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The map label for this gene is trpB

Identifier: 56963664

GI number: 56963664

Start: 2015673

End: 2016872

Strand: Direct

Name: trpB

Synonym: ABC1899

Alternate gene names: 56963664

Gene position: 2015673-2016872 (Clockwise)

Preceding gene: 56963663

Following gene: 56963665

Centisome position: 46.83

GC content: 50.67

Gene sequence:

>1200_bases
ATGCAAGAAACAATACCAGATAGCCGCGGCCGTTTTGGCGAGTTTGGCGGCAAATATGTTCCCGAAACATTAATGTCGGC
AATTGAAGAGTTGGAAGCTGGGCTGGCAAAAGCGATGGTTGATCCCGCTTTTATAGGAGAGCTAAAAGCCGACTTGGCTG
AATATGCAGGCAGGGAAACACCGCTGACGTTTGCGAAAAACATTAGCGCAAAATTAGGCGGAGCCAATATCTATTTAAAG
CGGGAAGATTTGGTTCATACGGGGGCCCATAAATTGAATAATGCAATTGGCCAAGGGCTCCTTGCAAAACGAATGGGCAA
AAACAAGCTTGTCGCCGAAACAGGGGCAGGCCAGCACGGCGTCGCCACGGCAACGGTTGCTAGCCGCCTTGGCATGGAAT
GCAAAGTGTTTATGGGCGTGGAAGACATGAAGCGGCAAGAGTTAAATGTATTTCGCATGGAATTACTTGGCGCCGAGGTT
GTGCCGGCGGAGACGGGGAGCCGAACGCTAAAAGACGCTACCAATGAAGCGATTCGCTATTGGGTCTCCCACGCAGATGA
TACGTTTTATCTAATCGGCTCCGTAGTCGGCCCGCATCCTTATCCGAAAATGGTCCGCAATTTCCAGCGCGTGATCGGCG
ATGAAGCCAAACAGCAGATGGCAGAAAAGACAGGGCGACTGCCTGATACAATTGTTGCTTGTGTTGGCGGTGGCAGCAAC
GCAATCGGTATGTTTTACCCGTTTCTCGACGATGAAGTGGAGCTTGTCGGCGTCGAAGCGGCAGGACGGGGGCTTGATAC
AGCCGAACATGCTGCCACGATCAGCAAAGGTTCGAAAGGAATTATCCACGGCTCGCTTACGTACTTGCTTCAAGATGAAT
CTGGGCAAATTAAGGAGCCTTATTCGATTTCCGCCGGACTGGATTACCCTGGCGTTGGCCCTGAGCATGCCTACTTGGCC
GCCCAAAAGCGAGTTCGTTATGAAGCTGTAACCGATAAGGAGGCGCTCGATGCACTTGCGCTTCTAGCCAAAGAGGAAGG
AATCATTCCCGCAATTGAATCGGCTCATGCGTTGGCTAAAGCTTTTCAAATGGCGAAAACGATGACGCCAAACCAATCTG
TACTCGTATGTTTATCAGGCAGAGGCGATAAGGATATGCACACATTGCAACGGGTTTATAAGGAGGGGTACGATGAATAA

Upstream 100 bases:

>100_bases
TACCAAGTAGACGGACTGGATGTATCGAGCGGAATTGAAGAGAACGGAAAAAAAAGCGTCGCAAAAATAGCGCGCCTTGA
ACAAGAAGCGGGGGTCCATT

Downstream 100 bases:

>100_bases
GCGGCTTCGTGATGCTGTAAAAAAGGGCAACTTGTTTATTCCGTTCATTACCGCCGGAGACCCGGTGCGAGAAGCAACCA
TCGCCCTCGCACTCTCATTA

Product: tryptophan synthase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MQETIPDSRGRFGEFGGKYVPETLMSAIEELEAGLAKAMVDPAFIGELKADLAEYAGRETPLTFAKNISAKLGGANIYLK
REDLVHTGAHKLNNAIGQGLLAKRMGKNKLVAETGAGQHGVATATVASRLGMECKVFMGVEDMKRQELNVFRMELLGAEV
VPAETGSRTLKDATNEAIRYWVSHADDTFYLIGSVVGPHPYPKMVRNFQRVIGDEAKQQMAEKTGRLPDTIVACVGGGSN
AIGMFYPFLDDEVELVGVEAAGRGLDTAEHAATISKGSKGIIHGSLTYLLQDESGQIKEPYSISAGLDYPGVGPEHAYLA
AQKRVRYEAVTDKEALDALALLAKEEGIIPAIESAHALAKAFQMAKTMTPNQSVLVCLSGRGDKDMHTLQRVYKEGYDE

Sequences:

>Translated_399_residues
MQETIPDSRGRFGEFGGKYVPETLMSAIEELEAGLAKAMVDPAFIGELKADLAEYAGRETPLTFAKNISAKLGGANIYLK
REDLVHTGAHKLNNAIGQGLLAKRMGKNKLVAETGAGQHGVATATVASRLGMECKVFMGVEDMKRQELNVFRMELLGAEV
VPAETGSRTLKDATNEAIRYWVSHADDTFYLIGSVVGPHPYPKMVRNFQRVIGDEAKQQMAEKTGRLPDTIVACVGGGSN
AIGMFYPFLDDEVELVGVEAAGRGLDTAEHAATISKGSKGIIHGSLTYLLQDESGQIKEPYSISAGLDYPGVGPEHAYLA
AQKRVRYEAVTDKEALDALALLAKEEGIIPAIESAHALAKAFQMAKTMTPNQSVLVCLSGRGDKDMHTLQRVYKEGYDE
>Mature_399_residues
MQETIPDSRGRFGEFGGKYVPETLMSAIEELEAGLAKAMVDPAFIGELKADLAEYAGRETPLTFAKNISAKLGGANIYLK
REDLVHTGAHKLNNAIGQGLLAKRMGKNKLVAETGAGQHGVATATVASRLGMECKVFMGVEDMKRQELNVFRMELLGAEV
VPAETGSRTLKDATNEAIRYWVSHADDTFYLIGSVVGPHPYPKMVRNFQRVIGDEAKQQMAEKTGRLPDTIVACVGGGSN
AIGMFYPFLDDEVELVGVEAAGRGLDTAEHAATISKGSKGIIHGSLTYLLQDESGQIKEPYSISAGLDYPGVGPEHAYLA
AQKRVRYEAVTDKEALDALALLAKEEGIIPAIESAHALAKAFQMAKTMTPNQSVLVCLSGRGDKDMHTLQRVYKEGYDE

Specific function: The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine

COG id: COG0133

COG function: function code E; Tryptophan synthase beta chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpB family

Homologues:

Organism=Escherichia coli, GI1787515, Length=387, Percent_Identity=53.4883720930233, Blast_Score=421, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6321412, Length=395, Percent_Identity=53.4177215189873, Blast_Score=443, Evalue=1e-125,

Paralogues:

None

Copy number: 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 5,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPB_BACSK (Q5WGS1)

Other databases:

- EMBL:   AP006627
- RefSeq:   YP_175395.1
- HSSP:   P0A2K1
- ProteinModelPortal:   Q5WGS1
- SMR:   Q5WGS1
- STRING:   Q5WGS1
- EnsemblBacteria:   EBBACT00000049754
- GeneID:   3203561
- GenomeReviews:   AP006627_GR
- KEGG:   bcl:ABC1899
- NMPDR:   fig|66692.3.peg.1943
- eggNOG:   COG0133
- GeneTree:   EBGT00050000001631
- HOGENOM:   HBG303148
- OMA:   LKREDLC
- ProtClustDB:   PRK04346
- BioCyc:   BCLA66692:ABC1899-MONOMER
- HAMAP:   MF_00133
- InterPro:   IPR001926
- InterPro:   IPR006653
- InterPro:   IPR006654
- InterPro:   IPR023026
- TIGRFAMs:   TIGR00263

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =4.2.1.20

Molecular weight: Translated: 43037; Mature: 43037

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00168 TRP_SYNTHASE_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQETIPDSRGRFGEFGGKYVPETLMSAIEELEAGLAKAMVDPAFIGELKADLAEYAGRET
CCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCC
PLTFAKNISAKLGGANIYLKREDLVHTGAHKLNNAIGQGLLAKRMGKNKLVAETGAGQHG
CHHHHHCCHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCC
VATATVASRLGMECKVFMGVEDMKRQELNVFRMELLGAEVVPAETGSRTLKDATNEAIRY
HHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
WVSHADDTFYLIGSVVGPHPYPKMVRNFQRVIGDEAKQQMAEKTGRLPDTIVACVGGGSN
HHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCEEEEECCCCC
AIGMFYPFLDDEVELVGVEAAGRGLDTAEHAATISKGSKGIIHGSLTYLLQDESGQIKEP
CEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCCCC
YSISAGLDYPGVGPEHAYLAAQKRVRYEAVTDKEALDALALLAKEEGIIPAIESAHALAK
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHH
AFQMAKTMTPNQSVLVCLSGRGDKDMHTLQRVYKEGYDE
HHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQETIPDSRGRFGEFGGKYVPETLMSAIEELEAGLAKAMVDPAFIGELKADLAEYAGRET
CCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCC
PLTFAKNISAKLGGANIYLKREDLVHTGAHKLNNAIGQGLLAKRMGKNKLVAETGAGQHG
CHHHHHCCHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCC
VATATVASRLGMECKVFMGVEDMKRQELNVFRMELLGAEVVPAETGSRTLKDATNEAIRY
HHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
WVSHADDTFYLIGSVVGPHPYPKMVRNFQRVIGDEAKQQMAEKTGRLPDTIVACVGGGSN
HHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCEEEEECCCCC
AIGMFYPFLDDEVELVGVEAAGRGLDTAEHAATISKGSKGIIHGSLTYLLQDESGQIKEP
CEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCCCC
YSISAGLDYPGVGPEHAYLAAQKRVRYEAVTDKEALDALALLAKEEGIIPAIESAHALAK
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHH
AFQMAKTMTPNQSVLVCLSGRGDKDMHTLQRVYKEGYDE
HHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA