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The map label for this gene is pgcA [H]

Identifier: 56963264

GI number: 56963264

Start: 1621437

End: 1623176

Strand: Direct

Name: pgcA [H]

Synonym: ABC1499

Alternate gene names: 56963264

Gene position: 1621437-1623176 (Clockwise)

Preceding gene: 56963263

Following gene: 56963265

Centisome position: 37.67

GC content: 46.55

Gene sequence:

>1740_bases
TTGAATATTGTGGAGAAAGTGGAACGCTGGAACCAATTTGCACAATTAGAACCAGATGTGCGTCAACAATTGGACGCCAT
TTTGGATAATGATAAGGCGCTTGAAGATTGTTTTTACCGGGAACTTGCCTTTGGGACAGGAGGCATGCGAGGGGAAATTG
GGCCAGGACCAAACCGGATGAATACATATACTGTTCGAAAAGCAGCCGAAGGACTGGCCCGCTTTATTGAAAAACGAGGC
GAGACGGCGAAAAGCAAAGGAGTGGCGATCGCTTTTGATTCCCGCCATAAGTCGGCAAAGTTTGCTCATGAAGCAGCAAT
CACGTTAGGCGCTCATGGCATTAAAGCGTACGTTTTCGAAAGTTTGCGGCCAACGCCAGAATTGTCGTTTGCCGTCCGTT
ATCTCGGGGCTGAAGCGGGCATTGTCATTACCGCTTCTCATAACCCGCCTGAATATAATGGATTTAAAGTATACGGCTCA
GATGGCTGCCAATTCCCGCCTGCCCCTGCAGAAGAGCTTGTTGCTTGTGTGCAATCAATCGAAGATGAATTGGCTATTGA
AGTTGGCGATGAAGAGGAATTGAAAGCAGCACAGTTATACGAGCTCATCTCCACTGAAATTGACGATGCTTATAACGATC
AATTGAAGACGATTTTGCTTCAGCCTGAAATGGACAAGCAGTATGGCGATGAGTTGGCCATTGTGTTTACACCGCTCCAT
GGCACAGCGAATGTTGCGGTTAGGCGCGCCCTAAAAGAAAGCGGGTTTACAAACGTTACAGTGGTGGCTGAACAAGAGCA
ACCTGATCCTGATTTTTCAACTGTTTCTTCACCCAACCCAGAGGAACATGCAGCTTTTACATTGGCGATGGACTATGGGG
AGCGCCAAGAGGCAGATCTTTTGCTTGCTACAGACCCGGATGCAGACCGAGTAGGGCTTGCAGTGAAAGATGACGAGGGA
AACTACGTTGTCTTGACTGGAAACCAAACTGGCGCGCTCTTGCTTGACTATCTTCTCGAAACACGCCAGCAAAAGGGGAC
GCTTCCGCAAAATGGCATAGTGCTCAAGACGATTGTCACGTCTGAACTAGGCCGAGCAGTTGCTGATGCTTACGGGCTGA
CAACCATCGATACATTAACAGGCTTCAAGTTTATCGGCGAAAAGATGGGCGAATATGAACGTTCTGGTGAACATACATTT
TTGTTCGGCTATGAAGAAAGCTATGGCTATTTAATAGGTGATTTCGTCCGCGATAAAGATGCTATACAAGCTTGCCTGTT
TGCTGCTGAGTTGGCACTCCATTATAAGCGTAAAGGCATGACGGTTTATGAAGCAATGCAGCAAGTTTATCGCAAGTACG
GCTATTACCGTGAAGGGTTGCAATCATTAACGTTAAAAGGAAAAGAAGGGGCAGAAAAAATTGCTTCTATTCTTGCCTCT
CTCCGTCAAGAAGCGCCTACACATATGGCTAGCAAGCTCATTACAACAGTCGAAGATTTTGAATCGAGACAAGCGCTTGC
CACAGCAACCGGAGAACGGACAGCGATTGAGTTACCAGCATCGAATGTACTGAAGTACACACTTGAGGACGGTTCGTGGT
TCTGTGTGCGTCCTTCTGGAACAGAACCTAAAGTGAAGTTTTATTTTGGTGTTGTCGGCTCTAGCAATGAAGAGAGCGAA
CAAAAACTGACTCAGTTGCAACAAGCGGTCATGTCTTATATGGAAGCTTTTATTTCTTAA

Upstream 100 bases:

>100_bases
TGATCAAGCCTGCAAGCAGGTAAGCCGTTTTTTTGCTGGCAAACCAGTGGAATGCTGTGTAAAATGATAGCGTAGAGCAG
TTTTTATGGGAGGGACTCTT

Downstream 100 bases:

>100_bases
CATTGCCCTTGCGTACAGGCTTGCTGTACGCCAAGGGTTTTTTCTTCGTTCATGTTCCCCCGCTGCTGTTCATAGAATAG
GAAGACAACGAAGGAGGGAG

Product: phosphomannomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 579; Mature: 579

Protein sequence:

>579_residues
MNIVEKVERWNQFAQLEPDVRQQLDAILDNDKALEDCFYRELAFGTGGMRGEIGPGPNRMNTYTVRKAAEGLARFIEKRG
ETAKSKGVAIAFDSRHKSAKFAHEAAITLGAHGIKAYVFESLRPTPELSFAVRYLGAEAGIVITASHNPPEYNGFKVYGS
DGCQFPPAPAEELVACVQSIEDELAIEVGDEEELKAAQLYELISTEIDDAYNDQLKTILLQPEMDKQYGDELAIVFTPLH
GTANVAVRRALKESGFTNVTVVAEQEQPDPDFSTVSSPNPEEHAAFTLAMDYGERQEADLLLATDPDADRVGLAVKDDEG
NYVVLTGNQTGALLLDYLLETRQQKGTLPQNGIVLKTIVTSELGRAVADAYGLTTIDTLTGFKFIGEKMGEYERSGEHTF
LFGYEESYGYLIGDFVRDKDAIQACLFAAELALHYKRKGMTVYEAMQQVYRKYGYYREGLQSLTLKGKEGAEKIASILAS
LRQEAPTHMASKLITTVEDFESRQALATATGERTAIELPASNVLKYTLEDGSWFCVRPSGTEPKVKFYFGVVGSSNEESE
QKLTQLQQAVMSYMEAFIS

Sequences:

>Translated_579_residues
MNIVEKVERWNQFAQLEPDVRQQLDAILDNDKALEDCFYRELAFGTGGMRGEIGPGPNRMNTYTVRKAAEGLARFIEKRG
ETAKSKGVAIAFDSRHKSAKFAHEAAITLGAHGIKAYVFESLRPTPELSFAVRYLGAEAGIVITASHNPPEYNGFKVYGS
DGCQFPPAPAEELVACVQSIEDELAIEVGDEEELKAAQLYELISTEIDDAYNDQLKTILLQPEMDKQYGDELAIVFTPLH
GTANVAVRRALKESGFTNVTVVAEQEQPDPDFSTVSSPNPEEHAAFTLAMDYGERQEADLLLATDPDADRVGLAVKDDEG
NYVVLTGNQTGALLLDYLLETRQQKGTLPQNGIVLKTIVTSELGRAVADAYGLTTIDTLTGFKFIGEKMGEYERSGEHTF
LFGYEESYGYLIGDFVRDKDAIQACLFAAELALHYKRKGMTVYEAMQQVYRKYGYYREGLQSLTLKGKEGAEKIASILAS
LRQEAPTHMASKLITTVEDFESRQALATATGERTAIELPASNVLKYTLEDGSWFCVRPSGTEPKVKFYFGVVGSSNEESE
QKLTQLQQAVMSYMEAFIS
>Mature_579_residues
MNIVEKVERWNQFAQLEPDVRQQLDAILDNDKALEDCFYRELAFGTGGMRGEIGPGPNRMNTYTVRKAAEGLARFIEKRG
ETAKSKGVAIAFDSRHKSAKFAHEAAITLGAHGIKAYVFESLRPTPELSFAVRYLGAEAGIVITASHNPPEYNGFKVYGS
DGCQFPPAPAEELVACVQSIEDELAIEVGDEEELKAAQLYELISTEIDDAYNDQLKTILLQPEMDKQYGDELAIVFTPLH
GTANVAVRRALKESGFTNVTVVAEQEQPDPDFSTVSSPNPEEHAAFTLAMDYGERQEADLLLATDPDADRVGLAVKDDEG
NYVVLTGNQTGALLLDYLLETRQQKGTLPQNGIVLKTIVTSELGRAVADAYGLTTIDTLTGFKFIGEKMGEYERSGEHTF
LFGYEESYGYLIGDFVRDKDAIQACLFAAELALHYKRKGMTVYEAMQQVYRKYGYYREGLQSLTLKGKEGAEKIASILAS
LRQEAPTHMASKLITTVEDFESRQALATATGERTAIELPASNVLKYTLEDGSWFCVRPSGTEPKVKFYFGVVGSSNEESE
QKLTQLQQAVMSYMEAFIS

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=567, Percent_Identity=32.2751322751323, Blast_Score=289, Evalue=6e-78,
Organism=Homo sapiens, GI31377548, Length=596, Percent_Identity=30.3691275167785, Blast_Score=262, Evalue=7e-70,
Organism=Escherichia coli, GI1789566, Length=413, Percent_Identity=26.3922518159806, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71993870, Length=560, Percent_Identity=31.25, Blast_Score=249, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI71993878, Length=304, Percent_Identity=34.8684210526316, Blast_Score=165, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6323934, Length=570, Percent_Identity=29.2982456140351, Blast_Score=202, Evalue=9e-53,
Organism=Drosophila melanogaster, GI20129809, Length=592, Percent_Identity=29.5608108108108, Blast_Score=258, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24651977, Length=545, Percent_Identity=28.9908256880734, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24653722, Length=590, Percent_Identity=28.135593220339, Blast_Score=228, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 63968; Mature: 63968

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIVEKVERWNQFAQLEPDVRQQLDAILDNDKALEDCFYRELAFGTGGMRGEIGPGPNRM
CCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NTYTVRKAAEGLARFIEKRGETAKSKGVAIAFDSRHKSAKFAHEAAITLGAHGIKAYVFE
CHHHHHHHHHHHHHHHHHCCCCHHHCCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHH
SLRPTPELSFAVRYLGAEAGIVITASHNPPEYNGFKVYGSDGCQFPPAPAEELVACVQSI
HCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHH
EDELAIEVGDEEELKAAQLYELISTEIDDAYNDQLKTILLQPEMDKQYGDELAIVFTPLH
HHHHEEEECCHHHHHHHHHHHHHHHHHCHHHHCCEEEEEECCCCCHHCCCCEEEEEECCC
GTANVAVRRALKESGFTNVTVVAEQEQPDPDFSTVSSPNPEEHAAFTLAMDYGERQEADL
CCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCHHCEEEEEECCCCCCCCCE
LLATDPDADRVGLAVKDDEGNYVVLTGNQTGALLLDYLLETRQQKGTLPQNGIVLKTIVT
EEEECCCCCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEEEHHHH
SELGRAVADAYGLTTIDTLTGFKFIGEKMGEYERSGEHTFLFGYEESYGYLIGDFVRDKD
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHCCHH
AIQACLFAAELALHYKRKGMTVYEAMQQVYRKYGYYREGLQSLTLKGKEGAEKIASILAS
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHH
LRQEAPTHMASKLITTVEDFESRQALATATGERTAIELPASNVLKYTLEDGSWFCVRPSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCEEEECCCC
TEPKVKFYFGVVGSSNEESEQKLTQLQQAVMSYMEAFIS
CCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNIVEKVERWNQFAQLEPDVRQQLDAILDNDKALEDCFYRELAFGTGGMRGEIGPGPNRM
CCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NTYTVRKAAEGLARFIEKRGETAKSKGVAIAFDSRHKSAKFAHEAAITLGAHGIKAYVFE
CHHHHHHHHHHHHHHHHHCCCCHHHCCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHH
SLRPTPELSFAVRYLGAEAGIVITASHNPPEYNGFKVYGSDGCQFPPAPAEELVACVQSI
HCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHH
EDELAIEVGDEEELKAAQLYELISTEIDDAYNDQLKTILLQPEMDKQYGDELAIVFTPLH
HHHHEEEECCHHHHHHHHHHHHHHHHHCHHHHCCEEEEEECCCCCHHCCCCEEEEEECCC
GTANVAVRRALKESGFTNVTVVAEQEQPDPDFSTVSSPNPEEHAAFTLAMDYGERQEADL
CCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCHHCEEEEEECCCCCCCCCE
LLATDPDADRVGLAVKDDEGNYVVLTGNQTGALLLDYLLETRQQKGTLPQNGIVLKTIVT
EEEECCCCCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEEEHHHH
SELGRAVADAYGLTTIDTLTGFKFIGEKMGEYERSGEHTFLFGYEESYGYLIGDFVRDKD
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHCCHH
AIQACLFAAELALHYKRKGMTVYEAMQQVYRKYGYYREGLQSLTLKGKEGAEKIASILAS
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHH
LRQEAPTHMASKLITTVEDFESRQALATATGERTAIELPASNVLKYTLEDGSWFCVRPSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCEEEECCCC
TEPKVKFYFGVVGSSNEESEQKLTQLQQAVMSYMEAFIS
CCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]