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The map label for this gene is hepA [H]

Identifier: 56963654

GI number: 56963654

Start: 2006280

End: 2007251

Strand: Direct

Name: hepA [H]

Synonym: ABC1889

Alternate gene names: 56963654

Gene position: 2006280-2007251 (Clockwise)

Preceding gene: 56963653

Following gene: 56963655

Centisome position: 46.62

GC content: 44.44

Gene sequence:

>972_bases
ATGAAGTTAGCAGATATTTATAAAGCATTTCAAGGAGATATAGAATTTATTGAAGCGGAATTGGAACGAACCCTTTCGGC
TAAACACCCTGTTTTAAAAGAAGCATCAACGGGGTTGTTAAAAGCCGGTGGGAAACGAATCCGTCCTGTGCTCGTGCTTT
TGGCCGGGAAGTTTGGCGATTATCAATTAGACAGATTAAAGCACATTGCCGTTACGCTTGAACTCATTCATATGGGTTCC
CTTGTCCATGATGATGTCATTGATAATGCGCCGCTAAGGCGTGGGCGGGAAACAGTGATGTCTCGTTGGGATAACCGTGT
AGCGATGTATACTGGCGACTACATTTTCGGGCACGCGATTGAAACGACAAAAGCCTTCAGCGATAAACGAGTCCATACGA
TTATTTCCGACGTCATGAACCAAATATGCCGAGGCGAAATTGAACAAATCCGAGACCAGTACAATTGGGATCAAGGTTTA
CGCATTTACTTGAGGAGGATTAAACGTAAAACGGCATTGTTGATTGCCGTTAGCTGCCAGCTGGGTGCCATCGTTTCAGG
CGCGACAGATGAACTCCAAAAAAACCTTTATTACTTTGCTTATTTTCTTGGGATGTCTTATCAAATTATGGACGACATAC
TCGATTTTGTAGGCACCAATGAACAGCTAGGCAAGCCAGCCGGGGGCGATTTACGCCAAGGCAATGTCACGTTGCCTGCG
CTGTATGCGATTGAGCACACGCCTGGATTTAAACAACGGCTAGAGAAGTCATTAACGAAAGAGTCTTCTTTAGAAATGGA
CATGGAGCCGCTATTAAATGAAGTCCGCACATCAGGCGGGATTGAATATGCACAGGCAATGAGTGATCGCTATTTGCACA
AGGCAAACACGCTTTTAATGGGATTTCCCGACATTGATGCCAAAAGGCATTTAATTGAAGTGGCCAGTTACATAGGACGG
AGAAAATACTAA

Upstream 100 bases:

>100_bases
GGCTTTCTTGAACGGGAAGTGCCTACATTGAGTAAGTGGAGGCCGACCACGTCTGTTATAAAATATAAGCAGTAACAGTT
TCTGCACGAGGGTGGCGTTG

Downstream 100 bases:

>100_bases
GCCAGCGGCAAGCTGGCTTTTTTGTTTGTAAAAAAGCCCCTCTATTCTAAGAAATCTTATTGTTAGCGTTTTCCTAATTT
GCTATACTTGAAACGTTCGG

Product: heptaprenyl diphosphate synthase component II

Products: NA

Alternate protein names: HEPPP synthase subunit 2; Spore germination protein C3 [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MKLADIYKAFQGDIEFIEAELERTLSAKHPVLKEASTGLLKAGGKRIRPVLVLLAGKFGDYQLDRLKHIAVTLELIHMGS
LVHDDVIDNAPLRRGRETVMSRWDNRVAMYTGDYIFGHAIETTKAFSDKRVHTIISDVMNQICRGEIEQIRDQYNWDQGL
RIYLRRIKRKTALLIAVSCQLGAIVSGATDELQKNLYYFAYFLGMSYQIMDDILDFVGTNEQLGKPAGGDLRQGNVTLPA
LYAIEHTPGFKQRLEKSLTKESSLEMDMEPLLNEVRTSGGIEYAQAMSDRYLHKANTLLMGFPDIDAKRHLIEVASYIGR
RKY

