.906976744186, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1786680, Length=219, Percent_Identity=31.0502283105023, Blast_Score=103, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17552384, Length=213, Percent_Identity=32.8638497652582, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17567503, Length=207, Percent_Identity=30.9178743961353, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17537943, Length=192, Percent_Identity=27.0833333333333, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6321018, Length=189, Percent_Identity=35.978835978836, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320432, Length=211, Percent_Identity=31.2796208530806, Blast_Score=109, Evalue=3e-25,
Organism=Drosophila melanogaster, GI22026816, Length=201, Percent_Identity=34.8258706467662, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17737899, Length=190, Percent_Identity=32.6315789473684, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24645822, Length=190, Percent_Identity=32.6315789473684, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17647141, Length=131, Percent_Identity=34.3511450381679, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24663208, Length=131, Percent_Identity=34.3511450381679, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 25309; Mature: 25309

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENKINMLIFGPPGSGKGTQCRILSEIYPSISVISTGDLLRDQAKLDTDDGRKIRHIMES
CCCCEEEEEECCCCCCCCCCEEEHHHHCCCEEEEECCHHHHHHHCCCCCCCHHHHHHHHC
GDLVDDDLVCRMFSVSINSISNGFLLDGFPRNLSQAKFLTKILEERNNKINIVIQLQLDL
CCCCCHHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEECH
DTIKSRLCGRIVCKDCGQVSNLHFFDKAIDEITCKFCKGRLDYRYDDKIEVIVKRVNQYY
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
EEMKDLELYYHDKIIQIDAGKSIDKVTQDIKVRIEYLIID
HHHHHHHEEECCEEEEEECCCCHHHHHHHHEEEEEEEEEC
>Mature Secondary Structure
MENKINMLIFGPPGSGKGTQCRILSEIYPSISVISTGDLLRDQAKLDTDDGRKIRHIMES
CCCCEEEEEECCCCCCCCCCEEEHHHHCCCEEEEECCHHHHHHHCCCCCCCHHHHHHHHC
GDLVDDDLVCRMFSVSINSISNGFLLDGFPRNLSQAKFLTKILEERNNKINIVIQLQLDL
CCCCCHHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEECH
DTIKSRLCGRIVCKDCGQVSNLHFFDKAIDEITCKFCKGRLDYRYDDKIEVIVKRVNQYY
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
EEMKDLELYYHDKIIQIDAGKSIDKVTQDIKVRIEYLIID
HHHHHHHEEECCEEEEEECCCCHHHHHHHHEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA