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The map label for this gene is pepQ [H]

Identifier: 58617281

GI number: 58617281

Start: 903723

End: 905468

Strand: Reverse

Name: pepQ [H]

Synonym: ERGA_CDS_05540

Alternate gene names: 58617281

Gene position: 905468-903723 (Counterclockwise)

Preceding gene: 58617282

Following gene: 58617279

Centisome position: 60.37

GC content: 29.21

Gene sequence:

>1746_bases
GTGTTGGCTAATAGAGGTTTTGATTTTATGGAAAATAGATTAAGCAGCTTAATTAGTATAATGAGAGAATATGAGATTGA
TGTTTTATTATTATATAATACAGATGAGTATCAGTCAGAATATATACATGAGAGTAAACAAAGATTAAGATGGTTATGTG
GTTTTTCTGGATCAAATGCTACTTTAATAATATCAAAACAGGAAAAACAGCATTTCTTCACTGATGGTAGGTATATATTG
CAGGCTCAACAGGAGTTGGATCTTAATTATTATCAAATACACAATGTTGCTGATATTACACCTTGGCAGTGGTGTATGAG
AAATTTACCTGCAGGTGTTATAGTAGGATATGAAGCTCAACTATTTACATTAAATCATATAAAAAAATATACAAATCATC
ATATTATTTTAAAGCCCATAGATGACATTTTAATTGATAGATTATGGGTTCGTGATTTCAATGTACCGCAAAACATAGTG
GATCATGATTTAAAATATTCTGGAATTGCAGGTTATGAGAAAGCTGGTGAAGCTATAAAATGTTTGCATGGTAAGGATGT
AGCGTTAATTACAGATACTGATGTTATTTCATGGTTATTAAACATCCGTAATAAAGATTTTGTTTTTAATCCTTCTGTAT
TATCTCGTGCAATTTTGTATAAAGATGGAACAATTGATTTCTTTATTGAAGATGTTGAATCAGTTAATTTTGAGTATGAA
TATATTAGAATATATCATATTGATGAATTATTTAGTGTTTTAAAATCTATACAATCAATAGTGATAGATGCATCTACTGT
TCCAATGAATATTTTTAAGCACTTGAGTCAGAAAGATGTATTAGTTAAAGATTTTGATGCTTGTCTTATAATGAAATCTA
TAAAAAATAATACTGAAATTTCTGGTGCAGTTAATGCACATGTTAGAGATGGTGTTGCTGTGATTAATTTGCTGTATTGG
TTAGATGTTCAATTGAGTAATAATGCAAGAATTACAGAATTAGATGTTGTATCGCAGTTGTTAATGTTTAGACAACAACA
GGATTTATTTTGTGGAGATAGCTTTGCTACGATTTCTGGATTTGCAGAGAATGGGGCTGTAATACATTATAAAGTAAATA
ATGAAACAAATAAGTTAATTTGTAAAAATGGACTATATTTATTAGATTCTGGTGGGCAATATCTTGATGGTACAACTGAT
GTTACACGTACTATTGCAATAGGTGAACCTACGTATGAGCAGATTGTTAATTTTACTTTGGTATTGAAAGGTCATATAGC
AATAGCAATGGCAGTTTTTCCTTTAAAAACTACTGGTGGAATGTTGGATATATTGGCTAGACAGTATTTATGGAAAAGTG
GACTTGATTATCAGCATGGTACAGGTCATGGTGTAGGAAGTTTCCTTTCAGTGCATGAAGGTCCTTGTGCTATTTCTTAT
GGTAATAATATTATATTACAGCAAAATATGATTTTATCTAATGAACCTGGGTATTATAAAGATGGAGAATATGGAATAAG
AATTGAAAATTTAATGTATGTTGAAAAATGTTGTGATAAATTTCTAAGATTTAAACAATTAACATGTGTTCCTATAGATT
TAAACTTAATTAATGTTGATATGTTAAGTAAAGAGGAAATTGACTATATAAATAAATATCATGATTTTGTATATACAACA
GTTGCTCCATATCTGAATGCGAAAGTAAAAGATTGGTTATGGAATTCATGTCGCAGTATAAAGTGA

Upstream 100 bases:

>100_bases
GTATTAGTTATATACTAATAGCTCATGATTTATCAAGAACTATTATATTGTACCATGATAGTTTTTGATTTTGTAGCGTA
AATCTGTTTAAGAGTATTAG

Downstream 100 bases:

>100_bases
TAATATAATAAAAACTGTAAGTGTTTATACTAGCTATTTTATATTTTTATACAATAATATTGCTGTGAAGAATTATGTTA
ATTTTTATTTTATAGAGAAA

Product: hypothetical protein

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 581; Mature: 581

Protein sequence:

>581_residues
MLANRGFDFMENRLSSLISIMREYEIDVLLLYNTDEYQSEYIHESKQRLRWLCGFSGSNATLIISKQEKQHFFTDGRYIL
QAQQELDLNYYQIHNVADITPWQWCMRNLPAGVIVGYEAQLFTLNHIKKYTNHHIILKPIDDILIDRLWVRDFNVPQNIV
DHDLKYSGIAGYEKAGEAIKCLHGKDVALITDTDVISWLLNIRNKDFVFNPSVLSRAILYKDGTIDFFIEDVESVNFEYE
YIRIYHIDELFSVLKSIQSIVIDASTVPMNIFKHLSQKDVLVKDFDACLIMKSIKNNTEISGAVNAHVRDGVAVINLLYW
LDVQLSNNARITELDVVSQLLMFRQQQDLFCGDSFATISGFAENGAVIHYKVNNETNKLICKNGLYLLDSGGQYLDGTTD
VTRTIAIGEPTYEQIVNFTLVLKGHIAIAMAVFPLKTTGGMLDILARQYLWKSGLDYQHGTGHGVGSFLSVHEGPCAISY
GNNIILQQNMILSNEPGYYKDGEYGIRIENLMYVEKCCDKFLRFKQLTCVPIDLNLINVDMLSKEEIDYINKYHDFVYTT
VAPYLNAKVKDWLWNSCRSIK

Sequences:

>Translated_581_residues
MLANRGFDFMENRLSSLISIMREYEIDVLLLYNTDEYQSEYIHESKQRLRWLCGFSGSNATLIISKQEKQHFFTDGRYIL
QAQQELDLNYYQIHNVADITPWQWCMRNLPAGVIVGYEAQLFTLNHIKKYTNHHIILKPIDDILIDRLWVRDFNVPQNIV
DHDLKYSGIAGYEKAGEAIKCLHGKDVALITDTDVISWLLNIRNKDFVFNPSVLSRAILYKDGTIDFFIEDVESVNFEYE
YIRIYHIDELFSVLKSIQSIVIDASTVPMNIFKHLSQKDVLVKDFDACLIMKSIKNNTEISGAVNAHVRDGVAVINLLYW
LDVQLSNNARITELDVVSQLLMFRQQQDLFCGDSFATISGFAENGAVIHYKVNNETNKLICKNGLYLLDSGGQYLDGTTD
VTRTIAIGEPTYEQIVNFTLVLKGHIAIAMAVFPLKTTGGMLDILARQYLWKSGLDYQHGTGHGVGSFLSVHEGPCAISY
GNNIILQQNMILSNEPGYYKDGEYGIRIENLMYVEKCCDKFLRFKQLTCVPIDLNLINVDMLSKEEIDYINKYHDFVYTT
VAPYLNAKVKDWLWNSCRSIK
>Mature_581_residues
MLANRGFDFMENRLSSLISIMREYEIDVLLLYNTDEYQSEYIHESKQRLRWLCGFSGSNATLIISKQEKQHFFTDGRYIL
QAQQELDLNYYQIHNVADITPWQWCMRNLPAGVIVGYEAQLFTLNHIKKYTNHHIILKPIDDILIDRLWVRDFNVPQNIV
DHDLKYSGIAGYEKAGEAIKCLHGKDVALITDTDVISWLLNIRNKDFVFNPSVLSRAILYKDGTIDFFIEDVESVNFEYE
YIRIYHIDELFSVLKSIQSIVIDASTVPMNIFKHLSQKDVLVKDFDACLIMKSIKNNTEISGAVNAHVRDGVAVINLLYW
LDVQLSNNARITELDVVSQLLMFRQQQDLFCGDSFATISGFAENGAVIHYKVNNETNKLICKNGLYLLDSGGQYLDGTTD
VTRTIAIGEPTYEQIVNFTLVLKGHIAIAMAVFPLKTTGGMLDILARQYLWKSGLDYQHGTGHGVGSFLSVHEGPCAISY
GNNIILQQNMILSNEPGYYKDGEYGIRIENLMYVEKCCDKFLRFKQLTCVPIDLNLINVDMLSKEEIDYINKYHDFVYTT
VAPYLNAKVKDWLWNSCRSIK

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=585, Percent_Identity=37.7777777777778, Blast_Score=353, Evalue=3e-97,
Organism=Homo sapiens, GI264681565, Length=585, Percent_Identity=36.0683760683761, Blast_Score=321, Evalue=1e-87,
Organism=Homo sapiens, GI93141226, Length=586, Percent_Identity=32.5938566552901, Blast_Score=306, Evalue=3e-83,
Organism=Escherichia coli, GI1788728, Length=194, Percent_Identity=30.4123711340206, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17509539, Length=589, Percent_Identity=34.46519524618, Blast_Score=302, Evalue=3e-82,
Organism=Caenorhabditis elegans, GI25149105, Length=598, Percent_Identity=28.7625418060201, Blast_Score=224, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6322999, Length=640, Percent_Identity=34.0625, Blast_Score=332, Evalue=8e-92,
Organism=Drosophila melanogaster, GI17137632, Length=571, Percent_Identity=36.077057793345, Blast_Score=322, Evalue=4e-88,
Organism=Drosophila melanogaster, GI161078230, Length=598, Percent_Identity=27.4247491638796, Blast_Score=228, Evalue=1e-59,
Organism=Drosophila melanogaster, GI21357287, Length=598, Percent_Identity=27.4247491638796, Blast_Score=228, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 66645; Mature: 66645

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLANRGFDFMENRLSSLISIMREYEIDVLLLYNTDEYQSEYIHESKQRLRWLCGFSGSNA
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCE
TLIISKQEKQHFFTDGRYILQAQQELDLNYYQIHNVADITPWQWCMRNLPAGVIVGYEAQ
EEEEEECCCCHHCCCCEEEEEEHHHCCCCEEEECCCCCCCHHHHHHHCCCCCEEEECCEE
LFTLNHIKKYTNHHIILKPIDDILIDRLWVRDFNVPQNIVDHDLKYSGIAGYEKAGEAIK
EEEHHHHHHHHCCEEEEECHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCHHHCCCCEE
CLHGKDVALITDTDVISWLLNIRNKDFVFNPSVLSRAILYKDGTIDFFIEDVESVNFEYE
EECCCCEEEEECHHHHHHHHHCCCCCEEECHHHHHHHHEEECCCEEEEEEHHHHCCEEEE
YIRIYHIDELFSVLKSIQSIVIDASTVPMNIFKHLSQKDVLVKDFDACLIMKSIKNNTEI
EEEEEEHHHHHHHHHHHHHHEECCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCC
SGAVNAHVRDGVAVINLLYWLDVQLSNNARITELDVVSQLLMFRQQQDLFCGDSFATISG
CCEEECHHHCCHHHHEEEHHEEEEECCCCEEEHHHHHHHHHHHHCCCCCCCCCCCHHHCC
FAENGAVIHYKVNNETNKLICKNGLYLLDSGGQYLDGTTDVTRTIAIGEPTYEQIVNFTL
CCCCCCEEEEEECCCCCEEEEECCEEEEECCCCCCCCCCCCEEEEEECCCCHHHHHCEEE
VLKGHIAIAMAVFPLKTTGGMLDILARQYLWKSGLDYQHGTGHGVGSFLSVHEGPCAISY
EEECCEEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHEECCCCEEEEC
GNNIILQQNMILSNEPGYYKDGEYGIRIENLMYVEKCCDKFLRFKQLTCVPIDLNLINVD
CCEEEEEECEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEE
MLSKEEIDYINKYHDFVYTTVAPYLNAKVKDWLWNSCRSIK
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MLANRGFDFMENRLSSLISIMREYEIDVLLLYNTDEYQSEYIHESKQRLRWLCGFSGSNA
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCE
TLIISKQEKQHFFTDGRYILQAQQELDLNYYQIHNVADITPWQWCMRNLPAGVIVGYEAQ
EEEEEECCCCHHCCCCEEEEEEHHHCCCCEEEECCCCCCCHHHHHHHCCCCCEEEECCEE
LFTLNHIKKYTNHHIILKPIDDILIDRLWVRDFNVPQNIVDHDLKYSGIAGYEKAGEAIK
EEEHHHHHHHHCCEEEEECHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCHHHCCCCEE
CLHGKDVALITDTDVISWLLNIRNKDFVFNPSVLSRAILYKDGTIDFFIEDVESVNFEYE
EECCCCEEEEECHHHHHHHHHCCCCCEEECHHHHHHHHEEECCCEEEEEEHHHHCCEEEE
YIRIYHIDELFSVLKSIQSIVIDASTVPMNIFKHLSQKDVLVKDFDACLIMKSIKNNTEI
EEEEEEHHHHHHHHHHHHHHEECCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCC
SGAVNAHVRDGVAVINLLYWLDVQLSNNARITELDVVSQLLMFRQQQDLFCGDSFATISG
CCEEECHHHCCHHHHEEEHHEEEEECCCCEEEHHHHHHHHHHHHCCCCCCCCCCCHHHCC
FAENGAVIHYKVNNETNKLICKNGLYLLDSGGQYLDGTTDVTRTIAIGEPTYEQIVNFTL
CCCCCCEEEEEECCCCCEEEEECCEEEEECCCCCCCCCCCCEEEEEECCCCHHHHHCEEE
VLKGHIAIAMAVFPLKTTGGMLDILARQYLWKSGLDYQHGTGHGVGSFLSVHEGPCAISY
EEECCEEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHEECCCCEEEEC
GNNIILQQNMILSNEPGYYKDGEYGIRIENLMYVEKCCDKFLRFKQLTCVPIDLNLINVD
CCEEEEEECEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEE
MLSKEEIDYINKYHDFVYTTVAPYLNAKVKDWLWNSCRSIK
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]