Click here to switch to the map view.

The map label for this gene is lysA [H]

Identifier: 56963566

GI number: 56963566

Start: 1917241

End: 1918572

Strand: Direct

Name: lysA [H]

Synonym: ABC1801

Alternate gene names: 56963566

Gene position: 1917241-1918572 (Clockwise)

Preceding gene: 56963565

Following gene: 56963567

Centisome position: 44.55

GC content: 47.07

Gene sequence:

>1332_bases
ATGTATTTACACGGGACAATGACGATTAACGAAGCTGGCCATTTGGAAATTGGCGGCGTCGATACAGTGGATTTAGCAAA
AAAATACGATACGCCCTTGTTTGTTTATGACACAGCCCTCATAAAAGAACGAGCCCGCGCTTTTAAACAAGCATTTGAGG
CAGAAGGGGTTTCCTATCAAGTGGCCTATGCGAGCAAGGCTTTTAGCTGCATTGCCATGTACCAACTAGCCGCCTCGCTT
GACTTAAGCATTGACGTTGTTTCAGGTGGCGAGCTGTATACTGCCCTAAAAGCAGGCGTCGAGCCAGGAAAGATCCATTT
CCACGGCAACAACAAAAGCCATGGAGAATTAGAAATGGCCATTAAAGCAGGAATCGGCTGTATCGTCGCGGACAATTTTT
ACGAGCTAGAATTGCTTGAGGAACTCGCCGCAAACATGGAGCAAACAGTTTCAGTTTTGCTCCGTTTAACTCCAGGGGTT
GAAGCCCATACCCATGAATTTATCGCAACAGGGCAAGAAGACTCAAAGTTCGGATTTGACATTGCTAGCGGACAGGCGGA
CAAGGCCGCGCAGATTGCTGAACGCAGCAAATTCATTGATTTGCTTGGCGTCCATAGCCATATCGGTTCGCAAATTTTTG
AAACAGAAGGTTTTGTGCTTGCAATTGAAAAAGTCTTTAACCAGCTTCAAGCTTGGCAAGAAGAATTCGATTTTGTCCCG
CGTGTGCTCAATTTCGGAGGTGGCTTCGGCATTCGTTACGTAGAGGGAGACAAGCCGCTAGAGCCTGAAACGTACATTCG
AGAAATTGTAAAGGAAACAAAAAAACATGCTGACCGTTTAGGGTTAGCGATCCCAGAAATTTGGATTGAGCCTGGGCGTT
CCCTTGTCGGAGATGCAGCTACAACGCTGTATACAATTGGGTCAACGAAAGATATTCCCAATGTCCGGCGCTATCTATCT
GTAGATGGGGGAATGAGCGATAACTTGCGCCCAGCTTTGTACGATGCGAAATACGAAGGGTTGCTTGCCAACCGCGCCCA
TGACAAAGCAGAAGAAACATTTTCTGTAGCCGGAAAATGTTGTGAAAGCGGCGATATGCTTGTTTGGGATATGCCTCTGC
CAGAGGTGCAGCATGGCGACGTCCTGGCGATGTTCTGTACTGGTGCGTATGGATACTCAATGGCAAATAATTACAACCGT
ATTCCGCGCCCGGCTGTAGTGTTTGCAGAAGACGGGGCAGATCAACTAGTGATTCAACGGGAGAGTTATGAGGATTTAAC
CAAGCTCGATCTTGCTTATCAAGCGAACGTAAAAGAAACGAGTGACGTTTGA

Upstream 100 bases:

>100_bases
ACGAACATGGATTTGATACACTAATGGAAAAACGCGAAAAAGCAGCTTAGCCTTTTTGGCCGAAGTTGCTTTTTTTAAAG
GGATACAAGGGAGTGGAGCC

Downstream 100 bases:

>100_bases
GAATTACTGGAGATTTGTGTACAATGGAACAAGCGCTTGCCGCTACTTCATAGTTGAGAGTGAGGGTTTTTGGATGAAAA
AAGGAAGCATTGAATTTGAA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MYLHGTMTINEAGHLEIGGVDTVDLAKKYDTPLFVYDTALIKERARAFKQAFEAEGVSYQVAYASKAFSCIAMYQLAASL
DLSIDVVSGGELYTALKAGVEPGKIHFHGNNKSHGELEMAIKAGIGCIVADNFYELELLEELAANMEQTVSVLLRLTPGV
EAHTHEFIATGQEDSKFGFDIASGQADKAAQIAERSKFIDLLGVHSHIGSQIFETEGFVLAIEKVFNQLQAWQEEFDFVP
RVLNFGGGFGIRYVEGDKPLEPETYIREIVKETKKHADRLGLAIPEIWIEPGRSLVGDAATTLYTIGSTKDIPNVRRYLS
VDGGMSDNLRPALYDAKYEGLLANRAHDKAEETFSVAGKCCESGDMLVWDMPLPEVQHGDVLAMFCTGAYGYSMANNYNR
IPRPAVVFAEDGADQLVIQRESYEDLTKLDLAYQANVKETSDV

Sequences:

>Translated_443_residues
MYLHGTMTINEAGHLEIGGVDTVDLAKKYDTPLFVYDTALIKERARAFKQAFEAEGVSYQVAYASKAFSCIAMYQLAASL
DLSIDVVSGGELYTALKAGVEPGKIHFHGNNKSHGELEMAIKAGIGCIVADNFYELELLEELAANMEQTVSVLLRLTPGV
EAHTHEFIATGQEDSKFGFDIASGQADKAAQIAERSKFIDLLGVHSHIGSQIFETEGFVLAIEKVFNQLQAWQEEFDFVP
RVLNFGGGFGIRYVEGDKPLEPETYIREIVKETKKHADRLGLAIPEIWIEPGRSLVGDAATTLYTIGSTKDIPNVRRYLS
VDGGMSDNLRPALYDAKYEGLLANRAHDKAEETFSVAGKCCESGDMLVWDMPLPEVQHGDVLAMFCTGAYGYSMANNYNR
IPRPAVVFAEDGADQLVIQRESYEDLTKLDLAYQANVKETSDV
>Mature_443_residues
MYLHGTMTINEAGHLEIGGVDTVDLAKKYDTPLFVYDTALIKERARAFKQAFEAEGVSYQVAYASKAFSCIAMYQLAASL
DLSIDVVSGGELYTALKAGVEPGKIHFHGNNKSHGELEMAIKAGIGCIVADNFYELELLEELAANMEQTVSVLLRLTPGV
EAHTHEFIATGQEDSKFGFDIASGQADKAAQIAERSKFIDLLGVHSHIGSQIFETEGFVLAIEKVFNQLQAWQEEFDFVP
RVLNFGGGFGIRYVEGDKPLEPETYIREIVKETKKHADRLGLAIPEIWIEPGRSLVGDAATTLYTIGSTKDIPNVRRYLS
VDGGMSDNLRPALYDAKYEGLLANRAHDKAEETFSVAGKCCESGDMLVWDMPLPEVQHGDVLAMFCTGAYGYSMANNYNR
IPRPAVVFAEDGADQLVIQRESYEDLTKLDLAYQANVKETSDV

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=419, Percent_Identity=29.8329355608592, Blast_Score=134, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 48768; Mature: 48768

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLHGTMTINEAGHLEIGGVDTVDLAKKYDTPLFVYDTALIKERARAFKQAFEAEGVSYQ
CEEEEEEEECCCCCEEECCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHCCCCEEE
VAYASKAFSCIAMYQLAASLDLSIDVVSGGELYTALKAGVEPGKIHFHGNNKSHGELEMA
EEEHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHCCCCCCEEEECCCCCCCCCEEEE
IKAGIGCIVADNFYELELLEELAANMEQTVSVLLRLTPGVEAHTHEFIATGQEDSKFGFD
EHHCCCEEEECCCHHHHHHHHHHHCHHHHHHHHHHCCCCCCHHCHHHEECCCCCCCCCCE
IASGQADKAAQIAERSKFIDLLGVHSHIGSQIFETEGFVLAIEKVFNQLQAWQEEFDFVP
ECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEEHHHHHHHHHHHHHHHHHHH
RVLNFGGGFGIRYVEGDKPLEPETYIREIVKETKKHADRLGLAIPEIWIEPGRSLVGDAA
HHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHCCCH
TTLYTIGSTKDIPNVRRYLSVDGGMSDNLRPALYDAKYEGLLANRAHDKAEETFSVAGKC
HEEEECCCCCCCCHHHHHEEECCCCCCCCCCHHCCCCCCCHHHHCCHHHHHHHHHHHHHH
CESGDMLVWDMPLPEVQHGDVLAMFCTGAYGYSMANNYNRIPRPAVVFAEDGADQLVIQR
CCCCCEEEEECCCCCCCCCCEEEEEECCCCCHHHCCCCCCCCCCEEEEECCCCCEEEEEC
ESYEDLTKLDLAYQANVKETSDV
CCHHHHHHHHHHEECCCCCCCCC
>Mature Secondary Structure
MYLHGTMTINEAGHLEIGGVDTVDLAKKYDTPLFVYDTALIKERARAFKQAFEAEGVSYQ
CEEEEEEEECCCCCEEECCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHCCCCEEE
VAYASKAFSCIAMYQLAASLDLSIDVVSGGELYTALKAGVEPGKIHFHGNNKSHGELEMA
EEEHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHCCCCCCEEEECCCCCCCCCEEEE
IKAGIGCIVADNFYELELLEELAANMEQTVSVLLRLTPGVEAHTHEFIATGQEDSKFGFD
EHHCCCEEEECCCHHHHHHHHHHHCHHHHHHHHHHCCCCCCHHCHHHEECCCCCCCCCCE
IASGQADKAAQIAERSKFIDLLGVHSHIGSQIFETEGFVLAIEKVFNQLQAWQEEFDFVP
ECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEEHHHHHHHHHHHHHHHHHHH
RVLNFGGGFGIRYVEGDKPLEPETYIREIVKETKKHADRLGLAIPEIWIEPGRSLVGDAA
HHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHCCCH
TTLYTIGSTKDIPNVRRYLSVDGGMSDNLRPALYDAKYEGLLANRAHDKAEETFSVAGKC
HEEEECCCCCCCCHHHHHEEECCCCCCCCCCHHCCCCCCCHHHHCCHHHHHHHHHHHHHH
CESGDMLVWDMPLPEVQHGDVLAMFCTGAYGYSMANNYNRIPRPAVVFAEDGADQLVIQR
CCCCCEEEEECCCCCCCCCCEEEEEECCCCCHHHCCCCCCCCCCEEEEECCCCCEEEEEC
ESYEDLTKLDLAYQANVKETSDV
CCHHHHHHHHHHEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]