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The map label for this gene is pdp [H]

Identifier: 56963549

GI number: 56963549

Start: 1903331

End: 1904638

Strand: Direct

Name: pdp [H]

Synonym: ABC1784

Alternate gene names: 56963549

Gene position: 1903331-1904638 (Clockwise)

Preceding gene: 56963548

Following gene: 56963550

Centisome position: 44.22

GC content: 47.78

Gene sequence:

>1308_bases
ATGAGAATGGTCGATCTAATCGATAAAAAGCGTGATGGCGAAGCTCTCACAAAAGAAGAAATCCGCTGGGTCATTGATGG
GTATACAAACGGCACCATTCCTGATTACCAAATGGCAGCGCTATCAATGGCGATTTACTTTAAGGACATGAACAAAGAAG
AACGGGCAGAGCTGACGCTGGCAATGGCGGAATCAGGGGATATGATTGATTTGAGCGCGATCAAAGGAGTAAAAGTTGAT
AAGCATTCTACAGGAGGTGTAGGCGATAAAACGACGATCGCGCTTGCTCCACTCGTTGCTTCTGTTGGCGTTCCAGTTGC
GAAAATGTCAGGAAGGGGGCTCGGCCATACTGGCGGTACGATTGATAAGCTCGAAGCCATTCCCGGTTTTTCTGTTGAAA
TGGATACAGATACGTTTCTGAAGCAGGTGAATGAACAACGTCTTGCCCTCGCAGGCCAAACGGGCAATTTAACGCCTGCC
GACAAAAAGCTTTATAGCTTACGCGATGTCACTGGCACAGTCAACTCAACCCCGTTAATCGCAAGCTCGATTATGAGTAA
AAAAATTGCTTCAGGTGCTGATGCGATTGTACTAGACGTGAAATGCGGATCGGGCGCTTTTATGAAGACGTTGGACCATG
CCGTTGAGCTTGCCGAAGCCATGGTGGAAATTGGTTCGAGCGTTGGCCGTGAGACGATGGCAGTCATTTCCGACATGAGC
CAACCTTTAGGAAGGGCAGTCGGCAATGCGCTAGAAGTGAAAGAAGCTTTTGCTGTTTTGAAAGGCGAAGGCCCAGCTGA
TGTCCGGGAGCTTTGTCTTGTATTAGGCAGCCATATGGTTTATTTGGCTAAACGAGCAGAGTCTGTTCAAGCGGCGCGGC
AACTTCTTGAAGAGGCGATTCAAAACGGTGACGCGTTGGAGAAGCTGAAAGCATTTATCGCTTCACAAGGCGGTGACCCA
TCGGTCGTAGAAAATCCAGCACAAATGCCTCAAGCATCCGAGCAAATCGCTGTCTCAGCTCAAAAAGCAGGCTATATTAA
AGAAATTGCAGCCGATAAAATTGGCACAGCCGCCATGCAGCTTGGCGCAGGAAGGGCAACCAAAGAAGACCAAATTGATT
TAGCTGTCGGCCTTGTGCTTGAAAAGAAAACAGGCGATTACGTAGAGGAAGGGGAAACGCTTGCAACCCTTTTTGCCAAC
GAACAAGGGATAGAGGAAGCAAGAAAGCTTGTAGAACAGGCTTATCACATTGTCGATGAGAAGGTGGAACAACCAACGCT
TATTTATAAAGAAATCTACGGCCAATAG

Upstream 100 bases:

>100_bases
TTCAGTTAAAAAAGTCGGATCTTAAGCAGGGCAGGCTAGCAAAAAATTATGGCAAGGAAACAGCAGCTGCTTTTCTTTGC
CGTTGGAGGGAGAATGAGCG

Downstream 100 bases:

>100_bases
TTCGCTAAAATGTTCCTCATTTTGTCATGAAGCATACCCGCAGCGAATAGATTAACTAACACCTAAAGAGGCGCCTTTCA
CTGCTATAAATAATGAGGTT

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MRMVDLIDKKRDGEALTKEEIRWVIDGYTNGTIPDYQMAALSMAIYFKDMNKEERAELTLAMAESGDMIDLSAIKGVKVD
KHSTGGVGDKTTIALAPLVASVGVPVAKMSGRGLGHTGGTIDKLEAIPGFSVEMDTDTFLKQVNEQRLALAGQTGNLTPA
DKKLYSLRDVTGTVNSTPLIASSIMSKKIASGADAIVLDVKCGSGAFMKTLDHAVELAEAMVEIGSSVGRETMAVISDMS
QPLGRAVGNALEVKEAFAVLKGEGPADVRELCLVLGSHMVYLAKRAESVQAARQLLEEAIQNGDALEKLKAFIASQGGDP
SVVENPAQMPQASEQIAVSAQKAGYIKEIAADKIGTAAMQLGAGRATKEDQIDLAVGLVLEKKTGDYVEEGETLATLFAN
EQGIEEARKLVEQAYHIVDEKVEQPTLIYKEIYGQ

Sequences:

>Translated_435_residues
MRMVDLIDKKRDGEALTKEEIRWVIDGYTNGTIPDYQMAALSMAIYFKDMNKEERAELTLAMAESGDMIDLSAIKGVKVD
KHSTGGVGDKTTIALAPLVASVGVPVAKMSGRGLGHTGGTIDKLEAIPGFSVEMDTDTFLKQVNEQRLALAGQTGNLTPA
DKKLYSLRDVTGTVNSTPLIASSIMSKKIASGADAIVLDVKCGSGAFMKTLDHAVELAEAMVEIGSSVGRETMAVISDMS
QPLGRAVGNALEVKEAFAVLKGEGPADVRELCLVLGSHMVYLAKRAESVQAARQLLEEAIQNGDALEKLKAFIASQGGDP
SVVENPAQMPQASEQIAVSAQKAGYIKEIAADKIGTAAMQLGAGRATKEDQIDLAVGLVLEKKTGDYVEEGETLATLFAN
EQGIEEARKLVEQAYHIVDEKVEQPTLIYKEIYGQ
>Mature_435_residues
MRMVDLIDKKRDGEALTKEEIRWVIDGYTNGTIPDYQMAALSMAIYFKDMNKEERAELTLAMAESGDMIDLSAIKGVKVD
KHSTGGVGDKTTIALAPLVASVGVPVAKMSGRGLGHTGGTIDKLEAIPGFSVEMDTDTFLKQVNEQRLALAGQTGNLTPA
DKKLYSLRDVTGTVNSTPLIASSIMSKKIASGADAIVLDVKCGSGAFMKTLDHAVELAEAMVEIGSSVGRETMAVISDMS
QPLGRAVGNALEVKEAFAVLKGEGPADVRELCLVLGSHMVYLAKRAESVQAARQLLEEAIQNGDALEKLKAFIASQGGDP
SVVENPAQMPQASEQIAVSAQKAGYIKEIAADKIGTAAMQLGAGRATKEDQIDLAVGLVLEKKTGDYVEEGETLATLFAN
EQGIEEARKLVEQAYHIVDEKVEQPTLIYKEIYGQ

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=400, Percent_Identity=39, Blast_Score=268, Evalue=6e-72,
Organism=Homo sapiens, GI4503445, Length=400, Percent_Identity=39, Blast_Score=268, Evalue=6e-72,
Organism=Homo sapiens, GI166158922, Length=400, Percent_Identity=39, Blast_Score=268, Evalue=6e-72,
Organism=Escherichia coli, GI1790842, Length=434, Percent_Identity=42.6267281105991, Blast_Score=318, Evalue=5e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 46364; Mature: 46364

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMVDLIDKKRDGEALTKEEIRWVIDGYTNGTIPDYQMAALSMAIYFKDMNKEERAELTL
CCCHHHHHCCCCCCCCCHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHEEE
AMAESGDMIDLSAIKGVKVDKHSTGGVGDKTTIALAPLVASVGVPVAKMSGRGLGHTGGT
EEECCCCEEEHHHHCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLEAIPGFSVEMDTDTFLKQVNEQRLALAGQTGNLTPADKKLYSLRDVTGTVNSTPLI
HHHHHCCCCCEEEECHHHHHHHHCHHHHEEECCCCCCCCHHHHHHHHHHHCCCCCCCHHH
ASSIMSKKIASGADAIVLDVKCGSGAFMKTLDHAVELAEAMVEIGSSVGRETMAVISDMS
HHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
QPLGRAVGNALEVKEAFAVLKGEGPADVRELCLVLGSHMVYLAKRAESVQAARQLLEEAI
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QNGDALEKLKAFIASQGGDPSVVENPAQMPQASEQIAVSAQKAGYIKEIAADKIGTAAMQ
HCCHHHHHHHHHHHCCCCCCHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGAGRATKEDQIDLAVGLVLEKKTGDYVEEGETLATLFANEQGIEEARKLVEQAYHIVDE
HCCCCCCCCCCHHEEEEEEEECCCCCHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHH
KVEQPTLIYKEIYGQ
HCCCCHHHHHHHHCC
>Mature Secondary Structure
MRMVDLIDKKRDGEALTKEEIRWVIDGYTNGTIPDYQMAALSMAIYFKDMNKEERAELTL
CCCHHHHHCCCCCCCCCHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHEEE
AMAESGDMIDLSAIKGVKVDKHSTGGVGDKTTIALAPLVASVGVPVAKMSGRGLGHTGGT
EEECCCCEEEHHHHCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLEAIPGFSVEMDTDTFLKQVNEQRLALAGQTGNLTPADKKLYSLRDVTGTVNSTPLI
HHHHHCCCCCEEEECHHHHHHHHCHHHHEEECCCCCCCCHHHHHHHHHHHCCCCCCCHHH
ASSIMSKKIASGADAIVLDVKCGSGAFMKTLDHAVELAEAMVEIGSSVGRETMAVISDMS
HHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
QPLGRAVGNALEVKEAFAVLKGEGPADVRELCLVLGSHMVYLAKRAESVQAARQLLEEAI
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QNGDALEKLKAFIASQGGDPSVVENPAQMPQASEQIAVSAQKAGYIKEIAADKIGTAAMQ
HCCHHHHHHHHHHHCCCCCCHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGAGRATKEDQIDLAVGLVLEKKTGDYVEEGETLATLFANEQGIEEARKLVEQAYHIVDE
HCCCCCCCCCCHHEEEEEEEECCCCCHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHH
KVEQPTLIYKEIYGQ
HCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8987664; 9817849 [H]