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The map label for this gene is Hgd [H]

Identifier: 56963573

GI number: 56963573

Start: 1926169

End: 1927074

Strand: Direct

Name: Hgd [H]

Synonym: ABC1808

Alternate gene names: 56963573

Gene position: 1926169-1927074 (Clockwise)

Preceding gene: 56963572

Following gene: 56963574

Centisome position: 44.75

GC content: 45.25

Gene sequence:

>906_bases
GTGAAAGTCGGGTTCATCGGTTTAGGCAATATGGGCATGCCAATGTCGAAAAATTTGCTTGAGTCTGGATATGAAGTAGT
TGGTTATGACATCAATGAAACTTCGCTTTTAGCGTTTGAACAGGCTGGGGGAAAGCGGGCCCGTGATTTGGCAGACATCG
TGCTGGCAAGCGAGCTCATCTTTACAAGCCTCCCTTCTTCGGAAGCGGTTGAAAATGTGTATTTAGGAGAGAAGGGTGTA
TTCGCTTCTGCCCCTTCAAGCATTCTATTTGTCGACACGAGCACAGTCGCCCCAGAGCTTGTAATGCGGATTGGGCAAGC
GGCAGAAGAAAAAGGGTTATCGTTTTTGGCTGCTCCTGTTAGTGGCGGTGTCGTTGGAGCGGAAAACCGTACCTTGACGT
TCATGGTGGGCGGTCCAAAAAAACTGCTTGAGTCAGTATCCGATCATTTAATGACACTAGGAAGCCATGTCTTTCATATT
AGTGAAAGTTATGACAGCGGCATCAATGCAAAGTTGATTAATAATTTGTTGATTGGCTTTTATACGGCCGGTGTCGCAGA
AGCATTGGCACTTGCCAAAAAGAGCGACTTAAACTTGGATTTTTTGTTTAATGTCCTAAATGTTAGTTATGGCCAGAGCC
GCATTTATGAGCGAAACTACAAGTCGTTTATGGCAACAGGCAATTATGAACCTGGATTCGCTTTAAAGTTGCTTAATAAA
GATTTGCGTTTTGCGATGGATCTTGCAAAAGAGCGTGGCGTGAAATTGCCGATTAGTGAAGCTTTAGTTGAACTGTATGC
CGACGCTGAGCGAGCAGGACTTGGAGAAAAGGACATGGCCGTGCTGTTTGAACGGATTGGGGAACAGACAATTTCCTTTA
AAGCGGAAGGAGTGGCTAAACGATGA

Upstream 100 bases:

>100_bases
AACGAATCGATGCGAGCGTTTGTCTATAAATGTGAGAGCCTGCTTGGCAGGCTCTTGAGCTTATGCTAAAGTCGACAAAA
TCACCAGAGGGGGAGATGTC

Downstream 100 bases:

>100_bases
CAACTACGAAAGTGAAAACGGTGAAAAACTGGATTGACGGCGCTTGGGTCGAAGCATCTACGGCTGATACGGAAGTCGTA
CCAAACCCGGCGACGGGAGA

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MKVGFIGLGNMGMPMSKNLLESGYEVVGYDINETSLLAFEQAGGKRARDLADIVLASELIFTSLPSSEAVENVYLGEKGV
FASAPSSILFVDTSTVAPELVMRIGQAAEEKGLSFLAAPVSGGVVGAENRTLTFMVGGPKKLLESVSDHLMTLGSHVFHI
SESYDSGINAKLINNLLIGFYTAGVAEALALAKKSDLNLDFLFNVLNVSYGQSRIYERNYKSFMATGNYEPGFALKLLNK
DLRFAMDLAKERGVKLPISEALVELYADAERAGLGEKDMAVLFERIGEQTISFKAEGVAKR

Sequences:

>Translated_301_residues
MKVGFIGLGNMGMPMSKNLLESGYEVVGYDINETSLLAFEQAGGKRARDLADIVLASELIFTSLPSSEAVENVYLGEKGV
FASAPSSILFVDTSTVAPELVMRIGQAAEEKGLSFLAAPVSGGVVGAENRTLTFMVGGPKKLLESVSDHLMTLGSHVFHI
SESYDSGINAKLINNLLIGFYTAGVAEALALAKKSDLNLDFLFNVLNVSYGQSRIYERNYKSFMATGNYEPGFALKLLNK
DLRFAMDLAKERGVKLPISEALVELYADAERAGLGEKDMAVLFERIGEQTISFKAEGVAKR
>Mature_301_residues
MKVGFIGLGNMGMPMSKNLLESGYEVVGYDINETSLLAFEQAGGKRARDLADIVLASELIFTSLPSSEAVENVYLGEKGV
FASAPSSILFVDTSTVAPELVMRIGQAAEEKGLSFLAAPVSGGVVGAENRTLTFMVGGPKKLLESVSDHLMTLGSHVFHI
SESYDSGINAKLINNLLIGFYTAGVAEALALAKKSDLNLDFLFNVLNVSYGQSRIYERNYKSFMATGNYEPGFALKLLNK
DLRFAMDLAKERGVKLPISEALVELYADAERAGLGEKDMAVLFERIGEQTISFKAEGVAKR

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=295, Percent_Identity=31.864406779661, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI40556376, Length=285, Percent_Identity=29.4736842105263, Blast_Score=121, Evalue=1e-27,
Organism=Escherichia coli, GI145693186, Length=295, Percent_Identity=34.5762711864407, Blast_Score=164, Evalue=5e-42,
Organism=Escherichia coli, GI1790315, Length=284, Percent_Identity=30.2816901408451, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1786719, Length=286, Percent_Identity=31.4685314685315, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1789092, Length=279, Percent_Identity=30.1075268817204, Blast_Score=102, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17557316, Length=297, Percent_Identity=31.6498316498317, Blast_Score=131, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24655230, Length=298, Percent_Identity=31.8791946308725, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI19922568, Length=298, Percent_Identity=31.8791946308725, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI28574115, Length=283, Percent_Identity=24.7349823321555, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 32460; Mature: 32460

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGFIGLGNMGMPMSKNLLESGYEVVGYDINETSLLAFEQAGGKRARDLADIVLASELI
CEEEEEEECCCCCCCHHHHHHCCCEEEEECCCCCEEEEEHHCCCCHHHHHHHHHHHHHHH
FTSLPSSEAVENVYLGEKGVFASAPSSILFVDTSTVAPELVMRIGQAAEEKGLSFLAAPV
HHCCCCHHHHHHHHCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCEEEEECC
SGGVVGAENRTLTFMVGGPKKLLESVSDHLMTLGSHVFHISESYDSGINAKLINNLLIGF
CCCEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHEEEEHHHCCCCCHHHHHHHHHHH
YTAGVAEALALAKKSDLNLDFLFNVLNVSYGQSRIYERNYKSFMATGNYEPGFALKLLNK
HHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
DLRFAMDLAKERGVKLPISEALVELYADAERAGLGEKDMAVLFERIGEQTISFKAEGVAK
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHEEEECCCCCC
R
C
>Mature Secondary Structure
MKVGFIGLGNMGMPMSKNLLESGYEVVGYDINETSLLAFEQAGGKRARDLADIVLASELI
CEEEEEEECCCCCCCHHHHHHCCCEEEEECCCCCEEEEEHHCCCCHHHHHHHHHHHHHHH
FTSLPSSEAVENVYLGEKGVFASAPSSILFVDTSTVAPELVMRIGQAAEEKGLSFLAAPV
HHCCCCHHHHHHHHCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCEEEEECC
SGGVVGAENRTLTFMVGGPKKLLESVSDHLMTLGSHVFHISESYDSGINAKLINNLLIGF
CCCEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHEEEEHHHCCCCCHHHHHHHHHHH
YTAGVAEALALAKKSDLNLDFLFNVLNVSYGQSRIYERNYKSFMATGNYEPGFALKLLNK
HHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
DLRFAMDLAKERGVKLPISEALVELYADAERAGLGEKDMAVLFERIGEQTISFKAEGVAK
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHEEEECCCCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA