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The map label for this gene is apt

Identifier: 56963334

GI number: 56963334

Start: 1690407

End: 1690922

Strand: Direct

Name: apt

Synonym: ABC1569

Alternate gene names: 56963334

Gene position: 1690407-1690922 (Clockwise)

Preceding gene: 56963333

Following gene: 56963335

Centisome position: 39.28

GC content: 45.54

Gene sequence:

>516_bases
ATGGATTATAAACAATATATAACAATTGTCGAAGATTGGCCGCAAGAGGGCATACGCTTTAAAGACATTACGACGTTGAT
GCAAAACGGCACAGCCTACAAGCGCGCCGTTGAAGAACTTGCCGTTTATGCAAAAGAAAAACAAGCAGACGTCATTGTCG
GCCCTGAAGCACGTGGCTTTGTTGTTGGTTGCCCAATCGCGACTGAACTTGAAATCGGTTTTGTCCCTGTTAGGAAAAAA
GGCAAATTGCCTCGGGAAGTCATTGAAGCCAACTATGGTCTTGAATATGGAAAAGACTGTTTAACCATCCATAAAGACAG
CATCCAGCCAGGCCAACGCGTCGTCATTACCGATGACCTCCTCGCAACAGGGGGTACGATTGAGGCAACGGCTAAAATGG
TAGAGCAACTTGGCGGGAAAGTGGTCGGGATTGCCTTCTTGATCGAATTGGCTTATATAGGCGGCCGCGATAAACTAAAG
CAGTACGACTTGTTTTCATTAATGTCTTACGAATAA

Upstream 100 bases:

>100_bases
CTTGAGAATGAATTTGTTTTTGCTTCTTATCAACAGTTAAAAGAATGGTTCCAGGCTGCCATCGAAGGGAGCGCTGAAAC
AAAAGAGGAGTCGATCCTAA

Downstream 100 bases:

>100_bases
ATCGCTTACAGACTGGTTGTGCGAATCGGCACACCGGTCTTTTTGCAATTTCTAAGCCGCTCTCCCTTTACAACACTGAA
CGAGTAGCGGATAATAGAAA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MDYKQYITIVEDWPQEGIRFKDITTLMQNGTAYKRAVEELAVYAKEKQADVIVGPEARGFVVGCPIATELEIGFVPVRKK
GKLPREVIEANYGLEYGKDCLTIHKDSIQPGQRVVITDDLLATGGTIEATAKMVEQLGGKVVGIAFLIELAYIGGRDKLK
QYDLFSLMSYE

Sequences:

>Translated_171_residues
MDYKQYITIVEDWPQEGIRFKDITTLMQNGTAYKRAVEELAVYAKEKQADVIVGPEARGFVVGCPIATELEIGFVPVRKK
GKLPREVIEANYGLEYGKDCLTIHKDSIQPGQRVVITDDLLATGGTIEATAKMVEQLGGKVVGIAFLIELAYIGGRDKLK
QYDLFSLMSYE
>Mature_171_residues
MDYKQYITIVEDWPQEGIRFKDITTLMQNGTAYKRAVEELAVYAKEKQADVIVGPEARGFVVGCPIATELEIGFVPVRKK
GKLPREVIEANYGLEYGKDCLTIHKDSIQPGQRVVITDDLLATGGTIEATAKMVEQLGGKVVGIAFLIELAYIGGRDKLK
QYDLFSLMSYE

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=171, Percent_Identity=41.5204678362573, Blast_Score=137, Evalue=3e-33,
Organism=Homo sapiens, GI71773201, Length=124, Percent_Identity=43.5483870967742, Blast_Score=106, Evalue=1e-23,
Organism=Escherichia coli, GI1786675, Length=169, Percent_Identity=47.3372781065089, Blast_Score=161, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17509087, Length=174, Percent_Identity=43.6781609195402, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=162, Percent_Identity=38.8888888888889, Blast_Score=112, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320649, Length=161, Percent_Identity=32.2981366459627, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136334, Length=173, Percent_Identity=41.0404624277457, Blast_Score=119, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_BACSK (Q5WHQ1)

Other databases:

- EMBL:   AP006627
- RefSeq:   YP_175065.1
- ProteinModelPortal:   Q5WHQ1
- SMR:   Q5WHQ1
- STRING:   Q5WHQ1
- EnsemblBacteria:   EBBACT00000046696
- GeneID:   3201704
- GenomeReviews:   AP006627_GR
- KEGG:   bcl:ABC1569
- NMPDR:   fig|66692.3.peg.1531
- eggNOG:   COG0503
- GeneTree:   EBGT00050000001499
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   BCLA66692:ABC1569-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19023; Mature: 19023

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKQYITIVEDWPQEGIRFKDITTLMQNGTAYKRAVEELAVYAKEKQADVIVGPEARGF
CCHHHEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCE
VVGCPIATELEIGFVPVRKKGKLPREVIEANYGLEYGKDCLTIHKDSIQPGQRVVITDDL
EEECCCEEEEEEEEEECCCCCCCCHHHHHCCCCCCCCCCEEEEECCCCCCCCEEEEECCH
LATGGTIEATAKMVEQLGGKVVGIAFLIELAYIGGRDKLKQYDLFSLMSYE
HHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDYKQYITIVEDWPQEGIRFKDITTLMQNGTAYKRAVEELAVYAKEKQADVIVGPEARGF
CCHHHEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCE
VVGCPIATELEIGFVPVRKKGKLPREVIEANYGLEYGKDCLTIHKDSIQPGQRVVITDDL
EEECCCEEEEEEEEEECCCCCCCCHHHHHCCCCCCCCCCEEEEECCCCCCCCEEEEECCH
LATGGTIEATAKMVEQLGGKVVGIAFLIELAYIGGRDKLKQYDLFSLMSYE
HHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA