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The map label for this gene is hemN [H]

Identifier: 56963421

GI number: 56963421

Start: 1785217

End: 1786383

Strand: Direct

Name: hemN [H]

Synonym: ABC1656

Alternate gene names: 56963421

Gene position: 1785217-1786383 (Clockwise)

Preceding gene: 56963420

Following gene: 56963422

Centisome position: 41.48

GC content: 45.33

Gene sequence:

>1167_bases
GTGAGCCACTCGCTATATGTGCATATTCCATTTTGTGAACATATCTGTCATTATTGTGATTTTAATAAAGTATTTATTGA
AAACCAGCCTGTGGATGCCTACATTGACGCTTTAATTGAAGAAATGAAACAAGCCCGTGCCCGTCGAAGAGATGGCCTAG
TGAAAACGATTTATGTTGGTGGTGGCACGCCGACAGCGTTAACGGCTATACAACTAGAACGACTGTTTTCAGCGATAGAG
AGCCTTTTCGATTTAAGCGCACTGGAAGAATGGACGGTTGAAGTGAACCCAGACAGCGCCGATGAAGATAAGCTCGGAGT
TATGAAACGTTACGGTGTCAACCGCTTAAGCATAGGCGCGCAAACATTCAACCAAAAGCTGTTAGCGGATATTGGACGAA
CCCATTCGCCCGAAGGGGTGGAGCAGGCTGTTCGCAAGGCGCGTTCATTAGGGTTTACCAATCTTTCTATTGATTTAATG
CTCGGCTTGCCAAACCAATCAGTTGCCGACTTTGAACGCTCAGTCGATCGCGCTTTGTCCTTAGACGTAGAACATATTTC
CGCTTATGCATTAAAAATTGAAAAACAAACTGTCTTTTATAACCGTTACAAAAAAGGGCAGCTCCACTTGCCCCCTGAAG
ACGATGATGTAGCGATGTATGAGCTGCTTAAGAAAAAAACAGCTGCAGCTGGGCTTGACCAGTATGAAATTAGCAATTTC
GGCAAACCTGGCTATGAGAGCAAACATAATCTTGTCTATTGGCGCAATGAACCATATGCCGGTTTTGGCGCCGGTGCTTC
TGGCTACGAAAATCAAGTGCGCTACCAAAATATCAATCCCGTTGCAAAATATATTGAAGCTGTGTGGGCTACTGGAGAGC
CGCGGTTGCGGACCCATGTCGTCAGTCGGGCCGAGTGTTTAGAAGAGGCTGTTTTTTTAGGGCTTCGTATTCGTAGCGGT
ATAAATAAAGCTGATTTTTTTGCGCGTTATGGGCTAGACGTGGAGTCGCTGTTTGCCAAAGAAATCGCAGAGGGGAAACG
AAAAGGGCTTCTAGAAGAAAACGACCACGTGATTCGTTTGACAGAAAATGGGTTGTTGCTTGGGAATGAAGCATTTGCAT
TGTTTGTGGCTGTTTTAGAAGACAGCGAGCTGCAAGGCGATCATTGA

Upstream 100 bases:

>100_bases
CAAATCAATTCCTTTTGCTACAAATTTGCTGGGGCTGCTACGCCTCCTCCAAGGGTAGGCTTGAGGAAAGGACACTTAAA
TGAGCAAGGAGGAGAGACGC

Downstream 100 bases:

>100_bases
GCGTTTTTTCATTGACAAATGGACACCTGTTTGATAGTGTATCAATAGTATTAGCACTCGTTGCATTTGAGTGCTAACAG
GAGGTGCTGGGATGTTAACG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MSHSLYVHIPFCEHICHYCDFNKVFIENQPVDAYIDALIEEMKQARARRRDGLVKTIYVGGGTPTALTAIQLERLFSAIE
SLFDLSALEEWTVEVNPDSADEDKLGVMKRYGVNRLSIGAQTFNQKLLADIGRTHSPEGVEQAVRKARSLGFTNLSIDLM
LGLPNQSVADFERSVDRALSLDVEHISAYALKIEKQTVFYNRYKKGQLHLPPEDDDVAMYELLKKKTAAAGLDQYEISNF
GKPGYESKHNLVYWRNEPYAGFGAGASGYENQVRYQNINPVAKYIEAVWATGEPRLRTHVVSRAECLEEAVFLGLRIRSG
INKADFFARYGLDVESLFAKEIAEGKRKGLLEENDHVIRLTENGLLLGNEAFALFVAVLEDSELQGDH

Sequences:

>Translated_388_residues
MSHSLYVHIPFCEHICHYCDFNKVFIENQPVDAYIDALIEEMKQARARRRDGLVKTIYVGGGTPTALTAIQLERLFSAIE
SLFDLSALEEWTVEVNPDSADEDKLGVMKRYGVNRLSIGAQTFNQKLLADIGRTHSPEGVEQAVRKARSLGFTNLSIDLM
LGLPNQSVADFERSVDRALSLDVEHISAYALKIEKQTVFYNRYKKGQLHLPPEDDDVAMYELLKKKTAAAGLDQYEISNF
GKPGYESKHNLVYWRNEPYAGFGAGASGYENQVRYQNINPVAKYIEAVWATGEPRLRTHVVSRAECLEEAVFLGLRIRSG
INKADFFARYGLDVESLFAKEIAEGKRKGLLEENDHVIRLTENGLLLGNEAFALFVAVLEDSELQGDH
>Mature_387_residues
SHSLYVHIPFCEHICHYCDFNKVFIENQPVDAYIDALIEEMKQARARRRDGLVKTIYVGGGTPTALTAIQLERLFSAIES
LFDLSALEEWTVEVNPDSADEDKLGVMKRYGVNRLSIGAQTFNQKLLADIGRTHSPEGVEQAVRKARSLGFTNLSIDLML
GLPNQSVADFERSVDRALSLDVEHISAYALKIEKQTVFYNRYKKGQLHLPPEDDDVAMYELLKKKTAAAGLDQYEISNFG
KPGYESKHNLVYWRNEPYAGFGAGASGYENQVRYQNINPVAKYIEAVWATGEPRLRTHVVSRAECLEEAVFLGLRIRSGI
NKADFFARYGLDVESLFAKEIAEGKRKGLLEENDHVIRLTENGLLLGNEAFALFVAVLEDSELQGDH

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=286, Percent_Identity=33.5664335664336, Blast_Score=162, Evalue=7e-40,
Organism=Escherichia coli, GI1789325, Length=392, Percent_Identity=33.4183673469388, Blast_Score=205, Evalue=5e-54,
Organism=Escherichia coli, GI87082341, Length=380, Percent_Identity=27.3684210526316, Blast_Score=139, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 43642; Mature: 43511

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHSLYVHIPFCEHICHYCDFNKVFIENQPVDAYIDALIEEMKQARARRRDGLVKTIYVG
CCCCEEEEECHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
GGTPTALTAIQLERLFSAIESLFDLSALEEWTVEVNPDSADEDKLGVMKRYGVNRLSIGA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHCCCCEEEECH
QTFNQKLLADIGRTHSPEGVEQAVRKARSLGFTNLSIDLMLGLPNQSVADFERSVDRALS
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHHHHH
LDVEHISAYALKIEKQTVFYNRYKKGQLHLPPEDDDVAMYELLKKKTAAAGLDQYEISNF
CCHHHHEEEHEEEEHHHHEECCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHCC
GKPGYESKHNLVYWRNEPYAGFGAGASGYENQVRYQNINPVAKYIEAVWATGEPRLRTHV
CCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHCCCCCHHHHHH
VSRAECLEEAVFLGLRIRSGINKADFFARYGLDVESLFAKEIAEGKRKGLLEENDHVIRL
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEEE
TENGLLLGNEAFALFVAVLEDSELQGDH
ECCCEEECCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SHSLYVHIPFCEHICHYCDFNKVFIENQPVDAYIDALIEEMKQARARRRDGLVKTIYVG
CCCEEEEECHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
GGTPTALTAIQLERLFSAIESLFDLSALEEWTVEVNPDSADEDKLGVMKRYGVNRLSIGA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHCCCCEEEECH
QTFNQKLLADIGRTHSPEGVEQAVRKARSLGFTNLSIDLMLGLPNQSVADFERSVDRALS
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHHHHH
LDVEHISAYALKIEKQTVFYNRYKKGQLHLPPEDDDVAMYELLKKKTAAAGLDQYEISNF
CCHHHHEEEHEEEEHHHHEECCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHCC
GKPGYESKHNLVYWRNEPYAGFGAGASGYENQVRYQNINPVAKYIEAVWATGEPRLRTHV
CCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHCCCCCHHHHHH
VSRAECLEEAVFLGLRIRSGINKADFFARYGLDVESLFAKEIAEGKRKGLLEENDHVIRL
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEEE
TENGLLLGNEAFALFVAVLEDSELQGDH
ECCCEEECCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]