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The map label for this gene is iscS1 [H]

Identifier: 56963350

GI number: 56963350

Start: 1709390

End: 1710550

Strand: Direct

Name: iscS1 [H]

Synonym: ABC1585

Alternate gene names: 56963350

Gene position: 1709390-1710550 (Clockwise)

Preceding gene: 56963349

Following gene: 56963351

Centisome position: 39.72

GC content: 46.77

Gene sequence:

>1161_bases
ATGAAGCAAATTTATTTAGACCATGCAGCCACATCAGTGTTGCATCCCCAAGCGTTGGAAGCGATGATGCCTTATTTTTC
TACGGTTTTTGGTAATCCATCAAGCATCCATCAGTTTGGACGCCAAGCGAAACAAGCGTTAATCGAAGCCCGTGAATCAA
TTGCGTCATTGCTAAACGCTAACAGCAATGAGGTGCTGTTTACGAGCGGCGGTACAGAGGCGAATAATTTAGCGCTTATT
GGCTTTGCCCGTGCCAACCGTGAAAAAGGCACGCATATCATCACTTCAGAAATTGAACATCATGCTGTCCTGCATACGCT
GGAGGAATTGGCAAAGGAAGGGTTTTCGATAACAAAGCTGCCTGTCAATGAAAATGGGCAAATTTCGTTTGCGCAATTGA
AAAATGCGTTAACCGAAGAAACGATCCTTGTCTCCATCATGTTTGCGAACAATGAGGTTGGCACAGTGCAACCGATTAAA
GAAATTGGCGAGCTGCTAAAAGGGCATCAAGCAGCTTTTCATTCCGATGCTGTTCAAGCAGCTGGGCTATATGAGCTCAA
TACGGACGAGCTCGCCGTAGACTTGATGACCATTGCAAGCCATAAGCTAAATGGGCCAAAAGGGATTGGCTGTTTGTTTG
TACGTGAAGGCATCGAATTAGAACCGCTGTTGCATGGGGGCGAGCAAGAACGGAAACGCAGGGCAGGTACAGAAAATGTC
GCCGGTGCTGTTGGTTTTGCTCATGCTTTCAACCAAGCATACGCTGAACGTGAGCAGCGTCGCCAAAGCTACAAATTATA
CAGGACAATGTTTTTTGAAACGATGGAGCGGCGCGGTGTAGCAGTGCTGGAAAATGGCGAGAGTGGGGAACGGCTTGATC
ACATTTTGAACGTTTGTTTTCCAGGTGCGTCTACAGAAGCGCTTTTGATGAAATTAGACTTGCAAGGCATTGCTGCGTCT
GGAGGTTCTGCTTGCACGGCAGGGACGCTTCAACCTTCTCATGTCATTCAAGCGATGTATGGAAAAGATAGCCATCGTGT
CAAAGAAGCGATCCGCTTTAGTTTTGGCATGACCAATTCAAAGGAAGAGTTGGCTTATGCGTTTGAGCAAATCGCGGATT
GCGTCTTGTCTGAGCAAGGGAAAAAGGCGTTCATTGAATAG

Upstream 100 bases:

>100_bases
GACTCTTGCCGACTTAGCCAATTTTAAGGAAGATGGAGAACAAGAGTACTATATGTTTTATATTTAACAAAACGGAGCAA
GGGGACGGAAGGTGCCACTC

Downstream 100 bases:

>100_bases
TGGCGAGCAATAGAAAGTGGGGAACCAATATGAAAAAACGAGAAGATACACGTGTCGTTGTCGGCATGTCTGGAGGTGTA
GATTCTTCTGTAACAGCTTT

Product: iron-sulfur cofactor synthesis

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MKQIYLDHAATSVLHPQALEAMMPYFSTVFGNPSSIHQFGRQAKQALIEARESIASLLNANSNEVLFTSGGTEANNLALI
GFARANREKGTHIITSEIEHHAVLHTLEELAKEGFSITKLPVNENGQISFAQLKNALTEETILVSIMFANNEVGTVQPIK
EIGELLKGHQAAFHSDAVQAAGLYELNTDELAVDLMTIASHKLNGPKGIGCLFVREGIELEPLLHGGEQERKRRAGTENV
AGAVGFAHAFNQAYAEREQRRQSYKLYRTMFFETMERRGVAVLENGESGERLDHILNVCFPGASTEALLMKLDLQGIAAS
GGSACTAGTLQPSHVIQAMYGKDSHRVKEAIRFSFGMTNSKEELAYAFEQIADCVLSEQGKKAFIE

Sequences:

>Translated_386_residues
MKQIYLDHAATSVLHPQALEAMMPYFSTVFGNPSSIHQFGRQAKQALIEARESIASLLNANSNEVLFTSGGTEANNLALI
GFARANREKGTHIITSEIEHHAVLHTLEELAKEGFSITKLPVNENGQISFAQLKNALTEETILVSIMFANNEVGTVQPIK
EIGELLKGHQAAFHSDAVQAAGLYELNTDELAVDLMTIASHKLNGPKGIGCLFVREGIELEPLLHGGEQERKRRAGTENV
AGAVGFAHAFNQAYAEREQRRQSYKLYRTMFFETMERRGVAVLENGESGERLDHILNVCFPGASTEALLMKLDLQGIAAS
GGSACTAGTLQPSHVIQAMYGKDSHRVKEAIRFSFGMTNSKEELAYAFEQIADCVLSEQGKKAFIE
>Mature_386_residues
MKQIYLDHAATSVLHPQALEAMMPYFSTVFGNPSSIHQFGRQAKQALIEARESIASLLNANSNEVLFTSGGTEANNLALI
GFARANREKGTHIITSEIEHHAVLHTLEELAKEGFSITKLPVNENGQISFAQLKNALTEETILVSIMFANNEVGTVQPIK
EIGELLKGHQAAFHSDAVQAAGLYELNTDELAVDLMTIASHKLNGPKGIGCLFVREGIELEPLLHGGEQERKRRAGTENV
AGAVGFAHAFNQAYAEREQRRQSYKLYRTMFFETMERRGVAVLENGESGERLDHILNVCFPGASTEALLMKLDLQGIAAS
GGSACTAGTLQPSHVIQAMYGKDSHRVKEAIRFSFGMTNSKEELAYAFEQIADCVLSEQGKKAFIE

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=373, Percent_Identity=37.5335120643432, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI156713448, Length=411, Percent_Identity=30.9002433090024, Blast_Score=178, Evalue=8e-45,
Organism=Escherichia coli, GI48994898, Length=381, Percent_Identity=39.8950131233596, Blast_Score=265, Evalue=3e-72,
Organism=Escherichia coli, GI1787970, Length=394, Percent_Identity=26.9035532994924, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1789175, Length=270, Percent_Identity=29.2592592592593, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI25143064, Length=372, Percent_Identity=38.4408602150538, Blast_Score=272, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17533177, Length=333, Percent_Identity=31.5315315315315, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6319831, Length=382, Percent_Identity=38.7434554973822, Blast_Score=270, Evalue=3e-73,
Organism=Drosophila melanogaster, GI20129463, Length=372, Percent_Identity=39.247311827957, Blast_Score=279, Evalue=3e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 42219; Mature: 42219

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQIYLDHAATSVLHPQALEAMMPYFSTVFGNPSSIHQFGRQAKQALIEARESIASLLNA
CCEEEECHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NSNEVLFTSGGTEANNLALIGFARANREKGTHIITSEIEHHAVLHTLEELAKEGFSITKL
CCCEEEEECCCCCCCCEEEEEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCEEEEE
PVNENGQISFAQLKNALTEETILVSIMFANNEVGTVQPIKEIGELLKGHQAAFHSDAVQA
CCCCCCCEEHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AGLYELNTDELAVDLMTIASHKLNGPKGIGCLFVREGIELEPLLHGGEQERKRRAGTENV
CCEEECCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHCCCHHHHHHHCCCCHH
AGAVGFAHAFNQAYAEREQRRQSYKLYRTMFFETMERRGVAVLENGESGERLDHILNVCF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHC
PGASTEALLMKLDLQGIAASGGSACTAGTLQPSHVIQAMYGKDSHRVKEAIRFSFGMTNS
CCCCHHHEEEEEEHHHHCCCCCCCCEECCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
KEELAYAFEQIADCVLSEQGKKAFIE
HHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKQIYLDHAATSVLHPQALEAMMPYFSTVFGNPSSIHQFGRQAKQALIEARESIASLLNA
CCEEEECHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NSNEVLFTSGGTEANNLALIGFARANREKGTHIITSEIEHHAVLHTLEELAKEGFSITKL
CCCEEEEECCCCCCCCEEEEEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCEEEEE
PVNENGQISFAQLKNALTEETILVSIMFANNEVGTVQPIKEIGELLKGHQAAFHSDAVQA
CCCCCCCEEHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AGLYELNTDELAVDLMTIASHKLNGPKGIGCLFVREGIELEPLLHGGEQERKRRAGTENV
CCEEECCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHCCCHHHHHHHCCCCHH
AGAVGFAHAFNQAYAEREQRRQSYKLYRTMFFETMERRGVAVLENGESGERLDHILNVCF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHC
PGASTEALLMKLDLQGIAASGGSACTAGTLQPSHVIQAMYGKDSHRVKEAIRFSFGMTNS
CCCCHHHEEEEEEHHHHCCCCCCCCEECCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
KEELAYAFEQIADCVLSEQGKKAFIE
HHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]