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The map label for this gene is recS [H]

Identifier: 56963611

GI number: 56963611

Start: 1963562

End: 1965064

Strand: Direct

Name: recS [H]

Synonym: ABC1846

Alternate gene names: 56963611

Gene position: 1963562-1965064 (Clockwise)

Preceding gene: 56963610

Following gene: 56963612

Centisome position: 45.62

GC content: 47.5

Gene sequence:

>1503_bases
ATGTTAGAACGCCATTTGCAGGCTTTGTTTGGTTTTACTTCATTTAGGCAAGGGCAAAAAGAAATCATTGAAGCGCTCAT
AAATGGGGCAGACGTGTTGGCTATGCTCCCGACAGGACGGGGCAAGTCCCTTTGTTACCAGCTGCCTGCTTTTCTTGCCA
ACGGGGTTACGATTGTCGTTTCACCGCTGCTCGCATTGATGGAAGACCAAGTCCAGCAGTTGAAATCAATCGGGCTGAAA
CAAACGGCCGCTCTCAACAGCTTTACGGAAAAGGCAGAACGGAGACGTTTGCTCCGCAATCTTGCAAGAGTGAAACTGTT
GTACACGTCGCCAGAAATGTTGCAATCACGAGAACTGCTCGCTGCTTTGGCAAAGGTCAAAGTCGCTTATATTGTCGTCG
ATGAAGCCCATTGCGTGTCTTATTGGGGGCATGACTTTCGCGCTGATTATTTGCGGATCTGCGACATTAAACAGGCGCTC
GGTTCACCGCCTTGTTTAGCGATTACAGCCACAGCAACGAAAGAAGTCCGCGCTGATATTAAAAAGCAGCTTGATTTACG
GACACCGTTTGAACATATTGAGAGTGTCAACCGCTCCAATATTGTGCTACTAGCTGAGGAGGCTGCTGACCAAGCACAAA
AACAGCAGCGCCTTGTGGAAATGGTCGCTACTTATCAAGCACCAGGAATTATTTATGTTCAGAGCAGAGCCCAGGCAGAA
GCATGCAGCGCTTATCTTGCTCAGGAAGTGAAGCATGTTCGGACGAGCTTTTATCATGGCGGCATGGAAAACGCTGACCG
CTTGCTTGTCCAACAACAATTTATGAATGGCCAACTGGATGTGATTTGTGCGACGAACGCATTTGGGATGGGGCTTAACA
AAACAGATGTGCGTTATGTCATCCATTTGCATTACCCACTTGACATCGCCTCCTACATCCAAGAAATTGGTCGCGCTGGG
CGCGATGGGGCTTTAAGCTTTGCTTTGCTTCTAACTGCTCGAGAAGATCGTGTACAAGCGAAAAATTTACTTAAAAAAAA
CGATTTTACTGCCGATGAATGGGTATGGGCACTTTCACAGTTAAAAGTAGGAGAGCCGCTTGATTTTCCATCATTTGAGA
ACCGGCTTTTAGCCATGCAATCCGATCAAGCACGGACGGTTGGCTATTTGTTAGAAAAATGGGGTGTAATCAAGGGAGGG
CTTGTCCAATCCTTTTCAATGGCAAAACTAACAAGTTTGCTCCACCGCCATTTTAAAGAGCAAATCGCCGCCAAACAGAA
CCGGCTGTTACCGGTGTTTCACTATGGTCGTGATGACCAAACTTGCCGGCGCCAACAACTACTTTCTTATTTCGACGAGG
TTCCAGCCCCCCATAATCCGTGCTGTGATGTGTGTGGCCTTACCCTTGACTCGTTTAAACGGACGCCTGTTAACGTAAAT
GAAGCGCCGTTTTTGTGGGAAGAAGAGCTTAAAGCCGTTTTTGCAGTGGCGGAGGGAAAATGA

Upstream 100 bases:

>100_bases
AACTCCGTACATTAAAGTTAAAAACGATTCGAACAGCGCTTAACAATGAAGTCACGTATTTTGACATTCGGCTTACGCTG
GCGAGGAAAGGATTCATACA

Downstream 100 bases:

>100_bases
TGAAAGCAAACCGCCGCGCCACCACTCAGCTGGATAAAAAAGATTTCTACATCAGCCTATACGGTTCGCAATTGCTGCTT
TTGGTCATTGGCATCGCGTT

Product: ATP-dependent DNA helicase RecS

Products: NA

Alternate protein names: Recombination protein S [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MLERHLQALFGFTSFRQGQKEIIEALINGADVLAMLPTGRGKSLCYQLPAFLANGVTIVVSPLLALMEDQVQQLKSIGLK
QTAALNSFTEKAERRRLLRNLARVKLLYTSPEMLQSRELLAALAKVKVAYIVVDEAHCVSYWGHDFRADYLRICDIKQAL
GSPPCLAITATATKEVRADIKKQLDLRTPFEHIESVNRSNIVLLAEEAADQAQKQQRLVEMVATYQAPGIIYVQSRAQAE
ACSAYLAQEVKHVRTSFYHGGMENADRLLVQQQFMNGQLDVICATNAFGMGLNKTDVRYVIHLHYPLDIASYIQEIGRAG
RDGALSFALLLTAREDRVQAKNLLKKNDFTADEWVWALSQLKVGEPLDFPSFENRLLAMQSDQARTVGYLLEKWGVIKGG
LVQSFSMAKLTSLLHRHFKEQIAAKQNRLLPVFHYGRDDQTCRRQQLLSYFDEVPAPHNPCCDVCGLTLDSFKRTPVNVN
EAPFLWEEELKAVFAVAEGK

Sequences:

>Translated_500_residues
MLERHLQALFGFTSFRQGQKEIIEALINGADVLAMLPTGRGKSLCYQLPAFLANGVTIVVSPLLALMEDQVQQLKSIGLK
QTAALNSFTEKAERRRLLRNLARVKLLYTSPEMLQSRELLAALAKVKVAYIVVDEAHCVSYWGHDFRADYLRICDIKQAL
GSPPCLAITATATKEVRADIKKQLDLRTPFEHIESVNRSNIVLLAEEAADQAQKQQRLVEMVATYQAPGIIYVQSRAQAE
ACSAYLAQEVKHVRTSFYHGGMENADRLLVQQQFMNGQLDVICATNAFGMGLNKTDVRYVIHLHYPLDIASYIQEIGRAG
RDGALSFALLLTAREDRVQAKNLLKKNDFTADEWVWALSQLKVGEPLDFPSFENRLLAMQSDQARTVGYLLEKWGVIKGG
LVQSFSMAKLTSLLHRHFKEQIAAKQNRLLPVFHYGRDDQTCRRQQLLSYFDEVPAPHNPCCDVCGLTLDSFKRTPVNVN
EAPFLWEEELKAVFAVAEGK
>Mature_500_residues
MLERHLQALFGFTSFRQGQKEIIEALINGADVLAMLPTGRGKSLCYQLPAFLANGVTIVVSPLLALMEDQVQQLKSIGLK
QTAALNSFTEKAERRRLLRNLARVKLLYTSPEMLQSRELLAALAKVKVAYIVVDEAHCVSYWGHDFRADYLRICDIKQAL
GSPPCLAITATATKEVRADIKKQLDLRTPFEHIESVNRSNIVLLAEEAADQAQKQQRLVEMVATYQAPGIIYVQSRAQAE
ACSAYLAQEVKHVRTSFYHGGMENADRLLVQQQFMNGQLDVICATNAFGMGLNKTDVRYVIHLHYPLDIASYIQEIGRAG
RDGALSFALLLTAREDRVQAKNLLKKNDFTADEWVWALSQLKVGEPLDFPSFENRLLAMQSDQARTVGYLLEKWGVIKGG
LVQSFSMAKLTSLLHRHFKEQIAAKQNRLLPVFHYGRDDQTCRRQQLLSYFDEVPAPHNPCCDVCGLTLDSFKRTPVNVN
EAPFLWEEELKAVFAVAEGK

Specific function: Probable DNA helicase. Required in synaptic and/or post- synaptic stages of recombination. Probably has overlapping function with recQ (AC O34748). It probably acts to help generate ss-DNA from ds-DNA breaks [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI51242947, Length=363, Percent_Identity=41.0468319559229, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI51242943, Length=363, Percent_Identity=41.0468319559229, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI148612816, Length=361, Percent_Identity=40.1662049861496, Blast_Score=242, Evalue=5e-64,
Organism=Homo sapiens, GI4557365, Length=347, Percent_Identity=39.7694524495677, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI110735439, Length=348, Percent_Identity=35.632183908046, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI169218196, Length=348, Percent_Identity=35.632183908046, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI14591902, Length=329, Percent_Identity=35.5623100303951, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI14591904, Length=329, Percent_Identity=35.5623100303951, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI284005309, Length=350, Percent_Identity=37.1428571428571, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI222352149, Length=360, Percent_Identity=23.0555555555556, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI4758138, Length=345, Percent_Identity=24.9275362318841, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI148613856, Length=341, Percent_Identity=24.9266862170088, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI38201710, Length=341, Percent_Identity=24.9266862170088, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI188035877, Length=330, Percent_Identity=23.6363636363636, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI48994977, Length=328, Percent_Identity=42.6829268292683, Blast_Score=259, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI32564293, Length=339, Percent_Identity=37.4631268436578, Blast_Score=235, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI25145561, Length=358, Percent_Identity=36.3128491620112, Blast_Score=234, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI71987997, Length=337, Percent_Identity=38.2789317507418, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI71987993, Length=337, Percent_Identity=38.2789317507418, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17552866, Length=338, Percent_Identity=37.8698224852071, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI115533224, Length=340, Percent_Identity=25.8823529411765, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17537549, Length=372, Percent_Identity=22.8494623655914, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323844, Length=359, Percent_Identity=38.7186629526462, Blast_Score=241, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6324217, Length=329, Percent_Identity=23.4042553191489, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321360, Length=343, Percent_Identity=24.4897959183673, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24646066, Length=346, Percent_Identity=39.5953757225434, Blast_Score=238, Evalue=6e-63,
Organism=Drosophila melanogaster, GI62472181, Length=369, Percent_Identity=37.3983739837398, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24664230, Length=369, Percent_Identity=37.3983739837398, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24664226, Length=369, Percent_Identity=37.1273712737127, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI21358123, Length=355, Percent_Identity=35.2112676056338, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24644479, Length=342, Percent_Identity=23.0994152046784, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24644487, Length=342, Percent_Identity=23.0994152046784, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45551833, Length=342, Percent_Identity=23.0994152046784, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24644485, Length=342, Percent_Identity=23.0994152046784, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281361218, Length=342, Percent_Identity=23.0994152046784, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24644481, Length=342, Percent_Identity=23.0994152046784, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24644483, Length=342, Percent_Identity=23.0994152046784, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28574962, Length=342, Percent_Identity=23.9766081871345, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21355075, Length=361, Percent_Identity=22.7146814404432, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI18857967, Length=367, Percent_Identity=25.6130790190736, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24642151, Length=376, Percent_Identity=23.936170212766, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24584399, Length=363, Percent_Identity=22.038567493113, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR002464
- InterPro:   IPR004589
- InterPro:   IPR001650
- InterPro:   IPR014021 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 56214; Mature: 56214

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: PS00690 DEAH_ATP_HELICASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERHLQALFGFTSFRQGQKEIIEALINGADVLAMLPTGRGKSLCYQLPAFLANGVTIVV
CCHHHHHHHHHHHHHHCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCHHHHH
SPLLALMEDQVQQLKSIGLKQTAALNSFTEKAERRRLLRNLARVKLLYTSPEMLQSRELL
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHH
AALAKVKVAYIVVDEAHCVSYWGHDFRADYLRICDIKQALGSPPCLAITATATKEVRADI
HHHHHHEEEEEEEECHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHH
KKQLDLRTPFEHIESVNRSNIVLLAEEAADQAQKQQRLVEMVATYQAPGIIYVQSRAQAE
HHHCCCCCCHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHH
ACSAYLAQEVKHVRTSFYHGGMENADRLLVQQQFMNGQLDVICATNAFGMGLNKTDVRYV
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEE
IHLHYPLDIASYIQEIGRAGRDGALSFALLLTAREDRVQAKNLLKKNDFTADEWVWALSQ
EEEECCCCHHHHHHHHHCCCCCCHHEEHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHH
LKVGEPLDFPSFENRLLAMQSDQARTVGYLLEKWGVIKGGLVQSFSMAKLTSLLHRHFKE
HCCCCCCCCCCHHCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
QIAAKQNRLLPVFHYGRDDQTCRRQQLLSYFDEVPAPHNPCCDVCGLTLDSFKRTPVNVN
HHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHCCCCCCCCC
EAPFLWEEELKAVFAVAEGK
CCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLERHLQALFGFTSFRQGQKEIIEALINGADVLAMLPTGRGKSLCYQLPAFLANGVTIVV
CCHHHHHHHHHHHHHHCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCHHHHH
SPLLALMEDQVQQLKSIGLKQTAALNSFTEKAERRRLLRNLARVKLLYTSPEMLQSRELL
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHH
AALAKVKVAYIVVDEAHCVSYWGHDFRADYLRICDIKQALGSPPCLAITATATKEVRADI
HHHHHHEEEEEEEECHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHH
KKQLDLRTPFEHIESVNRSNIVLLAEEAADQAQKQQRLVEMVATYQAPGIIYVQSRAQAE
HHHCCCCCCHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHH
ACSAYLAQEVKHVRTSFYHGGMENADRLLVQQQFMNGQLDVICATNAFGMGLNKTDVRYV
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEE
IHLHYPLDIASYIQEIGRAGRDGALSFALLLTAREDRVQAKNLLKKNDFTADEWVWALSQ
EEEECCCCHHHHHHHHHCCCCCCHHEEHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHH
LKVGEPLDFPSFENRLLAMQSDQARTVGYLLEKWGVIKGGLVQSFSMAKLTSLLHRHFKE
HCCCCCCCCCCHHCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
QIAAKQNRLLPVFHYGRDDQTCRRQQLLSYFDEVPAPHNPCCDVCGLTLDSFKRTPVNVN
HHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHCCCCCCCCC
EAPFLWEEELKAVFAVAEGK
CCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377; 9642195 [H]