Click here to switch to the map view.

The map label for this gene is cofH [H]

Identifier: 56964697

GI number: 56964697

Start: 3058543

End: 3059637

Strand: Direct

Name: cofH [H]

Synonym: ABC2933

Alternate gene names: 56964697

Gene position: 3058543-3059637 (Clockwise)

Preceding gene: 56964695

Following gene: 56964701

Centisome position: 71.06

GC content: 44.93

Gene sequence:

>1095_bases
ATGAGTGTACTACTTGCAGACACGAAGCTTCAAGAAGTGAAAGAGAAAGTGTTGCATGGCGAGCGCCTTTCGATAGAAGA
TGGCCTTGTTTTATATGAAACGCCTGATTTGCTCGGAGTTGCACAATTGGCTAATATCGTCAACGAGCGAAAAAACGGGC
AAAACGTTTATTTCATCGAGAACCTTTATATCAACCCAACGAATGTGTGTGAAGCCAACTGCGGATTTTGCGGCTTTAAG
CGCAAACCAGGCGAAGAAGGCGCTTATACAATGGATGAAGAAGCGCTATTAAAATATGTAGAAGATCGTTGGAACGACAA
CATCCGCGAATTTCATATCGTTGGCGGTCACAACAATGAAGTCGGTTTTGAGTATTATGTGAATACCGTAAAAACGTTGA
AAAAGCACTACCCGCAAGTGACGATTAAAGCGTATACAGGGGCAGAGATTGAATTTTTCTCACGCCTTGCTGGCATTTCT
ATGAAAGAAGTAATCCAAACGCTCATGGATGCGGGGCTGGCCACTTTAACTGGAGGCGGTGCAGAAATTTTGACCGAGCG
CTATCGTGCTATTATGAGCCCGGATAAAGCATCAACAGACCAATGGCTCGAAGCACACGAAACCGCTCACAACCTTGGCT
TGCGCACTCATTCAACGATGCTTTACGGCTCAGTTGAAACGAAAGAAGAGCGCTTGATTCATATGCAACGCGTCCGCGAC
TTGCAAGACCGTACAAATGGTTTTATGGTTTTCATCCCTCTAGCGATGCAGCCGCGCAATGTAAAGGCAGGCTTAAACCG
CCGTACGTCTGCATACGATGATATGCGTACGATTGCGGTCAGCCGCCTTATGCTCGACAATTTCCAGCATATAAAAGCGT
ACTGGATTAACATTGGCGTTCAATTGACGCAAATGGCGTTGACTTTTGGCTCCAGCGACATCCATGGCACATTAATAGAA
GAACGAATTTCCCATTCTGTTGGCGCATTAACGTCTGCAGGCATCACGAGAAAAGAACTGATTCATATGATCAAAACAGC
TGGCAAAACACCAATTGAACGCGACACTTTCTACAATGAAATAAAACGCTATTAA

Upstream 100 bases:

>100_bases
CGCTCCTTTCATTCTAAAAATGGTAGTAGTATAATAGGTTCGTACGGATTTGAAGGGAACACGATGTGAATGTGAATTGT
TCCAAAAGGAGGAAATGAAG

Downstream 100 bases:

>100_bases
CAGATTAAAAGCCTGTCCGCAAACGTGCGGAACAGGCTTTTAAAAGCATCCGTTAAAGAAAGACATTCCCTGTGCAAATA
TACTCTGCTGGCCCACGCAT

Product: hypothetical protein

Products: NA

Alternate protein names: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 2 [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MSVLLADTKLQEVKEKVLHGERLSIEDGLVLYETPDLLGVAQLANIVNERKNGQNVYFIENLYINPTNVCEANCGFCGFK
RKPGEEGAYTMDEEALLKYVEDRWNDNIREFHIVGGHNNEVGFEYYVNTVKTLKKHYPQVTIKAYTGAEIEFFSRLAGIS
MKEVIQTLMDAGLATLTGGGAEILTERYRAIMSPDKASTDQWLEAHETAHNLGLRTHSTMLYGSVETKEERLIHMQRVRD
LQDRTNGFMVFIPLAMQPRNVKAGLNRRTSAYDDMRTIAVSRLMLDNFQHIKAYWINIGVQLTQMALTFGSSDIHGTLIE
ERISHSVGALTSAGITRKELIHMIKTAGKTPIERDTFYNEIKRY

Sequences:

>Translated_364_residues
MSVLLADTKLQEVKEKVLHGERLSIEDGLVLYETPDLLGVAQLANIVNERKNGQNVYFIENLYINPTNVCEANCGFCGFK
RKPGEEGAYTMDEEALLKYVEDRWNDNIREFHIVGGHNNEVGFEYYVNTVKTLKKHYPQVTIKAYTGAEIEFFSRLAGIS
MKEVIQTLMDAGLATLTGGGAEILTERYRAIMSPDKASTDQWLEAHETAHNLGLRTHSTMLYGSVETKEERLIHMQRVRD
LQDRTNGFMVFIPLAMQPRNVKAGLNRRTSAYDDMRTIAVSRLMLDNFQHIKAYWINIGVQLTQMALTFGSSDIHGTLIE
ERISHSVGALTSAGITRKELIHMIKTAGKTPIERDTFYNEIKRY
>Mature_363_residues
SVLLADTKLQEVKEKVLHGERLSIEDGLVLYETPDLLGVAQLANIVNERKNGQNVYFIENLYINPTNVCEANCGFCGFKR
KPGEEGAYTMDEEALLKYVEDRWNDNIREFHIVGGHNNEVGFEYYVNTVKTLKKHYPQVTIKAYTGAEIEFFSRLAGISM
KEVIQTLMDAGLATLTGGGAEILTERYRAIMSPDKASTDQWLEAHETAHNLGLRTHSTMLYGSVETKEERLIHMQRVRDL
QDRTNGFMVFIPLAMQPRNVKAGLNRRTSAYDDMRTIAVSRLMLDNFQHIKAYWINIGVQLTQMALTFGSSDIHGTLIEE
RISHSVGALTSAGITRKELIHMIKTAGKTPIERDTFYNEIKRY

Specific function: Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) [H]

COG id: COG1060

COG function: function code HR; Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. CofH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR019940
- InterPro:   IPR006638
- InterPro:   IPR020050
- InterPro:   IPR005244
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 41317; Mature: 41186

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLLADTKLQEVKEKVLHGERLSIEDGLVLYETPDLLGVAQLANIVNERKNGQNVYFIE
CCEEECCHHHHHHHHHHHCCCCEEECCCEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEE
NLYINPTNVCEANCGFCGFKRKPGEEGAYTMDEEALLKYVEDRWNDNIREFHIVGGHNNE
EEEECCCCCCCCCCCCCCCCCCCCCCCCEECCHHHHHHHHHHHHCCCCEEEEEECCCCCC
VGFEYYVNTVKTLKKHYPQVTIKAYTGAEIEFFSRLAGISMKEVIQTLMDAGLATLTGGG
CCHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHCCHHEECCCC
AEILTERYRAIMSPDKASTDQWLEAHETAHNLGLRTHSTMLYGSVETKEERLIHMQRVRD
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHH
LQDRTNGFMVFIPLAMQPRNVKAGLNRRTSAYDDMRTIAVSRLMLDNFQHIKAYWINIGV
HHHCCCCEEEEEEECCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEHCCCH
QLTQMALTFGSSDIHGTLIEERISHSVGALTSAGITRKELIHMIKTAGKTPIERDTFYNE
HEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHH
IKRY
HHCC
>Mature Secondary Structure 
SVLLADTKLQEVKEKVLHGERLSIEDGLVLYETPDLLGVAQLANIVNERKNGQNVYFIE
CEEECCHHHHHHHHHHHCCCCEEECCCEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEE
NLYINPTNVCEANCGFCGFKRKPGEEGAYTMDEEALLKYVEDRWNDNIREFHIVGGHNNE
EEEECCCCCCCCCCCCCCCCCCCCCCCCEECCHHHHHHHHHHHHCCCCEEEEEECCCCCC
VGFEYYVNTVKTLKKHYPQVTIKAYTGAEIEFFSRLAGISMKEVIQTLMDAGLATLTGGG
CCHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHCCHHEECCCC
AEILTERYRAIMSPDKASTDQWLEAHETAHNLGLRTHSTMLYGSVETKEERLIHMQRVRD
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHH
LQDRTNGFMVFIPLAMQPRNVKAGLNRRTSAYDDMRTIAVSRLMLDNFQHIKAYWINIGV
HHHCCCCEEEEEEECCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEHCCCH
QLTQMALTFGSSDIHGTLIEERISHSVGALTSAGITRKELIHMIKTAGKTPIERDTFYNE
HEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHH
IKRY
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA