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The map label for this gene is mccB [H]

Identifier: 56963710

GI number: 56963710

Start: 2060058

End: 2061194

Strand: Direct

Name: mccB [H]

Synonym: ABC1945

Alternate gene names: 56963710

Gene position: 2060058-2061194 (Clockwise)

Preceding gene: 56963709

Following gene: 56963711

Centisome position: 47.87

GC content: 46.26

Gene sequence:

>1137_bases
GTGAGGAAAAAGACACAGCTTATCCATGGTGGCATTGGAATGGATGCTGAAACAGGCGCAGTCACGCCACCGATCCATCC
AGCCAGCACATTTAAACAAAAAGGAATTGGCAACTTTCAATATGAGTATGGGCGAACGGGCAACCCGACGCGCCATGCGC
TTGAGTCTTTGCTTGCTGATATAGAAAGCGGGGCCCATGGGTTTGCCTTTGCCTCAGGATTGGCTGCGATCACCGCAGTG
ATGAAGCTTTTTTCATCTGGTGATCATATCATTGTAACCGACGATGTGTATGGCGGGACATACCGGCTATTTACAAAGAT
TTTGCAAAGGGAAGGGATTGCAGCTACTTTTGTCGATACGGAGGATCAAGCGGCTGTCGCAAGGGCAAGAACAAGCAAAA
CGAAAGCGATTTTTATTGAAACGCCAACAAATCCATTGCTGAAAGTAACGGATATACGGAAACTGGCCAGCTATGCGCAA
GCGGAAGAATTGCTTCTTATTGTTGATAATACGTTTGCCACCCCTTATTGGCAAAACCCTCTTGTATTAGGAGCGGATAT
CGTCGTCCATAGCGCTACAAAATATTTAGGCGGCCATAGTGACGTTGTTGCTGGCGCGGTAGTCGTTAAAGACGAAAAAC
TAGCTGAAACGCTCGCTTTTATTCAAAATGCGACAGGCGCTGTTCTTGGCCCAACTGACAGTTGGCTATTGATGCGGGGC
ATCAAAACGCTCGGTGTAAGAATGGAAGAAATTGAAACGAATGCGCGTATGCTCGTGAAATTTTTGCTTGGCCATCCAAA
TGTCAGCCGGATTTACTATCCAGGTTTAGTTGAACATCCTGGCCATGCAACGCATGCTTTGCAAGCGAGAGGGTTTGGCG
GCATTATTTCTTTTGAGGCTGCGAGTGAAGAAATTGCTGACAATGTGTTAAACAAAACGACCTATTTTACTTTAGCAGAG
AGTCTCGGAGCAGTTGAAAGCCTGATTTCATTGCCAGCTAAAATGACTCATGCCTCGATCCCAGAAGACAGGCGCAGTGC
CCTTGGCATTACAAATACACTCGTTCGTTTGTCTGTTGGTTTAGAAGACTTTGAGGATCTGGCCGAAGATTTGGAAATAG
GGCTTACAGTGTTTTAA

Upstream 100 bases:

>100_bases
GAGAGGCTGAAATGGCCGACGAAGGTGCCCATATCGTCACTGTCTTTCCTGACGGGGCGGAACGGTATTTGAGCAAAGGC
ATTTATGAGGAGGAACCTTT

Downstream 100 bases:

>100_bases
ACACGTGCGATACGCGCGTGTTTTTTTATGTAACTAGGACGTTTGTCACGTTTTGAGGAAGCAAAAATGAGAGGATAAAA
CGACAATGTATGTTTTTCAG

Product: cystathionine gamma-synthase

Products: NA

Alternate protein names: Gamma-cystathionase; Homocysteine gamma-lyase [H]

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MRKKTQLIHGGIGMDAETGAVTPPIHPASTFKQKGIGNFQYEYGRTGNPTRHALESLLADIESGAHGFAFASGLAAITAV
MKLFSSGDHIIVTDDVYGGTYRLFTKILQREGIAATFVDTEDQAAVARARTSKTKAIFIETPTNPLLKVTDIRKLASYAQ
AEELLLIVDNTFATPYWQNPLVLGADIVVHSATKYLGGHSDVVAGAVVVKDEKLAETLAFIQNATGAVLGPTDSWLLMRG
IKTLGVRMEEIETNARMLVKFLLGHPNVSRIYYPGLVEHPGHATHALQARGFGGIISFEAASEEIADNVLNKTTYFTLAE
SLGAVESLISLPAKMTHASIPEDRRSALGITNTLVRLSVGLEDFEDLAEDLEIGLTVF

Sequences:

