BacMap

Definition	Bacillus clausii KSM-K16, complete genome.
Accession	NC_006582
Length	4,303,871

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The map label for this gene is ppiB [H]

Identifier: 56963567

GI number: 56963567

Start: 1918646

End: 1919080

Strand: Direct

Name: ppiB [H]

Synonym: ABC1802

Alternate gene names: 56963567

Gene position: 1918646-1919080 (Clockwise)

Preceding gene: 56963566

Following gene: 56963569

Centisome position: 44.58

GC content: 47.36

Gene sequence:

>435_bases
ATGAAAAAAGGAAGCATTGAATTTGAAAACGGTGAAAAGATTGTCATCGAATTTTATGAGGACGCCGCGCCTGGTACGGT
AGAAAATTTCGAAACACTGGCCAATAAAGGGTTTTATAATGGTCTTACATTCCACCGTGTCATCCCTGGATTTGTGGCCC
AAGGGGGAGACCCGAATGGAAATGGAACAGGTGGTCCAGGCTATACGATAAAATGCGAGACAGAAGGCAACCCACATAAA
CACGTCCCAGGCGCGCTTTCAATGGCACACGCCGGCCGAGACACAGGTGGCAGCCAATTCTTTATCGTCCATGAGCCTCA
ACCCCATCTTGATGGTGTCCACACAGTGTTCGGGCAAGTTGTTGAAGGACTAGACAGTGTGTACCGCATTAAACAAGGCG
ATGTGATGCTAGAAGTGAAAGTTTGGGAAGAATAA

Upstream 100 bases:

>100_bases
AACGTAAAAGAAACGAGTGACGTTTGAGAATTACTGGAGATTTGTGTACAATGGAACAAGCGCTTGCCGCTACTTCATAG
TTGAGAGTGAGGGTTTTTGG

Downstream 100 bases:

>100_bases
GTGTACAGCAGAAAGCCCTGTCGTGATGACAGGGCTTTACTTCACGCCACGACCGTTCTATTTCTAATTAGACGTTGTTT
TAAGAGGAGATGGCGGCAGC

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MKKGSIEFENGEKIVIEFYEDAAPGTVENFETLANKGFYNGLTFHRVIPGFVAQGGDPNGNGTGGPGYTIKCETEGNPHK
HVPGALSMAHAGRDTGGSQFFIVHEPQPHLDGVHTVFGQVVEGLDSVYRIKQGDVMLEVKVWEE

Sequences:

>Translated_144_residues
MKKGSIEFENGEKIVIEFYEDAAPGTVENFETLANKGFYNGLTFHRVIPGFVAQGGDPNGNGTGGPGYTIKCETEGNPHK
HVPGALSMAHAGRDTGGSQFFIVHEPQPHLDGVHTVFGQVVEGLDSVYRIKQGDVMLEVKVWEE
>Mature_144_residues
MKKGSIEFENGEKIVIEFYEDAAPGTVENFETLANKGFYNGLTFHRVIPGFVAQGGDPNGNGTGGPGYTIKCETEGNPHK
HVPGALSMAHAGRDTGGSQFFIVHEPQPHLDGVHTVFGQVVEGLDSVYRIKQGDVMLEVKVWEE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=120, Percent_Identity=49.1666666666667, Blast_Score=110, Evalue=4e-25,
Organism=Homo sapiens, GI4826932, Length=132, Percent_Identity=49.2424242424242, Blast_Score=103, Evalue=7e-23,
Organism=Homo sapiens, GI5031987, Length=126, Percent_Identity=50.7936507936508, Blast_Score=102, Evalue=8e-23,
Organism=Homo sapiens, GI24308049, Length=116, Percent_Identity=48.2758620689655, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI19557636, Length=122, Percent_Identity=45.9016393442623, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI10863927, Length=126, Percent_Identity=48.4126984126984, Blast_Score=98, Evalue=2e-21,
Organism=Homo sapiens, GI45439316, Length=126, Percent_Identity=46.8253968253968, Blast_Score=98, Evalue=2e-21,
Organism=Homo sapiens, GI303305009, Length=125, Percent_Identity=47.2, Blast_Score=97, Evalue=4e-21,
Organism=Homo sapiens, GI5174637, Length=125, Percent_Identity=47.2, Blast_Score=97, Evalue=5e-21,
Organism=Homo sapiens, GI150418007, Length=125, Percent_Identity=45.6, Blast_Score=92, Evalue=1e-19,
Organism=Homo sapiens, GI310127646, Length=125, Percent_Identity=46.4, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI310114371, Length=125, Percent_Identity=46.4, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI310119221, Length=125, Percent_Identity=46.4, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI4758950, Length=130, Percent_Identity=43.8461538461538, Blast_Score=91, Evalue=3e-19,
Organism=Homo sapiens, GI42560244, Length=133, Percent_Identity=44.3609022556391, Blast_Score=91, Evalue=3e-19,
Organism=Homo sapiens, GI6631100, Length=133, Percent_Identity=41.3533834586466, Blast_Score=91, Evalue=3e-19,
Organism=Homo sapiens, GI256017253, Length=122, Percent_Identity=46.7213114754098, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI221139811, Length=122, Percent_Identity=46.7213114754098, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI256017251, Length=122, Percent_Identity=46.7213114754098, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI178057341, Length=122, Percent_Identity=46.7213114754098, Blast_Score=88, Evalue=2e-18,
Organism=Homo sapiens, GI310129267, Length=125, Percent_Identity=44.8, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI310120620, Length=125, Percent_Identity=44.8, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI209417936, Length=121, Percent_Identity=46.2809917355372, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI30102944, Length=121, Percent_Identity=46.2809917355372, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI219842199, Length=121, Percent_Identity=46.2809917355372, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI4505991, Length=127, Percent_Identity=48.0314960629921, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI310110104, Length=125, Percent_Identity=44, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI64276486, Length=120, Percent_Identity=39.1666666666667, Blast_Score=83, Evalue=8e-17,
Organism=Homo sapiens, GI5454154, Length=131, Percent_Identity=40.4580152671756, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI169164185, Length=120, Percent_Identity=45, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI169163623, Length=120, Percent_Identity=45, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI310127745, Length=120, Percent_Identity=45.8333333333333, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI310119290, Length=120, Percent_Identity=45.8333333333333, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI169163387, Length=120, Percent_Identity=45, Blast_Score=81, Evalue=2e-16,
Organism=Homo sapiens, GI310114540, Length=120, Percent_Identity=45.8333333333333, Blast_Score=81, Evalue=3e-16,
Organism=Homo sapiens, GI310132444, Length=118, Percent_Identity=44.0677966101695, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI310113152, Length=118, Percent_Identity=44.0677966101695, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI169214050, Length=120, Percent_Identity=44.1666666666667, Blast_Score=77, Evalue=4e-15,
Organism=Homo sapiens, GI239751853, Length=120, Percent_Identity=44.1666666666667, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI113428306, Length=120, Percent_Identity=44.1666666666667, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI20911035, Length=130, Percent_Identity=38.4615384615385, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI22547212, Length=128, Percent_Identity=43.75, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI7657473, Length=128, Percent_Identity=43.75, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI22547215, Length=128, Percent_Identity=43.75, Blast_Score=69, Evalue=9e-13,
Organism=Homo sapiens, GI27735045, Length=135, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1789763, Length=126, Percent_Identity=39.6825396825397, Blast_Score=73, Evalue=7e-15,
Organism=Escherichia coli, GI1786736, Length=129, Percent_Identity=37.984496124031, Blast_Score=65, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17539496, Length=126, Percent_Identity=46.8253968253968, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17506311, Length=123, Percent_Identity=49.5934959349593, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17539498, Length=126, Percent_Identity=48.4126984126984, Blast_Score=103, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17566266, Length=132, Percent_Identity=47.7272727272727, Blast_Score=99, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17552782, Length=137, Percent_Identity=43.0656934306569, Blast_Score=96, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17551284, Length=139, Percent_Identity=45.3237410071942, Blast_Score=96, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17551282, Length=139, Percent_Identity=45.3237410071942, Blast_Score=96, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17559074, Length=133, Percent_Identity=45.8646616541353, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17552780, Length=125, Percent_Identity=48, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17565860, Length=141, Percent_Identity=43.9716312056738, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17506307, Length=126, Percent_Identity=48.4126984126984, Blast_Score=93, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17532641, Length=121, Percent_Identity=41.3223140495868, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17532643, Length=130, Percent_Identity=43.8461538461538, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71980590, Length=121, Percent_Identity=41.3223140495868, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71980594, Length=121, Percent_Identity=41.3223140495868, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71997782, Length=123, Percent_Identity=40.650406504065, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17552784, Length=129, Percent_Identity=38.7596899224806, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI32563659, Length=130, Percent_Identity=34.6153846153846, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320359, Length=126, Percent_Identity=50.7936507936508, Blast_Score=102, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6323562, Length=126, Percent_Identity=47.6190476190476, Blast_Score=96, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323246, Length=126, Percent_Identity=48.4126984126984, Blast_Score=94, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320510, Length=128, Percent_Identity=46.09375, Blast_Score=92, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6321848, Length=144, Percent_Identity=46.5277777777778, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17986117, Length=129, Percent_Identity=45.7364341085271, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24650807, Length=133, Percent_Identity=45.8646616541353, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI45549139, Length=126, Percent_Identity=51.5873015873016, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI19922376, Length=123, Percent_Identity=43.0894308943089, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24664125, Length=126, Percent_Identity=49.2063492063492, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21357783, Length=126, Percent_Identity=49.2063492063492, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI20130249, Length=124, Percent_Identity=45.9677419354839, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17647301, Length=126, Percent_Identity=44.4444444444444, Blast_Score=90, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21357249, Length=120, Percent_Identity=38.3333333333333, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24652460, Length=122, Percent_Identity=36.0655737704918, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI19922912, Length=120, Percent_Identity=47.5, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17136360, Length=129, Percent_Identity=40.3100775193798, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24586038, Length=132, Percent_Identity=39.3939393939394, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21355677, Length=136, Percent_Identity=34.5588235294118, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 15616; Mature: 15616

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKGSIEFENGEKIVIEFYEDAAPGTVENFETLANKGFYNGLTFHRVIPGFVAQGGDPNG
CCCCCEEECCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCEEHHHHHHHHHHCCCCCCC
NGTGGPGYTIKCETEGNPHKHVPGALSMAHAGRDTGGSQFFIVHEPQPHLDGVHTVFGQV
CCCCCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHH
VEGLDSVYRIKQGDVMLEVKVWEE
HHHHHHHHEECCCCEEEEEEEECC
>Mature Secondary Structure
MKKGSIEFENGEKIVIEFYEDAAPGTVENFETLANKGFYNGLTFHRVIPGFVAQGGDPNG
CCCCCEEECCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCEEHHHHHHHHHHCCCCCCC
NGTGGPGYTIKCETEGNPHKHVPGALSMAHAGRDTGGSQFFIVHEPQPHLDGVHTVFGQV
CCCCCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHH
VEGLDSVYRIKQGDVMLEVKVWEE
HHHHHHHHEECCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7934829; 8022278; 9384377; 8755892 [H]