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The map label for this gene is ypdA [H]

Identifier: 56963628

GI number: 56963628

Start: 1980135

End: 1981103

Strand: Direct

Name: ypdA [H]

Synonym: ABC1863

Alternate gene names: 56963628

Gene position: 1980135-1981103 (Clockwise)

Preceding gene: 56963627

Following gene: 56963629

Centisome position: 46.01

GC content: 47.06

Gene sequence:

>969_bases
GTGGTAGATGCAGTCATTATTGGCGGCGGCCCGTGTGGCCTTGCTGCGGCAATTGCATGTCAAGAAAAGGGGTTGTCTGC
TGTTGTTGTGGAAAAAGAGAACATTGTCCACTCAATTTACCGCTATCCAACGCACCAAACCTTTTTCAGTACAAGCGAAC
GCTTAGAAATAGGCGGCGTCCCTTTCATTGTGGAGGACCGCAAACCCCGGAGGAACCAGGCGCTTGTCTATTATCGGAAT
GTAGCAAAATTAAAAAGGCTCCACATTCGTGCATTTGAAAAAGTGCTCCGTGTAGTAAAACGGGCTGATCGTTCATTTGA
AGTGACGACGACAAAAGGAACACTTGATGCGAAGCATGTGATTGTGGCCACAGGCTATTATGATTCTCCCAATATGATGG
GAATACCAGGTGAAGATAAAAGCCATGTGATGCACTATTTTAAAGAAGCCCATCCTTATTTTGACCATGATGTGGTTGTG
ATAGGCGGCAAAAATTCGGCTGTTGATGCGGCGCTTGAGTTAGAAAAAGCGGGTGCCCGCGTCACTATGCTTTATCGGGG
CAGCGATTATTCGGCAAGCGTAAAGCCGTGGATTTTGCCAGAGCTTGTGTCCCTTGTGCGCAATGAAAAGATCAAATTGG
CCTTTCATGCCGATGTGCATGAGATTACGGACAGCCACGTACACTACCGGATAGGGAAACAAGAGCACAAAGCTAAAGCG
CAGTTTGTGTTTGCGATGACGGGCTATCACCCTGATCACTCCTTTATTCGCAGTCTTGGTGTACATGTCGATGAAGCAAC
AGGACGGCCTGTATATGACGAGCAAACGATGGAAACAAATGTGGAAGGCATTTTTATCGCCGGCGTCATTGCTGCTGGAA
ACAATGCTAATGAAATTTTTATTGAAAATGGTCGTCTCCACGGCCCTTTGATTGCACAAGCAATTGCGCGCAGGATCGAA
ATGGAGTGA

Upstream 100 bases:

>100_bases
GATGGGTTTGATCTGCTATACTATGATGAGAAAATAAGTGCCCTTGTCCAAAGTTGCCTTTGAGGACAAGGGTTTTGAAT
GTTTTGATGAGGTGAGGAAT

Downstream 100 bases:

>100_bases
TGAATATGCGCCATGTGATGTTGCTGACAACTGGAGGCACGATTGCAAGCACTACAAGCGAAAGCGGCAAATTGGTTGCT
GGTGAACTTTCTGGAGAAGA

Product: thioredoxin reductase

Products: an alcohol; H2O; NAD [C]

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MVDAVIIGGGPCGLAAAIACQEKGLSAVVVEKENIVHSIYRYPTHQTFFSTSERLEIGGVPFIVEDRKPRRNQALVYYRN
VAKLKRLHIRAFEKVLRVVKRADRSFEVTTTKGTLDAKHVIVATGYYDSPNMMGIPGEDKSHVMHYFKEAHPYFDHDVVV
IGGKNSAVDAALELEKAGARVTMLYRGSDYSASVKPWILPELVSLVRNEKIKLAFHADVHEITDSHVHYRIGKQEHKAKA
QFVFAMTGYHPDHSFIRSLGVHVDEATGRPVYDEQTMETNVEGIFIAGVIAAGNNANEIFIENGRLHGPLIAQAIARRIE
ME

Sequences:

>Translated_322_residues
MVDAVIIGGGPCGLAAAIACQEKGLSAVVVEKENIVHSIYRYPTHQTFFSTSERLEIGGVPFIVEDRKPRRNQALVYYRN
VAKLKRLHIRAFEKVLRVVKRADRSFEVTTTKGTLDAKHVIVATGYYDSPNMMGIPGEDKSHVMHYFKEAHPYFDHDVVV
IGGKNSAVDAALELEKAGARVTMLYRGSDYSASVKPWILPELVSLVRNEKIKLAFHADVHEITDSHVHYRIGKQEHKAKA
QFVFAMTGYHPDHSFIRSLGVHVDEATGRPVYDEQTMETNVEGIFIAGVIAAGNNANEIFIENGRLHGPLIAQAIARRIE
ME
>Mature_322_residues
MVDAVIIGGGPCGLAAAIACQEKGLSAVVVEKENIVHSIYRYPTHQTFFSTSERLEIGGVPFIVEDRKPRRNQALVYYRN
VAKLKRLHIRAFEKVLRVVKRADRSFEVTTTKGTLDAKHVIVATGYYDSPNMMGIPGEDKSHVMHYFKEAHPYFDHDVVV
IGGKNSAVDAALELEKAGARVTMLYRGSDYSASVKPWILPELVSLVRNEKIKLAFHADVHEITDSHVHYRIGKQEHKAKA
QFVFAMTGYHPDHSFIRSLGVHVDEATGRPVYDEQTMETNVEGIFIAGVIAAGNNANEIFIENGRLHGPLIAQAIARRIE
ME

Specific function: Serves To Protect The Cell Against DNA Damage By Alkyl Hydroperoxides. It Can Use Either NADH Or NADPH As Electron Donor For Direct Reduction Of Redox Dyes Or Of Alkyl Hydroperoxides When Combined With The Ahpc Protein. [C]

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.6.4.- [C]

Molecular weight: Translated: 35918; Mature: 35918

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDAVIIGGGPCGLAAAIACQEKGLSAVVVEKENIVHSIYRYPTHQTFFSTSERLEIGGV
CCEEEEECCCCHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHCCCCCHHHCCCCCEEECCC
PFIVEDRKPRRNQALVYYRNVAKLKRLHIRAFEKVLRVVKRADRSFEVTTTKGTLDAKHV
CEEECCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEE
IVATGYYDSPNMMGIPGEDKSHVMHYFKEAHPYFDHDVVVIGGKNSAVDAALELEKAGAR
EEEEEEECCCCEECCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHCCCE
VTMLYRGSDYSASVKPWILPELVSLVRNEKIKLAFHADVHEITDSHVHYRIGKQEHKAKA
EEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHCCCCEEEEECCHHHCCCE
QFVFAMTGYHPDHSFIRSLGVHVDEATGRPVYDEQTMETNVEGIFIAGVIAAGNNANEIF
EEEEEEECCCCCHHHHHHHCCEEECCCCCCCCCCCHHHCCCCEEEEEEEEEECCCCCEEE
IENGRLHGPLIAQAIARRIEME
EECCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MVDAVIIGGGPCGLAAAIACQEKGLSAVVVEKENIVHSIYRYPTHQTFFSTSERLEIGGV
CCEEEEECCCCHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHCCCCCHHHCCCCCEEECCC
PFIVEDRKPRRNQALVYYRNVAKLKRLHIRAFEKVLRVVKRADRSFEVTTTKGTLDAKHV
CEEECCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEE
IVATGYYDSPNMMGIPGEDKSHVMHYFKEAHPYFDHDVVVIGGKNSAVDAALELEKAGAR
EEEEEEECCCCEECCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHCCCE
VTMLYRGSDYSASVKPWILPELVSLVRNEKIKLAFHADVHEITDSHVHYRIGKQEHKAKA
EEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHCCCCEEEEECCHHHCCCE
QFVFAMTGYHPDHSFIRSLGVHVDEATGRPVYDEQTMETNVEGIFIAGVIAAGNNANEIF
EEEEEEECCCCCHHHHHHHCCEEECCCCCCCCCCCHHHCCCCEEEEEEEEEECCCCCEEE
IENGRLHGPLIAQAIARRIEME
EECCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ROOH; Proton; NADH [C]

Specific reaction: ROOH + Proton + NADH = an alcohol + H2O + NAD [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377 [H]