Sequences:

>Translated_323_residues
MKLADIYKAFQGDIEFIEAELERTLSAKHPVLKEASTGLLKAGGKRIRPVLVLLAGKFGDYQLDRLKHIAVTLELIHMGS
LVHDDVIDNAPLRRGRETVMSRWDNRVAMYTGDYIFGHAIETTKAFSDKRVHTIISDVMNQICRGEIEQIRDQYNWDQGL
RIYLRRIKRKTALLIAVSCQLGAIVSGATDELQKNLYYFAYFLGMSYQIMDDILDFVGTNEQLGKPAGGDLRQGNVTLPA
LYAIEHTPGFKQRLEKSLTKESSLEMDMEPLLNEVRTSGGIEYAQAMSDRYLHKANTLLMGFPDIDAKRHLIEVASYIGR
RKY
>Mature_323_residues
MKLADIYKAFQGDIEFIEAELERTLSAKHPVLKEASTGLLKAGGKRIRPVLVLLAGKFGDYQLDRLKHIAVTLELIHMGS
LVHDDVIDNAPLRRGRETVMSRWDNRVAMYTGDYIFGHAIETTKAFSDKRVHTIISDVMNQICRGEIEQIRDQYNWDQGL
RIYLRRIKRKTALLIAVSCQLGAIVSGATDELQKNLYYFAYFLGMSYQIMDDILDFVGTNEQLGKPAGGDLRQGNVTLPA
LYAIEHTPGFKQRLEKSLTKESSLEMDMEPLLNEVRTSGGIEYAQAMSDRYLHKANTLLMGFPDIDAKRHLIEVASYIGR
RKY

Specific function: Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7) [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=323, Percent_Identity=29.4117647058824, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1789578, Length=316, Percent_Identity=30.379746835443, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1786623, Length=233, Percent_Identity=30.9012875536481, Blast_Score=76, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17505681, Length=316, Percent_Identity=28.7974683544304, Blast_Score=145, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6319475, Length=306, Percent_Identity=27.7777777777778, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6325188, Length=231, Percent_Identity=25.1082251082251, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24651612, Length=301, Percent_Identity=28.5714285714286, Blast_Score=145, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014119
- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.30 [H]

Molecular weight: Translated: 36663; Mature: 36663

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLADIYKAFQGDIEFIEAELERTLSAKHPVLKEASTGLLKAGGKRIRPVLVLLAGKFGD
CCHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
YQLDRLKHIAVTLELIHMGSLVHDDVIDNAPLRRGRETVMSRWDNRVAMYTGDYIFGHAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEECCCHHHHHH
ETTKAFSDKRVHTIISDVMNQICRGEIEQIRDQYNWDQGLRIYLRRIKRKTALLIAVSCQ
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEEECH
LGAIVSGATDELQKNLYYFAYFLGMSYQIMDDILDFVGTNEQLGKPAGGDLRQGNVTLPA
HHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCE
LYAIEHTPGFKQRLEKSLTKESSLEMDMEPLLNEVRTSGGIEYAQAMSDRYLHKANTLLM
EEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCEEEE
GFPDIDAKRHLIEVASYIGRRKY
ECCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKLADIYKAFQGDIEFIEAELERTLSAKHPVLKEASTGLLKAGGKRIRPVLVLLAGKFGD
CCHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
YQLDRLKHIAVTLELIHMGSLVHDDVIDNAPLRRGRETVMSRWDNRVAMYTGDYIFGHAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEECCCHHHHHH
ETTKAFSDKRVHTIISDVMNQICRGEIEQIRDQYNWDQGLRIYLRRIKRKTALLIAVSCQ
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEEECH
LGAIVSGATDELQKNLYYFAYFLGMSYQIMDDILDFVGTNEQLGKPAGGDLRQGNVTLPA
HHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCE
LYAIEHTPGFKQRLEKSLTKESSLEMDMEPLLNEVRTSGGIEYAQAMSDRYLHKANTLLM
EEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCEEEE
GFPDIDAKRHLIEVASYIGRRKY
ECCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 2121900; 9720033 [H]