>Translated_378_residues
MRKKTQLIHGGIGMDAETGAVTPPIHPASTFKQKGIGNFQYEYGRTGNPTRHALESLLADIESGAHGFAFASGLAAITAV
MKLFSSGDHIIVTDDVYGGTYRLFTKILQREGIAATFVDTEDQAAVARARTSKTKAIFIETPTNPLLKVTDIRKLASYAQ
AEELLLIVDNTFATPYWQNPLVLGADIVVHSATKYLGGHSDVVAGAVVVKDEKLAETLAFIQNATGAVLGPTDSWLLMRG
IKTLGVRMEEIETNARMLVKFLLGHPNVSRIYYPGLVEHPGHATHALQARGFGGIISFEAASEEIADNVLNKTTYFTLAE
SLGAVESLISLPAKMTHASIPEDRRSALGITNTLVRLSVGLEDFEDLAEDLEIGLTVF
>Mature_378_residues
MRKKTQLIHGGIGMDAETGAVTPPIHPASTFKQKGIGNFQYEYGRTGNPTRHALESLLADIESGAHGFAFASGLAAITAV
MKLFSSGDHIIVTDDVYGGTYRLFTKILQREGIAATFVDTEDQAAVARARTSKTKAIFIETPTNPLLKVTDIRKLASYAQ
AEELLLIVDNTFATPYWQNPLVLGADIVVHSATKYLGGHSDVVAGAVVVKDEKLAETLAFIQNATGAVLGPTDSWLLMRG
IKTLGVRMEEIETNARMLVKFLLGHPNVSRIYYPGLVEHPGHATHALQARGFGGIISFEAASEEIADNVLNKTTYFTLAE
SLGAVESLISLPAKMTHASIPEDRRSALGITNTLVRLSVGLEDFEDLAEDLEIGLTVF

Specific function: Catalyzes the conversion of cystathionine to cysteine, and homocysteine to sulfide [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=362, Percent_Identity=46.6850828729282, Blast_Score=309, Evalue=3e-84,
Organism=Homo sapiens, GI299473759, Length=362, Percent_Identity=41.4364640883978, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI25453487, Length=361, Percent_Identity=41.8282548476454, Blast_Score=246, Evalue=2e-65,
Organism=Escherichia coli, GI1790375, Length=377, Percent_Identity=44.2970822281167, Blast_Score=312, Evalue=3e-86,
Organism=Escherichia coli, GI1789383, Length=391, Percent_Identity=28.9002557544757, Blast_Score=162, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17560056, Length=351, Percent_Identity=45.2991452991453, Blast_Score=307, Evalue=7e-84,
Organism=Caenorhabditis elegans, GI17538055, Length=351, Percent_Identity=44.1595441595442, Blast_Score=300, Evalue=8e-82,
Organism=Caenorhabditis elegans, GI71980708, Length=367, Percent_Identity=38.4196185286104, Blast_Score=242, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6319307, Length=383, Percent_Identity=43.8642297650131, Blast_Score=300, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6321254, Length=398, Percent_Identity=34.4221105527638, Blast_Score=217, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6323333, Length=386, Percent_Identity=32.9015544041451, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6321170, Length=299, Percent_Identity=32.4414715719064, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6321904, Length=390, Percent_Identity=32.0512820512821, Blast_Score=149, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6322590, Length=246, Percent_Identity=30.0813008130081, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6323557, Length=250, Percent_Identity=28, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322970, Length=264, Percent_Identity=27.6515151515151, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI19922554, Length=378, Percent_Identity=47.3544973544974, Blast_Score=341, Evalue=4e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.1; =4.4.1.2 [H]

Molecular weight: Translated: 40750; Mature: 40750

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKKTQLIHGGIGMDAETGAVTPPIHPASTFKQKGIGNFQYEYGRTGNPTRHALESLLAD
CCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHH
IESGAHGFAFASGLAAITAVMKLFSSGDHIIVTDDVYGGTYRLFTKILQREGIAATFVDT
HHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEECC
EDQAAVARARTSKTKAIFIETPTNPLLKVTDIRKLASYAQAEELLLIVDNTFATPYWQNP
CCHHHHHHHHCCCCEEEEEECCCCCCEEHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCC
LVLGADIVVHSATKYLGGHSDVVAGAVVVKDEKLAETLAFIQNATGAVLGPTDSWLLMRG
EEEECHHHHHHHHHHHCCCCHHHEEEEEECHHHHHHHHHHHHCCCCCEECCCCHHHHHHH
IKTLGVRMEEIETNARMLVKFLLGHPNVSRIYYPGLVEHPGHATHALQARGFGGIISFEA
HHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHCCCCCEEEECH
ASEEIADNVLNKTTYFTLAESLGAVESLISLPAKMTHASIPEDRRSALGITNTLVRLSVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHCCHHHHHHHHHCC
LEDFEDLAEDLEIGLTVF
HHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRKKTQLIHGGIGMDAETGAVTPPIHPASTFKQKGIGNFQYEYGRTGNPTRHALESLLAD
CCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHH
IESGAHGFAFASGLAAITAVMKLFSSGDHIIVTDDVYGGTYRLFTKILQREGIAATFVDT
HHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEECC
EDQAAVARARTSKTKAIFIETPTNPLLKVTDIRKLASYAQAEELLLIVDNTFATPYWQNP
CCHHHHHHHHCCCCEEEEEECCCCCCEEHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCC
LVLGADIVVHSATKYLGGHSDVVAGAVVVKDEKLAETLAFIQNATGAVLGPTDSWLLMRG
EEEECHHHHHHHHHHHCCCCHHHEEEEEECHHHHHHHHHHHHCCCCCEECCCCHHHHHHH
IKTLGVRMEEIETNARMLVKFLLGHPNVSRIYYPGLVEHPGHATHALQARGFGGIISFEA
HHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHCCCCCEEEECH
ASEEIADNVLNKTTYFTLAESLGAVESLISLPAKMTHASIPEDRRSALGITNTLVRLSVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHCCHHHHHHHHHCC
LEDFEDLAEDLEIGLTVF
HHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377 [H]