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The map label for this gene is yfhQ [H]

Identifier: 56963081

GI number: 56963081

Start: 1428438

End: 1429595

Strand: Direct

Name: yfhQ [H]

Synonym: ABC1309

Alternate gene names: 56963081

Gene position: 1428438-1429595 (Clockwise)

Preceding gene: 56963077

Following gene: 56963082

Centisome position: 33.19

GC content: 44.39

Gene sequence:

>1158_bases
GTGGAAAATAAGCGTATCTTCATCATGAAGGCATTTGGTTTTCAGGTCAAGTCAAAGGGATATCAGGTGAGAAGAGTGAC
AGAAACATACAATGAAAACATATCATACAGCGATTTTAGGCGCCAGCTAATCGAGTGGTATCAGGCTCATAAACGGGAAT
TGCCTTGGCGTGAATCGAACGATCCCTACCATATATGGGTGTCAGAAATTATGCTGCAACAAACAAGAGTCGATACGGTT
ATTCCTTACTATGAACAATTCATGCGTAAATTTCCTGAGATGGAAGACCTTGCTTATGCTGAAGAGGAAGAGATATTGAA
AGTATGGGAAGGGCTTGGCTATTATTCCCGTGTCCGCAATTTACAGGCCGCTGTGAGGGAAGTCGTAGAACACTATGGCA
GCGTCGTGCCCGATACGCGCAAGGAAATCGAACAATTAAAAGGAGTCGGCCCCTATACCGCCGGTGCGATTTTAAGTATT
GCTTATGCAAAAGCAGAACCTGCCGTTGACGGCAATGTGATGCGTGTATTGTCGCGCGTTTTTTGCATGGAAGATGATAT
TGGCAAACCGCAAACGAGAAAAAAGCATGAAGCGATTTTATATGAACTAATTGACAAGAGCGACCCATCAAGTTTTAACC
AAGGATTAATGGAACTAGGCGCTCTTGTGTGTACACCGACTTCGCCAGGCTGCCTGCTTTGTCCCGTGCGAACGCAATGC
CTCGCCTATGAACGAGGACAACAAGAGCGGCTGCCGATAAAAATGAAAAAGAAAAAAGCAAAATCGATTGAGCTTGAATC
GTTTTTATTGAAAACAGAAAAGGGCGAACTGCTGATTGAAAAGCGTCCAGACAAGGGGCTATTAGCTGGCTTATGGCAGC
TTCCTGTGCTTGAAGGACGGTTTGATCCAGGGGAGCGCCAACAAAAGTTGGCTGAAAAATACCATATAGAAGCGGAGCCC
AGTGCTGCTAATTTTCAAGTGAAACATATATTTAGCCATTTAATTTGGGAAATTGAGTTGTACGTAGGCAGGGCGAATCG
AAATGGTGAACTACCGGCGAATTGCCGCATCATAAAAGCGGAAGAACTAGAGCAGTATGCCTTTCCAGTTTCACAGCAAA
AATTGTTGAATCATTGTTTGGAGGAGGGATGGCTATGA

Upstream 100 bases:

>100_bases
ATACGAAGAGAGCATCCTCCTTTTGCAACCAATCATGCACAATTTCGTAATTGGCGGCTGTACCTAAAAGTAATTTATGC
TATAGTTATACCCGACGTTA

Downstream 100 bases:

>100_bases
ATTTGGGCTTAACGGGAAAACGCGTATTCGTAACAGGAGGAACAAAAGGGATTGGCAAAGCAATTGCCAATGCTTTTGCT
GCAGAAGGAGCCAAAGTGGC

Product: A/G-specific adenine DNA glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MENKRIFIMKAFGFQVKSKGYQVRRVTETYNENISYSDFRRQLIEWYQAHKRELPWRESNDPYHIWVSEIMLQQTRVDTV
IPYYEQFMRKFPEMEDLAYAEEEEILKVWEGLGYYSRVRNLQAAVREVVEHYGSVVPDTRKEIEQLKGVGPYTAGAILSI
AYAKAEPAVDGNVMRVLSRVFCMEDDIGKPQTRKKHEAILYELIDKSDPSSFNQGLMELGALVCTPTSPGCLLCPVRTQC
LAYERGQQERLPIKMKKKKAKSIELESFLLKTEKGELLIEKRPDKGLLAGLWQLPVLEGRFDPGERQQKLAEKYHIEAEP
SAANFQVKHIFSHLIWEIELYVGRANRNGELPANCRIIKAEELEQYAFPVSQQKLLNHCLEEGWL

Sequences:

>Translated_385_residues
MENKRIFIMKAFGFQVKSKGYQVRRVTETYNENISYSDFRRQLIEWYQAHKRELPWRESNDPYHIWVSEIMLQQTRVDTV
IPYYEQFMRKFPEMEDLAYAEEEEILKVWEGLGYYSRVRNLQAAVREVVEHYGSVVPDTRKEIEQLKGVGPYTAGAILSI
AYAKAEPAVDGNVMRVLSRVFCMEDDIGKPQTRKKHEAILYELIDKSDPSSFNQGLMELGALVCTPTSPGCLLCPVRTQC
LAYERGQQERLPIKMKKKKAKSIELESFLLKTEKGELLIEKRPDKGLLAGLWQLPVLEGRFDPGERQQKLAEKYHIEAEP
SAANFQVKHIFSHLIWEIELYVGRANRNGELPANCRIIKAEELEQYAFPVSQQKLLNHCLEEGWL
>Mature_385_residues
MENKRIFIMKAFGFQVKSKGYQVRRVTETYNENISYSDFRRQLIEWYQAHKRELPWRESNDPYHIWVSEIMLQQTRVDTV
IPYYEQFMRKFPEMEDLAYAEEEEILKVWEGLGYYSRVRNLQAAVREVVEHYGSVVPDTRKEIEQLKGVGPYTAGAILSI
AYAKAEPAVDGNVMRVLSRVFCMEDDIGKPQTRKKHEAILYELIDKSDPSSFNQGLMELGALVCTPTSPGCLLCPVRTQC
LAYERGQQERLPIKMKKKKAKSIELESFLLKTEKGELLIEKRPDKGLLAGLWQLPVLEGRFDPGERQQKLAEKYHIEAEP
SAANFQVKHIFSHLIWEIELYVGRANRNGELPANCRIIKAEELEQYAFPVSQQKLLNHCLEEGWL

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=411, Percent_Identity=34.5498783454988, Blast_Score=218, Evalue=5e-57,
Organism=Homo sapiens, GI6912520, Length=411, Percent_Identity=34.5498783454988, Blast_Score=218, Evalue=5e-57,
Organism=Homo sapiens, GI115298654, Length=404, Percent_Identity=35.1485148514851, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI115298652, Length=404, Percent_Identity=35.1485148514851, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI190358497, Length=411, Percent_Identity=34.5498783454988, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI115298650, Length=411, Percent_Identity=34.5498783454988, Blast_Score=218, Evalue=7e-57,
Organism=Escherichia coli, GI1789331, Length=307, Percent_Identity=39.7394136807818, Blast_Score=219, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 44755; Mature: 44755

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00764 ENDONUCLEASE_III_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENKRIFIMKAFGFQVKSKGYQVRRVTETYNENISYSDFRRQLIEWYQAHKRELPWRESN
CCCCEEEEEEECCCEECCCCCEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
DPYHIWVSEIMLQQTRVDTVIPYYEQFMRKFPEMEDLAYAEEEEILKVWEGLGYYSRVRN
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCCHHHHHHH
LQAAVREVVEHYGSVVPDTRKEIEQLKGVGPYTAGAILSIAYAKAEPAVDGNVMRVLSRV
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
FCMEDDIGKPQTRKKHEAILYELIDKSDPSSFNQGLMELGALVCTPTSPGCLLCPVRTQC
HHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEECCCCCCEEECCHHHHH
LAYERGQQERLPIKMKKKKAKSIELESFLLKTEKGELLIEKRPDKGLLAGLWQLPVLEGR
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCCCC
FDPGERQQKLAEKYHIEAEPSAANFQVKHIFSHLIWEIELYVGRANRNGELPANCRIIKA
CCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCEEEEEH
EELEQYAFPVSQQKLLNHCLEEGWL
HHHHHHHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MENKRIFIMKAFGFQVKSKGYQVRRVTETYNENISYSDFRRQLIEWYQAHKRELPWRESN
CCCCEEEEEEECCCEECCCCCEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
DPYHIWVSEIMLQQTRVDTVIPYYEQFMRKFPEMEDLAYAEEEEILKVWEGLGYYSRVRN
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCCHHHHHHH
LQAAVREVVEHYGSVVPDTRKEIEQLKGVGPYTAGAILSIAYAKAEPAVDGNVMRVLSRV
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
FCMEDDIGKPQTRKKHEAILYELIDKSDPSSFNQGLMELGALVCTPTSPGCLLCPVRTQC
HHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEECCCCCCEEECCHHHHH
LAYERGQQERLPIKMKKKKAKSIELESFLLKTEKGELLIEKRPDKGLLAGLWQLPVLEGR
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCCCC
FDPGERQQKLAEKYHIEAEPSAANFQVKHIFSHLIWEIELYVGRANRNGELPANCRIIKA
CCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCEEEEEH
EELEQYAFPVSQQKLLNHCLEEGWL
HHHHHHHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]