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The map label for this gene is clpA [C]

Identifier: 58617205

GI number: 58617205

Start: 772737

End: 775031

Strand: Reverse

Name: clpA [C]

Synonym: ERGA_CDS_04780

Alternate gene names: 58617205

Gene position: 775031-772737 (Counterclockwise)

Preceding gene: 58617207

Following gene: 58617204

Centisome position: 51.67

GC content: 29.5

Gene sequence:

>2295_bases
GTGTTATCAAAGAATCTTGAAGATAGTTTGCATAAGGCATTATCAATTGCGTTTGATTTTCATCATGAATATGCTACTTT
AGAACATCTTTTATTGGCGTTAACGGATGATATAGATGCTAGGCGTGTTTTTTATGCATTTCGTGTATCTATTGATAAGC
TAAAAATTACTATTATAAATTTTTTAAGATATGAAATACCCACTCTAATTGATAAAGGTATCTCAGAAGTTAAGCCTACT
ATTATTTTTGAAAGGTTAGTTCATAGAGCTATTATACATGCTCATAGTTCTGGTATAAGTGAAATAACTGGTGCAGATAT
TCTTAGTGAAATTCTAGCTGAGAAAGATTCTTATAGTGCATCTTTTTTACATGAACAAAATATAAAATATATAGATGTTG
TAAATTATATATCAAATAATAATAGTGGTTCTTATGTTAATGATTTTAGCATGGATCAAGAATTTAGAGATTATGAATAC
AATAAGCCTATTAATTCATTTGTTACTGTACCTAAGGATATATTAAAAGATAATGAAATTTTGAATGCTTATTGTATAAA
TTTAAATGAGTCAGCTAAGAAAGGTAAAATAGATTATGTAATTGGTAGATCATATGAATTGAGTAGAACTATGGAAGTTC
TATTACGAAGGAGAAAAAATAATCCATTGTATGTTGGAGATCCTGGTGTTGGTAAGACTGCAATTGTTGAAGGATTAGCA
TTAAATATTATAGATGGTAATGTACCAGAACAATTAAAGAAAATGGTTATATATTCTTTAGATATGGGATCATTATTAGC
TGGAACGCGTTATCGTGGAGATTTTGAGGAAAGAATAAAATCTGTTATTAAAGCAATCGAAGCAAAAGAAAATGCAATAT
TATTCATTGATGAAATTCACACAATTGTTGGGGCAGGTTCTACCAGTGGTGGATCTCTTGATGCAAGTAACTTACTTAAA
CCTGCTTTGGCTAGGGGAACTTTGAGATGTATTGGTGCTACTACTTATAAGGAGTATAATAATAATTTTGAAAAAGATAG
AGCATTGGCTAGGAGGTATCAAAAAATTAATGTTGAAGAATCATCAGTTGATGAAACTGTGAGAATATTACGTGGAATAC
AATCTTATTATGCATCATATCATAATGTTACATATAGTGAAGATTCAATAGATCGTGCTGCAGAGTTATCAGATAGGTAT
ATTTCAGAAAAAATGCTTCCAGATAAAGCTGTAGATGTCATTGATGAGGCAGGGGCATATTGTAATTTACATAATAGTAA
CGGTAATAGGGTTATTACTGGTAGTGATATAGAACATATAGTGTCTAGGATTACTGGAATACCATCTCGTAATCTAGCAC
ATAATGATTTAGACAAAGTAAAAAATCTAGAAAAAAATTTAAAACAACATATATTTGGTCAAGATTTTGCTATTTCTAGT
CTTGTAGATTCAATAAAAATAGCTAAAGCTGGACTTAGAGATCATAGAAAACCTTTAGCTAGTTATTTATTTACTGGGCC
TACTGGAGTTGGAAAAACTGAATTAGCAAAACAACTCGCAAATCACATGGGTATGAAGTTGATAAGATTTGATATGTCTG
AATATATGGAATCTCATTCTATTTCTAAAATTATAGGATCTCCTCCAGGGTATGTAGGATATGATCAAGGAGGCTTATTG
ACAGATTCTATATCTAGACATCAATATAGCGTATTGTTACTTGATGAAATAGAGAAAGCGCATAGTGATATATATAATAT
ATTATTACAGATAATGGACTATGGATGTGTTACTGATACTTATGGAAGAAAAGTGAGTTTTCATAATGTAATAGTTATTC
TAACAACTAATGCTGGTGCTTTTGAACTAAGTAGAAATTCTATTGGATTTAGTAGGAATAGAAGCTTTAATCAAGGTGAT
GATAAACAAGCAATTGAGAGAATTTTTAGTCCAGAATTTAGGAATAGATTAGATGCTATAATTTCCTTTTCATCTTTGAA
TCAAAGTGCAGTGTTGCAAGTAGTGAATAAATTTATTAATGAACTTAAAGAACAGTTAGCTAAGAAAGGTATACATTTTA
ATATAGGTGATGATGTATTATTGTATTTAGCAAAATCTGGATATGATAGTATACCTGGTGTTAGGAATATAGAGAGCATT
ATTTCTCAAAAAATTAAAAGATATTTATCGGATGAAATACTTTTTGGTAGGTTATCTAATGGTGGATATGTAAAAATTAT
ACTTGATCCTAACACTAATGATTTAATATATGATTTTTGTTGTGCAGAAGTGTAA

Upstream 100 bases:

>100_bases
TATTGCACAGTATTGATTATGAAATTGATGTATTATCATTTGCAACTTATTTTTAATTTTTCAGTGATAGAGTGTCTGAA
AATATAGATTAGGGACATTA

Downstream 100 bases:

>100_bases
CTTAATTATTCTATTGAGATTGTATGTTTTAATCTGTACTTTTCTTAGCTAACTGTTTTTTAAGTTCATTAATAAACTTA
TTATTTACTAAAATTTTAAC

Product: ATP-dependent Clp protease ATP-binding subunit clpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 764; Mature: 764

Protein sequence:

>764_residues
MLSKNLEDSLHKALSIAFDFHHEYATLEHLLLALTDDIDARRVFYAFRVSIDKLKITIINFLRYEIPTLIDKGISEVKPT
IIFERLVHRAIIHAHSSGISEITGADILSEILAEKDSYSASFLHEQNIKYIDVVNYISNNNSGSYVNDFSMDQEFRDYEY
NKPINSFVTVPKDILKDNEILNAYCINLNESAKKGKIDYVIGRSYELSRTMEVLLRRRKNNPLYVGDPGVGKTAIVEGLA
LNIIDGNVPEQLKKMVIYSLDMGSLLAGTRYRGDFEERIKSVIKAIEAKENAILFIDEIHTIVGAGSTSGGSLDASNLLK
PALARGTLRCIGATTYKEYNNNFEKDRALARRYQKINVEESSVDETVRILRGIQSYYASYHNVTYSEDSIDRAAELSDRY
ISEKMLPDKAVDVIDEAGAYCNLHNSNGNRVITGSDIEHIVSRITGIPSRNLAHNDLDKVKNLEKNLKQHIFGQDFAISS
LVDSIKIAKAGLRDHRKPLASYLFTGPTGVGKTELAKQLANHMGMKLIRFDMSEYMESHSISKIIGSPPGYVGYDQGGLL
TDSISRHQYSVLLLDEIEKAHSDIYNILLQIMDYGCVTDTYGRKVSFHNVIVILTTNAGAFELSRNSIGFSRNRSFNQGD
DKQAIERIFSPEFRNRLDAIISFSSLNQSAVLQVVNKFINELKEQLAKKGIHFNIGDDVLLYLAKSGYDSIPGVRNIESI
ISQKIKRYLSDEILFGRLSNGGYVKIILDPNTNDLIYDFCCAEV

Sequences:

>Translated_764_residues
MLSKNLEDSLHKALSIAFDFHHEYATLEHLLLALTDDIDARRVFYAFRVSIDKLKITIINFLRYEIPTLIDKGISEVKPT
IIFERLVHRAIIHAHSSGISEITGADILSEILAEKDSYSASFLHEQNIKYIDVVNYISNNNSGSYVNDFSMDQEFRDYEY
NKPINSFVTVPKDILKDNEILNAYCINLNESAKKGKIDYVIGRSYELSRTMEVLLRRRKNNPLYVGDPGVGKTAIVEGLA
LNIIDGNVPEQLKKMVIYSLDMGSLLAGTRYRGDFEERIKSVIKAIEAKENAILFIDEIHTIVGAGSTSGGSLDASNLLK
PALARGTLRCIGATTYKEYNNNFEKDRALARRYQKINVEESSVDETVRILRGIQSYYASYHNVTYSEDSIDRAAELSDRY
ISEKMLPDKAVDVIDEAGAYCNLHNSNGNRVITGSDIEHIVSRITGIPSRNLAHNDLDKVKNLEKNLKQHIFGQDFAISS
LVDSIKIAKAGLRDHRKPLASYLFTGPTGVGKTELAKQLANHMGMKLIRFDMSEYMESHSISKIIGSPPGYVGYDQGGLL
TDSISRHQYSVLLLDEIEKAHSDIYNILLQIMDYGCVTDTYGRKVSFHNVIVILTTNAGAFELSRNSIGFSRNRSFNQGD
DKQAIERIFSPEFRNRLDAIISFSSLNQSAVLQVVNKFINELKEQLAKKGIHFNIGDDVLLYLAKSGYDSIPGVRNIESI
ISQKIKRYLSDEILFGRLSNGGYVKIILDPNTNDLIYDFCCAEV
>Mature_764_residues
MLSKNLEDSLHKALSIAFDFHHEYATLEHLLLALTDDIDARRVFYAFRVSIDKLKITIINFLRYEIPTLIDKGISEVKPT
IIFERLVHRAIIHAHSSGISEITGADILSEILAEKDSYSASFLHEQNIKYIDVVNYISNNNSGSYVNDFSMDQEFRDYEY
NKPINSFVTVPKDILKDNEILNAYCINLNESAKKGKIDYVIGRSYELSRTMEVLLRRRKNNPLYVGDPGVGKTAIVEGLA
LNIIDGNVPEQLKKMVIYSLDMGSLLAGTRYRGDFEERIKSVIKAIEAKENAILFIDEIHTIVGAGSTSGGSLDASNLLK
PALARGTLRCIGATTYKEYNNNFEKDRALARRYQKINVEESSVDETVRILRGIQSYYASYHNVTYSEDSIDRAAELSDRY
ISEKMLPDKAVDVIDEAGAYCNLHNSNGNRVITGSDIEHIVSRITGIPSRNLAHNDLDKVKNLEKNLKQHIFGQDFAISS
LVDSIKIAKAGLRDHRKPLASYLFTGPTGVGKTELAKQLANHMGMKLIRFDMSEYMESHSISKIIGSPPGYVGYDQGGLL
TDSISRHQYSVLLLDEIEKAHSDIYNILLQIMDYGCVTDTYGRKVSFHNVIVILTTNAGAFELSRNSIGFSRNRSFNQGD
DKQAIERIFSPEFRNRLDAIISFSSLNQSAVLQVVNKFINELKEQLAKKGIHFNIGDDVLLYLAKSGYDSIPGVRNIESI
ISQKIKRYLSDEILFGRLSNGGYVKIILDPNTNDLIYDFCCAEV

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=324, Percent_Identity=33.0246913580247, Blast_Score=166, Evalue=7e-41,
Organism=Escherichia coli, GI1787109, Length=765, Percent_Identity=47.3202614379085, Blast_Score=728, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=247, Percent_Identity=54.6558704453441, Blast_Score=278, Evalue=8e-76,
Organism=Saccharomyces cerevisiae, GI6320464, Length=332, Percent_Identity=36.4457831325301, Blast_Score=249, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6323002, Length=238, Percent_Identity=50, Blast_Score=235, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 85885; Mature: 85885

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSKNLEDSLHKALSIAFDFHHEYATLEHLLLALTDDIDARRVFYAFRVSIDKLKITIIN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEHHHHHHHHHH
FLRYEIPTLIDKGISEVKPTIIFERLVHRAIIHAHSSGISEITGADILSEILAEKDSYSA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCH
SFLHEQNIKYIDVVNYISNNNSGSYVNDFSMDQEFRDYEYNKPINSFVTVPKDILKDNEI
HHHHHCCCCEEEHHHHHCCCCCCCEECCCCCCCHHHCCCCCCCHHHHHCCCHHHHCCCCE
LNAYCINLNESAKKGKIDYVIGRSYELSRTMEVLLRRRKNNPLYVGDPGVGKTAIVEGLA
EEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHE
LNIIDGNVPEQLKKMVIYSLDMGSLLAGTRYRGDFEERIKSVIKAIEAKENAILFIDEIH
EEEECCCCHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEHHH
TIVGAGSTSGGSLDASNLLKPALARGTLRCIGATTYKEYNNNFEKDRALARRYQKINVEE
HHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHCCHHHHHHCCCCHHHHHHHHHHHHCCCCH
SSVDETVRILRGIQSYYASYHNVTYSEDSIDRAAELSDRYISEKMLPDKAVDVIDEAGAY
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCE
CNLHNSNGNRVITGSDIEHIVSRITGIPSRNLAHNDLDKVKNLEKNLKQHIFGQDFAISS
EEEECCCCCEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
LVDSIKIAKAGLRDHRKPLASYLFTGPTGVGKTELAKQLANHMGMKLIRFDMSEYMESHS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
ISKIIGSPPGYVGYDQGGLLTDSISRHQYSVLLLDEIEKAHSDIYNILLQIMDYGCVTDT
HHHHHCCCCCCCCCCCCCCCCCCCCCHHEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCC
YGRKVSFHNVIVILTTNAGAFELSRNSIGFSRNRSFNQGDDKQAIERIFSPEFRNRLDAI
CCCEEEECCEEEEEECCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHH
ISFSSLNQSAVLQVVNKFINELKEQLAKKGIHFNIGDDVLLYLAKSGYDSIPGVRNIESI
HHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHCCCCCCCCHHHHHHH
ISQKIKRYLSDEILFGRLSNGGYVKIILDPNTNDLIYDFCCAEV
HHHHHHHHHCHHHEEEEECCCCEEEEEECCCCCCEEHHHHHCCC
>Mature Secondary Structure
MLSKNLEDSLHKALSIAFDFHHEYATLEHLLLALTDDIDARRVFYAFRVSIDKLKITIIN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEHHHHHHHHHH
FLRYEIPTLIDKGISEVKPTIIFERLVHRAIIHAHSSGISEITGADILSEILAEKDSYSA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCH
SFLHEQNIKYIDVVNYISNNNSGSYVNDFSMDQEFRDYEYNKPINSFVTVPKDILKDNEI
HHHHHCCCCEEEHHHHHCCCCCCCEECCCCCCCHHHCCCCCCCHHHHHCCCHHHHCCCCE
LNAYCINLNESAKKGKIDYVIGRSYELSRTMEVLLRRRKNNPLYVGDPGVGKTAIVEGLA
EEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHE
LNIIDGNVPEQLKKMVIYSLDMGSLLAGTRYRGDFEERIKSVIKAIEAKENAILFIDEIH
EEEECCCCHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEHHH
TIVGAGSTSGGSLDASNLLKPALARGTLRCIGATTYKEYNNNFEKDRALARRYQKINVEE
HHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHCCHHHHHHCCCCHHHHHHHHHHHHCCCCH
SSVDETVRILRGIQSYYASYHNVTYSEDSIDRAAELSDRYISEKMLPDKAVDVIDEAGAY
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCE
CNLHNSNGNRVITGSDIEHIVSRITGIPSRNLAHNDLDKVKNLEKNLKQHIFGQDFAISS
EEEECCCCCEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
LVDSIKIAKAGLRDHRKPLASYLFTGPTGVGKTELAKQLANHMGMKLIRFDMSEYMESHS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
ISKIIGSPPGYVGYDQGGLLTDSISRHQYSVLLLDEIEKAHSDIYNILLQIMDYGCVTDT
HHHHHCCCCCCCCCCCCCCCCCCCCCHHEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCC
YGRKVSFHNVIVILTTNAGAFELSRNSIGFSRNRSFNQGDDKQAIERIFSPEFRNRLDAI
CCCEEEECCEEEEEECCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHH
ISFSSLNQSAVLQVVNKFINELKEQLAKKGIHFNIGDDVLLYLAKSGYDSIPGVRNIESI
HHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHCCCCCCCCHHHHHHH
ISQKIKRYLSDEILFGRLSNGGYVKIILDPNTNDLIYDFCCAEV
HHHHHHHHHCHHHEEEEECCCCEEEEEECCCCCCEEHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6209404 [H]