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The map label for this gene is pbpE [H]

Identifier: 56963167

GI number: 56963167

Start: 1508611

End: 1509996

Strand: Direct

Name: pbpE [H]

Synonym: ABC1396

Alternate gene names: 56963167

Gene position: 1508611-1509996 (Clockwise)

Preceding gene: 56963166

Following gene: 56963169

Centisome position: 35.05

GC content: 47.4

Gene sequence:

>1386_bases
GTGAAAAAAGAAAAGGTGGAACAACAATTCAAGGCATTATTCGAAGACGTCAAACAGCAAGGAAGTTTCAATGGTGTTGT
TCTTGTAGCTGTTGGTGGGGAAGCAATTTTTTGTGAAGCGATGGGGGTAGCAGAATACTACGACGGTAGCGCACGCGATT
TAACAACGGACTCCATGTTTGAACTCGCTTCTGTATCCAAACCGATTACCGCTTTAGGTATTATCCGTTTGCAGCAACTG
GGGCAATTGCACTGCGATGATCTGATCGCTAATTGGATTCCCGAACTGCCGTATCCAGGGATTACGATACGGCATCTGTT
AAACCATACATCAGGCTTGCCTGATTACATGGAGTTATTTGCAAACGTGTGGGATCCTACGCGTTATGCTCGCAATGAGG
ATGTGTTGCAAATGCTGATTAAGCATCAGCCTGATCCGTTGTTCGCTCCTAATGACAGTTGGATGTACAGCAACACGGGC
TATATTATGCTAGCTATCCTGATTGAGAAGATTAGTGGCAAGCGTTATGGCGACTTTTTGGACGAGCAGATCTTTCAACC
GCTTGGAATGACGCGAACGCAAGTGTATAATCGCCGGGTGGATCCGGGTCCTGTGCCTGATGATTATGCTTGGGGATACG
TCTATCGGATTGGACATGGCGGATATGTGCTGCCTGATGAAGTGCCTGAACTACATTACGTACACTATTTAGACGGCTTG
CAAGGAGATGGAATGGTCAACAGTACAGTGGGCGATTTGTTGCGACTGGATCGAGCCTTGTATAATGATGAGTTTGTTCG
TCCAATGCTGCGTCAACTCATGTTTTCGCCGGTGAAGATGAATAATGGCGAGACATTCAATTATGGGATGGGTTGGCTGA
TCGAGCGTGACGAGCAGCTGGGGCGTTTCGTCCACCATACCGGGGGATGGCCGGGCTACTCTACATGGTTTAAACGTTAT
ATCGATCGAGATATGACATTGATTATGCTGCAAAACGGAGAGCGCGACCATGCTTATACGCAGCAACTAGTGAAGAGCAT
CGAACAGATTATGGCTGGAGAAGAATACGATGTACCGAGGCCTTTGGAGACAAAGAAAGTGATTCCGCTTGACCCAAAGA
ATGTGGAAACGCTGCTTGGGAAGTACAGATTTGCCAGCGAGACGGAAGGTTCCCTTGATGTAGACGTATATATGGAACAG
GATAAGCTCTATATGAAGTTGGACAATGGAATGCGGTTGTCATTGCTGCCACTGACATCGACCCGTTATTATGAAGAACA
GACGGCGACGGAGCTTGAGTTTCTTGACAGTGAAGATGGCAAGGGCATGCGTCTGTTCTGGTATACAGAGGATGAGCCAG
AAGTGGCTGAACGGGTCGGCTGTTGA

Upstream 100 bases:

>100_bases
CAAGGCGAGCTAACAGCGAGTGCTCCTATTATTACCCGAGAATCATGAAAGTTGCGTAGAATGGGATCGTTCACTCACAA
TTAAACGGAGGTGCAAAATA

Downstream 100 bases:

>100_bases
ACACCCTTCCTGAAAAATGACCTGCAAAACTGCAGTCTCTGACGAATCAGTCATTGCGCTGCAGCTGCAGGCTATAAATT
TGTAAAAAACAACTCCGGCT

Product: penicillin-binding protein 4

Products: NA

Alternate protein names: PBP 4*; PBP 4A; Penicillin-binding protein E [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MKKEKVEQQFKALFEDVKQQGSFNGVVLVAVGGEAIFCEAMGVAEYYDGSARDLTTDSMFELASVSKPITALGIIRLQQL
GQLHCDDLIANWIPELPYPGITIRHLLNHTSGLPDYMELFANVWDPTRYARNEDVLQMLIKHQPDPLFAPNDSWMYSNTG
YIMLAILIEKISGKRYGDFLDEQIFQPLGMTRTQVYNRRVDPGPVPDDYAWGYVYRIGHGGYVLPDEVPELHYVHYLDGL
QGDGMVNSTVGDLLRLDRALYNDEFVRPMLRQLMFSPVKMNNGETFNYGMGWLIERDEQLGRFVHHTGGWPGYSTWFKRY
IDRDMTLIMLQNGERDHAYTQQLVKSIEQIMAGEEYDVPRPLETKKVIPLDPKNVETLLGKYRFASETEGSLDVDVYMEQ
DKLYMKLDNGMRLSLLPLTSTRYYEEQTATELEFLDSEDGKGMRLFWYTEDEPEVAERVGC

Sequences:

>Translated_461_residues
MKKEKVEQQFKALFEDVKQQGSFNGVVLVAVGGEAIFCEAMGVAEYYDGSARDLTTDSMFELASVSKPITALGIIRLQQL
GQLHCDDLIANWIPELPYPGITIRHLLNHTSGLPDYMELFANVWDPTRYARNEDVLQMLIKHQPDPLFAPNDSWMYSNTG
YIMLAILIEKISGKRYGDFLDEQIFQPLGMTRTQVYNRRVDPGPVPDDYAWGYVYRIGHGGYVLPDEVPELHYVHYLDGL
QGDGMVNSTVGDLLRLDRALYNDEFVRPMLRQLMFSPVKMNNGETFNYGMGWLIERDEQLGRFVHHTGGWPGYSTWFKRY
IDRDMTLIMLQNGERDHAYTQQLVKSIEQIMAGEEYDVPRPLETKKVIPLDPKNVETLLGKYRFASETEGSLDVDVYMEQ
DKLYMKLDNGMRLSLLPLTSTRYYEEQTATELEFLDSEDGKGMRLFWYTEDEPEVAERVGC
>Mature_461_residues
MKKEKVEQQFKALFEDVKQQGSFNGVVLVAVGGEAIFCEAMGVAEYYDGSARDLTTDSMFELASVSKPITALGIIRLQQL
GQLHCDDLIANWIPELPYPGITIRHLLNHTSGLPDYMELFANVWDPTRYARNEDVLQMLIKHQPDPLFAPNDSWMYSNTG
YIMLAILIEKISGKRYGDFLDEQIFQPLGMTRTQVYNRRVDPGPVPDDYAWGYVYRIGHGGYVLPDEVPELHYVHYLDGL
QGDGMVNSTVGDLLRLDRALYNDEFVRPMLRQLMFSPVKMNNGETFNYGMGWLIERDEQLGRFVHHTGGWPGYSTWFKRY
IDRDMTLIMLQNGERDHAYTQQLVKSIEQIMAGEEYDVPRPLETKKVIPLDPKNVETLLGKYRFASETEGSLDVDVYMEQ
DKLYMKLDNGMRLSLLPLTSTRYYEEQTATELEFLDSEDGKGMRLFWYTEDEPEVAERVGC

Specific function: Probably involved in peptidoglycan modification during cortex synthesis [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-lactamase family [H]

Homologues:

Organism=Escherichia coli, GI87082101, Length=351, Percent_Identity=24.7863247863248, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI115533026, Length=345, Percent_Identity=24.0579710144928, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17550934, Length=154, Percent_Identity=31.1688311688312, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466
- InterPro:   IPR021860 [H]

Pfam domain/function: PF00144 Beta-lactamase; PF11954 DUF3471 [H]

EC number: NA

Molecular weight: Translated: 53075; Mature: 53075

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKEKVEQQFKALFEDVKQQGSFNGVVLVAVGGEAIFCEAMGVAEYYDGSARDLTTDSMF
CCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEHHCHHHHCCCCCCCCCHHHHH
ELASVSKPITALGIIRLQQLGQLHCDDLIANWIPELPYPGITIRHLLNHTSGLPDYMELF
HHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHH
ANVWDPTRYARNEDVLQMLIKHQPDPLFAPNDSWMYSNTGYIMLAILIEKISGKRYGDFL
HHHCCHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEECCCCHHHHHHHHHHHCCCHHHHHH
DEQIFQPLGMTRTQVYNRRVDPGPVPDDYAWGYVYRIGHGGYVLPDEVPELHYVHYLDGL
HHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEECCCCCCCCEEHHHHCCC
QGDGMVNSTVGDLLRLDRALYNDEFVRPMLRQLMFSPVKMNNGETFNYGMGWLIERDEQL
CCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEECCCCCEEECCCCEEEECHHHH
GRFVHHTGGWPGYSTWFKRYIDRDMTLIMLQNGERDHAYTQQLVKSIEQIMAGEEYDVPR
HHHHHHCCCCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCC
PLETKKVIPLDPKNVETLLGKYRFASETEGSLDVDVYMEQDKLYMKLDNGMRLSLLPLTS
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEEECCEEEEEECCCCEEEEEECCC
TRYYEEQTATELEFLDSEDGKGMRLFWYTEDEPEVAERVGC
CHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHCCC
>Mature Secondary Structure
MKKEKVEQQFKALFEDVKQQGSFNGVVLVAVGGEAIFCEAMGVAEYYDGSARDLTTDSMF
CCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEHHCHHHHCCCCCCCCCHHHHH
ELASVSKPITALGIIRLQQLGQLHCDDLIANWIPELPYPGITIRHLLNHTSGLPDYMELF
HHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHH
ANVWDPTRYARNEDVLQMLIKHQPDPLFAPNDSWMYSNTGYIMLAILIEKISGKRYGDFL
HHHCCHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEECCCCHHHHHHHHHHHCCCHHHHHH
DEQIFQPLGMTRTQVYNRRVDPGPVPDDYAWGYVYRIGHGGYVLPDEVPELHYVHYLDGL
HHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEECCCCCCCCEEHHHHCCC
QGDGMVNSTVGDLLRLDRALYNDEFVRPMLRQLMFSPVKMNNGETFNYGMGWLIERDEQL
CCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEECCCCCEEECCCCEEEECHHHH
GRFVHHTGGWPGYSTWFKRYIDRDMTLIMLQNGERDHAYTQQLVKSIEQIMAGEEYDVPR
HHHHHHCCCCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCC
PLETKKVIPLDPKNVETLLGKYRFASETEGSLDVDVYMEQDKLYMKLDNGMRLSLLPLTS
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEEECCEEEEEECCCCEEEEEECCC
TRYYEEQTATELEFLDSEDGKGMRLFWYTEDEPEVAERVGC
CHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8491712; 9384377 [H]