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The map label for this gene is aroE

Identifier: 56963668

GI number: 56963668

Start: 2019986

End: 2021278

Strand: Direct

Name: aroE

Synonym: ABC1903

Alternate gene names: 56963668

Gene position: 2019986-2021278 (Clockwise)

Preceding gene: 56963667

Following gene: 56963669

Centisome position: 46.93

GC content: 50.35

Gene sequence:

>1293_bases
ATGGACGAGACGATAAAGCTGCTAAACAAAGCAGAATCGGGTTTGTCAGGGACAATTGTCGTACCTGGCGATAAATCGAT
TTCACACCGCGCTGTCATGTTTGGCGCTATGGCGAATGGTACTACAAACGTCAGCGGATTTCTTCCTGGCGATGATTGTT
TAAGCACGATTGCCTGTTTCCGGCAAATGGGTGTAGCGATTGAACAAGAAGGCGACAAAGTCACGGTTGAAGGCAAAGGG
TTAGATGGGCTGAAGGAGCCAAATGGTGTGCTAGATGTCGGCAATTCCGGTACAACAATCCGTTTGCTATTGGGCGTCCT
CTCTGGTCGGCCTTTTCATTCGGTCGTTGTCGGTGACGATTCGATTGGCAAACGCCCGATGGCACGGGTGACGGCGCCAC
TTCGGCAAATGGGCGCGCAAATCGACGGACGGGAAACGGGAAATAAAACACCGTTATCGATCCGTGGTGGGCAAACGAAA
GCAATCGAGTATACGATGCCTGTAGCAAGCGCACAAGTCAAATCAGCGCTTCTGTTAGCGGGATTGCAAGCAGAAGGGGA
AACATCTGTTACAGAGCCGCAAACAACAAGAGACCATACAGAGCGAATGCTCCATGCTTTTGGCGTGAAAGTGACGACAG
CGGGCAAGACCATTTCCATTCAAGGCGGCCAGTCCCTTCAAGCAGCTGACGTCGTTGTTCCAGGGGATATTTCATCGGCG
GCGTTTTTTCTTGTCGCAGGCTGTATCGTTCCAGGGAGTCGCGTCCACTTAAAGAATGTAGGCTTAAATCCAACGCGTGC
CGGCATTCTTGAAGTCTTAAAGCGGAGTGGAGCAAAGCTGTCGATTGACGAGCAAGTGACGACAGGTGGTGAACCACGGG
GAGATATGACGATATCAACAAGCGAGCTCTCACCGTTTGTCATTGAAGGAGAGGAAGTGCCTACGCTAATTGATGAAATA
CCGGTGTTAGCAGTGCTTGCTACGCAAATTTCAGGCACCACTATTATCCGTGATGCTGAAGAGCTAAAAGTGAAAGAAAC
GAACCGCATTGATACGGTTGTAGGCGAATTGGCTAAGCTTGGGGCTGACATTGAAGCGACCGATGACGGCATGATTATCC
GTGGCGGCAAGCCGCTTACAGGCGGAAAAGTGGATTCCCATGGCGACCACCGTATTGGCATGGCGCTTGTCATTGCCTCT
TTATGCGCAAATGGGCCGGTAGAATTAGCAAACATAGGTGCCATTTCTGTATCGTATCCTCAGTTTTTTGAGCATTTACA
GTCGCTACAGTAG

Upstream 100 bases:

>100_bases
TTTTGCGCCTTAGTTTCCGTTCAGAAGACGATCGAGTATATGCCCAGGAAGAACTGAAACGGCATATGTATGAAACTTAC
ACGATATAAGGAGAAGAAGT

Downstream 100 bases:

>100_bases
AAGAGCGTCCAAGCGAATCGAAATCGATTGTAGCAGAGGCGTGTAGGCATGGAGAACGAGGACAGGAGCAAATGGTTCCG
TCTGCGTGAACAGTTGTAAA

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MDETIKLLNKAESGLSGTIVVPGDKSISHRAVMFGAMANGTTNVSGFLPGDDCLSTIACFRQMGVAIEQEGDKVTVEGKG
LDGLKEPNGVLDVGNSGTTIRLLLGVLSGRPFHSVVVGDDSIGKRPMARVTAPLRQMGAQIDGRETGNKTPLSIRGGQTK
AIEYTMPVASAQVKSALLLAGLQAEGETSVTEPQTTRDHTERMLHAFGVKVTTAGKTISIQGGQSLQAADVVVPGDISSA
AFFLVAGCIVPGSRVHLKNVGLNPTRAGILEVLKRSGAKLSIDEQVTTGGEPRGDMTISTSELSPFVIEGEEVPTLIDEI
PVLAVLATQISGTTIIRDAEELKVKETNRIDTVVGELAKLGADIEATDDGMIIRGGKPLTGGKVDSHGDHRIGMALVIAS
LCANGPVELANIGAISVSYPQFFEHLQSLQ

Sequences:

>Translated_430_residues
MDETIKLLNKAESGLSGTIVVPGDKSISHRAVMFGAMANGTTNVSGFLPGDDCLSTIACFRQMGVAIEQEGDKVTVEGKG
LDGLKEPNGVLDVGNSGTTIRLLLGVLSGRPFHSVVVGDDSIGKRPMARVTAPLRQMGAQIDGRETGNKTPLSIRGGQTK
AIEYTMPVASAQVKSALLLAGLQAEGETSVTEPQTTRDHTERMLHAFGVKVTTAGKTISIQGGQSLQAADVVVPGDISSA
AFFLVAGCIVPGSRVHLKNVGLNPTRAGILEVLKRSGAKLSIDEQVTTGGEPRGDMTISTSELSPFVIEGEEVPTLIDEI
PVLAVLATQISGTTIIRDAEELKVKETNRIDTVVGELAKLGADIEATDDGMIIRGGKPLTGGKVDSHGDHRIGMALVIAS
LCANGPVELANIGAISVSYPQFFEHLQSLQ
>Mature_430_residues
MDETIKLLNKAESGLSGTIVVPGDKSISHRAVMFGAMANGTTNVSGFLPGDDCLSTIACFRQMGVAIEQEGDKVTVEGKG
LDGLKEPNGVLDVGNSGTTIRLLLGVLSGRPFHSVVVGDDSIGKRPMARVTAPLRQMGAQIDGRETGNKTPLSIRGGQTK
AIEYTMPVASAQVKSALLLAGLQAEGETSVTEPQTTRDHTERMLHAFGVKVTTAGKTISIQGGQSLQAADVVVPGDISSA
AFFLVAGCIVPGSRVHLKNVGLNPTRAGILEVLKRSGAKLSIDEQVTTGGEPRGDMTISTSELSPFVIEGEEVPTLIDEI
PVLAVLATQISGTTIIRDAEELKVKETNRIDTVVGELAKLGADIEATDDGMIIRGGKPLTGGKVDSHGDHRIGMALVIAS
LCANGPVELANIGAISVSYPQFFEHLQSLQ

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family

Homologues:

Organism=Escherichia coli, GI1787137, Length=427, Percent_Identity=29.2740046838407, Blast_Score=141, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6320332, Length=462, Percent_Identity=26.1904761904762, Blast_Score=104, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROA_BACSK (Q5WGR7)

Other databases:

- EMBL:   AP006627
- RefSeq:   YP_175399.1
- ProteinModelPortal:   Q5WGR7
- SMR:   Q5WGR7
- STRING:   Q5WGR7
- EnsemblBacteria:   EBBACT00000047664
- GeneID:   3201725
- GenomeReviews:   AP006627_GR
- KEGG:   bcl:ABC1903
- NMPDR:   fig|66692.3.peg.1947
- eggNOG:   COG0128
- GeneTree:   EBGT00050000001036
- HOGENOM:   HBG646626
- OMA:   DVEIRAD
- ProtClustDB:   PRK02427
- BioCyc:   BCLA66692:ABC1903-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00210
- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792
- Gene3D:   G3DSA:3.65.10.10
- PIRSF:   PIRSF000505
- TIGRFAMs:   TIGR01356

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.19

Molecular weight: Translated: 44876; Mature: 44876

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00104 EPSP_SYNTHASE_1; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDETIKLLNKAESGLSGTIVVPGDKSISHRAVMFGAMANGTTNVSGFLPGDDCLSTIACF
CCHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHH
RQMGVAIEQEGDKVTVEGKGLDGLKEPNGVLDVGNSGTTIRLLLGVLSGRPFHSVVVGDD
HHHCCEEECCCCEEEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCCEEEEEECCC
SIGKRPMARVTAPLRQMGAQIDGRETGNKTPLSIRGGQTKAIEYTMPVASAQVKSALLLA
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHC
GLQAEGETSVTEPQTTRDHTERMLHAFGVKVTTAGKTISIQGGQSLQAADVVVPGDISSA
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCEEEECCCCCCEEEEEEECCCCCHH
AFFLVAGCIVPGSRVHLKNVGLNPTRAGILEVLKRSGAKLSIDEQVTTGGEPRGDMTIST
HHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEECCHHCCCCCCCCCEEEEC
SELSPFVIEGEEVPTLIDEIPVLAVLATQISGTTIIRDAEELKVKETNRIDTVVGELAKL
CCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEECHHHHEECCCCHHHHHHHHHHHH
GADIEATDDGMIIRGGKPLTGGKVDSHGDHRIGMALVIASLCANGPVELANIGAISVSYP
CCCCEECCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCEEEECHH
QFFEHLQSLQ
HHHHHHHHCC
>Mature Secondary Structure
MDETIKLLNKAESGLSGTIVVPGDKSISHRAVMFGAMANGTTNVSGFLPGDDCLSTIACF
CCHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHH
RQMGVAIEQEGDKVTVEGKGLDGLKEPNGVLDVGNSGTTIRLLLGVLSGRPFHSVVVGDD
HHHCCEEECCCCEEEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCCEEEEEECCC
SIGKRPMARVTAPLRQMGAQIDGRETGNKTPLSIRGGQTKAIEYTMPVASAQVKSALLLA
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHC
GLQAEGETSVTEPQTTRDHTERMLHAFGVKVTTAGKTISIQGGQSLQAADVVVPGDISSA
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCEEEECCCCCCEEEEEEECCCCCHH
AFFLVAGCIVPGSRVHLKNVGLNPTRAGILEVLKRSGAKLSIDEQVTTGGEPRGDMTIST
HHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEECCHHCCCCCCCCCEEEEC
SELSPFVIEGEEVPTLIDEIPVLAVLATQISGTTIIRDAEELKVKETNRIDTVVGELAKL
CCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEECHHHHEECCCCHHHHHHHHHHHH
GADIEATDDGMIIRGGKPLTGGKVDSHGDHRIGMALVIASLCANGPVELANIGAISVSYP
CCCCEECCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCEEEECHH
QFFEHLQSLQ
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA