Click here to switch to the map view.

The map label for this gene is lpd [H]

Identifier: 58616861

GI number: 58616861

Start: 221598

End: 223073

Strand: Reverse

Name: lpd [H]

Synonym: ERGA_CDS_01340

Alternate gene names: 58616861

Gene position: 223073-221598 (Counterclockwise)

Preceding gene: 58616867

Following gene: 58616860

Centisome position: 14.87

GC content: 30.96

Gene sequence:

>1476_bases
ATGTTACACTTGCAAACAACAGTTCTGTTCTTTATCATTACAGAATTCTCATTTAAAGTAATAAACATGAACAAACATGA
GTTTCTCATAATCGGAAGTGGACCAGGTGGGTACATAGCAGCTATTCGAGCAGCACAACTAGGATATAATGTTGCTATTA
TAGAAAAAGAGAATACGTTAGGAGGAGTATGTTTAAATTGGGGATGTATTCCTACAAAATCTCTATTACATTCTGCACTA
ATTTATCATAACATAAAAAAAGCAGATGTTTTTGGTATCAATGTAACAAATGTAACATGTAATTTTACTAAAATAATAGA
ACGCTCACGTAATGTTGTAGAAAAACTATCAAATGGAATTAGTGGGCTAATGAAAAAAAACAATATAAAAGTTTACTCTG
GAACTGCAAAATTACTAGGAGAAGGAACAGTAGAGGTTTTAGATAATAATAATGATAAAATTAATATCACATCAAAACAC
ATAATTATTGCAACAGGATCTCATCCTAGAAATTTACCGAACATAAATTTTGATAATAACATAATATGGAATGCTAAAAA
TGCAATGACACCAAATATCCTTCCTAAGTCATTAGCAATAATAGGAACTGGAGCTATTGGTATAGAATTTGCAAGTTTCT
ACAACACATTCGGTACTCAAGTAACAATGATAGAACTCAGAGATAATATACTACCACTTGAAGATCACGAAGTATCTAAA
TCAATGCATCAAATTTTAAATCAAAAAGGAATAAAAATTTACACAAAAAGTTCTGTAACAAAACTAGAAAAATCCAATAA
TAATGCCAGAATTCAAATATCAAATACAATAGATTTAGAAGTAGATAAAGTCATATTAGCAGTTGGCATACAACCTAATA
CTGATAATCTTGGCCTGGATAACACAAAAATACAAATCGATCAAGCAGGATTCATTATTACAGATAAATACTGTTGTACT
TCTGAATCAGGAGTTTATGCTATCGGTGACGTTGCAGGTCCACCATGTTTAGCACACAAAGCAAGCCATGAAGCAATACT
ATGTGTTGAAAATATAGCAGCACAAGAAAAAAAAATAACAGATCGTAATATACATCATATCAATAAAGAGAACATACCCA
GTTGTATATTCTCAATACCTCAGATAGCTAGTATTGGATTAACTGAACATCAAGCAAAGAGTATGGGATATGATATCAAA
ATAGGAAAATTCAATGCAAATTGTAGTGGGAAAGCTATAGCTATAGATGAAACAGAAGGGTTCGTAAAAGTTATAATTAA
CAAAACCACTGGAGAATTATTAGGTGCACATATGATTGGAGCAGAAGTAACAGAAATGATTAATGGATACATTATAGGCA
AACAATTAGAAGCAACAGATCGTGATATCATTTCATCTATTTTTCCACATCCAACATTATCAGAAATGATTCACGAAGCA
GTACTTGCATCAAATAATGAATCACTGAATAGTTAG

Upstream 100 bases:

>100_bases
TTAATAATTATTAATACTATTACAAATAATTAATAAATCAATAATTATTATTAAATATTTCATAAACAAACAAATCACAT
CATATAGTGATTACATAAAA

Downstream 100 bases:

>100_bases
CACACATACATTTTATACATAGTAAGAGATGTTTAAATAGGCACTTAAAATTGATAGTACCATATTCTCTATCATACTTA
CTATTATGCAGGTAATTTTT

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MLHLQTTVLFFIITEFSFKVINMNKHEFLIIGSGPGGYIAAIRAAQLGYNVAIIEKENTLGGVCLNWGCIPTKSLLHSAL
IYHNIKKADVFGINVTNVTCNFTKIIERSRNVVEKLSNGISGLMKKNNIKVYSGTAKLLGEGTVEVLDNNNDKINITSKH
IIIATGSHPRNLPNINFDNNIIWNAKNAMTPNILPKSLAIIGTGAIGIEFASFYNTFGTQVTMIELRDNILPLEDHEVSK
SMHQILNQKGIKIYTKSSVTKLEKSNNNARIQISNTIDLEVDKVILAVGIQPNTDNLGLDNTKIQIDQAGFIITDKYCCT
SESGVYAIGDVAGPPCLAHKASHEAILCVENIAAQEKKITDRNIHHINKENIPSCIFSIPQIASIGLTEHQAKSMGYDIK
IGKFNANCSGKAIAIDETEGFVKVIINKTTGELLGAHMIGAEVTEMINGYIIGKQLEATDRDIISSIFPHPTLSEMIHEA
VLASNNESLNS

Sequences:

>Translated_491_residues
MLHLQTTVLFFIITEFSFKVINMNKHEFLIIGSGPGGYIAAIRAAQLGYNVAIIEKENTLGGVCLNWGCIPTKSLLHSAL
IYHNIKKADVFGINVTNVTCNFTKIIERSRNVVEKLSNGISGLMKKNNIKVYSGTAKLLGEGTVEVLDNNNDKINITSKH
IIIATGSHPRNLPNINFDNNIIWNAKNAMTPNILPKSLAIIGTGAIGIEFASFYNTFGTQVTMIELRDNILPLEDHEVSK
SMHQILNQKGIKIYTKSSVTKLEKSNNNARIQISNTIDLEVDKVILAVGIQPNTDNLGLDNTKIQIDQAGFIITDKYCCT
SESGVYAIGDVAGPPCLAHKASHEAILCVENIAAQEKKITDRNIHHINKENIPSCIFSIPQIASIGLTEHQAKSMGYDIK
IGKFNANCSGKAIAIDETEGFVKVIINKTTGELLGAHMIGAEVTEMINGYIIGKQLEATDRDIISSIFPHPTLSEMIHEA
VLASNNESLNS
>Mature_491_residues
MLHLQTTVLFFIITEFSFKVINMNKHEFLIIGSGPGGYIAAIRAAQLGYNVAIIEKENTLGGVCLNWGCIPTKSLLHSAL
IYHNIKKADVFGINVTNVTCNFTKIIERSRNVVEKLSNGISGLMKKNNIKVYSGTAKLLGEGTVEVLDNNNDKINITSKH
IIIATGSHPRNLPNINFDNNIIWNAKNAMTPNILPKSLAIIGTGAIGIEFASFYNTFGTQVTMIELRDNILPLEDHEVSK
SMHQILNQKGIKIYTKSSVTKLEKSNNNARIQISNTIDLEVDKVILAVGIQPNTDNLGLDNTKIQIDQAGFIITDKYCCT
SESGVYAIGDVAGPPCLAHKASHEAILCVENIAAQEKKITDRNIHHINKENIPSCIFSIPQIASIGLTEHQAKSMGYDIK
IGKFNANCSGKAIAIDETEGFVKVIINKTTGELLGAHMIGAEVTEMINGYIIGKQLEATDRDIISSIFPHPTLSEMIHEA
VLASNNESLNS

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=465, Percent_Identity=35.9139784946237, Blast_Score=285, Evalue=6e-77,
Organism=Homo sapiens, GI50301238, Length=473, Percent_Identity=27.061310782241, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI22035672, Length=466, Percent_Identity=24.4635193133047, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI33519430, Length=462, Percent_Identity=21.8614718614719, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI33519428, Length=462, Percent_Identity=21.8614718614719, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI33519426, Length=462, Percent_Identity=21.8614718614719, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI148277065, Length=462, Percent_Identity=21.8614718614719, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI148277071, Length=462, Percent_Identity=21.8614718614719, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI291045266, Length=443, Percent_Identity=22.1218961625282, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI291045268, Length=431, Percent_Identity=22.0417633410673, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1786307, Length=457, Percent_Identity=32.6039387308534, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI87082354, Length=460, Percent_Identity=28.0434782608696, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI87081717, Length=471, Percent_Identity=29.723991507431, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1789915, Length=439, Percent_Identity=26.6514806378132, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1788892, Length=217, Percent_Identity=26.7281105990783, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789065, Length=143, Percent_Identity=31.4685314685315, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI32565766, Length=493, Percent_Identity=35.4969574036511, Blast_Score=292, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI17557007, Length=486, Percent_Identity=25.5144032921811, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71983419, Length=440, Percent_Identity=27.2727272727273, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71983429, Length=440, Percent_Identity=27.2727272727273, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI71982272, Length=469, Percent_Identity=21.1087420042644, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6321091, Length=490, Percent_Identity=34.4897959183673, Blast_Score=267, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6325240, Length=475, Percent_Identity=26.7368421052632, Blast_Score=179, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6325166, Length=473, Percent_Identity=25.369978858351, Blast_Score=153, Evalue=6e-38,
Organism=Drosophila melanogaster, GI21358499, Length=466, Percent_Identity=34.7639484978541, Blast_Score=288, Evalue=5e-78,
Organism=Drosophila melanogaster, GI24640549, Length=472, Percent_Identity=21.6101694915254, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=20.7188160676533, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24640553, Length=472, Percent_Identity=21.6101694915254, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24640551, Length=472, Percent_Identity=21.6101694915254, Blast_Score=102, Evalue=8e-22,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 53618; Mature: 53618

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHLQTTVLFFIITEFSFKVINMNKHEFLIIGSGPGGYIAAIRAAQLGYNVAIIEKENTL
CEEEHHHHEEEEEECCEEEEEECCCCEEEEEECCCCCEEEEEEHHHCCCEEEEEEECCCC
GGVCLNWGCIPTKSLLHSALIYHNIKKADVFGINVTNVTCNFTKIIERSRNVVEKLSNGI
CCEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHH
SGLMKKNNIKVYSGTAKLLGEGTVEVLDNNNDKINITSKHIIIATGSHPRNLPNINFDNN
HHHHCCCCEEEEECCHHCCCCCEEEEEECCCCEEEEEEEEEEEEECCCCCCCCCCCCCCC
IIWNAKNAMTPNILPKSLAIIGTGAIGIEFASFYNTFGTQVTMIELRDNILPLEDHEVSK
EEECCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHH
SMHQILNQKGIKIYTKSSVTKLEKSNNNARIQISNTIDLEVDKVILAVGIQPNTDNLGLD
HHHHHHCCCCCEEEECCCHHHHHCCCCCCEEEECCEEEEEEEEEEEEEECCCCCCCCCCC
NTKIQIDQAGFIITDKYCCTSESGVYAIGDVAGPPCLAHKASHEAILCVENIAAQEKKIT
CCEEEEECCCEEEECCEEECCCCCEEEEECCCCCCHHHCCCCCCEEEEEHHHHHHHHHCC
DRNIHHINKENIPSCIFSIPQIASIGLTEHQAKSMGYDIKIGKFNANCSGKAIAIDETEG
CCCCCCCCCCCCCHHHHCCCHHHHCCCCHHHHHHCCCEEEEEEECCCCCCCEEEEECCCC
FVKVIINKTTGELLGAHMIGAEVTEMINGYIIGKQLEATDRDIISSIFPHPTLSEMIHEA
EEEEEEECCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHCCCCCHHHHHHHH
VLASNNESLNS
HHCCCCCCCCC
>Mature Secondary Structure
MLHLQTTVLFFIITEFSFKVINMNKHEFLIIGSGPGGYIAAIRAAQLGYNVAIIEKENTL
CEEEHHHHEEEEEECCEEEEEECCCCEEEEEECCCCCEEEEEEHHHCCCEEEEEEECCCC
GGVCLNWGCIPTKSLLHSALIYHNIKKADVFGINVTNVTCNFTKIIERSRNVVEKLSNGI
CCEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHH
SGLMKKNNIKVYSGTAKLLGEGTVEVLDNNNDKINITSKHIIIATGSHPRNLPNINFDNN
HHHHCCCCEEEEECCHHCCCCCEEEEEECCCCEEEEEEEEEEEEECCCCCCCCCCCCCCC
IIWNAKNAMTPNILPKSLAIIGTGAIGIEFASFYNTFGTQVTMIELRDNILPLEDHEVSK
EEECCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHH
SMHQILNQKGIKIYTKSSVTKLEKSNNNARIQISNTIDLEVDKVILAVGIQPNTDNLGLD
HHHHHHCCCCCEEEECCCHHHHHCCCCCCEEEECCEEEEEEEEEEEEEECCCCCCCCCCC
NTKIQIDQAGFIITDKYCCTSESGVYAIGDVAGPPCLAHKASHEAILCVENIAAQEKKIT
CCEEEEECCCEEEECCEEECCCCCEEEEECCCCCCHHHCCCCCCEEEEEHHHHHHHHHCC
DRNIHHINKENIPSCIFSIPQIASIGLTEHQAKSMGYDIKIGKFNANCSGKAIAIDETEG
CCCCCCCCCCCCCHHHHCCCHHHHCCCCHHHHHHCCCEEEEEEECCCCCCCEEEEECCCC
FVKVIINKTTGELLGAHMIGAEVTEMINGYIIGKQLEATDRDIISSIFPHPTLSEMIHEA
EEEEEEECCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHCCCCCHHHHHHHH
VLASNNESLNS
HHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]