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The map label for this gene is fruA [H]

Identifier: 56963043

GI number: 56963043

Start: 1392839

End: 1394731

Strand: Direct

Name: fruA [H]

Synonym: ABC1271

Alternate gene names: 56963043

Gene position: 1392839-1394731 (Clockwise)

Preceding gene: 56963042

Following gene: 56963045

Centisome position: 32.36

GC content: 47.49

Gene sequence:

>1893_bases
ATGAAAATTTCTGATTTGCTCAAGAAAGAAACAATGATTCTCGACTTGGCGTCAACGACGAAAGAAGCGGTTATTGATGA
ATTAATCGCCAAGCTTGGGGAAGCAGGGCGATTAAACGATGCAGAAGCGTACAAAAAAGCGATTTTGGCAAGGGAAGCGC
AAAGCACGACCGGCCTTGGCGACGGCATTGCGATTCCACATGCTAAAACGGCAGCTGTCAAAACGCCAGCGATTGCGTTT
GGCCGCTCGAAAGCAGGGATTGATTACGACGCATTGGACGGACAGCCAAGCCATCTATTTTTCATGATTGCTGCCTCTGA
AGGGGCAAACAATGAACATTTAGCAACGTTAGCAAAGCTGTCAACTTATTTAATGGACGACGATTTTCGAAAAGGCTTGC
TCAACGCAGCTTCATTGGATGACATTCTGGCATTGATTGATGAAAAGCAAGCAATGGAAGACAAAGAAGCGGAGCCAGAG
GAACAAACCGAAAGCGCTTCCGAAGATTCTGGCAAATTCATTCTCGCTGTGACTGGCTGTCCAACTGGGATTGCCCATAC
GTTTATGGCTGCCGATGCGATCAAGAAAGAAGCGACTGACCGCGGCTATAAAGTAAAGGTTGAGACAAACGGGTCTGGAG
GCGTGAAAAACCGTTTAAAAGCAGCGGAAATTGACGAAGCTGACGGCATCATTGTTGCTGCTGATACAAAAGTAGAAATG
GACCGTTTTAGCGGCAAACGCGTGGTCATTGCTCCAGTGGCAGATGGCGTCCGTAAGCCAGCAGAGTTAATTGATCGTTC
CCTTTCAGGAAAAGAACCTGTTTACCAAGGCAGTGGCGGCAAAGGCGAAAACGAGCAAAGCGAAGAGAAAAAATCAGGCG
GCGCTGCTATTTACAAGCATTTAATGAATGGCGTTTCCAATATGCTTCCATTTGTCATTGGCGGCGGAATTTTGATTGCC
TTAAGCTTTGTATTTGAGACAGCTTTCGGCGCAGATAACCCGATCCGCGAATTGTTAATGGCAATTGGTAGTGAGAATGC
ATTTGCACTCTTTATCCCTGTTCTTGCTGCGTTTATTGCAATGAGCATAGCCGACCGGCCAGGATTTGCCCCTGGTTTAA
TTGGCGGGTTTATGGCCGTAAATGGCCATTCTGGATTTTTAGGCGGCTTGCTCGCTGGATTTTTAGCAGGCTACTTAGCC
TTGTTTGTACGCAAATTGCTGTCTGGCATTCCTCAATCGCTTGAAGGGTTAAAAACGATCTTATTTACGCCTGTGTTAAA
TATTTTGTTTACAGGCACAATTATGTACTACTTAATTGCGCCCCTTGCTTGGGTGAACACAGGAATGCAAAATTGGCTAG
GCGACCTCGGCACAGGGAACATGGTCATTCTAGGCACGGTTCTTGGAATCATGATGGCGATTGACATGGGCGGTCCGATT
AATAAAGCAGCCTATACGTTTGGGATTGCGATGATTGATGCTGGCAACCTTGGGCCCCAGGCAGCAGTCATGGCTGCAGG
AATGGTGCCGCCACTAGGGATTGCCATCGCCACAACGTTTTGGAAGCATAAATTTACGAAGCAGCAACGAGAGTCAGGGC
GGACAAACTATGTCCTTGGCGCTTCTTTCATTACAGAAGGGGCGATTCCGTTTGCGGCGGCAGACCCAATCCGTGTTATT
TCGGCAAGCGTTGTCGGCGCCGCTGTGGCTGGCGGTTTAACCGGATTGTTCCATATACAGCTCCCTGCGCCACATGGAGG
CATTTTTACAATGTTCCTAGTCAATGAGAGCACATGGTCTTACATCGGCCTGTATGCGTTGGCTATCGCAATTGGCGCGA
TTGTGACTGGAATCATATATGGAATCATTAAAAAGCCAATTGAGAACAAGTAA

Upstream 100 bases:

>100_bases
GCGCTACAGCCTTTTCAACAGGCTTTGCTGAACGGACGACGATCGAAGCGCTCATGGACGAGGTAGCGGTCACTATTTAT
AGAGAGGGGTAAACAAAGGA

Downstream 100 bases:

>100_bases
CGAAAAGCCTGTTTTGACATAACGGTCAAAACAGGCTTTTTCACTAGGAGCAAATAATAAAAAAACCCAGGCCTTAGAAA
GCCTGAGCGTGGCTAAATCG

Product: PTS system, fructose-specific enzyme II, BC component

Products: NA

Alternate protein names: EIIABC-Fru; Fructose-specific phosphotransferase enzyme IIA component; EII-Fru; PTS system fructose-specific EIIA component; Fructose-specific phosphotransferase enzyme IIB component; EIII-Fru; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 630; Mature: 630

Protein sequence:

>630_residues
MKISDLLKKETMILDLASTTKEAVIDELIAKLGEAGRLNDAEAYKKAILAREAQSTTGLGDGIAIPHAKTAAVKTPAIAF
GRSKAGIDYDALDGQPSHLFFMIAASEGANNEHLATLAKLSTYLMDDDFRKGLLNAASLDDILALIDEKQAMEDKEAEPE
EQTESASEDSGKFILAVTGCPTGIAHTFMAADAIKKEATDRGYKVKVETNGSGGVKNRLKAAEIDEADGIIVAADTKVEM
DRFSGKRVVIAPVADGVRKPAELIDRSLSGKEPVYQGSGGKGENEQSEEKKSGGAAIYKHLMNGVSNMLPFVIGGGILIA
LSFVFETAFGADNPIRELLMAIGSENAFALFIPVLAAFIAMSIADRPGFAPGLIGGFMAVNGHSGFLGGLLAGFLAGYLA
LFVRKLLSGIPQSLEGLKTILFTPVLNILFTGTIMYYLIAPLAWVNTGMQNWLGDLGTGNMVILGTVLGIMMAIDMGGPI
NKAAYTFGIAMIDAGNLGPQAAVMAAGMVPPLGIAIATTFWKHKFTKQQRESGRTNYVLGASFITEGAIPFAAADPIRVI
SASVVGAAVAGGLTGLFHIQLPAPHGGIFTMFLVNESTWSYIGLYALAIAIGAIVTGIIYGIIKKPIENK

Sequences:

>Translated_630_residues
MKISDLLKKETMILDLASTTKEAVIDELIAKLGEAGRLNDAEAYKKAILAREAQSTTGLGDGIAIPHAKTAAVKTPAIAF
GRSKAGIDYDALDGQPSHLFFMIAASEGANNEHLATLAKLSTYLMDDDFRKGLLNAASLDDILALIDEKQAMEDKEAEPE
EQTESASEDSGKFILAVTGCPTGIAHTFMAADAIKKEATDRGYKVKVETNGSGGVKNRLKAAEIDEADGIIVAADTKVEM
DRFSGKRVVIAPVADGVRKPAELIDRSLSGKEPVYQGSGGKGENEQSEEKKSGGAAIYKHLMNGVSNMLPFVIGGGILIA
LSFVFETAFGADNPIRELLMAIGSENAFALFIPVLAAFIAMSIADRPGFAPGLIGGFMAVNGHSGFLGGLLAGFLAGYLA
LFVRKLLSGIPQSLEGLKTILFTPVLNILFTGTIMYYLIAPLAWVNTGMQNWLGDLGTGNMVILGTVLGIMMAIDMGGPI
NKAAYTFGIAMIDAGNLGPQAAVMAAGMVPPLGIAIATTFWKHKFTKQQRESGRTNYVLGASFITEGAIPFAAADPIRVI
SASVVGAAVAGGLTGLFHIQLPAPHGGIFTMFLVNESTWSYIGLYALAIAIGAIVTGIIYGIIKKPIENK
>Mature_630_residues
MKISDLLKKETMILDLASTTKEAVIDELIAKLGEAGRLNDAEAYKKAILAREAQSTTGLGDGIAIPHAKTAAVKTPAIAF
GRSKAGIDYDALDGQPSHLFFMIAASEGANNEHLATLAKLSTYLMDDDFRKGLLNAASLDDILALIDEKQAMEDKEAEPE
EQTESASEDSGKFILAVTGCPTGIAHTFMAADAIKKEATDRGYKVKVETNGSGGVKNRLKAAEIDEADGIIVAADTKVEM
DRFSGKRVVIAPVADGVRKPAELIDRSLSGKEPVYQGSGGKGENEQSEEKKSGGAAIYKHLMNGVSNMLPFVIGGGILIA
LSFVFETAFGADNPIRELLMAIGSENAFALFIPVLAAFIAMSIADRPGFAPGLIGGFMAVNGHSGFLGGLLAGFLAGYLA
LFVRKLLSGIPQSLEGLKTILFTPVLNILFTGTIMYYLIAPLAWVNTGMQNWLGDLGTGNMVILGTVLGIMMAIDMGGPI
NKAAYTFGIAMIDAGNLGPQAAVMAAGMVPPLGIAIATTFWKHKFTKQQRESGRTNYVLGASFITEGAIPFAAADPIRVI
SASVVGAAVAGGLTGLFHIQLPAPHGGIFTMFLVNESTWSYIGLYALAIAIGAIVTGIIYGIIKKPIENK

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=457, Percent_Identity=47.7024070021882, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1786951, Length=633, Percent_Identity=32.2274881516588, Blast_Score=335, Evalue=5e-93,
Organism=Escherichia coli, GI87082348, Length=461, Percent_Identity=32.9718004338395, Blast_Score=221, Evalue=9e-59,
Organism=Escherichia coli, GI1790386, Length=310, Percent_Identity=35.8064516129032, Blast_Score=175, Evalue=7e-45,
Organism=Escherichia coli, GI1788729, Length=395, Percent_Identity=28.8607594936709, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1790387, Length=94, Percent_Identity=40.4255319148936, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1788730, Length=95, Percent_Identity=41.0526315789474, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI48994992, Length=144, Percent_Identity=28.4722222222222, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI2367327, Length=135, Percent_Identity=25.1851851851852, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788726, Length=146, Percent_Identity=28.7671232876712, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789597, Length=162, Percent_Identity=28.3950617283951, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788494, Length=138, Percent_Identity=37.6811594202899, Blast_Score=63, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004715
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 66239; Mature: 66239

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00372 PTS_EIIA_TYPE_2_HIS ; PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISDLLKKETMILDLASTTKEAVIDELIAKLGEAGRLNDAEAYKKAILAREAQSTTGLG
CCHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCC
DGIAIPHAKTAAVKTPAIAFGRSKAGIDYDALDGQPSHLFFMIAASEGANNEHLATLAKL
CCEECCCCCHHHCCCCHHEECCCCCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHH
STYLMDDDFRKGLLNAASLDDILALIDEKQAMEDKEAEPEEQTESASEDSGKFILAVTGC
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCEEEEEECC
PTGIAHTFMAADAIKKEATDRGYKVKVETNGSGGVKNRLKAAEIDEADGIIVAADTKVEM
CHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHCCCCCCCCCCCCEEEEECCEEEH
DRFSGKRVVIAPVADGVRKPAELIDRSLSGKEPVYQGSGGKGENEQSEEKKSGGAAIYKH
HHCCCCEEEEEECHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHH
LMNGVSNMLPFVIGGGILIALSFVFETAFGADNPIRELLMAIGSENAFALFIPVLAAFIA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
MSIADRPGFAPGLIGGFMAVNGHSGFLGGLLAGFLAGYLALFVRKLLSGIPQSLEGLKTI
HHHHCCCCCCHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
LFTPVLNILFTGTIMYYLIAPLAWVNTGMQNWLGDLGTGNMVILGTVLGIMMAIDMGGPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCEEHHHHHHHHHHHHCCCCCC
NKAAYTFGIAMIDAGNLGPQAAVMAAGMVPPLGIAIATTFWKHKFTKQQRESGRTNYVLG
CHHHHHEEEEEEECCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
ASFITEGAIPFAAADPIRVISASVVGAAVAGGLTGLFHIQLPAPHGGIFTMFLVNESTWS
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEEECCCCHH
YIGLYALAIAIGAIVTGIIYGIIKKPIENK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKISDLLKKETMILDLASTTKEAVIDELIAKLGEAGRLNDAEAYKKAILAREAQSTTGLG
CCHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCC
DGIAIPHAKTAAVKTPAIAFGRSKAGIDYDALDGQPSHLFFMIAASEGANNEHLATLAKL
CCEECCCCCHHHCCCCHHEECCCCCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHH
STYLMDDDFRKGLLNAASLDDILALIDEKQAMEDKEAEPEEQTESASEDSGKFILAVTGC
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCEEEEEECC
PTGIAHTFMAADAIKKEATDRGYKVKVETNGSGGVKNRLKAAEIDEADGIIVAADTKVEM
CHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHCCCCCCCCCCCCEEEEECCEEEH
DRFSGKRVVIAPVADGVRKPAELIDRSLSGKEPVYQGSGGKGENEQSEEKKSGGAAIYKH
HHCCCCEEEEEECHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHH
LMNGVSNMLPFVIGGGILIALSFVFETAFGADNPIRELLMAIGSENAFALFIPVLAAFIA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
MSIADRPGFAPGLIGGFMAVNGHSGFLGGLLAGFLAGYLALFVRKLLSGIPQSLEGLKTI
HHHHCCCCCCHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
LFTPVLNILFTGTIMYYLIAPLAWVNTGMQNWLGDLGTGNMVILGTVLGIMMAIDMGGPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCEEHHHHHHHHHHHHCCCCCC
NKAAYTFGIAMIDAGNLGPQAAVMAAGMVPPLGIAIATTFWKHKFTKQQRESGRTNYVLG
CHHHHHEEEEEEECCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
ASFITEGAIPFAAADPIRVISASVVGAAVAGGLTGLFHIQLPAPHGGIFTMFLVNESTWS
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEEECCCCHH
YIGLYALAIAIGAIVTGIIYGIIKKPIENK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]