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The map label for this gene is argH

Identifier: 58616904

GI number: 58616904

Start: 289788

End: 291188

Strand: Reverse

Name: argH

Synonym: ERGA_CDS_01770

Alternate gene names: 58616904

Gene position: 291188-289788 (Counterclockwise)

Preceding gene: 58616907

Following gene: 58616902

Centisome position: 19.41

GC content: 32.19

Gene sequence:

>1401_bases
ATGACAAATCCTTTATGGGGAGGAAGGTTTACTACATCCTCCAACGATATTATGAAAAAAATTAACGAATCAATCTCATT
TGATCAAGCATTGTATGAAGAAGATATACTTACATCAATTGCACACTGTAAAATGCTAGTAAATCAAAAAATTATTAGCA
AATATGAAGGTCAACTTATCATTCATGGATTAGAAGTAATACAGAAACAAATTGAATCTGGTAATTTTGAGTTCAGTACA
GACTTAGAAGATATACATATGAATATAGAGTATAGCTTAAAAAAAATGATAGGCAACATTGCCGGTAAATTACATACCGC
AAGATCTCGTAATGATCAAATAGCAACAGATCTGAAACTATGGATTAGAAAATCAATTAAAAAATTAGAGCAACAACTAC
ACAAACTACAATCTACCTTATTAAATATAGCTGAAAACCATTATGATACGATTATGCCAGGTTTCACACATTTACAAATC
GCTCAACCAGTAACATTAGGACATCACTTAATGGCATATTTTGAAATGTTAAAAAGGGATCGTTCACGTTGGCAAGATTT
ATATAAGCGTATGAATCAGTGTCCTGCTGGATCTGCAGCACTAGCAGGTACTTCTTTTCCAATAGATCGTCATTTTATTG
CACAAGAACTAGGATTTGACAGTCCTACTGAGAATTCTATAGATGCAGTTTCAGATAGAGATTACATTATAGAGTTTCTA
TCTAACGCTTCAATATGTATAATGCATCTATCAAGATTAGCAGAGGAAATTATTCTATGGTGCAGCTATAACTTTAAATT
CATAACACTCTCTGACAATATAACAACTGGCAGCTCAATAATGCCACAGAAAAAAAACCCAGATGCTGCTGAACTCATTA
GAGGAAAAACTGGAAGAATTTTTTCATCACTTAACCATATACTAATTGTAATGAAAGGCCTTCCACTAGCATATAGCAAA
GATATGCAGGAAGACAAAGAACCTTTATTTGATGCAGAAAGAAACCTAATACTATGCATTGAAGCAATGAATAGTATGCT
AAATAATATCACAATTAACAGTGAAAATATGTTAAAAGCAGCAGAACACGATTATTCAACAGCAACAGATTTAGCAGATT
GGCTAGTAAAGCACATCAATTTATCATTTAGAGAGTCCCATGAAATTACTGGACAAATAGTAAAACTAGCAGAACATAAT
AAATGTAAAATACATGAACTAACATTAATACAGTTACAGAAAATCATCCCTTCTATTACCGAAGATGTATTTTCAGTTTT
ATCAGCAAAAAATTCTGTTACTAGCAGAACTAGCTACGGAGGTACTGCTCCTATCAACGTTCTACAAGCAATAAAAAACG
GTAGGATATACTTAGAAAATACAGATTCACTAACACAATAA

Upstream 100 bases:

>100_bases
TAACTGATACTCAGTCATATAACAGTAAATCATTAAATACTATTGTCATTTTTAATAATTTACAAGATAATACGTCAGTT
ACTTATATATAATAAACCAC

Downstream 100 bases:

>100_bases
CAAAAACGTATTTTTCAGTCTCATCAATGAAAAGCTACTCCTTATTAGTAGAAGCATTTATTGAGACATTGTCTCACATA
TAATAACTCTAAAAAGAATA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MTNPLWGGRFTTSSNDIMKKINESISFDQALYEEDILTSIAHCKMLVNQKIISKYEGQLIIHGLEVIQKQIESGNFEFST
DLEDIHMNIEYSLKKMIGNIAGKLHTARSRNDQIATDLKLWIRKSIKKLEQQLHKLQSTLLNIAENHYDTIMPGFTHLQI
AQPVTLGHHLMAYFEMLKRDRSRWQDLYKRMNQCPAGSAALAGTSFPIDRHFIAQELGFDSPTENSIDAVSDRDYIIEFL
SNASICIMHLSRLAEEIILWCSYNFKFITLSDNITTGSSIMPQKKNPDAAELIRGKTGRIFSSLNHILIVMKGLPLAYSK
DMQEDKEPLFDAERNLILCIEAMNSMLNNITINSENMLKAAEHDYSTATDLADWLVKHINLSFRESHEITGQIVKLAEHN
KCKIHELTLIQLQKIIPSITEDVFSVLSAKNSVTSRTSYGGTAPINVLQAIKNGRIYLENTDSLTQ

Sequences:

>Translated_466_residues
MTNPLWGGRFTTSSNDIMKKINESISFDQALYEEDILTSIAHCKMLVNQKIISKYEGQLIIHGLEVIQKQIESGNFEFST
DLEDIHMNIEYSLKKMIGNIAGKLHTARSRNDQIATDLKLWIRKSIKKLEQQLHKLQSTLLNIAENHYDTIMPGFTHLQI
AQPVTLGHHLMAYFEMLKRDRSRWQDLYKRMNQCPAGSAALAGTSFPIDRHFIAQELGFDSPTENSIDAVSDRDYIIEFL
SNASICIMHLSRLAEEIILWCSYNFKFITLSDNITTGSSIMPQKKNPDAAELIRGKTGRIFSSLNHILIVMKGLPLAYSK
DMQEDKEPLFDAERNLILCIEAMNSMLNNITINSENMLKAAEHDYSTATDLADWLVKHINLSFRESHEITGQIVKLAEHN
KCKIHELTLIQLQKIIPSITEDVFSVLSAKNSVTSRTSYGGTAPINVLQAIKNGRIYLENTDSLTQ
>Mature_465_residues
TNPLWGGRFTTSSNDIMKKINESISFDQALYEEDILTSIAHCKMLVNQKIISKYEGQLIIHGLEVIQKQIESGNFEFSTD
LEDIHMNIEYSLKKMIGNIAGKLHTARSRNDQIATDLKLWIRKSIKKLEQQLHKLQSTLLNIAENHYDTIMPGFTHLQIA
QPVTLGHHLMAYFEMLKRDRSRWQDLYKRMNQCPAGSAALAGTSFPIDRHFIAQELGFDSPTENSIDAVSDRDYIIEFLS
NASICIMHLSRLAEEIILWCSYNFKFITLSDNITTGSSIMPQKKNPDAAELIRGKTGRIFSSLNHILIVMKGLPLAYSKD
MQEDKEPLFDAERNLILCIEAMNSMLNNITINSENMLKAAEHDYSTATDLADWLVKHINLSFRESHEITGQIVKLAEHNK
CKIHELTLIQLQKIIPSITEDVFSVLSAKNSVTSRTSYGGTAPINVLQAIKNGRIYLENTDSLTQ

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=458, Percent_Identity=41.703056768559, Blast_Score=381, Evalue=1e-106,
Organism=Homo sapiens, GI68303542, Length=458, Percent_Identity=41.703056768559, Blast_Score=381, Evalue=1e-106,
Organism=Homo sapiens, GI68303549, Length=458, Percent_Identity=39.7379912663755, Blast_Score=352, Evalue=3e-97,
Organism=Homo sapiens, GI68303547, Length=458, Percent_Identity=39.7379912663755, Blast_Score=350, Evalue=1e-96,
Organism=Escherichia coli, GI1790398, Length=448, Percent_Identity=45.5357142857143, Blast_Score=406, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6321806, Length=455, Percent_Identity=41.5384615384615, Blast_Score=348, Evalue=1e-96,
Organism=Drosophila melanogaster, GI221473854, Length=448, Percent_Identity=37.9464285714286, Blast_Score=323, Evalue=2e-88,
Organism=Drosophila melanogaster, GI78706858, Length=448, Percent_Identity=37.9464285714286, Blast_Score=323, Evalue=2e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_EHRRG (Q5FH83)

Other databases:

- EMBL:   CR925677
- RefSeq:   YP_196103.1
- ProteinModelPortal:   Q5FH83
- SMR:   Q5FH83
- STRING:   Q5FH83
- GeneID:   3268734
- GenomeReviews:   CR925677_GR
- KEGG:   erg:ERGA_CDS_01770
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   EDIHTVI
- ProtClustDB:   PRK00855
- BioCyc:   ERUM302409:ERGA_CDS_01770-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 52892; Mature: 52761

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPLWGGRFTTSSNDIMKKINESISFDQALYEEDILTSIAHCKMLVNQKIISKYEGQLI
CCCCCCCCEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
IHGLEVIQKQIESGNFEFSTDLEDIHMNIEYSLKKMIGNIAGKLHTARSRNDQIATDLKL
EHHHHHHHHHHHCCCCEEECCHHHHEECHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
WIRKSIKKLEQQLHKLQSTLLNIAENHYDTIMPGFTHLQIAQPVTLGHHLMAYFEMLKRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHH
RSRWQDLYKRMNQCPAGSAALAGTSFPIDRHFIAQELGFDSPTENSIDAVSDRDYIIEFL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
SNASICIMHLSRLAEEIILWCSYNFKFITLSDNITTGSSIMPQKKNPDAAELIRGKTGRI
CCCHHHHHHHHHHHHHHEEHEECCEEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCCHHH
FSSLNHILIVMKGLPLAYSKDMQEDKEPLFDAERNLILCIEAMNSMLNNITINSENMLKA
HHHHHHHHHHCCCCCCHHHCCHHHHHCHHHHCCCCEEEEHHHHHHHHHCEECCCHHHHHH
AEHDYSTATDLADWLVKHINLSFRESHEITGQIVKLAEHNKCKIHELTLIQLQKIIPSIT
HHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHH
EDVFSVLSAKNSVTSRTSYGGTAPINVLQAIKNGRIYLENTDSLTQ
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCEEEEECCCCCCC
>Mature Secondary Structure 
TNPLWGGRFTTSSNDIMKKINESISFDQALYEEDILTSIAHCKMLVNQKIISKYEGQLI
CCCCCCCEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
IHGLEVIQKQIESGNFEFSTDLEDIHMNIEYSLKKMIGNIAGKLHTARSRNDQIATDLKL
EHHHHHHHHHHHCCCCEEECCHHHHEECHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
WIRKSIKKLEQQLHKLQSTLLNIAENHYDTIMPGFTHLQIAQPVTLGHHLMAYFEMLKRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHH
RSRWQDLYKRMNQCPAGSAALAGTSFPIDRHFIAQELGFDSPTENSIDAVSDRDYIIEFL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
SNASICIMHLSRLAEEIILWCSYNFKFITLSDNITTGSSIMPQKKNPDAAELIRGKTGRI
CCCHHHHHHHHHHHHHHEEHEECCEEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCCHHH
FSSLNHILIVMKGLPLAYSKDMQEDKEPLFDAERNLILCIEAMNSMLNNITINSENMLKA
HHHHHHHHHHCCCCCCHHHCCHHHHHCHHHHCCCCEEEEHHHHHHHHHCEECCCHHHHHH
AEHDYSTATDLADWLVKHINLSFRESHEITGQIVKLAEHNKCKIHELTLIQLQKIIPSIT
HHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHH
EDVFSVLSAKNSVTSRTSYGGTAPINVLQAIKNGRIYLENTDSLTQ
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA