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The map label for this gene is relA [H]

Identifier: 56963335

GI number: 56963335

Start: 1691036

End: 1693243

Strand: Direct

Name: relA [H]

Synonym: ABC1570

Alternate gene names: 56963335

Gene position: 1691036-1693243 (Clockwise)

Preceding gene: 56963334

Following gene: 56963336

Centisome position: 39.29

GC content: 42.98

Gene sequence:

>2208_bases
ATGAGTAAAGGTGATTTCATGACAATTGATCAGGTGCTCGAAAAAGCGCGTGCGTATTTGACAAAAGATGATATTGTCTT
TTTGGAAAAAGCGTACGAGTTTGCTGAAAAGGCACACAGTGGTCAGTACCGTAAATCGGGAGAGCCCTATATTTTACACC
CAGTCCAAGTAGCTGGCATTATTGTCGGGCTTGAATTAGATCCGAATACGATTGCCGCCGCTTTTCTTCATGATGTCGTT
GAAGATACCGAAGCAACAGTCGACGATTTGGAAGAAGCGTTTAACGAGGAAGTCGCTATGCTAGTTGACGGCGTAACAAA
ATTAAAGAAGTTTAAATATAAATCAAAAGAGGAGCAGCAAGCCGAAAACCACCGGAAAATGCTTATGGCTATGGCGAAAG
ATATCCGCGTCCTCTTGATTAAACTGGCAGACCGTCTCCATAATATGCGGACACTTAAATTTATGCCACCGCAGAAGCAG
CGGATTACTTCAAACGAAACGTTAGAGATCTTTGCTCCATTGGCACATCGTCTTGGAATTTCAACGATTAAATGGGAACT
GGAAGATACAGCGCTTCGTTATTTGGATCCACAGCAGTATTACCGTATTGTCAATTTAATGAAACGGAAACGTGCTGAAC
GGGAAGAGTATTTGACAGAAGTGATGGACAAAATCAAAGTCCAACTTAAAGAAGTGAACGTACAGGCAGAATTGTCAGGC
CGGCCAAAGCATATATACAGCATTTACCGCAAAATGGTGATTCAGCACAAACAATTTAATGAAATTTATGATTTGCTAGC
TGTACGAATTATTGTTAAAAACATTAAAGACTGTTATGCGGTTCTTGGCGTCATTCATACGTGCTGGCGCCCCATGCCAG
GACGCTTTAAAGATTACATTGCCATGCCAAAAGCAAATATGTATCAGTCGCTGCATACAACCGTAGTCGGACCGAACGGA
GACCCGCTGGAAGTGCAGATCCGTACAGAGGACATGCACCGGGTAGCTGAATATGGTGTTGCCGCCCATTGGGCGTATAA
AGAAGGGAAAACACTCTCAAGCAATCGCTATTCGTTTGAAGATAAATTAACGTGGTTCCGTGATGTGATTGAATCGCAGA
CAGACACAAATGACGCCCAAGAGTTTATGGAATCTATGAAAATGGACCTGTTTTCTGATATGGTGTTTGTGTTTACACCA
AAAGGAGACGTCATTGAATTGCCCCGGGGATCGGTTCCTCTTGATTTTGCTTATCGGATCCATAGTGAGATCGGCAACCG
TTGTATCGGTGCGAAAGTGAACAGCAAAATGGTCCCCCTTGACCATGAACTAAAAACGGGTGACATTGTCGAAGTGATGA
CGTCGAAACACTCATATGGGCCAAGCCATGACTGGTTGAAAATTACTAAGTCGTCACATGCTAAAAACAAAATCAAACAG
TGGTTCAAAAAAGAGAAACGCGAAGAAAATGTCGTCAAAGGGAAAGAAGCAATCGAAAAAGAAATACGGGCGCTTGATTT
CGATGTAAAAGACATTTTAACGCAGGAAAATTTACAAGAAGCGATTAGCAAGTTCAGTTTTGCTGGCGAAGAAGATATGT
ATGCAGCAGTTGGTTATGGCGGAATTAGCGCTAAACAAATTGTCAATCGCCTTACTGAAAAACAACGCAAAGCAAAAGAC
AGCGAGCAGGAGCAACAATCCCTTGATGCAGTGTTAAATGAAATCCAAACGGTTTCGCCAAACAAGCGGACAAATTCAAT
TGGCGTGCATGTAAAAGGGGTCGACAATATGCTTATCCGCCTAGCACGATGTTGCACGCCAGTGCCAGGAGATGAGATTG
TCGGCTACATTACGAAAGGCCGTGGCGTTTCCATTCACCGTGAAGATTGCCCGAATGTCATAGCCGATTCAGATTCGTCC
CGTTTGCTTGAAGTGGAATGGGAAGGAAATGAGCAGCAGGGCAAGTCGTATAATGTCGACATTGAAATTACTGGATTTGA
CCGCAACGGTCTGTTAAATGAAGTGTTGCACACATTGACAGAAACGCGCACGCAAATAAATACGATTTCTGGGCGTTCTG
ACCATAAGCATAAAATGGCGACGATTGAAATGAGCATTTCTATTTCCAATATCGCTCATTTGCAAAAAGTGGTCGACAAA
ATTAAACAGTTAAAAGACATTTACTCTGTGCGGAGGGTAACCCATTAG

Upstream 100 bases:

>100_bases
TGGTTGTGCGAATCGGCACACCGGTCTTTTTGCAATTTCTAAGCCGCTCTCCCTTTACAACACTGAACGAGTAGCGGATA
ATAGAAAGAAAACTTGTCGA

Downstream 100 bases:

>100_bases
AGTCGAGGCAGGTGAGAAAAAGTGCGAGTACTAGTCCAGCGAGCGAAACGGGGCAGTGTTCGAGTCGACCAAAAAACAGT
AGGCGACATTGGGCCAGGCC

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 735; Mature: 734

Protein sequence:

>735_residues
MSKGDFMTIDQVLEKARAYLTKDDIVFLEKAYEFAEKAHSGQYRKSGEPYILHPVQVAGIIVGLELDPNTIAAAFLHDVV
EDTEATVDDLEEAFNEEVAMLVDGVTKLKKFKYKSKEEQQAENHRKMLMAMAKDIRVLLIKLADRLHNMRTLKFMPPQKQ
RITSNETLEIFAPLAHRLGISTIKWELEDTALRYLDPQQYYRIVNLMKRKRAEREEYLTEVMDKIKVQLKEVNVQAELSG
RPKHIYSIYRKMVIQHKQFNEIYDLLAVRIIVKNIKDCYAVLGVIHTCWRPMPGRFKDYIAMPKANMYQSLHTTVVGPNG
DPLEVQIRTEDMHRVAEYGVAAHWAYKEGKTLSSNRYSFEDKLTWFRDVIESQTDTNDAQEFMESMKMDLFSDMVFVFTP
KGDVIELPRGSVPLDFAYRIHSEIGNRCIGAKVNSKMVPLDHELKTGDIVEVMTSKHSYGPSHDWLKITKSSHAKNKIKQ
WFKKEKREENVVKGKEAIEKEIRALDFDVKDILTQENLQEAISKFSFAGEEDMYAAVGYGGISAKQIVNRLTEKQRKAKD
SEQEQQSLDAVLNEIQTVSPNKRTNSIGVHVKGVDNMLIRLARCCTPVPGDEIVGYITKGRGVSIHREDCPNVIADSDSS
RLLEVEWEGNEQQGKSYNVDIEITGFDRNGLLNEVLHTLTETRTQINTISGRSDHKHKMATIEMSISISNIAHLQKVVDK
IKQLKDIYSVRRVTH

Sequences:

>Translated_735_residues
MSKGDFMTIDQVLEKARAYLTKDDIVFLEKAYEFAEKAHSGQYRKSGEPYILHPVQVAGIIVGLELDPNTIAAAFLHDVV
EDTEATVDDLEEAFNEEVAMLVDGVTKLKKFKYKSKEEQQAENHRKMLMAMAKDIRVLLIKLADRLHNMRTLKFMPPQKQ
RITSNETLEIFAPLAHRLGISTIKWELEDTALRYLDPQQYYRIVNLMKRKRAEREEYLTEVMDKIKVQLKEVNVQAELSG
RPKHIYSIYRKMVIQHKQFNEIYDLLAVRIIVKNIKDCYAVLGVIHTCWRPMPGRFKDYIAMPKANMYQSLHTTVVGPNG
DPLEVQIRTEDMHRVAEYGVAAHWAYKEGKTLSSNRYSFEDKLTWFRDVIESQTDTNDAQEFMESMKMDLFSDMVFVFTP
KGDVIELPRGSVPLDFAYRIHSEIGNRCIGAKVNSKMVPLDHELKTGDIVEVMTSKHSYGPSHDWLKITKSSHAKNKIKQ
WFKKEKREENVVKGKEAIEKEIRALDFDVKDILTQENLQEAISKFSFAGEEDMYAAVGYGGISAKQIVNRLTEKQRKAKD
SEQEQQSLDAVLNEIQTVSPNKRTNSIGVHVKGVDNMLIRLARCCTPVPGDEIVGYITKGRGVSIHREDCPNVIADSDSS
RLLEVEWEGNEQQGKSYNVDIEITGFDRNGLLNEVLHTLTETRTQINTISGRSDHKHKMATIEMSISISNIAHLQKVVDK
IKQLKDIYSVRRVTH
>Mature_734_residues
SKGDFMTIDQVLEKARAYLTKDDIVFLEKAYEFAEKAHSGQYRKSGEPYILHPVQVAGIIVGLELDPNTIAAAFLHDVVE
DTEATVDDLEEAFNEEVAMLVDGVTKLKKFKYKSKEEQQAENHRKMLMAMAKDIRVLLIKLADRLHNMRTLKFMPPQKQR
ITSNETLEIFAPLAHRLGISTIKWELEDTALRYLDPQQYYRIVNLMKRKRAEREEYLTEVMDKIKVQLKEVNVQAELSGR
PKHIYSIYRKMVIQHKQFNEIYDLLAVRIIVKNIKDCYAVLGVIHTCWRPMPGRFKDYIAMPKANMYQSLHTTVVGPNGD
PLEVQIRTEDMHRVAEYGVAAHWAYKEGKTLSSNRYSFEDKLTWFRDVIESQTDTNDAQEFMESMKMDLFSDMVFVFTPK
GDVIELPRGSVPLDFAYRIHSEIGNRCIGAKVNSKMVPLDHELKTGDIVEVMTSKHSYGPSHDWLKITKSSHAKNKIKQW
FKKEKREENVVKGKEAIEKEIRALDFDVKDILTQENLQEAISKFSFAGEEDMYAAVGYGGISAKQIVNRLTEKQRKAKDS
EQEQQSLDAVLNEIQTVSPNKRTNSIGVHVKGVDNMLIRLARCCTPVPGDEIVGYITKGRGVSIHREDCPNVIADSDSSR
LLEVEWEGNEQQGKSYNVDIEITGFDRNGLLNEVLHTLTETRTQINTISGRSDHKHKMATIEMSISISNIAHLQKVVDKI
KQLKDIYSVRRVTH

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=136, Percent_Identity=37.5, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1790082, Length=730, Percent_Identity=40.1369863013699, Blast_Score=565, Evalue=1e-162,
Organism=Escherichia coli, GI1789147, Length=692, Percent_Identity=39.0173410404624, Blast_Score=546, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI25143118, Length=131, Percent_Identity=37.4045801526718, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24650996, Length=135, Percent_Identity=36.2962962962963, Blast_Score=73, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 84317; Mature: 84186

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKGDFMTIDQVLEKARAYLTKDDIVFLEKAYEFAEKAHSGQYRKSGEPYILHPVQVAGI
CCCCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEE
IVGLELDPNTIAAAFLHDVVEDTEATVDDLEEAFNEEVAMLVDGVTKLKKFKYKSKEEQQ
EEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AENHRKMLMAMAKDIRVLLIKLADRLHNMRTLKFMPPQKQRITSNETLEIFAPLAHRLGI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHCCCCCHHHHHHHHHHHCCC
STIKWELEDTALRYLDPQQYYRIVNLMKRKRAEREEYLTEVMDKIKVQLKEVNVQAELSG
HHEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCC
RPKHIYSIYRKMVIQHKQFNEIYDLLAVRIIVKNIKDCYAVLGVIHTCWRPMPGRFKDYI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AMPKANMYQSLHTTVVGPNGDPLEVQIRTEDMHRVAEYGVAAHWAYKEGKTLSSNRYSFE
CCCCHHHHHHHHHEEECCCCCEEEEEEEHHHHHHHHHHCHHHEEECCCCCCCCCCCCCHH
DKLTWFRDVIESQTDTNDAQEFMESMKMDLFSDMVFVFTPKGDVIELPRGSVPLDFAYRI
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCEEECCCCCCCHHHHHHH
HSEIGNRCIGAKVNSKMVPLDHELKTGDIVEVMTSKHSYGPSHDWLKITKSSHAKNKIKQ
HHHHCCEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHH
WFKKEKREENVVKGKEAIEKEIRALDFDVKDILTQENLQEAISKFSFAGEEDMYAAVGYG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCC
GISAKQIVNRLTEKQRKAKDSEQEQQSLDAVLNEIQTVSPNKRTNSIGVHVKGVDNMLIR
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHH
LARCCTPVPGDEIVGYITKGRGVSIHREDCPNVIADSDSSRLLEVEWEGNEQQGKSYNVD
HHHHCCCCCCCHHEEEEECCCCCEEEHHCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEE
IEITGFDRNGLLNEVLHTLTETRTQINTISGRSDHKHKMATIEMSISISNIAHLQKVVDK
EEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEHHHHHHHHHHHHH
IKQLKDIYSVRRVTH
HHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKGDFMTIDQVLEKARAYLTKDDIVFLEKAYEFAEKAHSGQYRKSGEPYILHPVQVAGI
CCCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEE
IVGLELDPNTIAAAFLHDVVEDTEATVDDLEEAFNEEVAMLVDGVTKLKKFKYKSKEEQQ
EEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AENHRKMLMAMAKDIRVLLIKLADRLHNMRTLKFMPPQKQRITSNETLEIFAPLAHRLGI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHCCCCCHHHHHHHHHHHCCC
STIKWELEDTALRYLDPQQYYRIVNLMKRKRAEREEYLTEVMDKIKVQLKEVNVQAELSG
HHEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCC
RPKHIYSIYRKMVIQHKQFNEIYDLLAVRIIVKNIKDCYAVLGVIHTCWRPMPGRFKDYI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AMPKANMYQSLHTTVVGPNGDPLEVQIRTEDMHRVAEYGVAAHWAYKEGKTLSSNRYSFE
CCCCHHHHHHHHHEEECCCCCEEEEEEEHHHHHHHHHHCHHHEEECCCCCCCCCCCCCHH
DKLTWFRDVIESQTDTNDAQEFMESMKMDLFSDMVFVFTPKGDVIELPRGSVPLDFAYRI
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCEEECCCCCCCHHHHHHH
HSEIGNRCIGAKVNSKMVPLDHELKTGDIVEVMTSKHSYGPSHDWLKITKSSHAKNKIKQ
HHHHCCEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHH
WFKKEKREENVVKGKEAIEKEIRALDFDVKDILTQENLQEAISKFSFAGEEDMYAAVGYG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCC
GISAKQIVNRLTEKQRKAKDSEQEQQSLDAVLNEIQTVSPNKRTNSIGVHVKGVDNMLIR
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHH
LARCCTPVPGDEIVGYITKGRGVSIHREDCPNVIADSDSSRLLEVEWEGNEQQGKSYNVD
HHHHCCCCCCCHHEEEEECCCCCEEEHHCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEE
IEITGFDRNGLLNEVLHTLTETRTQINTISGRSDHKHKMATIEMSISISNIAHLQKVVDK
EEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEHHHHHHHHHHHHH
IKQLKDIYSVRRVTH
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9383190; 9384377 [H]