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The map label for this gene is hrcA

Identifier: 56963422

GI number: 56963422

Start: 1786475

End: 1787503

Strand: Direct

Name: hrcA

Synonym: ABC1657

Alternate gene names: 56963422

Gene position: 1786475-1787503 (Clockwise)

Preceding gene: 56963421

Following gene: 56963423

Centisome position: 41.51

GC content: 46.36

Gene sequence:

>1029_bases
ATGTTAACGGAAAGACAACTGTTGGTGTTACATGCGATCGTTGACGACTATGTTCGCTCTGCTGAGCCGGTTGGTTCGCG
CAGCATCTCGAAACGAGAGGATATCCCATACAGTCCAGCAACGATTCGGAACGAAATGGCTGATCTCGAAGAACTGGGAT
TTTTGGAAAAACCCCATAGTTCAGCTGGCCGTGTCCCCTCTCAACAAGGGTACCGGTACTATGTCGACCATTTATTGTCG
CCGCACCGTTTGACTGTAGCTGAGCGAGCTGGCCTTTCCAGGCTGACAACAGCCAGGCTCCAGGCAATGGAAGAGGTGTT
CCAAGAATCGGCGCGGATTTTGTCAGAAATGACTAGCTATGTGTCGATTGTACTTGGCCCAGAATCGATAAATGAACGTT
TGCGCCATATACAAATCATCCCGATGAGCAACCAAAAGGCTGTTGTGATCCTTGTAAGCGAAAACGGGCATGTTGAAAAC
AGGCTTGTCCAAGTGGATGAAAATGTGACGCCTTCCGATTTAGAGCGGACGGTCAATTTGTTAAATGAGCGCCTTGTTGG
CACGCCGTTGTCTTCTTTGCAACGGAAGTTGAATACAGAGCTTGCCCAACTTTTTAAAGCGCATATCAATAACTACGAAC
ATATTCTCCATATGCTTCAGCAGTCAATGGTTCCTGCTTCAGGAGAGAAACTATTCTTTTCAGGGAAAACCAATTTAATG
GAACAGCCTGAATTTCAAGATGTTGAGAAAATGAGGCTTCTCTATAAAGCACTTGAAGAGGAAAATTTATTGCAAAAGTG
GCTGCGCGCACAACAAACAGATGGGCTCCATGTTTCGATTGGCCAAGAAAACGAACTGGAAGCGTTCGAGTCTTGCAGTG
TCATTACAGCATCTTATGCCATTGACGGCCGCCATGTCGGGACGCTAGGCGTGATCGGACCGACAAGAATGGAATATAAG
CGGATGATTAAAGTGGTTGACTCCTTGTCGAAAGACTTGACAAAACGGTTAACTGGTTTTGAACGTTAG

Upstream 100 bases:

>100_bases
GATCATTGAGCGTTTTTTCATTGACAAATGGACACCTGTTTGATAGTGTATCAATAGTATTAGCACTCGTTGCATTTGAG
TGCTAACAGGAGGTGCTGGG

Downstream 100 bases:

>100_bases
TATTTCGTATACGCAGCAGTCCTCTGCTGCTATACATAGAAGGCGCGGGCAAATGTCCAAAGCCCGCAAGCTATAGACGA
TGATTTTACAGGAGGTGAAC

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MLTERQLLVLHAIVDDYVRSAEPVGSRSISKREDIPYSPATIRNEMADLEELGFLEKPHSSAGRVPSQQGYRYYVDHLLS
PHRLTVAERAGLSRLTTARLQAMEEVFQESARILSEMTSYVSIVLGPESINERLRHIQIIPMSNQKAVVILVSENGHVEN
RLVQVDENVTPSDLERTVNLLNERLVGTPLSSLQRKLNTELAQLFKAHINNYEHILHMLQQSMVPASGEKLFFSGKTNLM
EQPEFQDVEKMRLLYKALEEENLLQKWLRAQQTDGLHVSIGQENELEAFESCSVITASYAIDGRHVGTLGVIGPTRMEYK
RMIKVVDSLSKDLTKRLTGFER

Sequences:

>Translated_342_residues
MLTERQLLVLHAIVDDYVRSAEPVGSRSISKREDIPYSPATIRNEMADLEELGFLEKPHSSAGRVPSQQGYRYYVDHLLS
PHRLTVAERAGLSRLTTARLQAMEEVFQESARILSEMTSYVSIVLGPESINERLRHIQIIPMSNQKAVVILVSENGHVEN
RLVQVDENVTPSDLERTVNLLNERLVGTPLSSLQRKLNTELAQLFKAHINNYEHILHMLQQSMVPASGEKLFFSGKTNLM
EQPEFQDVEKMRLLYKALEEENLLQKWLRAQQTDGLHVSIGQENELEAFESCSVITASYAIDGRHVGTLGVIGPTRMEYK
RMIKVVDSLSKDLTKRLTGFER
>Mature_342_residues
MLTERQLLVLHAIVDDYVRSAEPVGSRSISKREDIPYSPATIRNEMADLEELGFLEKPHSSAGRVPSQQGYRYYVDHLLS
PHRLTVAERAGLSRLTTARLQAMEEVFQESARILSEMTSYVSIVLGPESINERLRHIQIIPMSNQKAVVILVSENGHVEN
RLVQVDENVTPSDLERTVNLLNERLVGTPLSSLQRKLNTELAQLFKAHINNYEHILHMLQQSMVPASGEKLFFSGKTNLM
EQPEFQDVEKMRLLYKALEEENLLQKWLRAQQTDGLHVSIGQENELEAFESCSVITASYAIDGRHVGTLGVIGPTRMEYK
RMIKVVDSLSKDLTKRLTGFER

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_BACSK (Q5WHG3)

Other databases:

- EMBL:   AP006627
- RefSeq:   YP_175153.1
- ProteinModelPortal:   Q5WHG3
- SMR:   Q5WHG3
- STRING:   Q5WHG3
- EnsemblBacteria:   EBBACT00000049345
- GeneID:   3201299
- GenomeReviews:   AP006627_GR
- KEGG:   bcl:ABC1657
- NMPDR:   fig|66692.3.peg.40
- eggNOG:   COG1420
- GeneTree:   EBGT00050000002539
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   PRK00082
- BioCyc:   BCLA66692:ABC1657-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR005104
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF03444 DUF293; PF01628 HrcA

EC number: NA

Molecular weight: Translated: 38849; Mature: 38849

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTERQLLVLHAIVDDYVRSAEPVGSRSISKREDIPYSPATIRNEMADLEELGFLEKPHS
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
SAGRVPSQQGYRYYVDHLLSPHRLTVAERAGLSRLTTARLQAMEEVFQESARILSEMTSY
CCCCCCCCCCHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSIVLGPESINERLRHIQIIPMSNQKAVVILVSENGHVENRLVQVDENVTPSDLERTVNL
HEEEECHHHHHHHHHEEEEEEECCCCEEEEEECCCCCHHHHHEEECCCCCHHHHHHHHHH
LNERLVGTPLSSLQRKLNTELAQLFKAHINNYEHILHMLQQSMVPASGEKLFFSGKTNLM
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEECCCCCCC
EQPEFQDVEKMRLLYKALEEENLLQKWLRAQQTDGLHVSIGQENELEAFESCSVITASYA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCEEEEEE
IDGRHVGTLGVIGPTRMEYKRMIKVVDSLSKDLTKRLTGFER
ECCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLTERQLLVLHAIVDDYVRSAEPVGSRSISKREDIPYSPATIRNEMADLEELGFLEKPHS
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
SAGRVPSQQGYRYYVDHLLSPHRLTVAERAGLSRLTTARLQAMEEVFQESARILSEMTSY
CCCCCCCCCCHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSIVLGPESINERLRHIQIIPMSNQKAVVILVSENGHVENRLVQVDENVTPSDLERTVNL
HEEEECHHHHHHHHHEEEEEEECCCCEEEEEECCCCCHHHHHEEECCCCCHHHHHHHHHH
LNERLVGTPLSSLQRKLNTELAQLFKAHINNYEHILHMLQQSMVPASGEKLFFSGKTNLM
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEECCCCCCC
EQPEFQDVEKMRLLYKALEEENLLQKWLRAQQTDGLHVSIGQENELEAFESCSVITASYA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCEEEEEE
IDGRHVGTLGVIGPTRMEYKRMIKVVDSLSKDLTKRLTGFER
ECCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA