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The map label for this gene is ndk

Identifier: 56963655

GI number: 56963655

Start: 2007381

End: 2007824

Strand: Direct

Name: ndk

Synonym: ABC1890

Alternate gene names: 56963655

Gene position: 2007381-2007824 (Clockwise)

Preceding gene: 56963654

Following gene: 56963656

Centisome position: 46.64

GC content: 45.27

Gene sequence:

>444_bases
ATGGAACGTACATACGTAATGGTTAAGCCTGATGGCGTACAACGTAATTTGATTGGAAACATTGTATCGCGGTTTGAACA
AAAAGGGTACACGCTTGCTGCAGCTAAGCTGGTCACTTTAAGCAAAGAAACGGCGGAAACGCATTATAGCGAACATCGGG
AACGCCCGTTTTTTGGCGAGCTTGTTAGCTTTATTACTTCCGGACCTGTGTTTGCGATGGTTTGGGAAGGAGAAGGAGTT
ATTAAAGCAGCTAGACAACTCATTGGCGCCACCAATCCTAGCGAGGCTGCTCCAGGGACGATACGCGGCGACTTAGCAGT
CAACGTTGGCATGAATGTCGTACACGGATCTGATTCCCCAGAATCAGCTGAGCGTGAAATCGCTATTTTCTTTAAAGAAG
AAGAGCTAAACGATTATCAAAAAGACAGCAATAAATGGGTTTAA

Upstream 100 bases:

>100_bases
AAAAAAGCCCCTCTATTCTAAGAAATCTTATTGTTAGCGTTTTCCTAATTTGCTATACTTGAAACGTTCGGTGTAAACAT
TCATAAAGCGAGGTTAGACA

Downstream 100 bases:

>100_bases
AACAAAGCCAGTTGGGTTCTGCTCAACTGGCTTTTTTATGTAAAACGAACGCGTTTTAAAAAGAAGTCTGCTTGACTGTG
TCGAGCTACCGTTAAACATG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 147; Mature: 147

Protein sequence:

>147_residues
MERTYVMVKPDGVQRNLIGNIVSRFEQKGYTLAAAKLVTLSKETAETHYSEHRERPFFGELVSFITSGPVFAMVWEGEGV
IKAARQLIGATNPSEAAPGTIRGDLAVNVGMNVVHGSDSPESAEREIAIFFKEEELNDYQKDSNKWV

Sequences:

>Translated_147_residues
MERTYVMVKPDGVQRNLIGNIVSRFEQKGYTLAAAKLVTLSKETAETHYSEHRERPFFGELVSFITSGPVFAMVWEGEGV
IKAARQLIGATNPSEAAPGTIRGDLAVNVGMNVVHGSDSPESAEREIAIFFKEEELNDYQKDSNKWV
>Mature_147_residues
MERTYVMVKPDGVQRNLIGNIVSRFEQKGYTLAAAKLVTLSKETAETHYSEHRERPFFGELVSFITSGPVFAMVWEGEGV
IKAARQLIGATNPSEAAPGTIRGDLAVNVGMNVVHGSDSPESAEREIAIFFKEEELNDYQKDSNKWV

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=146, Percent_Identity=56.8493150684932, Blast_Score=186, Evalue=6e-48,
Organism=Homo sapiens, GI66392203, Length=147, Percent_Identity=53.0612244897959, Blast_Score=180, Evalue=3e-46,
Organism=Homo sapiens, GI66392227, Length=147, Percent_Identity=53.0612244897959, Blast_Score=180, Evalue=3e-46,
Organism=Homo sapiens, GI66392205, Length=147, Percent_Identity=53.0612244897959, Blast_Score=180, Evalue=3e-46,
Organism=Homo sapiens, GI4505409, Length=147, Percent_Identity=53.0612244897959, Blast_Score=180, Evalue=3e-46,
Organism=Homo sapiens, GI66392192, Length=147, Percent_Identity=53.0612244897959, Blast_Score=180, Evalue=3e-46,
Organism=Homo sapiens, GI38045913, Length=146, Percent_Identity=51.3698630136986, Blast_Score=175, Evalue=1e-44,
Organism=Homo sapiens, GI4557797, Length=147, Percent_Identity=51.0204081632653, Blast_Score=175, Evalue=1e-44,
Organism=Homo sapiens, GI4826862, Length=138, Percent_Identity=49.2753623188406, Blast_Score=157, Evalue=4e-39,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=34.5864661654135, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=34.5864661654135, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI5031951, Length=137, Percent_Identity=34.3065693430657, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI4505413, Length=137, Percent_Identity=30.6569343065693, Blast_Score=66, Evalue=9e-12,
Organism=Escherichia coli, GI1788866, Length=136, Percent_Identity=48.5294117647059, Blast_Score=137, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17506807, Length=147, Percent_Identity=52.3809523809524, Blast_Score=175, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17507605, Length=105, Percent_Identity=41.9047619047619, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322783, Length=146, Percent_Identity=55.4794520547945, Blast_Score=184, Evalue=5e-48,
Organism=Drosophila melanogaster, GI45549037, Length=146, Percent_Identity=54.7945205479452, Blast_Score=183, Evalue=4e-47,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=33.8235294117647, Blast_Score=86, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_BACSK (Q5WGT0)

Other databases:

- EMBL:   AP006627
- RefSeq:   YP_175386.1
- ProteinModelPortal:   Q5WGT0
- SMR:   Q5WGT0
- STRING:   Q5WGT0
- EnsemblBacteria:   EBBACT00000048431
- GeneID:   3202037
- GenomeReviews:   AP006627_GR
- KEGG:   bcl:ABC1890
- NMPDR:   fig|66692.3.peg.1934
- eggNOG:   COG0105
- GeneTree:   EBGT00050000001953
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- BioCyc:   BCLA66692:ABC1890-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 16307; Mature: 16307

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTYVMVKPDGVQRNLIGNIVSRFEQKGYTLAAAKLVTLSKETAETHYSEHRERPFFGE
CCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHCHHHHHHHHHHHCCCCHHHH
LVSFITSGPVFAMVWEGEGVIKAARQLIGATNPSEAAPGTIRGDLAVNVGMNVVHGSDSP
HHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCEECCEEEECCCEEEECCCCC
ESAEREIAIFFKEEELNDYQKDSNKWV
CCCCCEEEEEEECCHHHHHHCCCCCCC
>Mature Secondary Structure
MERTYVMVKPDGVQRNLIGNIVSRFEQKGYTLAAAKLVTLSKETAETHYSEHRERPFFGE
CCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHCHHHHHHHHHHHCCCCHHHH
LVSFITSGPVFAMVWEGEGVIKAARQLIGATNPSEAAPGTIRGDLAVNVGMNVVHGSDSP
HHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCEECCEEEECCCEEEECCCCC
ESAEREIAIFFKEEELNDYQKDSNKWV
CCCCCEEEEEEECCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA