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The map label for this gene is ribA

Identifier: 56963577

GI number: 56963577

Start: 1931302

End: 1932495

Strand: Direct

Name: ribA

Synonym: ABC1812

Alternate gene names: 56963577

Gene position: 1931302-1932495 (Clockwise)

Preceding gene: 56963576

Following gene: 56963578

Centisome position: 44.87

GC content: 49.16

Gene sequence:

>1194_bases
GTGTTTGAATCGATTGATGAAGCGATCACACAATTAAAAGCGGGGGGAATGATCCTCGTTGTAGATGATGAAGACCGGGA
GAATGAAGGGGATTTTTTGGCTCTTGCTGAAACAGCGTCCCCTGAAACAATCAATTTTATGGCAACGCACGGACGCGGTC
TCATTTGTGTGCCTTTGACGGAAGAACAGGCTGAGCGCCTGCAGCTTGGGCAGATGGTGTCTCACAGCACAGACCCACAT
GGAACGGCATTTACTGTCAGCGTCGACCATTCACATACGACAACAGGCATCTCTGCTTTTGAGCGGGCAGAAACGGTCCG
CGCTTTAGCAGATGCCAATGCGCAGCCAAGTGATTTTAAACGGCCAGGGCATGTTTTTCCGCTTGTTGCCAAAAACGGCG
GTGTGCTGCGCCGGGCTGGCCATACCGAAGCCGCTGTTGATTTTGCAAAACTTTGTGGAGCAAAACCGGCAGGCGTTATT
TGCGAAGTGATGAACGAAGACGGATCGATGGCTAGAGTGCCTGAGTTGCGCATCATTGCCGATCAGCACAACCTGCCACT
GGTGACGATTAAAGATTTGATCGCTTACCGCCGTAAAACGGAGAAAGTTGTGACGAGAGAAGTGGCTATTTCGTTGCCGA
CTGAGTATGGCGACTTTAAAGCAGTTGGCTATACGAATACCATCGACGGCAAAGAAAGTGTCGCCCTTGTTAAAGGGGAC
GTTGGAAATGGTGAGCCTGTTCTAGTCCGCGTTCATTCCGAATGTCTGACTGGTGATGTATTTGGCTCTAAACGATGCGA
TTGTGGTCCACAATTGCACGCAGCGCTAAAGCAAATTGAAGCTGAAGGACGAGGCGTACTGCTCTATATGAAGCAGGAAG
GCCGTGGGATTGGGCTAATCAATAAATTCCGCGCCTATAAGCTGCAAGAAGAAGGCTACGATACAGTGGAAGCGAATGAG
CGCCTTGGGTTTCCAGCGGATTTGCGCGAATACGGGATTGGGGCGCAAATCCTACGTGATTTAGGCATCCGTGACATGCG
GCTTTTGACGAATAACCCTCGAAAAATTGCAGGGCTAGAAGGCTATGATTTAAACATTGTTGAGCGTGTGCCACTGCAAA
TGGAAGCTGTAGCCGAAAATGAACGTTATTTGCATACGAAAAGAGAAAAACTTGGGCATATGCTCAATTTATAG

Upstream 100 bases:

>100_bases
AAATACGTTGAGAAACTTCTTGCCCCGAAAGAAAGTGCCGTTCGTACGCCTTTGTCGCAGCTTCTTAAAGAAAATAGCTA
TATGTAAAGGGGAGAACAAC

Downstream 100 bases:

>100_bases
GAGGGCTTTAAATGGGGAAAAATTATGAAGGCCATTTGGTGGCATCTGGATTAAAGGTTGGAATTGTTGTGGGTCGTTTC
AATGAATTTATTACAAGCAA

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MFESIDEAITQLKAGGMILVVDDEDRENEGDFLALAETASPETINFMATHGRGLICVPLTEEQAERLQLGQMVSHSTDPH
GTAFTVSVDHSHTTTGISAFERAETVRALADANAQPSDFKRPGHVFPLVAKNGGVLRRAGHTEAAVDFAKLCGAKPAGVI
CEVMNEDGSMARVPELRIIADQHNLPLVTIKDLIAYRRKTEKVVTREVAISLPTEYGDFKAVGYTNTIDGKESVALVKGD
VGNGEPVLVRVHSECLTGDVFGSKRCDCGPQLHAALKQIEAEGRGVLLYMKQEGRGIGLINKFRAYKLQEEGYDTVEANE
RLGFPADLREYGIGAQILRDLGIRDMRLLTNNPRKIAGLEGYDLNIVERVPLQMEAVAENERYLHTKREKLGHMLNL

Sequences:

>Translated_397_residues
MFESIDEAITQLKAGGMILVVDDEDRENEGDFLALAETASPETINFMATHGRGLICVPLTEEQAERLQLGQMVSHSTDPH
GTAFTVSVDHSHTTTGISAFERAETVRALADANAQPSDFKRPGHVFPLVAKNGGVLRRAGHTEAAVDFAKLCGAKPAGVI
CEVMNEDGSMARVPELRIIADQHNLPLVTIKDLIAYRRKTEKVVTREVAISLPTEYGDFKAVGYTNTIDGKESVALVKGD
VGNGEPVLVRVHSECLTGDVFGSKRCDCGPQLHAALKQIEAEGRGVLLYMKQEGRGIGLINKFRAYKLQEEGYDTVEANE
RLGFPADLREYGIGAQILRDLGIRDMRLLTNNPRKIAGLEGYDLNIVERVPLQMEAVAENERYLHTKREKLGHMLNL
>Mature_397_residues
MFESIDEAITQLKAGGMILVVDDEDRENEGDFLALAETASPETINFMATHGRGLICVPLTEEQAERLQLGQMVSHSTDPH
GTAFTVSVDHSHTTTGISAFERAETVRALADANAQPSDFKRPGHVFPLVAKNGGVLRRAGHTEAAVDFAKLCGAKPAGVI
CEVMNEDGSMARVPELRIIADQHNLPLVTIKDLIAYRRKTEKVVTREVAISLPTEYGDFKAVGYTNTIDGKESVALVKGD
VGNGEPVLVRVHSECLTGDVFGSKRCDCGPQLHAALKQIEAEGRGVLLYMKQEGRGIGLINKFRAYKLQEEGYDTVEANE
RLGFPADLREYGIGAQILRDLGIRDMRLLTNNPRKIAGLEGYDLNIVERVPLQMEAVAENERYLHTKREKLGHMLNL

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family

Homologues:

Organism=Escherichia coli, GI1787533, Length=193, Percent_Identity=56.4766839378238, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI1789420, Length=202, Percent_Identity=49.5049504950495, Blast_Score=206, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6320695, Length=208, Percent_Identity=43.75, Blast_Score=179, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6319438, Length=170, Percent_Identity=45.8823529411765, Blast_Score=133, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIBBA_BACSK (Q5WH08)

Other databases:

- EMBL:   AP006627
- RefSeq:   YP_175308.1
- HSSP:   P0A7I7
- ProteinModelPortal:   Q5WH08
- STRING:   Q5WH08
- EnsemblBacteria:   EBBACT00000049481
- GeneID:   3201509
- GenomeReviews:   AP006627_GR
- KEGG:   bcl:ABC1812
- NMPDR:   fig|66692.3.peg.1760
- eggNOG:   COG0108
- GeneTree:   EBGT00050000001077
- HOGENOM:   HBG735778
- OMA:   RCDCRMQ
- ProtClustDB:   PRK09311
- BioCyc:   BCLA66692:ABC1812-MONOMER
- HAMAP:   MF_01283
- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299
- Gene3D:   G3DSA:3.90.870.10
- PIRSF:   PIRSF001259
- TIGRFAMs:   TIGR00505
- TIGRFAMs:   TIGR00506

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2; SSF55821 DHBP_synth_RibB-like_a/b_dom

EC number: =4.1.99.12; =3.5.4.25

Molecular weight: Translated: 43544; Mature: 43544

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: ACT_SITE 327-327 ACT_SITE 329-329 BINDING 31-31 BINDING 162-162 BINDING 271-271 BINDING 315-315 BINDING 350-350 BINDING 355-355

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFESIDEAITQLKAGGMILVVDDEDRENEGDFLALAETASPETINFMATHGRGLICVPLT
CCCCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCEEEEEEECCCEEEEEECC
EEQAERLQLGQMVSHSTDPHGTAFTVSVDHSHTTTGISAFERAETVRALADANAQPSDFK
HHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
RPGHVFPLVAKNGGVLRRAGHTEAAVDFAKLCGAKPAGVICEVMNEDGSMARVPELRIIA
CCCCEEEEEECCCCEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEECCCEEEEE
DQHNLPLVTIKDLIAYRRKTEKVVTREVAISLPTEYGDFKAVGYTNTIDGKESVALVKGD
CCCCCCEEEHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEECCCCCCCCCCCEEEEECC
VGNGEPVLVRVHSECLTGDVFGSKRCDCGPQLHAALKQIEAEGRGVLLYMKQEGRGIGLI
CCCCCEEEEEEECCHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCH
NKFRAYKLQEEGYDTVEANERLGFPADLREYGIGAQILRDLGIRDMRLLTNNPRKIAGLE
HHHHHEEECCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCEEEECCCCCCEEECCC
GYDLNIVERVPLQMEAVAENERYLHTKREKLGHMLNL
CCCCCCEECCCEEEEHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFESIDEAITQLKAGGMILVVDDEDRENEGDFLALAETASPETINFMATHGRGLICVPLT
CCCCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCEEEEEEECCCEEEEEECC
EEQAERLQLGQMVSHSTDPHGTAFTVSVDHSHTTTGISAFERAETVRALADANAQPSDFK
HHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
RPGHVFPLVAKNGGVLRRAGHTEAAVDFAKLCGAKPAGVICEVMNEDGSMARVPELRIIA
CCCCEEEEEECCCCEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEECCCEEEEE
DQHNLPLVTIKDLIAYRRKTEKVVTREVAISLPTEYGDFKAVGYTNTIDGKESVALVKGD
CCCCCCEEEHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEECCCCCCCCCCCEEEEECC
VGNGEPVLVRVHSECLTGDVFGSKRCDCGPQLHAALKQIEAEGRGVLLYMKQEGRGIGLI
CCCCCEEEEEEECCHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCH
NKFRAYKLQEEGYDTVEANERLGFPADLREYGIGAQILRDLGIRDMRLLTNNPRKIAGLE
HHHHHEEECCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCEEEECCCCCCEEECCC
GYDLNIVERVPLQMEAVAENERYLHTKREKLGHMLNL
CCCCCCEECCCEEEEHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA