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The map label for this gene is dhoD [H]

Identifier: 58616902

GI number: 58616902

Start: 286355

End: 287395

Strand: Reverse

Name: dhoD [H]

Synonym: ERGA_CDS_01750

Alternate gene names: 58616902

Gene position: 287395-286355 (Counterclockwise)

Preceding gene: 58616904

Following gene: 58616901

Centisome position: 19.16

GC content: 30.64

Gene sequence:

>1041_bases
ATGTTTACTAATGCACTGTTTTATATTCCTCCAGAGATTGCTCACAAAATGGCAATCTTTGCATTAAAAAATAATTTTAT
TCCAATAAAAAAAGTTGATCTTCCAAGATCACTTAACATTTCATTGTTTAACAAATCTCTTAAGACACCAATAGGAGTAG
CAGCTGGCTTTGATAAAAATGCTGAAGTAATTAGGCCTTTACTATCAACTGGCTTTAGTTTTGTTGAAGTAGGTACTGTA
ACAAGATACCCACAAAAAGGAAATAAGAAACCACGGGTATTTCGGCTAGTAAAAGAAGAAGCAATCATCAATAGTTTAGG
ATTTAATAATAAAGGAATAGACTTTGTAATAAAAAAAGTAAATGATGCAAAACTTAATCACTGTATATTTGGCATCAATA
TAGGGTATAATAAAACGTCACATAATCCAGTTCAAGATTATTTTGAATTAGTAAAAAAAATATACGGACTTAGTAATTAC
ATAACACTAAATATATCATCTCCTAATACTCCTGGATTACGGAACTTTCAAAAACAAGAGTTACTATCAGAGCTGTTAAC
AGCAATATCACAAGTCAGAAAACTTACAGATTATGCAGAATCTGTACCAATAATGTTAAAAATTTCACCAGATATTAGTG
ATAATGAAAAACAAGATATTGTAGATCTTTCACTAAAATACAAGGTATCTGGTCTAATAATAAGTAATACTTCATCTGAA
TATCACAAATTACTAGAAAACTCTTACACAAATATACAAGGTGGTCTAAGCGGGAAACCAATATTTGATTTATCAACCAA
AGTTTTATCTGAAGTATACAAAATTACACAACAAAAACTCTTACTAATAGGCTGTGGAGGAGTGAGTAGTGGATACCATG
CATACGAAAAAATAAAAGCTGGAGCATCACTAATACAGCTATATACAGCTATAGTATATCATGGATTTAATATAGCAAAT
AAAATTAGCCTCGAGCTAGCAGAACTATTATCTGCAGATGGTTTTCCAACAGTAAGCCATGCAATAGGACACAACAATTG
A

Upstream 100 bases:

>100_bases
ATACGTATTTAACCAGTTATACAAGTAGTATTTTATAAGAAATTGACATAATAAAAGTACAAGCATATAAACTAGTCATT
AATATTATGTTCCATAGTAC

Downstream 100 bases:

>100_bases
TATAGAAAATAATGTTAATAATAGATATAGGAAATACAAATATTAAATTTGGAATTTGCATTAATAATCAAATAATACAA
ACGCTAAGGATATCTTCACA

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MFTNALFYIPPEIAHKMAIFALKNNFIPIKKVDLPRSLNISLFNKSLKTPIGVAAGFDKNAEVIRPLLSTGFSFVEVGTV
TRYPQKGNKKPRVFRLVKEEAIINSLGFNNKGIDFVIKKVNDAKLNHCIFGINIGYNKTSHNPVQDYFELVKKIYGLSNY
ITLNISSPNTPGLRNFQKQELLSELLTAISQVRKLTDYAESVPIMLKISPDISDNEKQDIVDLSLKYKVSGLIISNTSSE
YHKLLENSYTNIQGGLSGKPIFDLSTKVLSEVYKITQQKLLLIGCGGVSSGYHAYEKIKAGASLIQLYTAIVYHGFNIAN
KISLELAELLSADGFPTVSHAIGHNN

Sequences:

>Translated_346_residues
MFTNALFYIPPEIAHKMAIFALKNNFIPIKKVDLPRSLNISLFNKSLKTPIGVAAGFDKNAEVIRPLLSTGFSFVEVGTV
TRYPQKGNKKPRVFRLVKEEAIINSLGFNNKGIDFVIKKVNDAKLNHCIFGINIGYNKTSHNPVQDYFELVKKIYGLSNY
ITLNISSPNTPGLRNFQKQELLSELLTAISQVRKLTDYAESVPIMLKISPDISDNEKQDIVDLSLKYKVSGLIISNTSSE
YHKLLENSYTNIQGGLSGKPIFDLSTKVLSEVYKITQQKLLLIGCGGVSSGYHAYEKIKAGASLIQLYTAIVYHGFNIAN
KISLELAELLSADGFPTVSHAIGHNN
>Mature_346_residues
MFTNALFYIPPEIAHKMAIFALKNNFIPIKKVDLPRSLNISLFNKSLKTPIGVAAGFDKNAEVIRPLLSTGFSFVEVGTV
TRYPQKGNKKPRVFRLVKEEAIINSLGFNNKGIDFVIKKVNDAKLNHCIFGINIGYNKTSHNPVQDYFELVKKIYGLSNY
ITLNISSPNTPGLRNFQKQELLSELLTAISQVRKLTDYAESVPIMLKISPDISDNEKQDIVDLSLKYKVSGLIISNTSSE
YHKLLENSYTNIQGGLSGKPIFDLSTKVLSEVYKITQQKLLLIGCGGVSSGYHAYEKIKAGASLIQLYTAIVYHGFNIAN
KISLELAELLSADGFPTVSHAIGHNN

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=345, Percent_Identity=39.7101449275362, Blast_Score=270, Evalue=1e-72,
Organism=Escherichia coli, GI1787177, Length=323, Percent_Identity=39.3188854489164, Blast_Score=216, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17509475, Length=350, Percent_Identity=40.2857142857143, Blast_Score=265, Evalue=3e-71,
Organism=Drosophila melanogaster, GI281361352, Length=347, Percent_Identity=42.0749279538905, Blast_Score=284, Evalue=7e-77,
Organism=Drosophila melanogaster, GI17137316, Length=347, Percent_Identity=42.0749279538905, Blast_Score=284, Evalue=7e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 38361; Mature: 38361

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTNALFYIPPEIAHKMAIFALKNNFIPIKKVDLPRSLNISLFNKSLKTPIGVAAGFDKN
CCCCCEEEECHHHHHHHHHEEECCCCCEEEEECCCCCCCHHHHHHHHCCCCCEECCCCCC
AEVIRPLLSTGFSFVEVGTVTRYPQKGNKKPRVFRLVKEEAIINSLGFNNKGIDFVIKKV
HHHHHHHHHCCCCEEEECCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEC
NDAKLNHCIFGINIGYNKTSHNPVQDYFELVKKIYGLSNYITLNISSPNTPGLRNFQKQE
CCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHH
LLSELLTAISQVRKLTDYAESVPIMLKISPDISDNEKQDIVDLSLKYKVSGLIISNTSSE
HHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEEEEEEEEEEEECCCHH
YHKLLENSYTNIQGGLSGKPIFDLSTKVLSEVYKITQQKLLLIGCGGVSSGYHAYEKIKA
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCHHHHHHHHH
GASLIQLYTAIVYHGFNIANKISLELAELLSADGFPTVSHAIGHNN
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCC
>Mature Secondary Structure
MFTNALFYIPPEIAHKMAIFALKNNFIPIKKVDLPRSLNISLFNKSLKTPIGVAAGFDKN
CCCCCEEEECHHHHHHHHHEEECCCCCEEEEECCCCCCCHHHHHHHHCCCCCEECCCCCC
AEVIRPLLSTGFSFVEVGTVTRYPQKGNKKPRVFRLVKEEAIINSLGFNNKGIDFVIKKV
HHHHHHHHHCCCCEEEECCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEC
NDAKLNHCIFGINIGYNKTSHNPVQDYFELVKKIYGLSNYITLNISSPNTPGLRNFQKQE
CCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHH
LLSELLTAISQVRKLTDYAESVPIMLKISPDISDNEKQDIVDLSLKYKVSGLIISNTSSE
HHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEEEEEEEEEEEECCCHH
YHKLLENSYTNIQGGLSGKPIFDLSTKVLSEVYKITQQKLLLIGCGGVSSGYHAYEKIKA
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCHHHHHHHHH
GASLIQLYTAIVYHGFNIANKISLELAELLSADGFPTVSHAIGHNN
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA