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The map label for this gene is nadC [H]

Identifier: 56963313

GI number: 56963313

Start: 1671551

End: 1672399

Strand: Direct

Name: nadC [H]

Synonym: ABC1548

Alternate gene names: 56963313

Gene position: 1671551-1672399 (Clockwise)

Preceding gene: 56963312

Following gene: 56963314

Centisome position: 38.84

GC content: 48.65

Gene sequence:

>849_bases
ATGAACCCGCTCAAGCTTGATCAGCAGTTAAGGGGATTTTTGGCAGAAGACATTGGTTATGGAGACCGTACAGCTGAAGC
GCTGTTCACTGTTGAAAGAGCAGAGGCCGTTATAGTTGCCAAAGGGGAAGGCATTTTTGCAGGGACACAAGTGGTCAACC
AGCTATACGCTTTGCTCGATTCTGACATTGAAGTCGAACTGTTTGTTCGCGATGGAGAGCAAGTGAAACGAGGGCAGCAA
TTGGCTCGCTTTACAGGGCCGGTCAAATCGCTATTATCGGGCGAACGGGTATTGCTCAATTTATTGCAGCGTATGTGCGG
CATTGCCACACTGACAGCAAAAGCAGTGGAAGAATTAGGCGATCCAAGCATTCGTGTTTGCGATACCCGAAAAACAGCGC
CAGGGCTTAGAATGTTTGACAAATTTGCAGTCAGGATAGGAGGGGGAGCCAACCACCGTTTTGGCCTTGACGATGCCCTC
ATGTTAAAAGAAAACCATATCGCCGCTAGCACGTCCATTGCTGCCGCAATCGAAAAAGCCCGCGCTTATGCTGGGCCGAT
GGCAAAAATTGAAGTAGAGACGACGACTTTAGACGAAGTCAAAGAAGCAGTCGCCGCGCAAGCGGATGTAATCATGTTTG
ATAACGCTACGCCAGAGGCGATTAGGACTTACTTGGCCTATGTCCCAGCTGGAATAAAGACGGAGGCCTCAGGAGGGATA
ACGATGGCCAATTTGCGGCAATTTGCCAATACTGGCGTTGATTTTCTGTCGCTTGGATTTTTGACACATTCAGTTGTTGC
ACTCGATTTGAGCATGCTTATACAAAAGGGGGAAGGACAATGCAAGTAA

Upstream 100 bases:

>100_bases
AGGCGCAGCGATTATCCGTCAGCAGACGAACAATGGCGGAAGCGCTCGATTTGTTTTTCTGTACAGAATAAAGCATTCGT
GAAAACAGAGGAGAGAGAAT

Downstream 100 bases:

>100_bases
TGCAACCAGCGAGATTGCCCCATCACTATCGGGAAATGTCAAGTGCTGAAAAAGAAGCCCGTATTCGCGAAGCAAAAGCA
TTTTTTGGCAATGACCTACT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: General stress protein 70; GSP70; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MNPLKLDQQLRGFLAEDIGYGDRTAEALFTVERAEAVIVAKGEGIFAGTQVVNQLYALLDSDIEVELFVRDGEQVKRGQQ
LARFTGPVKSLLSGERVLLNLLQRMCGIATLTAKAVEELGDPSIRVCDTRKTAPGLRMFDKFAVRIGGGANHRFGLDDAL
MLKENHIAASTSIAAAIEKARAYAGPMAKIEVETTTLDEVKEAVAAQADVIMFDNATPEAIRTYLAYVPAGIKTEASGGI
TMANLRQFANTGVDFLSLGFLTHSVVALDLSMLIQKGEGQCK

Sequences:

>Translated_282_residues
MNPLKLDQQLRGFLAEDIGYGDRTAEALFTVERAEAVIVAKGEGIFAGTQVVNQLYALLDSDIEVELFVRDGEQVKRGQQ
LARFTGPVKSLLSGERVLLNLLQRMCGIATLTAKAVEELGDPSIRVCDTRKTAPGLRMFDKFAVRIGGGANHRFGLDDAL
MLKENHIAASTSIAAAIEKARAYAGPMAKIEVETTTLDEVKEAVAAQADVIMFDNATPEAIRTYLAYVPAGIKTEASGGI
TMANLRQFANTGVDFLSLGFLTHSVVALDLSMLIQKGEGQCK
>Mature_282_residues
MNPLKLDQQLRGFLAEDIGYGDRTAEALFTVERAEAVIVAKGEGIFAGTQVVNQLYALLDSDIEVELFVRDGEQVKRGQQ
LARFTGPVKSLLSGERVLLNLLQRMCGIATLTAKAVEELGDPSIRVCDTRKTAPGLRMFDKFAVRIGGGANHRFGLDDAL
MLKENHIAASTSIAAAIEKARAYAGPMAKIEVETTTLDEVKEAVAAQADVIMFDNATPEAIRTYLAYVPAGIKTEASGGI
TMANLRQFANTGVDFLSLGFLTHSVVALDLSMLIQKGEGQCK

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=277, Percent_Identity=35.0180505415162, Blast_Score=147, Evalue=8e-36,
Organism=Escherichia coli, GI1786299, Length=265, Percent_Identity=42.6415094339623, Blast_Score=182, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6321162, Length=279, Percent_Identity=31.5412186379928, Blast_Score=137, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30365; Mature: 30365

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPLKLDQQLRGFLAEDIGYGDRTAEALFTVERAEAVIVAKGEGIFAGTQVVNQLYALLD
CCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHC
SDIEVELFVRDGEQVKRGQQLARFTGPVKSLLSGERVLLNLLQRMCGIATLTAKAVEELG
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHC
DPSIRVCDTRKTAPGLRMFDKFAVRIGGGANHRFGLDDALMLKENHIAASTSIAAAIEKA
CCCEEEECCCCCCCCHHHHHHHHHEECCCCCCCCCCCCHHEEECCCCHHHHHHHHHHHHH
RAYAGPMAKIEVETTTLDEVKEAVAAQADVIMFDNATPEAIRTYLAYVPAGIKTEASGGI
HHHCCCCEEEEEECCCHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHCCCCCCCCCCCCE
TMANLRQFANTGVDFLSLGFLTHSVVALDLSMLIQKGEGQCK
EHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNPLKLDQQLRGFLAEDIGYGDRTAEALFTVERAEAVIVAKGEGIFAGTQVVNQLYALLD
CCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHC
SDIEVELFVRDGEQVKRGQQLARFTGPVKSLLSGERVLLNLLQRMCGIATLTAKAVEELG
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHC
DPSIRVCDTRKTAPGLRMFDKFAVRIGGGANHRFGLDDALMLKENHIAASTSIAAAIEKA
CCCEEEECCCCCCCCHHHHHHHHHEECCCCCCCCCCCCHHEEECCCCHHHHHHHHHHHHH
RAYAGPMAKIEVETTTLDEVKEAVAAQADVIMFDNATPEAIRTYLAYVPAGIKTEASGGI
HHHCCCCEEEEEECCCHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHCCCCCCCCCCCCE
TMANLRQFANTGVDFLSLGFLTHSVVALDLSMLIQKGEGQCK
EHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8444804; 9298659 [H]